Motif ID: Tfap2a

Z-value: 0.841


Transcription factors associated with Tfap2a:

Gene SymbolEntrez IDGene Name
Tfap2a ENSMUSG00000021359.9 Tfap2a

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2amm10_v2_chr13_-_40733768_407338360.547.3e-03Click!


Activity profile for motif Tfap2a.

activity profile for motif Tfap2a


Sorted Z-values histogram for motif Tfap2a

Sorted Z-values for motif Tfap2a



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_21184103 2.219 ENSMUST00000115458.2
 Pde4a
phosphodiesterase 4A, cAMP specific
chr4_+_128883549 1.999 ENSMUST00000035667.8
 Trim62
tripartite motif-containing 62
chr2_+_172550991 1.955 ENSMUST00000170744.1
 Tfap2c
transcription factor AP-2, gamma
chr6_+_146888481 1.715 ENSMUST00000016631.7
ENSMUST00000111623.2
 Ppfibp1

PTPRF interacting protein, binding protein 1 (liprin beta 1)

chr19_+_59260878 1.594 ENSMUST00000026084.3
 Slc18a2
solute carrier family 18 (vesicular monoamine), member 2
chr5_+_114568016 1.588 ENSMUST00000043650.7
 Fam222a
family with sequence similarity 222, member A
chr10_+_100015817 1.516 ENSMUST00000130190.1
ENSMUST00000020129.7
 Kitl

kit ligand

chr18_+_60925612 1.412 ENSMUST00000102888.3
ENSMUST00000025519.4
 Camk2a

calcium/calmodulin-dependent protein kinase II alpha

chr1_-_75278345 1.363 ENSMUST00000039534.4
 Resp18
regulated endocrine-specific protein 18
chr2_-_172043466 1.322 ENSMUST00000087950.3
 Cbln4
cerebellin 4 precursor protein
chr2_-_64097994 1.308 ENSMUST00000131615.2
 Fign
fidgetin
chr7_+_4925802 1.264 ENSMUST00000057612.7
 Ssc5d
scavenger receptor cysteine rich domain containing (5 domains)
chr14_+_68083853 1.221 ENSMUST00000022639.7
 Nefl
neurofilament, light polypeptide
chr6_-_50456085 1.175 ENSMUST00000146341.1
ENSMUST00000071728.4
 Osbpl3

oxysterol binding protein-like 3

chr12_+_109452833 1.170 ENSMUST00000056110.8
 Dlk1
delta-like 1 homolog (Drosophila)
chr7_-_65156416 1.120 ENSMUST00000148459.1
ENSMUST00000119118.1
 Fam189a1

family with sequence similarity 189, member A1

chr13_-_53286052 1.094 ENSMUST00000021918.8
 Ror2
receptor tyrosine kinase-like orphan receptor 2
chr4_+_65124174 1.003 ENSMUST00000084501.3
 Pappa
pregnancy-associated plasma protein A
chr17_-_29237759 0.931 ENSMUST00000137727.1
ENSMUST00000024805.7
 Cpne5

copine V

chr12_-_40038025 0.908 ENSMUST00000101472.3
 Arl4a
ADP-ribosylation factor-like 4A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 190 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 2.5 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.1 2.4 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 2.2 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.1 2.1 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.3 1.6 GO:0098700 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842) neurotransmitter loading into synaptic vesicle(GO:0098700)
0.4 1.5 GO:0033024 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.3 1.4 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.1 1.4 GO:0070842 aggresome assembly(GO:0070842)
0.3 1.3 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
0.1 1.3 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
0.4 1.2 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.1 1.2 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 1.2 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.3 1.1 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.2 1.1 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.1 1.1 GO:0071281 cellular response to iron ion(GO:0071281)
0.0 1.1 GO:0050873 brown fat cell differentiation(GO:0050873)
0.1 1.0 GO:0035372 protein localization to microtubule(GO:0035372)
0.1 1.0 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.1 1.0 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.9 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 1.8 GO:0043196 varicosity(GO:0043196)
0.0 1.7 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.1 1.6 GO:0031045 dense core granule(GO:0031045)
0.1 1.6 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 1.6 GO:0016605 PML body(GO:0016605)
0.0 1.6 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.6 GO:0016363 nuclear matrix(GO:0016363)
0.1 1.5 GO:0070938 contractile ring(GO:0070938)
0.0 1.3 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.3 GO:0060076 excitatory synapse(GO:0060076)
0.4 1.2 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.1 1.2 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 1.2 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 1.1 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 1.0 GO:0000145 exocyst(GO:0000145)
0.2 0.9 GO:0000798 nuclear cohesin complex(GO:0000798) nuclear meiotic cohesin complex(GO:0034991)
0.0 0.9 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.9 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.9 GO:0016459 myosin complex(GO:0016459)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 130 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.0 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.0 2.2 GO:0035064 methylated histone binding(GO:0035064)
0.1 2.1 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 2.0 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 1.9 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.5 1.6 GO:0008504 monoamine transmembrane transporter activity(GO:0008504)
0.3 1.5 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 1.5 GO:0043274 phospholipase binding(GO:0043274)
0.0 1.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 1.4 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.1 1.3 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 1.3 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 1.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.2 GO:0015485 cholesterol binding(GO:0015485)
0.4 1.1 GO:0004998 transferrin receptor activity(GO:0004998)
0.2 1.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 1.1 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.2 0.9 GO:0036033 mediator complex binding(GO:0036033)
0.1 0.9 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.9 GO:0051787 misfolded protein binding(GO:0051787)