Motif ID: Tfap2c

Z-value: 0.969


Transcription factors associated with Tfap2c:

Gene SymbolEntrez IDGene Name
Tfap2c ENSMUSG00000028640.5 Tfap2c

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2cmm10_v2_chr2_+_172549581_172549605-0.351.0e-01Click!


Activity profile for motif Tfap2c.

activity profile for motif Tfap2c


Sorted Z-values histogram for motif Tfap2c

Sorted Z-values for motif Tfap2c



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2c

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_4505493 3.380 ENSMUST00000031668.8
Col1a2
collagen, type I, alpha 2
chr11_-_106715251 2.338 ENSMUST00000080853.4
ENSMUST00000183610.1
ENSMUST00000103069.3
ENSMUST00000106796.2
Pecam1



platelet/endothelial cell adhesion molecule 1



chr1_-_184883218 2.224 ENSMUST00000048308.5
C130074G19Rik
RIKEN cDNA C130074G19 gene
chr11_-_59964936 1.709 ENSMUST00000062405.7
Rasd1
RAS, dexamethasone-induced 1
chr2_-_34913976 1.664 ENSMUST00000028232.3
Phf19
PHD finger protein 19
chr9_+_89909775 1.616 ENSMUST00000034912.4
ENSMUST00000034909.4
Rasgrf1

RAS protein-specific guanine nucleotide-releasing factor 1

chr6_+_4504814 1.596 ENSMUST00000141483.1
Col1a2
collagen, type I, alpha 2
chr5_-_35679416 1.479 ENSMUST00000114233.2
Htra3
HtrA serine peptidase 3
chr4_-_147936713 1.370 ENSMUST00000105712.1
ENSMUST00000019199.7
Plod1

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1

chr1_-_75479271 1.333 ENSMUST00000079205.7
ENSMUST00000094818.2
Chpf

chondroitin polymerizing factor

chr2_+_152736244 1.316 ENSMUST00000038368.8
ENSMUST00000109824.1
Id1

inhibitor of DNA binding 1

chr8_+_70493156 1.303 ENSMUST00000008032.7
Crlf1
cytokine receptor-like factor 1
chr16_+_91225550 1.265 ENSMUST00000035608.8
Olig2
oligodendrocyte transcription factor 2
chr7_-_4789541 1.254 ENSMUST00000168578.1
Tmem238
transmembrane protein 238
chr2_+_76406529 1.235 ENSMUST00000111929.1
ENSMUST00000077972.4
ENSMUST00000111930.2
Osbpl6


oxysterol binding protein-like 6


chr4_+_125490688 1.171 ENSMUST00000030676.7
Grik3
glutamate receptor, ionotropic, kainate 3
chrX_-_142306170 1.155 ENSMUST00000134825.2
Kcne1l
potassium voltage-gated channel, Isk-related family, member 1-like, pseudogene
chr12_-_76709997 1.152 ENSMUST00000166101.1
Sptb
spectrin beta, erythrocytic
chr5_-_131307848 1.112 ENSMUST00000086023.5
Wbscr17
Williams-Beuren syndrome chromosome region 17 homolog (human)
chr6_-_125313844 1.100 ENSMUST00000032489.7
Ltbr
lymphotoxin B receptor

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.1 GO:0043589 skin morphogenesis(GO:0043589)
0.6 2.3 GO:0050904 diapedesis(GO:0050904)
0.5 2.0 GO:1904177 regulation of adipose tissue development(GO:1904177)
0.1 2.0 GO:0048535 lymph node development(GO:0048535)
0.4 1.9 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.1 1.9 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.6 1.7 GO:0021837 motogenic signaling involved in postnatal olfactory bulb interneuron migration(GO:0021837) positive regulation of mitotic cell cycle DNA replication(GO:1903465)
0.2 1.7 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.1 1.7 GO:0007263 nitric oxide mediated signal transduction(GO:0007263)
0.1 1.5 GO:0018126 protein hydroxylation(GO:0018126)
0.0 1.5 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.4 1.3 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.3 1.3 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.2 1.3 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.2 1.3 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.1 1.3 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.3 1.2 GO:0099624 regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372) atrial cardiac muscle cell membrane repolarization(GO:0099624)
0.1 1.2 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 1.2 GO:0033014 porphyrin-containing compound biosynthetic process(GO:0006779) tetrapyrrole biosynthetic process(GO:0033014)
0.2 1.1 GO:0003192 mitral valve formation(GO:0003192)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 5.0 GO:0005584 collagen type I trimer(GO:0005584)
0.5 2.3 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.3 2.0 GO:0005638 lamin filament(GO:0005638)
0.1 1.9 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 1.7 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.1 1.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 1.7 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.1 1.6 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.4 1.3 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.1 1.3 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 1.3 GO:0031594 neuromuscular junction(GO:0031594)
0.2 1.2 GO:0008091 spectrin(GO:0008091)
0.0 1.2 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 1.2 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 1.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.0 GO:0031519 PcG protein complex(GO:0031519)
0.1 0.9 GO:0031143 pseudopodium(GO:0031143)
0.0 0.9 GO:0000786 nucleosome(GO:0000786)
0.1 0.8 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.8 GO:0044295 axonal growth cone(GO:0044295)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.0 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 3.1 GO:0030246 carbohydrate binding(GO:0030246)
0.1 2.0 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 1.8 GO:0071837 HMG box domain binding(GO:0071837)
0.2 1.7 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 1.7 GO:0035064 methylated histone binding(GO:0035064)
0.0 1.6 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 1.6 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.1 1.5 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.3 1.4 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0 1.4 GO:0033613 activating transcription factor binding(GO:0033613)
0.4 1.3 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.2 1.3 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.1 1.3 GO:0050321 tau-protein kinase activity(GO:0050321)
0.1 1.3 GO:0070628 proteasome binding(GO:0070628)
0.2 1.2 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.2 1.2 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.1 1.2 GO:0030506 ankyrin binding(GO:0030506)
0.1 1.1 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 1.1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)