Motif ID: Tfap2d

Z-value: 0.928


Transcription factors associated with Tfap2d:

Gene SymbolEntrez IDGene Name
Tfap2d ENSMUSG00000042596.7 Tfap2d

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2dmm10_v2_chr1_+_19103022_191030430.772.0e-05Click!


Activity profile for motif Tfap2d.

activity profile for motif Tfap2d


Sorted Z-values histogram for motif Tfap2d

Sorted Z-values for motif Tfap2d



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2d

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_84009481 4.844 ENSMUST00000168120.1
 Acot1
acyl-CoA thioesterase 1
chr11_-_32222233 4.564 ENSMUST00000150381.1
ENSMUST00000144902.1
ENSMUST00000020524.8
 Rhbdf1


rhomboid family 1 (Drosophila)


chr18_+_64340225 3.668 ENSMUST00000175965.2
ENSMUST00000115145.3
 Onecut2

one cut domain, family member 2

chr12_+_83987854 2.734 ENSMUST00000021649.7
 Acot2
acyl-CoA thioesterase 2
chr7_+_130936172 2.696 ENSMUST00000006367.7
 Htra1
HtrA serine peptidase 1
chr5_+_129584169 2.625 ENSMUST00000031390.8
 Mmp17
matrix metallopeptidase 17
chr4_-_154636831 2.547 ENSMUST00000030902.6
ENSMUST00000105637.1
ENSMUST00000070313.7
ENSMUST00000105636.1
ENSMUST00000105638.2
ENSMUST00000097759.2
ENSMUST00000124771.1
 Prdm16






PR domain containing 16






chr9_-_79718631 2.510 ENSMUST00000180083.1
 Col12a1
collagen, type XII, alpha 1
chr11_-_31370066 2.494 ENSMUST00000020546.2
 Stc2
stanniocalcin 2
chr11_+_74619594 2.480 ENSMUST00000100866.2
 E130309D14Rik
RIKEN cDNA E130309D14 gene
chr2_-_173276144 2.372 ENSMUST00000139306.1
 Pmepa1
prostate transmembrane protein, androgen induced 1
chr9_-_79718518 2.277 ENSMUST00000071750.6
 Col12a1
collagen, type XII, alpha 1
chr5_-_113015473 2.272 ENSMUST00000065167.4
 Adrbk2
adrenergic receptor kinase, beta 2
chr2_+_91945703 2.247 ENSMUST00000178895.1
 Gm9821
predicted gene 9821
chr8_-_11008458 2.162 ENSMUST00000040514.6
 Irs2
insulin receptor substrate 2
chr9_-_79718720 2.139 ENSMUST00000121227.1
 Col12a1
collagen, type XII, alpha 1
chr13_-_101768154 2.074 ENSMUST00000055518.6
 Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr18_+_24709436 2.073 ENSMUST00000037097.7
 Fhod3
formin homology 2 domain containing 3
chr7_-_4789541 2.059 ENSMUST00000168578.1
 Tmem238
transmembrane protein 238
chr6_+_72355425 2.010 ENSMUST00000069695.2
ENSMUST00000132243.1
 Tmem150a

transmembrane protein 150A


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 141 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.0 GO:0042058 regulation of epidermal growth factor receptor signaling pathway(GO:0042058)
0.1 4.8 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.8 3.8 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.6 3.7 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.6 3.6 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
0.1 2.8 GO:0001919 regulation of receptor recycling(GO:0001919)
0.3 2.7 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.3 2.6 GO:0042756 drinking behavior(GO:0042756)
0.4 2.5 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.2 2.5 GO:0006817 phosphate ion transport(GO:0006817)
0.3 2.4 GO:1905206 positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300) positive regulation of hydrogen peroxide-induced cell death(GO:1905206)
0.3 2.3 GO:0048069 eye pigmentation(GO:0048069)
0.2 2.2 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.2 2.1 GO:0051639 actin filament network formation(GO:0051639)
0.2 2.1 GO:0010459 negative regulation of heart rate(GO:0010459)
0.1 2.0 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 2.0 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.4 1.9 GO:0090292 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.1 1.9 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 1.9 GO:0031952 regulation of protein autophosphorylation(GO:0031952)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 6.9 GO:0005595 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.0 5.8 GO:0031012 extracellular matrix(GO:0031012)
0.0 5.7 GO:0000139 Golgi membrane(GO:0000139)
0.1 5.2 GO:0031901 early endosome membrane(GO:0031901)
0.3 3.8 GO:0043083 synaptic cleft(GO:0043083)
0.0 2.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 2.6 GO:0016323 basolateral plasma membrane(GO:0016323)
0.2 2.3 GO:0044292 dendrite terminus(GO:0044292)
0.1 2.2 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 2.1 GO:0005865 striated muscle thin filament(GO:0005865)
0.2 1.9 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.2 1.9 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 1.7 GO:0005802 trans-Golgi network(GO:0005802)
0.0 1.6 GO:0016459 myosin complex(GO:0016459)
0.2 1.4 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.2 1.2 GO:0005827 polar microtubule(GO:0005827)
0.1 1.2 GO:0046930 pore complex(GO:0046930)
0.0 1.2 GO:0005814 centriole(GO:0005814)
0.2 1.1 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 0.9 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 99 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 8.2 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.1 3.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.5 3.8 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 3.8 GO:0070412 R-SMAD binding(GO:0070412)
0.1 3.4 GO:0020037 heme binding(GO:0020037)
0.1 3.0 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 3.0 GO:0046332 SMAD binding(GO:0046332)
0.1 2.7 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 2.7 GO:0001221 transcription cofactor binding(GO:0001221)
0.0 2.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.8 2.3 GO:0004686 elongation factor-2 kinase activity(GO:0004686)
0.5 2.3 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.1 2.3 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.5 2.1 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.1 1.9 GO:0005521 lamin binding(GO:0005521)
0.1 1.9 GO:0005112 Notch binding(GO:0005112)
0.0 1.8 GO:0017124 SH3 domain binding(GO:0017124)
0.0 1.5 GO:0045502 dynein binding(GO:0045502)
0.2 1.4 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0 1.4 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)