Motif ID: Tgif2_Tgif2lx1_Tgif2lx2

Z-value: 0.800

Transcription factors associated with Tgif2_Tgif2lx1_Tgif2lx2:

Gene SymbolEntrez IDGene Name
Tgif2 ENSMUSG00000062175.7 Tgif2
Tgif2lx1 ENSMUSG00000061283.4 Tgif2lx1
Tgif2lx2 ENSMUSG00000063242.6 Tgif2lx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tgif2mm10_v2_chr2_+_156840966_1568410170.434.2e-02Click!


Activity profile for motif Tgif2_Tgif2lx1_Tgif2lx2.

activity profile for motif Tgif2_Tgif2lx1_Tgif2lx2


Sorted Z-values histogram for motif Tgif2_Tgif2lx1_Tgif2lx2

Sorted Z-values for motif Tgif2_Tgif2lx1_Tgif2lx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tgif2_Tgif2lx1_Tgif2lx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 167 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_19103022 5.482 ENSMUST00000037294.7
 Tfap2d
transcription factor AP-2, delta
chr15_+_85510812 3.916 ENSMUST00000079690.2
 Gm4825
predicted pseudogene 4825
chr17_+_86753900 2.885 ENSMUST00000024954.9
 Epas1
endothelial PAS domain protein 1
chr6_+_112273758 2.356 ENSMUST00000032376.5
 Lmcd1
LIM and cysteine-rich domains 1
chr11_+_115154139 2.018 ENSMUST00000021076.5
 Rab37
RAB37, member of RAS oncogene family
chr7_-_44670820 1.781 ENSMUST00000048102.7
 Myh14
myosin, heavy polypeptide 14
chr10_-_81430966 1.753 ENSMUST00000117966.1
 Nfic
nuclear factor I/C
chr13_-_76385028 1.542 ENSMUST00000099365.1
 Gm10760
predicted gene 10760
chr2_+_105675429 1.535 ENSMUST00000111085.1
 Pax6
paired box gene 6
chr2_+_105675478 1.516 ENSMUST00000167211.2
ENSMUST00000111083.3
 Pax6

paired box gene 6

chr1_+_36307745 1.483 ENSMUST00000142319.1
ENSMUST00000097778.2
ENSMUST00000115031.1
ENSMUST00000115032.1
ENSMUST00000137906.1
ENSMUST00000115029.1
 Arid5a





AT rich interactive domain 5A (MRF1-like)





chr7_-_80401707 1.352 ENSMUST00000120753.1
 Furin
furin (paired basic amino acid cleaving enzyme)
chr2_-_27246814 1.261 ENSMUST00000149733.1
 Sardh
sarcosine dehydrogenase
chr14_-_31019055 1.249 ENSMUST00000037739.6
 Gnl3
guanine nucleotide binding protein-like 3 (nucleolar)
chr2_-_165473187 1.201 ENSMUST00000029208.8
ENSMUST00000109279.2
 Slc13a3

solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3

chr7_-_137410717 1.151 ENSMUST00000120340.1
ENSMUST00000117404.1
ENSMUST00000068996.6
 9430038I01Rik


RIKEN cDNA 9430038I01 gene


chr3_-_107969162 1.135 ENSMUST00000004136.8
ENSMUST00000106678.1
 Gstm3

glutathione S-transferase, mu 3

chr7_+_107370728 1.072 ENSMUST00000137663.1
ENSMUST00000073459.5
 Syt9

synaptotagmin IX

chr8_-_70439557 1.056 ENSMUST00000076615.5
 Crtc1
CREB regulated transcription coactivator 1
chr1_-_52727457 1.000 ENSMUST00000156876.1
ENSMUST00000087701.3
 Mfsd6

major facilitator superfamily domain containing 6


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.5 GO:0030901 midbrain development(GO:0030901)
0.6 3.1 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918)
0.7 2.9 GO:1903181 regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181)
0.2 2.4 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.1 1.8 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 1.8 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.0 1.5 GO:0035066 positive regulation of histone acetylation(GO:0035066)
0.3 1.4 GO:0032911 nerve growth factor production(GO:0032902) negative regulation of transforming growth factor beta1 production(GO:0032911)
0.1 1.4 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.1 1.4 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.1 1.3 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.1 1.3 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.3 1.2 GO:0006842 tricarboxylic acid transport(GO:0006842) succinate transport(GO:0015744) citrate transport(GO:0015746)
0.1 1.2 GO:1904816 positive regulation of protein localization to chromosome, telomeric region(GO:1904816)
0.1 1.1 GO:0060081 membrane hyperpolarization(GO:0060081)
0.0 1.1 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.1 1.0 GO:0007379 segment specification(GO:0007379)
0.1 0.9 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.8 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.0 0.7 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.1 GO:0005667 transcription factor complex(GO:0005667)
0.0 2.0 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.3 1.8 GO:0097513 myosin II filament(GO:0097513)
0.1 1.4 GO:0000124 SAGA complex(GO:0000124)
0.1 1.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 1.3 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 1.2 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 1.1 GO:0031045 dense core granule(GO:0031045)
0.0 0.9 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 0.5 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.1 0.4 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.4 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 0.4 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.4 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.4 GO:0097546 ciliary base(GO:0097546)
0.0 0.3 GO:0061617 MICOS complex(GO:0061617)
0.0 0.3 GO:0030312 external encapsulating structure(GO:0030312)
0.0 0.3 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.3 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 0.3 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.1 GO:0003680 AT DNA binding(GO:0003680)
0.0 3.0 GO:0003924 GTPase activity(GO:0003924)
0.2 2.9 GO:0050897 cobalt ion binding(GO:0050897)
0.0 2.3 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 1.8 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.2 1.4 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 1.4 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.4 1.3 GO:0046997 sarcosine dehydrogenase activity(GO:0008480) oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997)
0.2 1.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.4 1.2 GO:0017153 sodium:dicarboxylate symporter activity(GO:0017153)
0.1 1.1 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 1.1 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 0.9 GO:0005042 netrin receptor activity(GO:0005042)
0.1 0.7 GO:0016151 nickel cation binding(GO:0016151)
0.0 0.7 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.7 GO:0042605 peptide antigen binding(GO:0042605)
0.0 0.7 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.1 0.6 GO:0015440 peptide-transporting ATPase activity(GO:0015440)
0.0 0.6 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 0.6 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor(GO:0052890)