Motif ID: Tlx2

Z-value: 0.810


Transcription factors associated with Tlx2:

Gene SymbolEntrez IDGene Name
Tlx2 ENSMUSG00000068327.3 Tlx2



Activity profile for motif Tlx2.

activity profile for motif Tlx2


Sorted Z-values histogram for motif Tlx2

Sorted Z-values for motif Tlx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tlx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_117342831 2.487 ENSMUST00000178884.1
 Rasgrp1
RAS guanyl releasing protein 1
chr2_-_117342949 2.415 ENSMUST00000102534.4
 Rasgrp1
RAS guanyl releasing protein 1
chr2_-_117342709 2.073 ENSMUST00000173541.1
ENSMUST00000172901.1
ENSMUST00000173252.1
 Rasgrp1


RAS guanyl releasing protein 1


chr3_+_134236483 2.046 ENSMUST00000181904.1
ENSMUST00000053048.9
 Cxxc4

CXXC finger 4

chr14_-_48662740 2.025 ENSMUST00000122009.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr14_-_34374617 1.707 ENSMUST00000023826.4
 Sncg
synuclein, gamma
chr9_+_111311674 1.572 ENSMUST00000078626.3
 Trank1
tetratricopeptide repeat and ankyrin repeat containing 1
chr15_+_54745702 1.545 ENSMUST00000050027.8
 Nov
nephroblastoma overexpressed gene
chr14_+_46760526 1.425 ENSMUST00000067426.4
 Cdkn3
cyclin-dependent kinase inhibitor 3
chr2_-_181039286 1.353 ENSMUST00000067120.7
 Chrna4
cholinergic receptor, nicotinic, alpha polypeptide 4
chr13_+_13784278 1.329 ENSMUST00000021734.7
 Gng4
guanine nucleotide binding protein (G protein), gamma 4
chr8_+_94772009 1.287 ENSMUST00000034230.5
 Cx3cl1
chemokine (C-X3-C motif) ligand 1
chr3_-_110142996 1.212 ENSMUST00000156177.2
 Ntng1
netrin G1
chr10_+_78780470 1.121 ENSMUST00000005490.8
 Slc1a6
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
chr12_+_109540979 0.989 ENSMUST00000129245.1
ENSMUST00000143836.1
ENSMUST00000124106.1
 Meg3


maternally expressed 3


chr7_-_98309471 0.988 ENSMUST00000033020.7
 Acer3
alkaline ceramidase 3
chr9_-_10904766 0.985 ENSMUST00000160216.1
 Cntn5
contactin 5
chr6_+_56017489 0.945 ENSMUST00000052827.4
 Ppp1r17
protein phosphatase 1, regulatory subunit 17
chr5_+_146845071 0.941 ENSMUST00000031646.7
 Rasl11a
RAS-like, family 11, member A
chr2_-_181039160 0.938 ENSMUST00000108851.1
 Chrna4
cholinergic receptor, nicotinic, alpha polypeptide 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 196 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 7.0 GO:1902715 positive regulation of interferon-gamma secretion(GO:1902715)
0.7 2.7 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.8 2.3 GO:1903048 regulation of acetylcholine-gated cation channel activity(GO:1903048)
0.6 1.8 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.5 1.6 GO:2000562 negative regulation of interferon-gamma secretion(GO:1902714) negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.2 1.6 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.0 1.6 GO:0000082 G1/S transition of mitotic cell cycle(GO:0000082)
0.0 1.5 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.3 1.3 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.3 1.3 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.2 1.3 GO:0036233 glycine import(GO:0036233)
0.0 1.2 GO:0045773 positive regulation of axon extension(GO:0045773)
0.0 1.2 GO:0016052 carbohydrate catabolic process(GO:0016052)
0.2 1.1 GO:0070474 positive regulation of uterine smooth muscle contraction(GO:0070474)
0.0 1.1 GO:0000086 G2/M transition of mitotic cell cycle(GO:0000086)
0.1 1.0 GO:0034312 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512) sphingoid biosynthetic process(GO:0046520)
0.0 1.0 GO:0008340 determination of adult lifespan(GO:0008340)
0.0 1.0 GO:0007099 centriole replication(GO:0007099)
0.0 1.0 GO:0070206 protein trimerization(GO:0070206)
0.4 0.9 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.2 GO:0043679 axon terminus(GO:0043679)
0.0 2.7 GO:0030426 growth cone(GO:0030426)
0.0 2.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 2.4 GO:0031225 anchored component of membrane(GO:0031225)
0.2 2.3 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.3 2.2 GO:0000796 condensin complex(GO:0000796)
0.1 2.2 GO:0005921 gap junction(GO:0005921)
0.1 1.7 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.3 1.5 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1 1.5 GO:0000242 pericentriolar material(GO:0000242)
0.1 1.5 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 1.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 1.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.3 1.0 GO:0071942 XPC complex(GO:0071942)
0.0 1.0 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.2 0.9 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 0.9 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.9 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.9 GO:0016328 lateral plasma membrane(GO:0016328)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 120 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 7.0 GO:0019992 diacylglycerol binding(GO:0019992)
0.1 2.4 GO:0043014 alpha-tubulin binding(GO:0043014)
0.2 2.3 GO:0004889 acetylcholine-activated cation-selective channel activity(GO:0004889)
0.0 1.9 GO:0005525 GTP binding(GO:0005525)
0.0 1.7 GO:0030165 PDZ domain binding(GO:0030165)
0.3 1.6 GO:0016936 galactoside binding(GO:0016936)
0.1 1.6 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.3 1.5 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 1.5 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 1.5 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.5 1.4 GO:0004556 alpha-amylase activity(GO:0004556)
0.2 1.3 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.2 1.3 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.0 1.3 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.2 1.1 GO:0042610 CD8 receptor binding(GO:0042610)
0.2 1.0 GO:0017040 ceramidase activity(GO:0017040)
0.0 1.0 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0 1.0 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 1.0 GO:0003727 single-stranded RNA binding(GO:0003727)
0.2 0.9 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993) serotonin binding(GO:0051378) serotonin receptor activity(GO:0099589)