Motif ID: Trp53

Z-value: 0.979


Transcription factors associated with Trp53:

Gene SymbolEntrez IDGene Name
Trp53 ENSMUSG00000059552.7 Trp53

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Trp53mm10_v2_chr11_+_69580359_69580382-0.711.3e-04Click!


Activity profile for motif Trp53.

activity profile for motif Trp53


Sorted Z-values histogram for motif Trp53

Sorted Z-values for motif Trp53



Network of associatons between targets according to the STRING database.



First level regulatory network of Trp53

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_29090969 5.981 ENSMUST00000119901.1
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr1_+_6487231 5.603 ENSMUST00000140079.1
ENSMUST00000131494.1
St18

suppression of tumorigenicity 18

chr14_-_34374617 3.786 ENSMUST00000023826.4
Sncg
synuclein, gamma
chr15_-_98004634 3.198 ENSMUST00000131560.1
ENSMUST00000088355.5
Col2a1

collagen, type II, alpha 1

chr15_-_98004695 2.972 ENSMUST00000023123.8
Col2a1
collagen, type II, alpha 1
chr1_-_79858627 2.872 ENSMUST00000027467.4
Serpine2
serine (or cysteine) peptidase inhibitor, clade E, member 2
chr17_-_33890584 2.709 ENSMUST00000114361.2
ENSMUST00000173492.1
Kifc1

kinesin family member C1

chr2_-_69206146 2.653 ENSMUST00000127243.1
ENSMUST00000149643.1
ENSMUST00000167875.2
ENSMUST00000005365.8
Spc25



SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)



chr9_+_45138437 2.499 ENSMUST00000060125.5
Scn4b
sodium channel, type IV, beta
chr2_-_69206133 2.426 ENSMUST00000112320.1
Spc25
SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr4_-_134254076 2.398 ENSMUST00000060050.5
Grrp1
glycine/arginine rich protein 1
chr15_+_85859689 2.275 ENSMUST00000170629.1
Gtse1
G two S phase expressed protein 1
chr9_-_106158109 2.188 ENSMUST00000159809.1
ENSMUST00000162562.1
ENSMUST00000036382.6
ENSMUST00000112543.2
Glyctk



glycerate kinase



chr17_+_87282880 2.137 ENSMUST00000041110.5
ENSMUST00000125875.1
Ttc7

tetratricopeptide repeat domain 7

chr7_-_98309471 2.059 ENSMUST00000033020.7
Acer3
alkaline ceramidase 3
chr17_-_33890539 1.972 ENSMUST00000173386.1
Kifc1
kinesin family member C1
chr9_-_106656081 1.964 ENSMUST00000023959.7
Grm2
glutamate receptor, metabotropic 2
chr17_+_35821675 1.861 ENSMUST00000003635.6
Ier3
immediate early response 3
chr11_-_102925086 1.792 ENSMUST00000021311.9
Kif18b
kinesin family member 18B
chr5_-_115194283 1.788 ENSMUST00000112113.1
Cabp1
calcium binding protein 1
chr10_+_93641041 1.588 ENSMUST00000020204.4
Ntn4
netrin 4
chr7_+_19851994 1.543 ENSMUST00000172815.1
Gm19345
predicted gene, 19345
chr11_-_3527916 1.500 ENSMUST00000020718.4
Smtn
smoothelin
chr7_-_114927726 1.491 ENSMUST00000059737.2
Gm6816
predicted gene 6816
chr4_+_116596672 1.428 ENSMUST00000051869.7
Ccdc17
coiled-coil domain containing 17
chr11_-_17211504 1.374 ENSMUST00000020317.7
Pno1
partner of NOB1 homolog (S. cerevisiae)
chr6_-_136941494 1.317 ENSMUST00000111892.1
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr6_-_136941694 1.290 ENSMUST00000032344.5
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr9_-_70141484 1.280 ENSMUST00000034749.8
Fam81a
family with sequence similarity 81, member A
chr10_+_94550852 1.258 ENSMUST00000148910.1
ENSMUST00000117460.1
Tmcc3

transmembrane and coiled coil domains 3

chr8_+_68880491 1.195 ENSMUST00000015712.8
Lpl
lipoprotein lipase
chr8_-_22185758 1.155 ENSMUST00000046916.7
Ckap2
cytoskeleton associated protein 2
chr4_-_135573623 1.148 ENSMUST00000105855.1
Grhl3
grainyhead-like 3 (Drosophila)
chr6_-_136941887 1.119 ENSMUST00000111891.1
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr7_+_16309577 1.045 ENSMUST00000002152.6
Bbc3
BCL2 binding component 3
chr17_-_34862473 1.030 ENSMUST00000025229.4
ENSMUST00000176203.2
ENSMUST00000128767.1
Cfb


complement factor B


chr11_-_40755201 1.023 ENSMUST00000020576.7
Ccng1
cyclin G1
chr6_+_71707561 0.988 ENSMUST00000121469.1
Reep1
receptor accessory protein 1
chr11_-_93968242 0.984 ENSMUST00000107844.2
Nme1
NME/NM23 nucleoside diphosphate kinase 1
chr9_-_100486788 0.981 ENSMUST00000098458.3
Il20rb
interleukin 20 receptor beta
chr15_-_102350692 0.967 ENSMUST00000041208.7
Aaas
achalasia, adrenocortical insufficiency, alacrimia
chr1_-_65186456 0.942 ENSMUST00000169032.1
Idh1
isocitrate dehydrogenase 1 (NADP+), soluble
chr10_+_110745433 0.910 ENSMUST00000174857.1
ENSMUST00000073781.5
ENSMUST00000173471.1
ENSMUST00000173634.1
E2f7



E2F transcription factor 7



chr4_-_83285141 0.897 ENSMUST00000150522.1
Ttc39b
tetratricopeptide repeat domain 39B
chr13_+_21754067 0.889 ENSMUST00000091709.2
Hist1h2bn
histone cluster 1, H2bn
chr17_+_26917091 0.886 ENSMUST00000078961.4
Kifc5b
kinesin family member C5B
chr2_+_10372426 0.857 ENSMUST00000114864.2
ENSMUST00000116594.2
ENSMUST00000041105.6
Sfmbt2


Scm-like with four mbt domains 2


chr16_+_20651652 0.834 ENSMUST00000007212.8
Psmd2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr10_+_56377300 0.820 ENSMUST00000068581.7
Gja1
gap junction protein, alpha 1
chr4_-_9643638 0.796 ENSMUST00000108333.1
ENSMUST00000108334.1
ENSMUST00000108335.1
ENSMUST00000152526.1
ENSMUST00000103004.3
Asph




aspartate-beta-hydroxylase




chr3_+_90669063 0.776 ENSMUST00000069927.8
S100a8
S100 calcium binding protein A8 (calgranulin A)
chr13_+_113317084 0.752 ENSMUST00000136755.2
BC067074
cDNA sequence BC067074
chr14_+_74735641 0.740 ENSMUST00000177283.1
Esd
esterase D/formylglutathione hydrolase
chrX_+_74254782 0.732 ENSMUST00000119197.1
ENSMUST00000088313.4
Emd

emerin

chr13_-_22035589 0.714 ENSMUST00000091742.4
Hist1h2ah
histone cluster 1, H2ah
chr7_+_30712209 0.709 ENSMUST00000005692.6
ENSMUST00000170371.1
Atp4a

ATPase, H+/K+ exchanging, gastric, alpha polypeptide

chr2_-_155074447 0.707 ENSMUST00000137242.1
ENSMUST00000054607.9
Ahcy

S-adenosylhomocysteine hydrolase

chr2_-_17731035 0.695 ENSMUST00000028080.5
Nebl
nebulette
chr7_-_64872993 0.691 ENSMUST00000094331.2
Ndnl2
necdin-like 2
chr8_-_111854278 0.688 ENSMUST00000034432.5
Cfdp1
craniofacial development protein 1
chr17_+_27685197 0.673 ENSMUST00000097360.2
Pacsin1
protein kinase C and casein kinase substrate in neurons 1
chr8_+_94977101 0.649 ENSMUST00000179619.1
Gpr56
G protein-coupled receptor 56
chr18_+_66458587 0.649 ENSMUST00000025399.7
Pmaip1
phorbol-12-myristate-13-acetate-induced protein 1
chr14_+_73237891 0.645 ENSMUST00000044405.6
Lpar6
lysophosphatidic acid receptor 6
chr11_-_93968293 0.635 ENSMUST00000170303.1
Gm20390
predicted gene 20390
chr3_+_96172327 0.625 ENSMUST00000076372.4
Sf3b4
splicing factor 3b, subunit 4
chr1_+_161969179 0.625 ENSMUST00000111594.2
ENSMUST00000028021.6
Pigc

phosphatidylinositol glycan anchor biosynthesis, class C

chr13_+_22035821 0.622 ENSMUST00000110455.2
Hist1h2bk
histone cluster 1, H2bk
chr11_+_58948890 0.612 ENSMUST00000078267.3
Hist3h2ba
histone cluster 3, H2ba
chr9_+_66946057 0.603 ENSMUST00000040917.7
ENSMUST00000127896.1
Rps27l

ribosomal protein S27-like

chr5_-_30073554 0.597 ENSMUST00000026846.6
Tyms
thymidylate synthase
chr1_+_161969284 0.585 ENSMUST00000160881.1
ENSMUST00000159648.1
Pigc

phosphatidylinositol glycan anchor biosynthesis, class C

chr2_+_152962485 0.579 ENSMUST00000099197.2
ENSMUST00000103155.3
Ttll9

tubulin tyrosine ligase-like family, member 9

chr19_+_4097392 0.574 ENSMUST00000174514.1
ENSMUST00000174149.1
Cdk2ap2

CDK2-associated protein 2

chr8_-_105851981 0.570 ENSMUST00000040776.4
Cenpt
centromere protein T
chr9_-_59486323 0.566 ENSMUST00000165322.1
Arih1
ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1 (Drosophila)
chr16_-_59632520 0.564 ENSMUST00000118438.1
Arl6
ADP-ribosylation factor-like 6
chr9_-_114982739 0.556 ENSMUST00000053150.5
Gm9846
predicted gene 9846
chr5_+_114707760 0.551 ENSMUST00000094441.4
Tchp
trichoplein, keratin filament binding
chr6_+_127446819 0.547 ENSMUST00000112191.1
Parp11
poly (ADP-ribose) polymerase family, member 11
chr17_+_52602700 0.546 ENSMUST00000039366.10
Kcnh8
potassium voltage-gated channel, subfamily H (eag-related), member 8
chr11_+_52360824 0.539 ENSMUST00000102758.1
Vdac1
voltage-dependent anion channel 1
chr7_+_24884809 0.533 ENSMUST00000156372.1
ENSMUST00000124035.1
Rps19

ribosomal protein S19

chr2_+_136892168 0.532 ENSMUST00000099311.2
Slx4ip
SLX4 interacting protein
chr2_+_29889217 0.502 ENSMUST00000123335.1
Odf2
outer dense fiber of sperm tails 2
chr7_-_19458494 0.494 ENSMUST00000085715.5
Mark4
MAP/microtubule affinity-regulating kinase 4
chr2_-_164857542 0.483 ENSMUST00000109316.1
ENSMUST00000156255.1
ENSMUST00000128110.1
ENSMUST00000109317.3
Pltp



phospholipid transfer protein



chr4_-_129641060 0.449 ENSMUST00000046425.9
ENSMUST00000133803.1
Txlna

taxilin alpha

chr9_+_72438519 0.445 ENSMUST00000184604.1
Mns1
meiosis-specific nuclear structural protein 1
chr2_+_29890063 0.438 ENSMUST00000028128.6
Odf2
outer dense fiber of sperm tails 2
chr3_-_90389884 0.430 ENSMUST00000029541.5
Slc27a3
solute carrier family 27 (fatty acid transporter), member 3
chr7_+_75455534 0.429 ENSMUST00000147005.1
ENSMUST00000166315.1
Akap13

A kinase (PRKA) anchor protein 13

chr9_-_72985344 0.426 ENSMUST00000124565.2
Gm5918
predicted gene 5918
chr14_-_55944536 0.421 ENSMUST00000022834.6
Cma1
chymase 1, mast cell
chr14_-_59365410 0.417 ENSMUST00000161031.1
ENSMUST00000160425.1
Phf11d

PHD finger protein 11D

chr19_-_43524462 0.415 ENSMUST00000026196.7
Got1
glutamate oxaloacetate transaminase 1, soluble
chr19_-_4793851 0.408 ENSMUST00000178615.1
ENSMUST00000179189.1
ENSMUST00000164376.2
ENSMUST00000164209.2
ENSMUST00000180248.1
Rbm4




RNA binding motif protein 4




chr7_+_97332311 0.403 ENSMUST00000054107.5
Kctd21
potassium channel tetramerisation domain containing 21
chr15_+_83100281 0.402 ENSMUST00000167389.1
ENSMUST00000166427.1
Serhl

serine hydrolase-like

chr4_+_115057683 0.381 ENSMUST00000161601.1
Tal1
T cell acute lymphocytic leukemia 1
chr7_-_92637079 0.375 ENSMUST00000056106.7
ENSMUST00000118157.1
Ankrd42

ankyrin repeat domain 42

chr8_+_35587780 0.373 ENSMUST00000037666.5
Mfhas1
malignant fibrous histiocytoma amplified sequence 1
chr7_+_24884651 0.366 ENSMUST00000153451.2
ENSMUST00000108429.1
Rps19

ribosomal protein S19

chr4_+_132351768 0.348 ENSMUST00000172202.1
Gm17300
predicted gene, 17300
chr3_-_28765364 0.346 ENSMUST00000094335.3
Gm6505
predicted pseudogene 6505
chr6_-_134897815 0.340 ENSMUST00000165392.1
ENSMUST00000046255.7
ENSMUST00000111932.1
ENSMUST00000116515.2
Gpr19



G protein-coupled receptor 19



chr13_+_23574381 0.321 ENSMUST00000090776.4
Hist1h2ad
histone cluster 1, H2ad
chr6_+_134981998 0.318 ENSMUST00000167323.1
Apold1
apolipoprotein L domain containing 1
chr8_+_9977707 0.318 ENSMUST00000139793.1
ENSMUST00000048216.5
Abhd13

abhydrolase domain containing 13

chr2_+_136891501 0.317 ENSMUST00000141463.1
Slx4ip
SLX4 interacting protein
chr19_-_10604258 0.303 ENSMUST00000037678.6
Dak
dihydroxyacetone kinase 2 homolog (yeast)
chrX_-_38635066 0.300 ENSMUST00000058265.7
C1galt1c1
C1GALT1-specific chaperone 1
chr15_+_83100201 0.299 ENSMUST00000078218.4
Serhl
serine hydrolase-like
chr9_-_21963568 0.299 ENSMUST00000006397.5
Epor
erythropoietin receptor
chr10_+_80622677 0.299 ENSMUST00000079773.6
Csnk1g2
casein kinase 1, gamma 2
chr12_-_81532840 0.290 ENSMUST00000166664.1
ENSMUST00000164386.1
ENSMUST00000169158.1
ENSMUST00000164431.1
ENSMUST00000163402.1
Gm20498

Synj2bp


predicted gene 20498

synaptojanin 2 binding protein


chrX_-_37191160 0.278 ENSMUST00000016571.7
Ndufa1
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1
chr4_+_102430047 0.277 ENSMUST00000172616.1
Pde4b
phosphodiesterase 4B, cAMP specific
chr13_-_23574196 0.260 ENSMUST00000105106.1
Hist1h2bf
histone cluster 1, H2bf
chr3_-_19264959 0.258 ENSMUST00000121951.1
Pde7a
phosphodiesterase 7A
chr10_-_81350389 0.258 ENSMUST00000020454.4
ENSMUST00000105324.2
ENSMUST00000154609.2
ENSMUST00000105323.1
Hmg20b



high mobility group 20B



chr19_+_46328179 0.250 ENSMUST00000026256.2
ENSMUST00000177667.1
Fbxl15

F-box and leucine-rich repeat protein 15

chr3_-_19265007 0.247 ENSMUST00000091314.4
Pde7a
phosphodiesterase 7A
chr14_-_20496780 0.245 ENSMUST00000022353.3
Mss51
MSS51 mitochondrial translational activator
chr5_+_24100578 0.233 ENSMUST00000030841.5
ENSMUST00000163409.1
Klhl7

kelch-like 7

chr1_+_55237177 0.228 ENSMUST00000061334.8
Mars2
methionine-tRNA synthetase 2 (mitochondrial)
chr11_+_87760533 0.227 ENSMUST00000039627.5
ENSMUST00000100644.3
Bzrap1

benzodiazepine receptor associated protein 1

chr11_-_98438941 0.220 ENSMUST00000002655.7
Mien1
migration and invasion enhancer 1
chr11_+_88204396 0.217 ENSMUST00000118784.1
ENSMUST00000139170.1
ENSMUST00000107915.3
ENSMUST00000144070.1
Mrps23



mitochondrial ribosomal protein S23



chr14_+_47001336 0.216 ENSMUST00000125113.1
Samd4
sterile alpha motif domain containing 4
chr6_+_39592569 0.212 ENSMUST00000135671.1
ENSMUST00000119379.1
Ndufb2

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2

chr8_-_91133942 0.200 ENSMUST00000120213.1
ENSMUST00000109609.2
Aktip

thymoma viral proto-oncogene 1 interacting protein

chr2_+_72285637 0.200 ENSMUST00000090824.5
ENSMUST00000135469.1
Zak

sterile alpha motif and leucine zipper containing kinase AZK

chr9_+_72438534 0.196 ENSMUST00000034746.8
Mns1
meiosis-specific nuclear structural protein 1
chr4_-_129640959 0.191 ENSMUST00000132217.1
ENSMUST00000130017.1
ENSMUST00000154105.1
Txlna


taxilin alpha


chr10_-_81350191 0.189 ENSMUST00000122993.1
Hmg20b
high mobility group 20B
chr4_-_149099802 0.184 ENSMUST00000103217.4
Pex14
peroxisomal biogenesis factor 14
chr4_-_43030440 0.184 ENSMUST00000135660.1
Stoml2
stomatin (Epb7.2)-like 2
chr1_+_132880273 0.168 ENSMUST00000027706.3
Lrrn2
leucine rich repeat protein 2, neuronal
chr10_-_81350305 0.159 ENSMUST00000167481.1
Hmg20b
high mobility group 20B
chr8_-_91134027 0.138 ENSMUST00000125257.1
Aktip
thymoma viral proto-oncogene 1 interacting protein
chr5_-_138272733 0.135 ENSMUST00000161665.1
ENSMUST00000100530.1
Gal3st4

galactose-3-O-sulfotransferase 4

chr4_+_115057410 0.135 ENSMUST00000136946.1
Tal1
T cell acute lymphocytic leukemia 1
chr5_-_138272786 0.135 ENSMUST00000161279.1
ENSMUST00000161647.1
Gal3st4

galactose-3-O-sulfotransferase 4

chr8_-_84893887 0.133 ENSMUST00000003907.7
ENSMUST00000182458.1
ENSMUST00000109745.1
ENSMUST00000142748.1
Gcdh



glutaryl-Coenzyme A dehydrogenase



chr11_-_95699143 0.129 ENSMUST00000062249.2
Gm9796
predicted gene 9796
chr18_+_80253274 0.126 ENSMUST00000131780.1
ENSMUST00000157056.1
Pqlc1

PQ loop repeat containing 1

chr12_+_59129720 0.125 ENSMUST00000175912.1
ENSMUST00000176892.1
Ctage5

CTAGE family, member 5

chr12_+_59129757 0.106 ENSMUST00000069430.8
ENSMUST00000177370.1
Ctage5

CTAGE family, member 5

chr1_+_88103229 0.104 ENSMUST00000113135.3
ENSMUST00000113138.1
Ugt1a6a
Ugt1a6b
UDP glucuronosyltransferase 1 family, polypeptide A6A
UDP glucuronosyltransferase 1 family, polypeptide A6B
chr14_+_13453937 0.102 ENSMUST00000153954.1
Synpr
synaptoporin
chr11_-_116168138 0.099 ENSMUST00000139020.1
ENSMUST00000103031.1
ENSMUST00000124828.1
Fbf1


Fas (TNFRSF6) binding factor 1


chr15_+_100154379 0.097 ENSMUST00000023768.6
ENSMUST00000108971.2
Dip2b

DIP2 disco-interacting protein 2 homolog B (Drosophila)

chr11_-_102469839 0.089 ENSMUST00000103086.3
Itga2b
integrin alpha 2b
chr16_-_11909398 0.085 ENSMUST00000127972.1
ENSMUST00000121750.1
ENSMUST00000096272.4
ENSMUST00000073371.6
Cpped1



calcineurin-like phosphoesterase domain containing 1



chr1_-_191907527 0.080 ENSMUST00000069573.5
1700034H15Rik
RIKEN cDNA 1700034H15 gene
chr19_+_44203265 0.075 ENSMUST00000026220.5
Scd3
stearoyl-coenzyme A desaturase 3
chr16_+_17144600 0.068 ENSMUST00000115702.1
Ydjc
YdjC homolog (bacterial)
chr7_-_141902361 0.059 ENSMUST00000055819.6
ENSMUST00000130439.1
ENSMUST00000001950.5
Tollip


toll interacting protein


chr18_-_20002093 0.038 ENSMUST00000115848.3
Dsc3
desmocollin 3
chr7_+_24884611 0.037 ENSMUST00000108428.1
Rps19
ribosomal protein S19
chr11_+_17211912 0.025 ENSMUST00000046955.6
Wdr92
WD repeat domain 92
chr14_-_49066368 0.015 ENSMUST00000161504.1
Exoc5
exocyst complex component 5
chr18_+_61639542 0.014 ENSMUST00000183083.1
ENSMUST00000183087.1
Gm20748

predicted gene, 20748

chr2_+_112454997 0.007 ENSMUST00000069747.5
Emc7
ER membrane protein complex subunit 7
chr6_+_128438757 0.005 ENSMUST00000144745.1
Gm10069
predicted gene 10069

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.7 GO:0072385 minus-end-directed organelle transport along microtubule(GO:0072385)
1.0 2.9 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.7 3.7 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.7 6.0 GO:0090399 replicative senescence(GO:0090399)
0.4 1.7 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.4 4.6 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.3 1.0 GO:0002765 immune response-inhibiting signal transduction(GO:0002765)
0.3 1.6 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.3 0.9 GO:0006097 glyoxylate cycle(GO:0006097)
0.3 1.9 GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
0.3 0.9 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.3 1.2 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.3 0.8 GO:0003104 positive regulation of glomerular filtration(GO:0003104) cell communication by chemical coupling(GO:0010643)
0.3 0.8 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.3 0.8 GO:0070488 neutrophil aggregation(GO:0070488)
0.2 0.9 GO:0060266 positive regulation of respiratory burst involved in inflammatory response(GO:0060265) negative regulation of respiratory burst involved in inflammatory response(GO:0060266) negative regulation of respiratory burst(GO:0060268)
0.2 0.6 GO:0046078 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177) dUMP metabolic process(GO:0046078)
0.2 2.1 GO:0034312 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512) sphingoid biosynthetic process(GO:0046520)
0.2 0.7 GO:0046294 formaldehyde catabolic process(GO:0046294)
0.2 0.5 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.2 1.0 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 0.6 GO:0046909 intermembrane transport(GO:0046909)
0.1 3.8 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.1 0.4 GO:0006106 fumarate metabolic process(GO:0006106) aspartate catabolic process(GO:0006533) alditol biosynthetic process(GO:0019401)
0.1 2.5 GO:0086016 AV node cell action potential(GO:0086016) AV node cell to bundle of His cell signaling(GO:0086027) AV node cell to bundle of His cell communication(GO:0086067)
0.1 1.1 GO:0061436 establishment of skin barrier(GO:0061436)
0.1 0.5 GO:0042360 vitamin E metabolic process(GO:0042360)
0.1 0.6 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.1 0.4 GO:0097167 circadian regulation of translation(GO:0097167)
0.1 1.0 GO:0046036 GTP biosynthetic process(GO:0006183) CTP biosynthetic process(GO:0006241) CTP metabolic process(GO:0046036)
0.1 0.5 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.1 0.7 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 0.9 GO:0002227 innate immune response in mucosa(GO:0002227)
0.1 0.4 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.1 0.4 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.1 0.7 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.1 1.0 GO:0051205 protein insertion into membrane(GO:0051205)
0.1 2.0 GO:0014047 glutamate secretion(GO:0014047)
0.1 1.0 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 0.2 GO:0016561 protein import into peroxisome matrix, translocation(GO:0016561)
0.1 0.2 GO:1990046 positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046)
0.1 0.3 GO:0016266 O-glycan processing(GO:0016266)
0.1 0.7 GO:0036376 sodium ion export from cell(GO:0036376)
0.1 0.3 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.1 2.1 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.1 5.1 GO:0007052 mitotic spindle organization(GO:0007052)
0.0 2.9 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 0.6 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.7 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 0.5 GO:0006851 mitochondrial calcium ion transport(GO:0006851)
0.0 0.6 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 0.6 GO:0070986 left/right axis specification(GO:0070986)
0.0 0.1 GO:0009812 flavonoid metabolic process(GO:0009812) flavonoid biosynthetic process(GO:0009813) flavonoid glucuronidation(GO:0052696)
0.0 0.6 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.6 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.3 GO:0061032 visceral serous pericardium development(GO:0061032)
0.0 1.2 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.6 GO:0006220 pyrimidine nucleotide metabolic process(GO:0006220)
0.0 0.3 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.9 GO:1902017 regulation of cilium assembly(GO:1902017)
0.0 0.7 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.0 0.1 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.0 1.5 GO:0006334 nucleosome assembly(GO:0006334)
0.0 1.5 GO:0051028 mRNA transport(GO:0051028)
0.0 1.0 GO:0006342 chromatin silencing(GO:0006342)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 6.0 GO:0070557 PCNA-p21 complex(GO:0070557)
0.8 5.1 GO:0031262 Ndc80 complex(GO:0031262)
0.5 6.2 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.3 1.2 GO:0042627 chylomicron(GO:0042627)
0.3 1.8 GO:0000235 astral microtubule(GO:0000235)
0.3 4.7 GO:0031616 spindle pole centrosome(GO:0031616)
0.3 2.9 GO:0031091 platelet alpha granule(GO:0031091) extrinsic component of external side of plasma membrane(GO:0031232)
0.2 0.5 GO:0033193 Lsd1/2 complex(GO:0033193)
0.2 0.8 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.2 2.5 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.2 0.6 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.1 0.6 GO:0045179 apical cortex(GO:0045179)
0.1 0.7 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.1 1.2 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 0.8 GO:0005916 fascia adherens(GO:0005916)
0.1 2.4 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 0.8 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540) cytosolic proteasome complex(GO:0031597)
0.1 3.4 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.3 GO:0070695 FHF complex(GO:0070695)
0.0 0.7 GO:0005652 nuclear outer membrane(GO:0005640) nuclear lamina(GO:0005652)
0.0 0.5 GO:0046930 pore complex(GO:0046930)
0.0 2.1 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 1.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.4 GO:0097539 ciliary transition fiber(GO:0097539)
0.0 0.9 GO:0016235 aggresome(GO:0016235)
0.0 0.7 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 1.3 GO:0005882 intermediate filament(GO:0005882)
0.0 1.6 GO:0042734 presynaptic membrane(GO:0042734)
0.0 1.5 GO:0005643 nuclear pore(GO:0005643)
0.0 0.7 GO:0000786 nucleosome(GO:0000786)
0.0 0.2 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.9 GO:0005871 kinesin complex(GO:0005871)
0.0 1.1 GO:0072562 blood microparticle(GO:0072562)
0.0 0.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.2 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.3 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 1.3 GO:0000776 kinetochore(GO:0000776)
0.0 0.5 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.7 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.5 3.7 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.4 6.0 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.4 6.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.4 2.0 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.4 2.5 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.3 2.1 GO:0017040 ceramidase activity(GO:0017040)
0.3 0.9 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.2 0.7 GO:0018738 S-formylglutathione hydrolase activity(GO:0018738)
0.2 1.0 GO:0042015 interleukin-20 binding(GO:0042015)
0.2 1.6 GO:0043237 laminin-1 binding(GO:0043237)
0.2 0.8 GO:0071253 connexin binding(GO:0071253)
0.1 0.4 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.1 1.2 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 0.8 GO:0050786 arachidonic acid binding(GO:0050544) RAGE receptor binding(GO:0050786)
0.1 1.8 GO:1990939 ATP-dependent microtubule motor activity(GO:1990939)
0.1 3.8 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 1.2 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 0.7 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 0.6 GO:0008494 translation activator activity(GO:0008494)
0.1 0.5 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.1 0.7 GO:0103116 alpha-D-galactofuranose transporter activity(GO:0103116)
0.1 1.6 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.1 0.5 GO:0015288 porin activity(GO:0015288)
0.1 2.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 0.2 GO:1901611 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.1 0.2 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.0 0.3 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.4 GO:0034943 acyl-CoA ligase activity(GO:0003996) 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity(GO:0010435) 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity(GO:0018854) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity(GO:0018855) benzoyl acetate-CoA ligase activity(GO:0018856) 2,4-dichlorobenzoate-CoA ligase activity(GO:0018857) very long-chain fatty acid-CoA ligase activity(GO:0031957) pivalate-CoA ligase activity(GO:0034783) cyclopropanecarboxylate-CoA ligase activity(GO:0034793) adipate-CoA ligase activity(GO:0034796) citronellyl-CoA ligase activity(GO:0034823) mentha-1,3-dione-CoA ligase activity(GO:0034841) thiophene-2-carboxylate-CoA ligase activity(GO:0034842) 2,4,4-trimethylpentanoate-CoA ligase activity(GO:0034865) cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034942) trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034943) branched-chain acyl-CoA synthetase (ADP-forming) activity(GO:0043759) aryl-CoA synthetase (ADP-forming) activity(GO:0043762) 3-hydroxypropionyl-CoA synthetase activity(GO:0043955) perillic acid:CoA ligase (ADP-forming) activity(GO:0052685) perillic acid:CoA ligase (AMP-forming) activity(GO:0052686) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity(GO:0052687) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity(GO:0052688) pristanate-CoA ligase activity(GO:0070251) malonyl-CoA synthetase activity(GO:0090409)
0.0 0.4 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.0 0.6 GO:0005542 folic acid binding(GO:0005542)
0.0 0.9 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 0.3 GO:0048531 beta-1,3-galactosyltransferase activity(GO:0048531)
0.0 0.1 GO:0070051 fibrinogen binding(GO:0070051)
0.0 0.6 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 0.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.5 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.4 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.9 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.1 GO:0032896 palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.0 0.9 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.8 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.0 0.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.5 GO:0070888 E-box binding(GO:0070888)
0.0 0.8 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)