Motif ID: Trp53
Z-value: 0.979
Transcription factors associated with Trp53:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Trp53 | ENSMUSG00000059552.7 | Trp53 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Trp53 | mm10_v2_chr11_+_69580359_69580382 | -0.71 | 1.3e-04 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.2 | 4.7 | GO:0072385 | minus-end-directed organelle transport along microtubule(GO:0072385) |
1.0 | 2.9 | GO:0010757 | negative regulation of plasminogen activation(GO:0010757) |
0.7 | 3.7 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
0.7 | 6.0 | GO:0090399 | replicative senescence(GO:0090399) |
0.4 | 1.7 | GO:1900740 | regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740) |
0.4 | 4.6 | GO:0060272 | embryonic skeletal joint morphogenesis(GO:0060272) |
0.3 | 1.0 | GO:0002765 | immune response-inhibiting signal transduction(GO:0002765) |
0.3 | 1.6 | GO:0035426 | extracellular matrix-cell signaling(GO:0035426) |
0.3 | 0.9 | GO:0006097 | glyoxylate cycle(GO:0006097) |
0.3 | 1.9 | GO:1901029 | negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029) |
0.3 | 0.9 | GO:0032877 | positive regulation of DNA endoreduplication(GO:0032877) |
0.3 | 1.2 | GO:0010890 | positive regulation of sequestering of triglyceride(GO:0010890) |
0.3 | 0.8 | GO:0003104 | positive regulation of glomerular filtration(GO:0003104) cell communication by chemical coupling(GO:0010643) |
0.3 | 0.8 | GO:0042264 | peptidyl-aspartic acid hydroxylation(GO:0042264) |
0.3 | 0.8 | GO:0070488 | neutrophil aggregation(GO:0070488) |
0.2 | 0.9 | GO:0060266 | positive regulation of respiratory burst involved in inflammatory response(GO:0060265) negative regulation of respiratory burst involved in inflammatory response(GO:0060266) negative regulation of respiratory burst(GO:0060268) |
0.2 | 0.6 | GO:0046078 | deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177) dUMP metabolic process(GO:0046078) |
0.2 | 2.1 | GO:0034312 | diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512) sphingoid biosynthetic process(GO:0046520) |
0.2 | 0.7 | GO:0046294 | formaldehyde catabolic process(GO:0046294) |
0.2 | 0.5 | GO:0060217 | hemangioblast cell differentiation(GO:0060217) |
0.2 | 1.0 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
0.1 | 0.6 | GO:0046909 | intermembrane transport(GO:0046909) |
0.1 | 3.8 | GO:0014046 | dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059) |
0.1 | 0.4 | GO:0006106 | fumarate metabolic process(GO:0006106) aspartate catabolic process(GO:0006533) alditol biosynthetic process(GO:0019401) |
0.1 | 2.5 | GO:0086016 | AV node cell action potential(GO:0086016) AV node cell to bundle of His cell signaling(GO:0086027) AV node cell to bundle of His cell communication(GO:0086067) |
0.1 | 1.1 | GO:0061436 | establishment of skin barrier(GO:0061436) |
0.1 | 0.5 | GO:0042360 | vitamin E metabolic process(GO:0042360) |
0.1 | 0.6 | GO:1902018 | negative regulation of cilium assembly(GO:1902018) |
0.1 | 0.4 | GO:0097167 | circadian regulation of translation(GO:0097167) |
0.1 | 1.0 | GO:0046036 | GTP biosynthetic process(GO:0006183) CTP biosynthetic process(GO:0006241) CTP metabolic process(GO:0046036) |
0.1 | 0.5 | GO:0000160 | phosphorelay signal transduction system(GO:0000160) |
0.1 | 0.7 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
0.1 | 0.9 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
0.1 | 0.4 | GO:1900017 | positive regulation of cytokine production involved in inflammatory response(GO:1900017) |
0.1 | 0.4 | GO:0071883 | activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883) |
0.1 | 0.7 | GO:2000270 | negative regulation of fibroblast apoptotic process(GO:2000270) |
0.1 | 1.0 | GO:0051205 | protein insertion into membrane(GO:0051205) |
0.1 | 2.0 | GO:0014047 | glutamate secretion(GO:0014047) |
0.1 | 1.0 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
0.1 | 0.2 | GO:0016561 | protein import into peroxisome matrix, translocation(GO:0016561) |
0.1 | 0.2 | GO:1990046 | positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046) |
0.1 | 0.3 | GO:0016266 | O-glycan processing(GO:0016266) |
0.1 | 0.7 | GO:0036376 | sodium ion export from cell(GO:0036376) |
0.1 | 0.3 | GO:0048312 | intracellular distribution of mitochondria(GO:0048312) |
0.1 | 2.1 | GO:0006879 | cellular iron ion homeostasis(GO:0006879) |
0.1 | 5.1 | GO:0007052 | mitotic spindle organization(GO:0007052) |
0.0 | 2.9 | GO:0007019 | microtubule depolymerization(GO:0007019) |
0.0 | 0.6 | GO:0051382 | kinetochore assembly(GO:0051382) |
0.0 | 0.7 | GO:0035414 | negative regulation of catenin import into nucleus(GO:0035414) |
0.0 | 0.5 | GO:0006851 | mitochondrial calcium ion transport(GO:0006851) |
0.0 | 0.6 | GO:0033234 | negative regulation of protein sumoylation(GO:0033234) |
0.0 | 0.6 | GO:0070986 | left/right axis specification(GO:0070986) |
0.0 | 0.1 | GO:0009812 | flavonoid metabolic process(GO:0009812) flavonoid biosynthetic process(GO:0009813) flavonoid glucuronidation(GO:0052696) |
0.0 | 0.6 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
0.0 | 0.6 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
0.0 | 0.3 | GO:0061032 | visceral serous pericardium development(GO:0061032) |
0.0 | 1.2 | GO:0006506 | GPI anchor biosynthetic process(GO:0006506) |
0.0 | 0.6 | GO:0006220 | pyrimidine nucleotide metabolic process(GO:0006220) |
0.0 | 0.3 | GO:1901898 | negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898) |
0.0 | 0.9 | GO:1902017 | regulation of cilium assembly(GO:1902017) |
0.0 | 0.7 | GO:0048488 | synaptic vesicle endocytosis(GO:0048488) |
0.0 | 0.1 | GO:1903966 | monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966) |
0.0 | 1.5 | GO:0006334 | nucleosome assembly(GO:0006334) |
0.0 | 1.5 | GO:0051028 | mRNA transport(GO:0051028) |
0.0 | 1.0 | GO:0006342 | chromatin silencing(GO:0006342) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.0 | 6.0 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
0.8 | 5.1 | GO:0031262 | Ndc80 complex(GO:0031262) |
0.5 | 6.2 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
0.3 | 1.2 | GO:0042627 | chylomicron(GO:0042627) |
0.3 | 1.8 | GO:0000235 | astral microtubule(GO:0000235) |
0.3 | 4.7 | GO:0031616 | spindle pole centrosome(GO:0031616) |
0.3 | 2.9 | GO:0031091 | platelet alpha granule(GO:0031091) extrinsic component of external side of plasma membrane(GO:0031232) |
0.2 | 0.5 | GO:0033193 | Lsd1/2 complex(GO:0033193) |
0.2 | 0.8 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
0.2 | 2.5 | GO:0034706 | voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706) |
0.2 | 0.6 | GO:0002111 | BRCA2-BRAF35 complex(GO:0002111) |
0.1 | 0.6 | GO:0045179 | apical cortex(GO:0045179) |
0.1 | 0.7 | GO:0030915 | Smc5-Smc6 complex(GO:0030915) |
0.1 | 1.2 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
0.1 | 0.8 | GO:0005916 | fascia adherens(GO:0005916) |
0.1 | 2.4 | GO:0000788 | nuclear nucleosome(GO:0000788) |
0.1 | 0.8 | GO:0008540 | proteasome regulatory particle, base subcomplex(GO:0008540) cytosolic proteasome complex(GO:0031597) |
0.1 | 3.4 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
0.0 | 0.3 | GO:0070695 | FHF complex(GO:0070695) |
0.0 | 0.7 | GO:0005652 | nuclear outer membrane(GO:0005640) nuclear lamina(GO:0005652) |
0.0 | 0.5 | GO:0046930 | pore complex(GO:0046930) |
0.0 | 2.1 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
0.0 | 1.5 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
0.0 | 0.4 | GO:0097539 | ciliary transition fiber(GO:0097539) |
0.0 | 0.9 | GO:0016235 | aggresome(GO:0016235) |
0.0 | 0.7 | GO:0030137 | COPI-coated vesicle(GO:0030137) |
0.0 | 1.3 | GO:0005882 | intermediate filament(GO:0005882) |
0.0 | 1.6 | GO:0042734 | presynaptic membrane(GO:0042734) |
0.0 | 1.5 | GO:0005643 | nuclear pore(GO:0005643) |
0.0 | 0.7 | GO:0000786 | nucleosome(GO:0000786) |
0.0 | 0.2 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
0.0 | 0.9 | GO:0005871 | kinesin complex(GO:0005871) |
0.0 | 1.1 | GO:0072562 | blood microparticle(GO:0072562) |
0.0 | 0.3 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
0.0 | 0.2 | GO:0042101 | T cell receptor complex(GO:0042101) |
0.0 | 0.3 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
0.0 | 1.3 | GO:0000776 | kinetochore(GO:0000776) |
0.0 | 0.5 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.2 | 4.7 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
0.5 | 3.7 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
0.4 | 6.0 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
0.4 | 6.2 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
0.4 | 2.0 | GO:0001640 | adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) |
0.4 | 2.5 | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) |
0.3 | 2.1 | GO:0017040 | ceramidase activity(GO:0017040) |
0.3 | 0.9 | GO:0004450 | isocitrate dehydrogenase (NADP+) activity(GO:0004450) |
0.2 | 0.7 | GO:0018738 | S-formylglutathione hydrolase activity(GO:0018738) |
0.2 | 1.0 | GO:0042015 | interleukin-20 binding(GO:0042015) |
0.2 | 1.6 | GO:0043237 | laminin-1 binding(GO:0043237) |
0.2 | 0.8 | GO:0071253 | connexin binding(GO:0071253) |
0.1 | 0.4 | GO:0004069 | L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069) |
0.1 | 1.2 | GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176) |
0.1 | 0.8 | GO:0050786 | arachidonic acid binding(GO:0050544) RAGE receptor binding(GO:0050786) |
0.1 | 1.8 | GO:1990939 | ATP-dependent microtubule motor activity(GO:1990939) |
0.1 | 3.8 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
0.1 | 1.2 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
0.1 | 0.7 | GO:0004013 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
0.1 | 0.6 | GO:0008494 | translation activator activity(GO:0008494) |
0.1 | 0.5 | GO:0000155 | phosphorelay sensor kinase activity(GO:0000155) |
0.1 | 0.7 | GO:0103116 | alpha-D-galactofuranose transporter activity(GO:0103116) |
0.1 | 1.6 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
0.1 | 0.5 | GO:0015288 | porin activity(GO:0015288) |
0.1 | 2.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
0.1 | 0.2 | GO:1901611 | phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612) |
0.1 | 0.2 | GO:0030156 | benzodiazepine receptor binding(GO:0030156) |
0.0 | 0.3 | GO:0070699 | type II activin receptor binding(GO:0070699) |
0.0 | 0.4 | GO:0034943 | acyl-CoA ligase activity(GO:0003996) 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity(GO:0010435) 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity(GO:0018854) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity(GO:0018855) benzoyl acetate-CoA ligase activity(GO:0018856) 2,4-dichlorobenzoate-CoA ligase activity(GO:0018857) very long-chain fatty acid-CoA ligase activity(GO:0031957) pivalate-CoA ligase activity(GO:0034783) cyclopropanecarboxylate-CoA ligase activity(GO:0034793) adipate-CoA ligase activity(GO:0034796) citronellyl-CoA ligase activity(GO:0034823) mentha-1,3-dione-CoA ligase activity(GO:0034841) thiophene-2-carboxylate-CoA ligase activity(GO:0034842) 2,4,4-trimethylpentanoate-CoA ligase activity(GO:0034865) cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034942) trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034943) branched-chain acyl-CoA synthetase (ADP-forming) activity(GO:0043759) aryl-CoA synthetase (ADP-forming) activity(GO:0043762) 3-hydroxypropionyl-CoA synthetase activity(GO:0043955) perillic acid:CoA ligase (ADP-forming) activity(GO:0052685) perillic acid:CoA ligase (AMP-forming) activity(GO:0052686) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity(GO:0052687) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity(GO:0052688) pristanate-CoA ligase activity(GO:0070251) malonyl-CoA synthetase activity(GO:0090409) |
0.0 | 0.4 | GO:0097157 | pre-mRNA intronic binding(GO:0097157) |
0.0 | 0.6 | GO:0005542 | folic acid binding(GO:0005542) |
0.0 | 0.9 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
0.0 | 0.3 | GO:0048531 | beta-1,3-galactosyltransferase activity(GO:0048531) |
0.0 | 0.1 | GO:0070051 | fibrinogen binding(GO:0070051) |
0.0 | 0.6 | GO:0000400 | four-way junction DNA binding(GO:0000400) |
0.0 | 0.5 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
0.0 | 0.5 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
0.0 | 0.4 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
0.0 | 0.9 | GO:0048487 | beta-tubulin binding(GO:0048487) |
0.0 | 0.1 | GO:0032896 | palmitoyl-CoA 9-desaturase activity(GO:0032896) |
0.0 | 0.9 | GO:0003777 | microtubule motor activity(GO:0003777) |
0.0 | 0.8 | GO:0004120 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715) |
0.0 | 0.9 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
0.0 | 0.5 | GO:0070888 | E-box binding(GO:0070888) |
0.0 | 0.8 | GO:0016706 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706) |