Motif ID: Trp63

Z-value: 0.516


Transcription factors associated with Trp63:

Gene SymbolEntrez IDGene Name
Trp63 ENSMUSG00000022510.8 Trp63



Activity profile for motif Trp63.

activity profile for motif Trp63


Sorted Z-values histogram for motif Trp63

Sorted Z-values for motif Trp63



Network of associatons between targets according to the STRING database.



First level regulatory network of Trp63

PNG image of the network

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Top targets:


Showing 1 to 20 of 41 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_29090969 3.030 ENSMUST00000119901.1
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr12_-_108003414 2.229 ENSMUST00000109887.1
ENSMUST00000109891.2
 Bcl11b

B cell leukemia/lymphoma 11B

chr5_-_5265224 1.915 ENSMUST00000115450.1
 Cdk14
cyclin-dependent kinase 14
chr12_-_108003594 1.678 ENSMUST00000066060.4
 Bcl11b
B cell leukemia/lymphoma 11B
chr5_-_5266038 1.464 ENSMUST00000115451.1
ENSMUST00000115452.1
ENSMUST00000131392.1
 Cdk14


cyclin-dependent kinase 14


chr7_-_141443314 1.120 ENSMUST00000106005.2
 Lrdd
leucine-rich and death domain containing
chr7_-_116038734 1.009 ENSMUST00000166877.1
 Sox6
SRY-box containing gene 6
chr13_-_103334429 0.983 ENSMUST00000167058.1
ENSMUST00000164111.1
 Mast4

microtubule associated serine/threonine kinase family member 4

chr11_-_101466222 0.962 ENSMUST00000040430.7
 Vat1
vesicle amine transport protein 1 homolog (T californica)
chr6_+_34709610 0.627 ENSMUST00000031775.6
 Cald1
caldesmon 1
chr8_-_87959560 0.579 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr10_-_80671976 0.576 ENSMUST00000003433.6
 Mknk2
MAP kinase-interacting serine/threonine kinase 2
chr11_-_106487833 0.514 ENSMUST00000106801.1
 Ern1
endoplasmic reticulum (ER) to nucleus signalling 1
chr3_-_108402589 0.508 ENSMUST00000147565.1
 Celsr2
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)
chr4_-_134018829 0.481 ENSMUST00000051674.2
 Lin28a
lin-28 homolog A (C. elegans)
chr10_-_61452658 0.456 ENSMUST00000167087.1
ENSMUST00000020288.7
 Eif4ebp2

eukaryotic translation initiation factor 4E binding protein 2

chr2_-_170427828 0.451 ENSMUST00000013667.2
ENSMUST00000109152.2
ENSMUST00000068137.4
 Bcas1


breast carcinoma amplified sequence 1


chr8_+_84686300 0.416 ENSMUST00000177531.1
 Trmt1
tRNA methyltransferase 1
chr1_-_9700209 0.362 ENSMUST00000088658.4
 Mybl1
myeloblastosis oncogene-like 1
chr11_-_106487796 0.319 ENSMUST00000001059.2
ENSMUST00000106799.1
ENSMUST00000106800.1
 Ern1


endoplasmic reticulum (ER) to nucleus signalling 1



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 3.9 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
0.0 3.4 GO:0000086 G2/M transition of mitotic cell cycle(GO:0000086)
0.3 3.0 GO:0071493 cellular response to UV-B(GO:0071493) replicative senescence(GO:0090399)
0.2 1.0 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.1 1.0 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.2 0.8 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0 0.8 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
0.1 0.6 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.0 0.6 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.1 0.5 GO:0033326 cerebrospinal fluid secretion(GO:0033326)
0.1 0.5 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.5 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.1 0.4 GO:0002940 tRNA N2-guanine methylation(GO:0002940)
0.1 0.2 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.0 0.2 GO:0051127 positive regulation of actin nucleation(GO:0051127)
0.0 0.1 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.0 0.1 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)

Gene overrepresentation in cellular_component category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 3.4 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
1.0 3.0 GO:0070557 PCNA-p21 complex(GO:0070557)
0.2 0.8 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1 0.8 GO:0030478 actin cap(GO:0030478)
0.0 0.2 GO:0032591 dendritic spine membrane(GO:0032591)

Gene overrepresentation in molecular_function category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 3.4 GO:0030332 cyclin binding(GO:0030332)
0.2 3.0 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 1.0 GO:0008748 N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) epoxyqueuosine reductase activity(GO:0052693)
0.1 0.8 GO:0016443 bidentate ribonuclease III activity(GO:0016443)
0.0 0.6 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.5 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.5 GO:0035198 miRNA binding(GO:0035198)
0.1 0.4 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.1 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.1 GO:0016500 protein-hormone receptor activity(GO:0016500)