Motif ID: Trp73

Z-value: 0.547


Transcription factors associated with Trp73:

Gene SymbolEntrez IDGene Name
Trp73 ENSMUSG00000029026.10 Trp73

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Trp73mm10_v2_chr4_-_154097105_1540971730.556.4e-03Click!


Activity profile for motif Trp73.

activity profile for motif Trp73


Sorted Z-values histogram for motif Trp73

Sorted Z-values for motif Trp73



Network of associatons between targets according to the STRING database.



First level regulatory network of Trp73

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_153665274 2.121 ENSMUST00000152114.1
ENSMUST00000111812.1
Rgs8

regulator of G-protein signaling 8

chr16_-_17125106 1.847 ENSMUST00000093336.6
2610318N02Rik
RIKEN cDNA 2610318N02 gene
chr17_+_29090969 1.823 ENSMUST00000119901.1
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr13_+_48261427 1.740 ENSMUST00000021810.1
Id4
inhibitor of DNA binding 4
chr7_-_141443314 1.474 ENSMUST00000106005.2
Lrdd
leucine-rich and death domain containing
chr12_+_109747903 1.469 ENSMUST00000183084.1
ENSMUST00000182300.1
Mirg

miRNA containing gene

chr1_+_72824482 1.453 ENSMUST00000047328.4
Igfbp2
insulin-like growth factor binding protein 2
chr12_-_45074112 1.194 ENSMUST00000120531.1
ENSMUST00000143376.1
Stxbp6

syntaxin binding protein 6 (amisyn)

chrX_-_10216918 1.156 ENSMUST00000072393.2
ENSMUST00000044598.6
ENSMUST00000073392.4
ENSMUST00000115533.1
ENSMUST00000115532.1
Rpgr




retinitis pigmentosa GTPase regulator




chr2_-_164857542 1.144 ENSMUST00000109316.1
ENSMUST00000156255.1
ENSMUST00000128110.1
ENSMUST00000109317.3
Pltp



phospholipid transfer protein



chrX_+_10717390 1.139 ENSMUST00000115524.1
ENSMUST00000008179.6
Mid1ip1

Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))

chr3_+_159839729 1.133 ENSMUST00000068952.5
Wls
wntless homolog (Drosophila)
chr15_+_84232030 1.049 ENSMUST00000023072.6
Parvb
parvin, beta
chrX_+_10717451 1.047 ENSMUST00000156321.1
Mid1ip1
Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))
chr11_-_76468396 0.961 ENSMUST00000065028.7
Abr
active BCR-related gene
chr2_-_164857671 0.886 ENSMUST00000059954.7
Pltp
phospholipid transfer protein
chr12_-_45074457 0.801 ENSMUST00000053768.6
Stxbp6
syntaxin binding protein 6 (amisyn)
chr10_-_67912620 0.710 ENSMUST00000064656.7
Zfp365
zinc finger protein 365
chr9_-_109082372 0.696 ENSMUST00000167504.1
Tma7
translational machinery associated 7 homolog (S. cerevisiae)
chr5_+_43233928 0.643 ENSMUST00000114066.1
ENSMUST00000114065.1
Cpeb2

cytoplasmic polyadenylation element binding protein 2

chr4_+_62583568 0.602 ENSMUST00000098031.3
Rgs3
regulator of G-protein signaling 3
chr3_-_107931579 0.586 ENSMUST00000133947.2
ENSMUST00000124215.1
ENSMUST00000106688.1
ENSMUST00000106687.2
Gstm7



glutathione S-transferase, mu 7



chr10_+_110745433 0.575 ENSMUST00000174857.1
ENSMUST00000073781.5
ENSMUST00000173471.1
ENSMUST00000173634.1
E2f7



E2F transcription factor 7



chr1_-_12991109 0.494 ENSMUST00000115403.2
ENSMUST00000115402.1
Slco5a1

solute carrier organic anion transporter family, member 5A1

chr7_-_116038734 0.456 ENSMUST00000166877.1
Sox6
SRY-box containing gene 6
chr3_+_89245952 0.453 ENSMUST00000040888.5
Krtcap2
keratinocyte associated protein 2
chr14_+_53665912 0.450 ENSMUST00000181768.1
Trav3-3
T cell receptor alpha variable 3-3
chr2_+_34772089 0.448 ENSMUST00000028222.6
ENSMUST00000100171.2
Hspa5

heat shock protein 5

chr19_+_41911851 0.403 ENSMUST00000011896.6
Pgam1
phosphoglycerate mutase 1
chr16_+_57121705 0.403 ENSMUST00000166897.1
Tomm70a
translocase of outer mitochondrial membrane 70 homolog A (yeast)
chr11_-_120348513 0.399 ENSMUST00000071555.6
Actg1
actin, gamma, cytoplasmic 1
chr1_-_170215380 0.388 ENSMUST00000027979.7
ENSMUST00000123399.1
Uhmk1

U2AF homology motif (UHM) kinase 1

chr15_+_76696725 0.345 ENSMUST00000023203.4
Gpt
glutamic pyruvic transaminase, soluble
chr1_-_55088024 0.339 ENSMUST00000027123.8
Hspd1
heat shock protein 1 (chaperonin)
chr4_-_11386757 0.324 ENSMUST00000108313.1
ENSMUST00000108311.2
Esrp1

epithelial splicing regulatory protein 1

chr3_-_89245159 0.316 ENSMUST00000090924.6
Trim46
tripartite motif-containing 46
chr3_-_89245829 0.315 ENSMUST00000041022.8
Trim46
tripartite motif-containing 46
chr11_-_103344651 0.289 ENSMUST00000041385.7
Arhgap27
Rho GTPase activating protein 27
chr19_-_50030735 0.286 ENSMUST00000071866.1
Rpl13a-ps1
ribosomal protein 13A, pseudogene 1
chr4_-_45489794 0.268 ENSMUST00000146236.1
Shb
src homology 2 domain-containing transforming protein B
chr1_+_55088132 0.265 ENSMUST00000075242.6
Hspe1
heat shock protein 1 (chaperonin 10)
chr3_+_14641722 0.247 ENSMUST00000029071.8
Car13
carbonic anhydrase 13
chr7_-_5014645 0.241 ENSMUST00000165320.1
Fiz1
Flt3 interacting zinc finger protein 1
chr4_+_129820198 0.239 ENSMUST00000030578.7
Ptp4a2
protein tyrosine phosphatase 4a2
chr7_+_140881898 0.239 ENSMUST00000026560.7
Psmd13
proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
chr2_+_150909565 0.238 ENSMUST00000028948.4
Gins1
GINS complex subunit 1 (Psf1 homolog)
chr1_+_135729147 0.229 ENSMUST00000027677.7
Csrp1
cysteine and glycine-rich protein 1
chr10_+_39369750 0.224 ENSMUST00000063091.6
ENSMUST00000099967.3
ENSMUST00000126486.1
Fyn


Fyn proto-oncogene


chr7_-_116308241 0.220 ENSMUST00000183057.1
ENSMUST00000182487.1
ENSMUST00000181998.1
Plekha7


pleckstrin homology domain containing, family A member 7


chr4_-_106804998 0.202 ENSMUST00000065253.6
Acot11
acyl-CoA thioesterase 11
chr11_-_100738153 0.192 ENSMUST00000155500.1
ENSMUST00000107364.1
ENSMUST00000019317.5
Rab5c


RAB5C, member RAS oncogene family


chr14_-_73325773 0.176 ENSMUST00000022701.6
Rb1
retinoblastoma 1
chr7_+_140882430 0.174 ENSMUST00000164681.1
ENSMUST00000163610.1
Psmd13

proteasome (prosome, macropain) 26S subunit, non-ATPase, 13

chr7_-_31054815 0.155 ENSMUST00000071697.4
ENSMUST00000108110.3
Fxyd1

FXYD domain-containing ion transport regulator 1

chr9_-_44713196 0.153 ENSMUST00000144251.1
ENSMUST00000156918.1
Phldb1

pleckstrin homology-like domain, family B, member 1

chr11_+_98026918 0.142 ENSMUST00000017548.6
Rpl19
ribosomal protein L19
chr2_-_180920925 0.135 ENSMUST00000037299.8
ENSMUST00000108876.2
Ythdf1

YTH domain family 1

chr16_-_18629864 0.129 ENSMUST00000096987.5
Sept5
septin 5
chr10_-_57532489 0.126 ENSMUST00000020027.4
Serinc1
serine incorporator 1
chr9_-_67760208 0.124 ENSMUST00000068526.5
M5C1000I18Rik
RIKEN cDNA M5C1000I18 gene
chr2_-_90904827 0.093 ENSMUST00000005647.3
Ndufs3
NADH dehydrogenase (ubiquinone) Fe-S protein 3
chr14_-_52104015 0.092 ENSMUST00000111610.4
ENSMUST00000164655.1
Hnrnpc

heterogeneous nuclear ribonucleoprotein C

chr5_-_30960326 0.090 ENSMUST00000074840.5
Preb
prolactin regulatory element binding
chr11_+_69913888 0.087 ENSMUST00000072581.2
ENSMUST00000116358.1
Gps2

G protein pathway suppressor 2

chr11_-_102230091 0.063 ENSMUST00000008999.5
Hdac5
histone deacetylase 5
chr19_-_4943049 0.053 ENSMUST00000133254.1
ENSMUST00000120475.1
ENSMUST00000025834.7
Peli3


pellino 3


chr11_-_102230127 0.045 ENSMUST00000107150.1
ENSMUST00000156337.1
ENSMUST00000107151.2
ENSMUST00000107152.2
Hdac5



histone deacetylase 5



chr5_-_92083667 0.032 ENSMUST00000113127.3
G3bp2
GTPase activating protein (SH3 domain) binding protein 2
chr10_-_62651194 0.032 ENSMUST00000020270.4
Ddx50
DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
chr5_-_30960236 0.028 ENSMUST00000088063.2
Preb
prolactin regulatory element binding
chr5_-_92083455 0.024 ENSMUST00000169094.1
ENSMUST00000167918.1
G3bp2

GTPase activating protein (SH3 domain) binding protein 2

chr10_+_105841064 0.018 ENSMUST00000020049.8
Ccdc59
coiled-coil domain containing 59
chr13_+_12702362 0.006 ENSMUST00000104944.2
Gm2399
predicted gene 2399
chr4_+_109000606 0.004 ENSMUST00000065977.4
ENSMUST00000102736.2
Nrd1

nardilysin, N-arginine dibasic convertase, NRD convertase 1

chr3_-_89402650 0.002 ENSMUST00000168325.1
ENSMUST00000057431.5
Lenep

lens epithelial protein

chr18_+_56432116 0.001 ENSMUST00000070166.5
Gramd3
GRAM domain containing 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0042360 vitamin E metabolic process(GO:0042360)
0.4 1.7 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.2 2.0 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.2 0.7 GO:0033566 gamma-tubulin complex localization(GO:0033566)
0.2 1.8 GO:0071493 cellular response to UV-B(GO:0071493) replicative senescence(GO:0090399)
0.2 1.0 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313)
0.2 0.6 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.2 2.2 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
0.2 2.1 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.1 0.4 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.1 0.6 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.1 0.4 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.1 0.6 GO:0002182 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.1 0.3 GO:0002842 T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840) positive regulation of T cell mediated immune response to tumor cell(GO:0002842)
0.1 1.1 GO:0031017 exocrine pancreas development(GO:0031017)
0.1 1.5 GO:0042104 positive regulation of activated T cell proliferation(GO:0042104)
0.1 0.2 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.1 0.2 GO:1903795 regulation of inorganic anion transmembrane transport(GO:1903795)
0.0 0.5 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0 0.3 GO:1900194 negative regulation of oocyte development(GO:0060283) negative regulation of oocyte maturation(GO:1900194)
0.0 0.5 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.2 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 1.2 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 0.2 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.0 0.5 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.0 0.4 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.2 GO:1902969 mitotic DNA replication(GO:1902969)
0.0 0.1 GO:0090365 regulation of mRNA modification(GO:0090365)
0.0 0.2 GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein(GO:0042523)
0.0 0.3 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 0.1 GO:0070428 regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428)
0.0 0.2 GO:2001197 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.0 1.0 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.1 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.0 0.5 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.3 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 2.0 GO:0000145 exocyst(GO:0000145)
0.1 0.2 GO:0000811 GINS complex(GO:0000811)
0.1 0.3 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 1.5 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.4 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.6 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.2 GO:0035189 Rb-E2F complex(GO:0035189)
0.0 0.5 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.4 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 1.2 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.9 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 0.2 GO:0005915 zonula adherens(GO:0005915)
0.0 0.1 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.1 GO:0031105 septin complex(GO:0031105)
0.0 0.4 GO:0043034 costamere(GO:0043034)
0.0 0.2 GO:0045180 basal cortex(GO:0045180)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 0.4 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.1 1.8 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 1.1 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.1 0.6 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.1 2.0 GO:0017049 GTP-Rho binding(GO:0017049)
0.1 2.1 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 0.3 GO:0043559 insulin binding(GO:0043559)
0.1 0.5 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.5 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.2 GO:0042610 CD8 receptor binding(GO:0042610)
0.0 0.1 GO:1990932 5.8S rRNA binding(GO:1990932)
0.0 0.2 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.6 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0 0.4 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.2 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.2 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.1 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.0 0.3 GO:0008483 transaminase activity(GO:0008483)
0.0 0.2 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 1.9 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)