Motif ID: Twist1

Z-value: 0.839


Transcription factors associated with Twist1:

Gene SymbolEntrez IDGene Name
Twist1 ENSMUSG00000035799.5 Twist1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Twist1mm10_v2_chr12_+_33957645_339576710.067.8e-01Click!


Activity profile for motif Twist1.

activity profile for motif Twist1


Sorted Z-values histogram for motif Twist1

Sorted Z-values for motif Twist1



Network of associatons between targets according to the STRING database.



First level regulatory network of Twist1

PNG image of the network

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Top targets:


Showing 1 to 20 of 115 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_180225812 2.308 ENSMUST00000015791.5
 Lama5
laminin, alpha 5
chr19_+_5740885 2.205 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chr16_+_78930940 1.931 ENSMUST00000114216.1
ENSMUST00000069148.6
ENSMUST00000023568.7
 Chodl


chondrolectin


chr19_-_28963863 1.920 ENSMUST00000161813.1
 4430402I18Rik
RIKEN cDNA 4430402I18 gene
chr1_-_119053339 1.790 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
 Gli2


GLI-Kruppel family member GLI2


chr6_+_29398920 1.566 ENSMUST00000181464.1
ENSMUST00000180829.1
 Ccdc136

coiled-coil domain containing 136

chr9_+_60794468 1.531 ENSMUST00000050183.6
 Uaca
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr14_+_101729907 1.149 ENSMUST00000100337.3
 Lmo7
LIM domain only 7
chr5_-_62766153 1.067 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr5_+_149411749 1.040 ENSMUST00000093110.5
 Medag
mesenteric estrogen dependent adipogenesis
chr2_-_33942111 0.943 ENSMUST00000130988.1
ENSMUST00000127936.1
ENSMUST00000134271.1
 Gm13403


predicted gene 13403


chr1_+_74791516 0.900 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr10_-_127341583 0.736 ENSMUST00000026474.3
 Gli1
GLI-Kruppel family member GLI1
chr18_-_16809233 0.723 ENSMUST00000025166.7
 Cdh2
cadherin 2
chr6_-_134566913 0.699 ENSMUST00000032322.8
 Lrp6
low density lipoprotein receptor-related protein 6
chr9_+_118478851 0.687 ENSMUST00000150633.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr7_+_122289297 0.685 ENSMUST00000064989.5
ENSMUST00000064921.4
 Prkcb

protein kinase C, beta

chr14_-_54781886 0.668 ENSMUST00000022787.6
 Slc7a8
solute carrier family 7 (cationic amino acid transporter, y+ system), member 8
chr11_-_70687917 0.588 ENSMUST00000108545.2
ENSMUST00000120261.1
ENSMUST00000036299.7
ENSMUST00000119120.1
ENSMUST00000100933.3
 Camta2




calmodulin binding transcription activator 2




chr7_-_4789541 0.584 ENSMUST00000168578.1
 Tmem238
transmembrane protein 238

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 2.5 GO:0060032 notochord regression(GO:0060032)
0.7 2.2 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.1 2.1 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.1 1.5 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.0 1.1 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.0 0.9 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.1 0.8 GO:1904217 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.1 0.8 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.2 0.7 GO:0061324 mammary placode formation(GO:0060596) canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation(GO:0061324) planar cell polarity pathway involved in outflow tract morphogenesis(GO:0061347) planar cell polarity pathway involved in ventricular septum morphogenesis(GO:0061348) planar cell polarity pathway involved in cardiac right atrium morphogenesis(GO:0061349) planar cell polarity pathway involved in cardiac muscle tissue morphogenesis(GO:0061350) planar cell polarity pathway involved in pericardium morphogenesis(GO:0061354) regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901963)
0.2 0.7 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302) mesodermal to mesenchymal transition involved in gastrulation(GO:0060809)
0.1 0.7 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.1 0.7 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.1 0.7 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0 0.7 GO:0003333 amino acid transmembrane transport(GO:0003333) neutral amino acid transport(GO:0015804)
0.0 0.7 GO:0007520 myoblast fusion(GO:0007520)
0.2 0.6 GO:1904395 regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.2 0.6 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.6 GO:0014898 muscle hypertrophy in response to stress(GO:0003299) cardiac muscle hypertrophy in response to stress(GO:0014898)
0.2 0.5 GO:0033860 regulation of NAD(P)H oxidase activity(GO:0033860)
0.1 0.5 GO:0032911 nerve growth factor production(GO:0032902) negative regulation of transforming growth factor beta1 production(GO:0032911)

Gene overrepresentation in cellular_component category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.5 GO:0097542 ciliary tip(GO:0097542)
0.6 2.3 GO:0043259 laminin-10 complex(GO:0043259)
0.4 1.5 GO:0043293 apoptosome(GO:0043293)
0.0 1.1 GO:0005913 cell-cell adherens junction(GO:0005913)
0.3 0.8 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.2 0.7 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.1 0.7 GO:0005916 fascia adherens(GO:0005916)
0.2 0.6 GO:1990590 ATF1-ATF4 transcription factor complex(GO:1990590)
0.0 0.5 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.3 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.0 0.3 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.3 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.2 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.2 GO:0031045 dense core granule(GO:0031045)
0.0 0.1 GO:0036488 CHOP-C/EBP complex(GO:0036488)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.3 GO:0005178 integrin binding(GO:0005178)
0.1 2.2 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.1 2.1 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.6 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 1.5 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.2 1.4 GO:0019534 toxin transporter activity(GO:0019534)
0.0 1.1 GO:0042805 actinin binding(GO:0042805)
0.0 1.0 GO:0005109 frizzled binding(GO:0005109)
0.1 0.9 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 0.8 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.1 0.8 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.2 0.7 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.1 0.7 GO:0035184 histone threonine kinase activity(GO:0035184)
0.1 0.7 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.7 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.7 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 0.6 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.0 0.6 GO:0015026 coreceptor activity(GO:0015026)
0.1 0.5 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.1 0.5 GO:0005225 volume-sensitive anion channel activity(GO:0005225)