Motif ID: Vsx1_Uncx_Prrx2_Shox2_Noto

Z-value: 1.011

Transcription factors associated with Vsx1_Uncx_Prrx2_Shox2_Noto:

Gene SymbolEntrez IDGene Name
Noto ENSMUSG00000068302.7 Noto
Prrx2 ENSMUSG00000039476.7 Prrx2
Shox2 ENSMUSG00000027833.10 Shox2
Uncx ENSMUSG00000029546.11 Uncx
Vsx1 ENSMUSG00000033080.8 Vsx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Uncxmm10_v2_chr5_+_139543889_1395439040.883.8e-08Click!
Shox2mm10_v2_chr3_-_66981279_669813180.291.8e-01Click!
Prrx2mm10_v2_chr2_+_30845059_30845059-0.252.6e-01Click!


Activity profile for motif Vsx1_Uncx_Prrx2_Shox2_Noto.

activity profile for motif Vsx1_Uncx_Prrx2_Shox2_Noto


Sorted Z-values histogram for motif Vsx1_Uncx_Prrx2_Shox2_Noto

Sorted Z-values for motif Vsx1_Uncx_Prrx2_Shox2_Noto



Network of associatons between targets according to the STRING database.



First level regulatory network of Vsx1_Uncx_Prrx2_Shox2_Noto

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 22.234 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr3_+_55782500 16.369 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr12_+_38780284 10.496 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr12_+_38780817 10.366 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr3_+_125404072 9.376 ENSMUST00000173932.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr4_-_35845204 9.035 ENSMUST00000164772.1
ENSMUST00000065173.2
 Lingo2

leucine rich repeat and Ig domain containing 2

chr3_+_125404292 8.646 ENSMUST00000144344.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr7_-_49636847 8.636 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr6_+_8948608 7.988 ENSMUST00000160300.1
 Nxph1
neurexophilin 1
chr2_-_72986716 7.030 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr17_+_34592248 6.536 ENSMUST00000038149.6
 Pbx2
pre B cell leukemia homeobox 2
chr12_+_38781093 6.507 ENSMUST00000161513.1
 Etv1
ets variant gene 1
chr12_+_38783503 6.415 ENSMUST00000159334.1
 Etv1
ets variant gene 1
chr8_-_61902669 6.221 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr3_-_86548268 6.026 ENSMUST00000077524.3
 Mab21l2
mab-21-like 2 (C. elegans)
chr3_+_159839729 5.992 ENSMUST00000068952.5
 Wls
wntless homolog (Drosophila)
chr10_-_45470201 5.905 ENSMUST00000079390.6
 Lin28b
lin-28 homolog B (C. elegans)
chr3_-_17786834 5.573 ENSMUST00000099198.2
 Gm10742
predicted gene 10742
chr14_-_48665098 5.418 ENSMUST00000118578.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr12_+_109545390 5.107 ENSMUST00000146701.1
 Meg3
maternally expressed 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 131 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 30.0 GO:0007638 mechanosensory behavior(GO:0007638)
2.8 22.2 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 9.2 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.5 8.6 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.0 8.6 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.4 7.8 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.4 6.2 GO:0071803 positive regulation of podosome assembly(GO:0071803)
1.5 6.0 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.5 6.0 GO:0031017 exocrine pancreas development(GO:0031017)
0.7 5.9 GO:0010587 miRNA catabolic process(GO:0010587)
0.8 5.6 GO:0051798 positive regulation of hair follicle development(GO:0051798)
0.2 5.6 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.2 5.5 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.4 5.4 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.2 5.1 GO:0008340 determination of adult lifespan(GO:0008340)
1.7 5.0 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.0 4.9 GO:0007605 sensory perception of sound(GO:0007605)
0.3 4.2 GO:0007530 sex determination(GO:0007530)
0.1 4.1 GO:0006270 DNA replication initiation(GO:0006270)
0.1 4.0 GO:0009954 proximal/distal pattern formation(GO:0009954)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 81.5 GO:0005634 nucleus(GO:0005634)
0.0 14.0 GO:0005794 Golgi apparatus(GO:0005794)
0.1 7.8 GO:0000792 heterochromatin(GO:0000792)
0.2 6.2 GO:0002102 podosome(GO:0002102)
0.2 6.0 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 5.3 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1 5.1 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 3.2 GO:0030426 growth cone(GO:0030426)
0.0 2.7 GO:0016363 nuclear matrix(GO:0016363)
0.1 2.5 GO:0031527 filopodium membrane(GO:0031527)
0.1 2.3 GO:0032420 stereocilium(GO:0032420)
0.0 2.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 2.1 GO:0043034 costamere(GO:0043034)
0.3 2.0 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.1 2.0 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 1.9 GO:0070382 exocytic vesicle(GO:0070382)
0.1 1.5 GO:0042788 polysomal ribosome(GO:0042788)
0.1 1.4 GO:0031045 dense core granule(GO:0031045)
0.4 1.3 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.3 1.3 GO:0060187 cell pole(GO:0060187)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 47.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 29.4 GO:0043565 sequence-specific DNA binding(GO:0043565)
2.6 17.9 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.2 7.3 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 6.8 GO:0000287 magnesium ion binding(GO:0000287)
0.6 5.9 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.1 5.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 4.7 GO:0003779 actin binding(GO:0003779)
0.5 4.5 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 4.1 GO:0003714 transcription corepressor activity(GO:0003714)
0.3 3.7 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.3 3.6 GO:0048185 activin binding(GO:0048185)
0.5 3.1 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 2.7 GO:0003682 chromatin binding(GO:0003682)
0.0 2.6 GO:0003924 GTPase activity(GO:0003924)
0.0 2.1 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.2 2.0 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 2.0 GO:0030165 PDZ domain binding(GO:0030165)
0.1 1.7 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 1.7 GO:0005507 copper ion binding(GO:0005507)