Motif ID: Zfhx3

Z-value: 0.806


Transcription factors associated with Zfhx3:

Gene SymbolEntrez IDGene Name
Zfhx3 ENSMUSG00000038872.8 Zfhx3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zfhx3mm10_v2_chr8_+_108714644_108714644-0.193.8e-01Click!


Activity profile for motif Zfhx3.

activity profile for motif Zfhx3


Sorted Z-values histogram for motif Zfhx3

Sorted Z-values for motif Zfhx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Zfhx3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_101377897 4.973 ENSMUST00000075994.6
 Pdzrn3
PDZ domain containing RING finger 3
chr17_+_35076902 2.204 ENSMUST00000172494.1
ENSMUST00000172678.1
ENSMUST00000013910.4
 Ly6g6e


lymphocyte antigen 6 complex, locus G6E


chr4_-_32923455 2.060 ENSMUST00000035719.4
ENSMUST00000084749.1
 Ankrd6

ankyrin repeat domain 6

chr2_-_63184253 1.296 ENSMUST00000075052.3
ENSMUST00000112454.1
 Kcnh7

potassium voltage-gated channel, subfamily H (eag-related), member 7

chr1_-_157256682 1.149 ENSMUST00000134543.1
 Rasal2
RAS protein activator like 2
chr8_-_67818284 1.115 ENSMUST00000120071.1
 Psd3
pleckstrin and Sec7 domain containing 3
chr10_-_110000219 1.081 ENSMUST00000032719.7
 Nav3
neuron navigator 3
chr2_-_63184170 1.021 ENSMUST00000112452.1
 Kcnh7
potassium voltage-gated channel, subfamily H (eag-related), member 7
chr6_-_86765807 1.013 ENSMUST00000123732.1
 Anxa4
annexin A4
chr10_-_17947997 1.012 ENSMUST00000037879.6
 Heca
headcase homolog (Drosophila)
chr16_-_74411776 1.010 ENSMUST00000116586.2
 Robo2
roundabout homolog 2 (Drosophila)
chr9_+_95857597 1.003 ENSMUST00000034980.7
 Atr
ataxia telangiectasia and Rad3 related
chr5_-_107875035 0.992 ENSMUST00000138111.1
ENSMUST00000112642.1
 Evi5

ecotropic viral integration site 5

chr5_+_107497718 0.975 ENSMUST00000112671.2
 A830010M20Rik
RIKEN cDNA A830010M20 gene
chr9_+_86485407 0.970 ENSMUST00000034987.8
 Dopey1
dopey family member 1
chr1_+_179961110 0.928 ENSMUST00000076687.5
ENSMUST00000097450.3
 Cdc42bpa

CDC42 binding protein kinase alpha

chr10_-_30842765 0.898 ENSMUST00000019924.8
 Hey2
hairy/enhancer-of-split related with YRPW motif 2
chr13_-_110280103 0.839 ENSMUST00000167824.1
 Rab3c
RAB3C, member RAS oncogene family
chr2_+_3770673 0.816 ENSMUST00000177037.1
 Fam107b
family with sequence similarity 107, member B
chr5_+_107497762 0.804 ENSMUST00000152474.1
ENSMUST00000060553.7
 A830010M20Rik

RIKEN cDNA A830010M20 gene

chr3_+_90537306 0.803 ENSMUST00000107335.1
 S100a16
S100 calcium binding protein A16
chr10_-_56228636 0.787 ENSMUST00000099739.3
 Tbc1d32
TBC1 domain family, member 32
chr3_+_66985680 0.787 ENSMUST00000065047.6
 Rsrc1
arginine/serine-rich coiled-coil 1
chr3_+_90537242 0.747 ENSMUST00000098911.3
 S100a16
S100 calcium binding protein A16
chr6_-_86765866 0.742 ENSMUST00000113675.1
 Anxa4
annexin A4
chr2_+_82053222 0.707 ENSMUST00000047527.7
 Zfp804a
zinc finger protein 804A
chr10_+_115384951 0.707 ENSMUST00000036044.8
 Zfc3h1
zinc finger, C3H1-type containing
chr8_-_67818218 0.679 ENSMUST00000059374.4
 Psd3
pleckstrin and Sec7 domain containing 3
chr2_-_140671440 0.678 ENSMUST00000099301.1
 Flrt3
fibronectin leucine rich transmembrane protein 3
chr13_-_75943812 0.665 ENSMUST00000022078.5
ENSMUST00000109606.1
 Rhobtb3

Rho-related BTB domain containing 3

chrX_-_143933089 0.637 ENSMUST00000087313.3
 Dcx
doublecortin
chrM_-_14060 0.635 ENSMUST00000082419.1
 mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr2_+_177768044 0.630 ENSMUST00000108942.3
 Gm14322
predicted gene 14322
chr3_-_123385925 0.595 ENSMUST00000090371.7
ENSMUST00000174323.1
ENSMUST00000029759.9
 Mettl14


methyltransferase like 14


chr19_+_10015016 0.581 ENSMUST00000137637.1
ENSMUST00000149967.1
 Rab3il1

RAB3A interacting protein (rabin3)-like 1

chr14_+_64588112 0.577 ENSMUST00000181808.1
 A930011O12Rik
RIKEN cDNA A930011O12 gene
chr3_+_84952146 0.572 ENSMUST00000029727.7
 Fbxw7
F-box and WD-40 domain protein 7
chr3_+_28263205 0.563 ENSMUST00000159236.2
 Tnik
TRAF2 and NCK interacting kinase
chr3_-_39359128 0.530 ENSMUST00000056409.2
 Gm9845
predicted pseudogene 9845
chr12_+_71170589 0.526 ENSMUST00000129376.1
 2700049A03Rik
RIKEN cDNA 2700049A03 gene
chr1_+_74661794 0.510 ENSMUST00000129890.1
 Ttll4
tubulin tyrosine ligase-like family, member 4
chr2_-_140671400 0.502 ENSMUST00000056760.3
 Flrt3
fibronectin leucine rich transmembrane protein 3
chrM_+_9870 0.499 ENSMUST00000084013.1
 mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chr15_+_31224371 0.472 ENSMUST00000044524.9
 Dap
death-associated protein
chr13_+_83732438 0.466 ENSMUST00000182701.1
 C130071C03Rik
RIKEN cDNA C130071C03 gene
chr2_-_140671462 0.449 ENSMUST00000110057.2
 Flrt3
fibronectin leucine rich transmembrane protein 3
chr1_+_179960472 0.438 ENSMUST00000097453.2
ENSMUST00000111117.1
 Cdc42bpa

CDC42 binding protein kinase alpha

chr1_-_24612700 0.418 ENSMUST00000088336.1
 Gm10222
predicted gene 10222
chr7_-_99980431 0.405 ENSMUST00000080817.4
 Rnf169
ring finger protein 169
chrM_+_14138 0.384 ENSMUST00000082421.1
 mt-Cytb
mitochondrially encoded cytochrome b
chr8_-_9976294 0.359 ENSMUST00000095476.4
 Lig4
ligase IV, DNA, ATP-dependent
chrX_-_111536325 0.333 ENSMUST00000156639.1
 Rps6ka6
ribosomal protein S6 kinase polypeptide 6
chrX_-_139871637 0.332 ENSMUST00000033811.7
ENSMUST00000087401.5
 Morc4

microrchidia 4

chr2_+_110597298 0.332 ENSMUST00000045972.6
ENSMUST00000111026.2
 Slc5a12

solute carrier family 5 (sodium/glucose cotransporter), member 12

chr1_+_172698046 0.317 ENSMUST00000038495.3
 Crp
C-reactive protein, pentraxin-related
chr9_-_22208546 0.317 ENSMUST00000167359.1
 1810064F22Rik
RIKEN cDNA 1810064F22 gene
chr9_-_120068263 0.286 ENSMUST00000064165.3
ENSMUST00000177637.1
 Cx3cr1

chemokine (C-X3-C) receptor 1

chr18_+_55057557 0.275 ENSMUST00000181765.1
 Gm4221
predicted gene 4221
chr7_-_101837776 0.272 ENSMUST00000165052.1
 Inppl1
inositol polyphosphate phosphatase-like 1
chr18_+_37518341 0.248 ENSMUST00000097609.1
 Pcdhb22
protocadherin beta 22
chr17_-_32886083 0.245 ENSMUST00000178401.1
 Zfp870
zinc finger protein 870
chr7_+_55794146 0.222 ENSMUST00000032627.3
 Tubgcp5
tubulin, gamma complex associated protein 5
chr5_+_24394388 0.213 ENSMUST00000115074.1
 Abcb8
ATP-binding cassette, sub-family B (MDR/TAP), member 8
chrX_-_143933204 0.208 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr5_+_25246775 0.179 ENSMUST00000144971.1
 Galnt11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11
chr2_+_120977017 0.176 ENSMUST00000067582.7
 Tmem62
transmembrane protein 62
chr3_+_66985647 0.176 ENSMUST00000162362.1
ENSMUST00000065074.7
 Rsrc1

arginine/serine-rich coiled-coil 1

chr6_+_127453667 0.157 ENSMUST00000112193.1
 Parp11
poly (ADP-ribose) polymerase family, member 11
chr4_-_42168603 0.148 ENSMUST00000098121.3
 Gm13305
predicted gene 13305
chr10_+_23796946 0.133 ENSMUST00000119597.1
ENSMUST00000179321.1
 Slc18b1

solute carrier family 18, subfamily B, member 1

chr1_+_164275559 0.127 ENSMUST00000027867.6
 Ccdc181
coiled-coil domain containing 181
chr5_-_137786651 0.123 ENSMUST00000031740.9
 Mepce
methylphosphate capping enzyme
chrX_+_107255878 0.120 ENSMUST00000101294.2
ENSMUST00000118820.1
ENSMUST00000120971.1
 Gpr174


G protein-coupled receptor 174


chr3_+_76075583 0.119 ENSMUST00000160261.1
 Fstl5
follistatin-like 5
chr18_-_66022580 0.113 ENSMUST00000143990.1
 Lman1
lectin, mannose-binding, 1
chrM_+_2743 0.104 ENSMUST00000082392.1
 mt-Nd1
mitochondrially encoded NADH dehydrogenase 1
chr9_+_113812547 0.083 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
 Clasp2


CLIP associating protein 2


chrX_+_163911401 0.079 ENSMUST00000140845.1
 Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr8_+_83666827 0.079 ENSMUST00000019608.5
 Ptger1
prostaglandin E receptor 1 (subtype EP1)
chr11_+_24078173 0.075 ENSMUST00000109514.1
 Bcl11a
B cell CLL/lymphoma 11A (zinc finger protein)
chr7_-_100583072 0.075 ENSMUST00000152876.1
ENSMUST00000150042.1
 Mrpl48

mitochondrial ribosomal protein L48

chr10_+_79927039 0.074 ENSMUST00000019708.5
ENSMUST00000105377.1
 Arid3a

AT rich interactive domain 3A (BRIGHT-like)

chr10_+_79927330 0.051 ENSMUST00000105376.1
 Arid3a
AT rich interactive domain 3A (BRIGHT-like)
chr10_+_23797052 0.027 ENSMUST00000133289.1
 Slc18b1
solute carrier family 18, subfamily B, member 1
chr18_+_11633276 0.026 ENSMUST00000115861.2
 Rbbp8
retinoblastoma binding protein 8
chr2_-_37647199 0.021 ENSMUST00000028279.3
 Strbp
spermatid perinuclear RNA binding protein
chr8_-_66486494 0.004 ENSMUST00000026681.5
 Tma16
translation machinery associated 16 homolog (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
0.4 1.8 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
0.3 1.0 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.3 1.0 GO:1904884 telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.3 0.9 GO:0003195 tricuspid valve development(GO:0003175) tricuspid valve morphogenesis(GO:0003186) tricuspid valve formation(GO:0003195) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.1 0.6 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026) positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.1 0.8 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.1 2.1 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 0.6 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 5.0 GO:0007528 neuromuscular junction development(GO:0007528)
0.1 2.2 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.1 0.4 GO:0033762 response to glucagon(GO:0033762)
0.1 1.8 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 0.3 GO:1900272 negative regulation of long-term synaptic potentiation(GO:1900272)
0.1 0.4 GO:0097680 double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.1 1.4 GO:0007097 nuclear migration(GO:0007097)
0.1 0.5 GO:0018095 protein polyglutamylation(GO:0018095)
0.1 0.8 GO:0021860 pyramidal neuron development(GO:0021860)
0.1 0.6 GO:0080009 mRNA methylation(GO:0080009)
0.1 0.3 GO:0032929 negative regulation of macrophage derived foam cell differentiation(GO:0010745) negative regulation of superoxide anion generation(GO:0032929)
0.0 0.3 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.2 GO:0051418 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.0 0.4 GO:2000780 negative regulation of double-strand break repair(GO:2000780)
0.0 1.0 GO:0046677 response to antibiotic(GO:0046677)
0.0 0.3 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.0 0.2 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.0 1.1 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.0 1.7 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.1 GO:0040031 snRNA modification(GO:0040031)
0.0 0.5 GO:0034198 cellular response to amino acid starvation(GO:0034198)
0.0 2.3 GO:0051291 protein heterooligomerization(GO:0051291)
0.0 0.1 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091) negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 0.5 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 1.4 GO:0051592 response to calcium ion(GO:0051592)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 0.6 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.1 1.1 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 0.4 GO:0032807 DNA ligase IV complex(GO:0032807)
0.1 5.0 GO:0031594 neuromuscular junction(GO:0031594)
0.1 0.2 GO:0000931 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.0 0.4 GO:0045275 respiratory chain complex III(GO:0045275)
0.0 0.9 GO:0016580 Sin3 complex(GO:0016580)
0.0 1.0 GO:0001741 XY body(GO:0001741)
0.0 1.7 GO:0044295 axonal growth cone(GO:0044295)
0.0 1.0 GO:0030673 axolemma(GO:0030673)
0.0 0.4 GO:0035861 site of double-strand break(GO:0035861)
0.0 1.4 GO:0042641 actomyosin(GO:0042641)
0.0 0.5 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.3 GO:0070469 respiratory chain(GO:0070469)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
0.3 0.9 GO:0035939 microsatellite binding(GO:0035939)
0.2 1.0 GO:0032405 MutLalpha complex binding(GO:0032405) MutSalpha complex binding(GO:0032407)
0.1 2.3 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 0.6 GO:0050816 phosphothreonine binding(GO:0050816)
0.1 1.0 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 1.6 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 0.3 GO:0001849 complement component C1q binding(GO:0001849)
0.1 0.4 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.1 0.3 GO:0019960 C-X3-C chemokine binding(GO:0019960)
0.1 0.7 GO:0008758 thiamine-pyrophosphatase activity(GO:0004787) UDP-2,3-diacylglucosamine hydrolase activity(GO:0008758) dATP pyrophosphohydrolase activity(GO:0008828) dihydroneopterin monophosphate phosphatase activity(GO:0019176) dihydroneopterin triphosphate pyrophosphohydrolase activity(GO:0019177) dTTP diphosphatase activity(GO:0036218) phosphocholine hydrolase activity(GO:0044606)
0.0 1.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.4 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 1.8 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 0.1 GO:0004954 icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955)
0.0 0.5 GO:0070513 death domain binding(GO:0070513)
0.0 0.8 GO:0031489 myosin V binding(GO:0031489)
0.0 0.8 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.3 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445)
0.0 0.8 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.2 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 0.3 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 5.0 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.4 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.6 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)