Motif ID: Zfhx3

Z-value: 0.806


Transcription factors associated with Zfhx3:

Gene SymbolEntrez IDGene Name
Zfhx3 ENSMUSG00000038872.8 Zfhx3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zfhx3mm10_v2_chr8_+_108714644_108714644-0.193.8e-01Click!


Activity profile for motif Zfhx3.

activity profile for motif Zfhx3


Sorted Z-values histogram for motif Zfhx3

Sorted Z-values for motif Zfhx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Zfhx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 87 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_101377897 4.973 ENSMUST00000075994.6
 Pdzrn3
PDZ domain containing RING finger 3
chr17_+_35076902 2.204 ENSMUST00000172494.1
ENSMUST00000172678.1
ENSMUST00000013910.4
 Ly6g6e


lymphocyte antigen 6 complex, locus G6E


chr4_-_32923455 2.060 ENSMUST00000035719.4
ENSMUST00000084749.1
 Ankrd6

ankyrin repeat domain 6

chr2_-_63184253 1.296 ENSMUST00000075052.3
ENSMUST00000112454.1
 Kcnh7

potassium voltage-gated channel, subfamily H (eag-related), member 7

chr1_-_157256682 1.149 ENSMUST00000134543.1
 Rasal2
RAS protein activator like 2
chr8_-_67818284 1.115 ENSMUST00000120071.1
 Psd3
pleckstrin and Sec7 domain containing 3
chr10_-_110000219 1.081 ENSMUST00000032719.7
 Nav3
neuron navigator 3
chr2_-_63184170 1.021 ENSMUST00000112452.1
 Kcnh7
potassium voltage-gated channel, subfamily H (eag-related), member 7
chr6_-_86765807 1.013 ENSMUST00000123732.1
 Anxa4
annexin A4
chr10_-_17947997 1.012 ENSMUST00000037879.6
 Heca
headcase homolog (Drosophila)
chr16_-_74411776 1.010 ENSMUST00000116586.2
 Robo2
roundabout homolog 2 (Drosophila)
chr9_+_95857597 1.003 ENSMUST00000034980.7
 Atr
ataxia telangiectasia and Rad3 related
chr5_-_107875035 0.992 ENSMUST00000138111.1
ENSMUST00000112642.1
 Evi5

ecotropic viral integration site 5

chr5_+_107497718 0.975 ENSMUST00000112671.2
 A830010M20Rik
RIKEN cDNA A830010M20 gene
chr9_+_86485407 0.970 ENSMUST00000034987.8
 Dopey1
dopey family member 1
chr1_+_179961110 0.928 ENSMUST00000076687.5
ENSMUST00000097450.3
 Cdc42bpa

CDC42 binding protein kinase alpha

chr10_-_30842765 0.898 ENSMUST00000019924.8
 Hey2
hairy/enhancer-of-split related with YRPW motif 2
chr13_-_110280103 0.839 ENSMUST00000167824.1
 Rab3c
RAB3C, member RAS oncogene family
chr2_+_3770673 0.816 ENSMUST00000177037.1
 Fam107b
family with sequence similarity 107, member B
chr5_+_107497762 0.804 ENSMUST00000152474.1
ENSMUST00000060553.7
 A830010M20Rik

RIKEN cDNA A830010M20 gene


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.0 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 2.3 GO:0051291 protein heterooligomerization(GO:0051291)
0.1 2.2 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.1 2.1 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.4 1.8 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
0.1 1.8 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 1.7 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.5 1.6 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
0.1 1.4 GO:0007097 nuclear migration(GO:0007097)
0.0 1.4 GO:0051592 response to calcium ion(GO:0051592)
0.0 1.1 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.3 1.0 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.3 1.0 GO:1904884 telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.0 1.0 GO:0046677 response to antibiotic(GO:0046677)
0.3 0.9 GO:0003195 tricuspid valve development(GO:0003175) tricuspid valve morphogenesis(GO:0003186) tricuspid valve formation(GO:0003195) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.1 0.8 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.1 0.8 GO:0021860 pyramidal neuron development(GO:0021860)
0.1 0.6 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026) positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.1 0.6 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 0.6 GO:0080009 mRNA methylation(GO:0080009)

Gene overrepresentation in cellular_component category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.0 GO:0031594 neuromuscular junction(GO:0031594)
0.0 1.7 GO:0044295 axonal growth cone(GO:0044295)
0.0 1.4 GO:0042641 actomyosin(GO:0042641)
0.1 1.1 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 1.0 GO:0001741 XY body(GO:0001741)
0.0 1.0 GO:0030673 axolemma(GO:0030673)
0.0 0.9 GO:0016580 Sin3 complex(GO:0016580)
0.1 0.6 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 0.6 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.0 0.5 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 0.4 GO:0032807 DNA ligase IV complex(GO:0032807)
0.0 0.4 GO:0045275 respiratory chain complex III(GO:0045275)
0.0 0.4 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.3 GO:0070469 respiratory chain(GO:0070469)
0.1 0.2 GO:0000931 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.0 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 2.3 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.7 2.2 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
0.0 1.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 1.8 GO:0051059 NF-kappaB binding(GO:0051059)
0.1 1.6 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.2 1.0 GO:0032405 MutLalpha complex binding(GO:0032405) MutSalpha complex binding(GO:0032407)
0.1 1.0 GO:0008046 axon guidance receptor activity(GO:0008046)
0.3 0.9 GO:0035939 microsatellite binding(GO:0035939)
0.0 0.8 GO:0031489 myosin V binding(GO:0031489)
0.0 0.8 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.8 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.7 GO:0008758 thiamine-pyrophosphatase activity(GO:0004787) UDP-2,3-diacylglucosamine hydrolase activity(GO:0008758) dATP pyrophosphohydrolase activity(GO:0008828) dihydroneopterin monophosphate phosphatase activity(GO:0019176) dihydroneopterin triphosphate pyrophosphohydrolase activity(GO:0019177) dTTP diphosphatase activity(GO:0036218) phosphocholine hydrolase activity(GO:0044606)
0.1 0.6 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.6 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.5 GO:0070513 death domain binding(GO:0070513)
0.1 0.4 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 0.4 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.4 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 0.3 GO:0001849 complement component C1q binding(GO:0001849)