Motif ID: Zfp423

Z-value: 0.526


Transcription factors associated with Zfp423:

Gene SymbolEntrez IDGene Name
Zfp423 ENSMUSG00000045333.9 Zfp423

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zfp423mm10_v2_chr8_-_87804411_878044630.272.2e-01Click!


Activity profile for motif Zfp423.

activity profile for motif Zfp423


Sorted Z-values histogram for motif Zfp423

Sorted Z-values for motif Zfp423



Network of associatons between targets according to the STRING database.



First level regulatory network of Zfp423

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_54902743 1.076 ENSMUST00000082430.3
 Gpx3
glutathione peroxidase 3
chr11_+_54902917 0.928 ENSMUST00000149324.1
 Gpx3
glutathione peroxidase 3
chr9_-_37552904 0.902 ENSMUST00000065668.5
 Nrgn
neurogranin
chrX_+_7822289 0.861 ENSMUST00000009875.4
 Kcnd1
potassium voltage-gated channel, Shal-related family, member 1
chr2_+_180499893 0.817 ENSMUST00000029084.2
 Ntsr1
neurotensin receptor 1
chr8_+_58912257 0.789 ENSMUST00000160055.1
 BC030500
cDNA sequence BC030500
chr12_+_109459843 0.735 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chr6_+_110645572 0.701 ENSMUST00000071076.6
ENSMUST00000172951.1
 Grm7

glutamate receptor, metabotropic 7

chr4_+_42917234 0.607 ENSMUST00000107976.2
ENSMUST00000069184.2
 N28178

expressed sequence N28178

chr1_+_167598450 0.602 ENSMUST00000111386.1
ENSMUST00000111384.1
 Rxrg

retinoid X receptor gamma

chr6_+_86628174 0.528 ENSMUST00000043400.6
 Asprv1
aspartic peptidase, retroviral-like 1
chr19_+_6401675 0.515 ENSMUST00000113471.1
ENSMUST00000113469.2
 Rasgrp2

RAS, guanyl releasing protein 2

chr7_+_29307924 0.469 ENSMUST00000108230.1
ENSMUST00000065181.5
 Dpf1

D4, zinc and double PHD fingers family 1

chr19_+_10041548 0.450 ENSMUST00000115995.2
 Fads3
fatty acid desaturase 3
chr6_+_6863769 0.448 ENSMUST00000031768.6
 Dlx6
distal-less homeobox 6
chr8_+_27260327 0.446 ENSMUST00000033880.5
 Eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
chr17_-_10840285 0.437 ENSMUST00000041463.6
 Pacrg
PARK2 co-regulated
chr16_+_17489639 0.417 ENSMUST00000023448.6
 Aifm3
apoptosis-inducing factor, mitochondrion-associated 3
chr2_-_147085445 0.404 ENSMUST00000067020.2
 Nkx2-4
NK2 homeobox 4
chr10_-_62110945 0.395 ENSMUST00000142821.1
ENSMUST00000124615.1
ENSMUST00000064050.4
ENSMUST00000125704.1
ENSMUST00000142796.1
 2010107G23Rik




RIKEN cDNA 2010107G23 gene




chr7_-_105633525 0.343 ENSMUST00000153371.1
ENSMUST00000106789.1
ENSMUST00000057525.7
 Trim3


tripartite motif-containing 3


chr9_+_120492606 0.329 ENSMUST00000007139.4
 Eif1b
eukaryotic translation initiation factor 1B
chr11_+_11115784 0.321 ENSMUST00000056344.4
 Vwc2
von Willebrand factor C domain containing 2
chr1_+_167598384 0.307 ENSMUST00000015987.3
 Rxrg
retinoid X receptor gamma
chr11_+_102836296 0.305 ENSMUST00000021302.8
ENSMUST00000107072.1
 Higd1b

HIG1 domain family, member 1B

chr11_-_33203588 0.296 ENSMUST00000037746.6
 Tlx3
T cell leukemia, homeobox 3
chr17_-_32166879 0.289 ENSMUST00000087723.3
 Notch3
notch 3
chr4_+_129513581 0.282 ENSMUST00000062356.6
 Marcksl1
MARCKS-like 1
chr10_+_3973086 0.280 ENSMUST00000117291.1
ENSMUST00000120585.1
ENSMUST00000043735.7
 Mthfd1l


methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like


chr7_-_105633479 0.233 ENSMUST00000147044.1
ENSMUST00000106791.1
 Trim3

tripartite motif-containing 3

chrX_-_75130996 0.223 ENSMUST00000033775.2
 Mpp1
membrane protein, palmitoylated
chr17_-_29347902 0.209 ENSMUST00000095427.4
ENSMUST00000118366.1
 Mtch1

mitochondrial carrier homolog 1 (C. elegans)

chr18_+_4920509 0.202 ENSMUST00000126977.1
 Svil
supervillin
chr4_-_106464167 0.200 ENSMUST00000049507.5
 Pcsk9
proprotein convertase subtilisin/kexin type 9
chr10_+_82954344 0.193 ENSMUST00000095396.3
 Gm4799
predicted gene 4799
chr11_-_106160101 0.192 ENSMUST00000045923.3
 Limd2
LIM domain containing 2
chr7_-_141443314 0.188 ENSMUST00000106005.2
 Lrdd
leucine-rich and death domain containing
chrX_+_58030999 0.187 ENSMUST00000088631.4
ENSMUST00000088629.3
 Zic3

zinc finger protein of the cerebellum 3

chr12_-_69183986 0.187 ENSMUST00000110620.1
ENSMUST00000110619.1
 Rpl36al

ribosomal protein L36A-like

chrX_+_58030622 0.186 ENSMUST00000088627.4
 Zic3
zinc finger protein of the cerebellum 3
chr7_-_105744312 0.175 ENSMUST00000141116.1
 Taf10
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr7_-_5014645 0.152 ENSMUST00000165320.1
 Fiz1
Flt3 interacting zinc finger protein 1
chr6_-_124756478 0.150 ENSMUST00000088357.5
 Atn1
atrophin 1
chr11_+_82101836 0.149 ENSMUST00000000194.3
 Ccl12
chemokine (C-C motif) ligand 12
chr7_+_127485221 0.142 ENSMUST00000048896.6
 Fbrs
fibrosin
chr12_-_14152038 0.139 ENSMUST00000020926.6
 Fam84a
family with sequence similarity 84, member A
chr12_-_69184056 0.129 ENSMUST00000054544.6
 Rpl36al
ribosomal protein L36A-like
chr16_+_58408443 0.129 ENSMUST00000046663.7
 Dcbld2
discoidin, CUB and LCCL domain containing 2
chr7_-_19458494 0.123 ENSMUST00000085715.5
 Mark4
MAP/microtubule affinity-regulating kinase 4
chr15_-_78718113 0.117 ENSMUST00000088592.4
 Elfn2
leucine rich repeat and fibronectin type III, extracellular 2
chr5_-_135934590 0.115 ENSMUST00000055808.5
 Ywhag
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
chr8_-_94012558 0.110 ENSMUST00000053766.6
 Amfr
autocrine motility factor receptor
chr7_-_120670256 0.101 ENSMUST00000033178.2
 Pdzd9
PDZ domain containing 9
chr5_+_24423805 0.099 ENSMUST00000153274.1
 Slc4a2
solute carrier family 4 (anion exchanger), member 2
chr11_-_115536181 0.097 ENSMUST00000118155.1
ENSMUST00000153892.1
 Sumo2

SMT3 suppressor of mif two 3 homolog 2 (yeast)

chr5_+_115429944 0.090 ENSMUST00000067168.5
 Msi1
musashi RNA-binding protein 1
chr11_-_115535804 0.084 ENSMUST00000117589.1
ENSMUST00000121185.1
 Sumo2

SMT3 suppressor of mif two 3 homolog 2 (yeast)

chr2_-_180889660 0.084 ENSMUST00000137629.1
 Gm14342
predicted gene 14342
chr7_+_45705518 0.079 ENSMUST00000107740.1
ENSMUST00000107741.1
 Dbp

D site albumin promoter binding protein

chr14_+_119138415 0.078 ENSMUST00000065904.3
 Hs6st3
heparan sulfate 6-O-sulfotransferase 3
chr7_-_34196608 0.074 ENSMUST00000148381.1
ENSMUST00000002710.3
 Pdcd2l

programmed cell death 2-like

chr19_-_10869757 0.073 ENSMUST00000120524.1
ENSMUST00000025645.7
 Tmem132a

transmembrane protein 132A

chr1_-_51941261 0.070 ENSMUST00000097103.3
 Gm8420
predicted gene 8420
chr17_+_55986494 0.067 ENSMUST00000011733.8
 Fsd1
fibronectin type 3 and SPRY domain-containing protein
chr2_+_164785823 0.059 ENSMUST00000174070.1
ENSMUST00000172577.1
ENSMUST00000056181.6
 Snx21


sorting nexin family member 21


chr2_-_30359278 0.058 ENSMUST00000163668.2
ENSMUST00000028214.8
ENSMUST00000113621.3
 Sh3glb2


SH3-domain GRB2-like endophilin B2


chr4_+_129820198 0.058 ENSMUST00000030578.7
 Ptp4a2
protein tyrosine phosphatase 4a2
chr10_-_14705459 0.057 ENSMUST00000149485.1
ENSMUST00000154132.1
 Vta1

Vps20-associated 1 homolog (S. cerevisiae)

chr14_+_70553687 0.054 ENSMUST00000161069.1
 Hr
hairless
chr14_-_70520254 0.054 ENSMUST00000022693.7
 Bmp1
bone morphogenetic protein 1
chr19_+_4231899 0.052 ENSMUST00000025773.3
 Pold4
polymerase (DNA-directed), delta 4
chr12_+_69184158 0.045 ENSMUST00000060579.8
 Mgat2
mannoside acetylglucosaminyltransferase 2
chr2_-_30359190 0.039 ENSMUST00000100215.4
ENSMUST00000113620.3
 Sh3glb2

SH3-domain GRB2-like endophilin B2

chr9_-_21127346 0.034 ENSMUST00000001036.10
 Tyk2
tyrosine kinase 2
chr2_+_13573927 0.029 ENSMUST00000141365.1
ENSMUST00000028062.2
 Vim

vimentin

chr19_-_10101501 0.019 ENSMUST00000025567.7
 Fads2
fatty acid desaturase 2
chr13_+_3538075 0.015 ENSMUST00000059515.6
 Gdi2
guanosine diphosphate (GDP) dissociation inhibitor 2
chr7_-_133122615 0.012 ENSMUST00000167218.1
 Ctbp2
C-terminal binding protein 2
chr6_-_124415037 0.012 ENSMUST00000035861.5
ENSMUST00000112532.1
ENSMUST00000080557.5
 Pex5


peroxisomal biogenesis factor 5


chr13_-_47106176 0.007 ENSMUST00000021807.6
ENSMUST00000135278.1
 Dek

DEK oncogene (DNA binding)

chr5_-_22344690 0.003 ENSMUST00000062372.7
ENSMUST00000161356.1
 Reln

reelin

chr4_-_117125618 0.001 ENSMUST00000183310.1
 Btbd19
BTB (POZ) domain containing 19

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:1903802 positive regulation of arachidonic acid secretion(GO:0090238) L-glutamate(1-) import into cell(GO:1903802) L-glutamate import into cell(GO:1990123)
0.1 0.7 GO:0001661 conditioned taste aversion(GO:0001661)
0.1 2.0 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.1 0.4 GO:1990928 response to amino acid starvation(GO:1990928)
0.1 0.2 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.1 0.4 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.1 0.3 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.0 0.1 GO:2000501 natural killer cell chemotaxis(GO:0035747) negative regulation of lymphocyte migration(GO:2000402) regulation of natural killer cell chemotaxis(GO:2000501)
0.0 0.9 GO:1900273 positive regulation of long-term synaptic potentiation(GO:1900273)
0.0 0.2 GO:0070365 hepatocyte differentiation(GO:0070365)
0.0 0.7 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 0.3 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.0 0.9 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.2 GO:0009404 toxin metabolic process(GO:0009404)
0.0 0.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.1 GO:0071985 multivesicular body sorting pathway(GO:0071985)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0032280 symmetric synapse(GO:0032280)
0.1 0.7 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.1 0.9 GO:0044327 dendritic spine head(GO:0044327)
0.1 0.2 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.0 0.2 GO:0000125 PCAF complex(GO:0000125)
0.0 0.4 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.5 GO:0071565 nBAF complex(GO:0071565)
0.0 0.1 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 0.1 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0070905 serine binding(GO:0070905)
0.2 0.9 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 2.0 GO:0008430 selenium binding(GO:0008430)
0.1 0.9 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 0.3 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.1 0.2 GO:0034190 very-low-density lipoprotein particle binding(GO:0034189) apolipoprotein receptor binding(GO:0034190)
0.1 0.5 GO:0016215 acyl-CoA desaturase activity(GO:0016215)
0.1 0.9 GO:0070300 phosphatidic acid binding(GO:0070300)
0.1 0.5 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.1 0.2 GO:0050827 toxin receptor binding(GO:0050827)
0.0 0.8 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 0.1 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.0 0.4 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.1 GO:1904288 BAT3 complex binding(GO:1904288)
0.0 0.4 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.2 GO:0031386 protein tag(GO:0031386)
0.0 0.4 GO:0043014 alpha-tubulin binding(GO:0043014)