Motif ID: Zic2

Z-value: 0.688


Transcription factors associated with Zic2:

Gene SymbolEntrez IDGene Name
Zic2 ENSMUSG00000061524.8 Zic2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zic2mm10_v2_chr14_+_122475397_1224754350.331.3e-01Click!


Activity profile for motif Zic2.

activity profile for motif Zic2


Sorted Z-values histogram for motif Zic2

Sorted Z-values for motif Zic2



Network of associatons between targets according to the STRING database.



First level regulatory network of Zic2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_105471481 1.360 ENSMUST00000014990.6
 Tppp3
tubulin polymerization-promoting protein family member 3
chr10_-_18743691 1.113 ENSMUST00000019999.5
 D10Bwg1379e
DNA segment, Chr 10, Brigham & Women's Genetics 1379 expressed
chr11_+_84525669 1.071 ENSMUST00000126072.1
ENSMUST00000128121.1
 1500016L03Rik

RIKEN cDNA 1500016L03 gene

chr11_-_102946688 1.013 ENSMUST00000057849.5
 C1ql1
complement component 1, q subcomponent-like 1
chr7_-_142899985 1.008 ENSMUST00000000219.3
 Th
tyrosine hydroxylase
chr14_-_78725089 0.973 ENSMUST00000074729.5
 Dgkh
diacylglycerol kinase, eta
chr7_-_19699008 0.911 ENSMUST00000174355.1
ENSMUST00000172983.1
ENSMUST00000174710.1
ENSMUST00000167646.2
ENSMUST00000003066.9
ENSMUST00000174064.1
 Apoe





apolipoprotein E





chrX_+_170009659 0.851 ENSMUST00000179760.1
 Gm21887
predicted gene, 21887
chrY_+_90784738 0.848 ENSMUST00000179483.1
 Erdr1
erythroid differentiation regulator 1
chr14_-_34374617 0.833 ENSMUST00000023826.4
 Sncg
synuclein, gamma
chr11_+_84525647 0.782 ENSMUST00000134800.1
 1500016L03Rik
RIKEN cDNA 1500016L03 gene
chr2_+_92915080 0.763 ENSMUST00000028648.2
 Syt13
synaptotagmin XIII
chrX_+_170009892 0.752 ENSMUST00000180251.1
 Gm21887
predicted gene, 21887
chr14_-_122465677 0.728 ENSMUST00000039118.6
 Zic5
zinc finger protein of the cerebellum 5
chr18_-_24709348 0.675 ENSMUST00000067987.1
 Gm9955
predicted gene 9955
chr10_+_18845071 0.661 ENSMUST00000019998.7
 Perp
PERP, TP53 apoptosis effector
chr9_+_104002546 0.646 ENSMUST00000035167.8
ENSMUST00000117054.1
 Nphp3

nephronophthisis 3 (adolescent)

chr7_+_35119285 0.645 ENSMUST00000042985.9
 Cebpa
CCAAT/enhancer binding protein (C/EBP), alpha
chr6_+_65671590 0.633 ENSMUST00000054351.4
 Ndnf
neuron-derived neurotrophic factor
chr2_-_180225812 0.580 ENSMUST00000015791.5
 Lama5
laminin, alpha 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 126 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 1.6 GO:2001139 negative regulation of postsynaptic membrane organization(GO:1901627) negative regulation of dendritic spine maintenance(GO:1902951) negative regulation of phospholipid efflux(GO:1902999) regulation of lipid transport across blood brain barrier(GO:1903000) negative regulation of lipid transport across blood brain barrier(GO:1903001) positive regulation of lipid transport across blood brain barrier(GO:1903002) negative regulation of phospholipid transport(GO:2001139)
0.2 1.4 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.1 1.3 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 1.3 GO:0001578 microtubule bundle formation(GO:0001578)
0.3 1.0 GO:0061743 motor learning(GO:0061743)
0.3 1.0 GO:0042414 epinephrine metabolic process(GO:0042414)
0.1 1.0 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.2 0.9 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.1 0.8 GO:0045213 neurotransmitter receptor metabolic process(GO:0045213)
0.1 0.8 GO:0018095 protein polyglutamylation(GO:0018095)
0.1 0.8 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.0 0.8 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 0.8 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 0.7 GO:0002934 desmosome organization(GO:0002934)
0.1 0.7 GO:0015074 DNA integration(GO:0015074)
0.1 0.7 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.0 0.7 GO:0030574 collagen catabolic process(GO:0030574)
0.0 0.7 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.7 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.2 0.6 GO:0048496 maintenance of organ identity(GO:0048496)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 1.6 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.0 1.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 1.1 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.2 1.0 GO:0044301 climbing fiber(GO:0044301)
0.3 0.8 GO:0097233 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.0 0.7 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.2 0.6 GO:0097543 ciliary inversin compartment(GO:0097543)
0.2 0.6 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.0 0.6 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.2 0.5 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.0 0.5 GO:0043679 axon terminus(GO:0043679)
0.1 0.4 GO:1990597 AIP1-IRE1 complex(GO:1990597)
0.1 0.4 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.4 GO:0032982 myosin filament(GO:0032982)
0.0 0.4 GO:0043218 compact myelin(GO:0043218)
0.0 0.4 GO:0030673 axolemma(GO:0030673)
0.1 0.3 GO:0005940 septin ring(GO:0005940)
0.1 0.3 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.3 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 89 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 1.6 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.2 1.0 GO:0035240 dopamine binding(GO:0035240)
0.1 1.0 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.2 0.9 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.0 0.9 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.8 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 0.7 GO:0008517 folic acid transporter activity(GO:0008517) water channel activity(GO:0015250)
0.0 0.7 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.6 GO:0001013 RNA polymerase I regulatory region DNA binding(GO:0001013)
0.0 0.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.2 0.5 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.2 0.5 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.1 0.5 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.5 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.5 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.5 GO:0000146 microfilament motor activity(GO:0000146)
0.0 0.5 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.5 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 0.4 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.1 0.4 GO:0030368 interleukin-17 receptor activity(GO:0030368)