Motif ID: Zic3

Z-value: 0.887


Transcription factors associated with Zic3:

Gene SymbolEntrez IDGene Name
Zic3 ENSMUSG00000067860.5 Zic3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zic3mm10_v2_chrX_+_58030999_580310180.754.5e-05Click!


Activity profile for motif Zic3.

activity profile for motif Zic3


Sorted Z-values histogram for motif Zic3

Sorted Z-values for motif Zic3



Network of associatons between targets according to the STRING database.



First level regulatory network of Zic3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_53159885 2.572 ENSMUST00000030010.3
 Abca1
ATP-binding cassette, sub-family A (ABC1), member 1
chr4_+_108165449 1.552 ENSMUST00000116309.3
ENSMUST00000116307.1
 Echdc2

enoyl Coenzyme A hydratase domain containing 2

chr10_+_18845071 1.522 ENSMUST00000019998.7
 Perp
PERP, TP53 apoptosis effector
chr12_-_76709997 1.520 ENSMUST00000166101.1
 Sptb
spectrin beta, erythrocytic
chr4_+_108165432 1.461 ENSMUST00000052999.6
 Echdc2
enoyl Coenzyme A hydratase domain containing 2
chr2_-_39190687 1.409 ENSMUST00000142872.1
ENSMUST00000038874.5
 Scai

suppressor of cancer cell invasion

chr17_-_68004075 1.371 ENSMUST00000024840.5
 Arhgap28
Rho GTPase activating protein 28
chr5_-_114273702 1.365 ENSMUST00000144050.1
ENSMUST00000044790.5
 Foxn4

forkhead box N4

chr5_+_137288273 1.255 ENSMUST00000024099.4
ENSMUST00000085934.3
 Ache

acetylcholinesterase

chrY_-_1286563 1.241 ENSMUST00000091190.5
 Ddx3y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr2_-_146511899 1.214 ENSMUST00000131824.1
 Ralgapa2
Ral GTPase activating protein, alpha subunit 2 (catalytic)
chr2_+_70562007 1.209 ENSMUST00000094934.4
 Gad1
glutamate decarboxylase 1
chr10_+_106470281 1.208 ENSMUST00000029404.9
ENSMUST00000169303.1
 Ppfia2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

chr12_+_112620030 1.097 ENSMUST00000180015.1
ENSMUST00000021726.6
 Adssl1

adenylosuccinate synthetase like 1

chrX_+_56454871 1.074 ENSMUST00000039374.2
ENSMUST00000101553.2
 Ddx26b

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B

chr2_+_120629113 1.032 ENSMUST00000150912.1
ENSMUST00000180041.1
 Stard9

START domain containing 9

chr12_+_89812467 1.027 ENSMUST00000110133.2
ENSMUST00000110130.2
 Nrxn3

neurexin III

chr3_-_102204576 1.022 ENSMUST00000159388.1
 Vangl1
vang-like 1 (van gogh, Drosophila)
chr9_-_123678873 1.015 ENSMUST00000040960.6
 Slc6a20a
solute carrier family 6 (neurotransmitter transporter), member 20A
chr2_-_180776900 1.002 ENSMUST00000108878.1
 Bhlhe23
basic helix-loop-helix family, member e23

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 139 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 3.1 GO:0055099 response to high density lipoprotein particle(GO:0055099)
0.2 2.2 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.4 2.0 GO:0060178 regulation of exocyst localization(GO:0060178)
0.3 2.0 GO:0036233 glycine import(GO:0036233)
0.0 1.9 GO:0030835 negative regulation of actin filament depolymerization(GO:0030835)
0.3 1.8 GO:0002934 desmosome organization(GO:0002934)
0.1 1.6 GO:0008209 androgen metabolic process(GO:0008209)
0.3 1.5 GO:0006167 AMP biosynthetic process(GO:0006167)
0.3 1.4 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.2 1.4 GO:0035881 amacrine cell differentiation(GO:0035881)
0.1 1.4 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.1 1.4 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.0 1.4 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.2 1.3 GO:0019695 choline metabolic process(GO:0019695)
0.1 1.3 GO:0097352 autophagosome maturation(GO:0097352)
0.0 1.3 GO:0030851 granulocyte differentiation(GO:0030851)
0.2 1.2 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.1 1.2 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.3 1.1 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.1 1.1 GO:0071557 histone H3-K27 demethylation(GO:0071557)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.6 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.5 2.2 GO:0097165 nuclear stress granule(GO:0097165)
0.0 1.8 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 1.7 GO:0032587 ruffle membrane(GO:0032587)
0.1 1.6 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.3 1.5 GO:0008091 spectrin(GO:0008091)
0.1 1.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 1.3 GO:0005605 basal lamina(GO:0005605)
0.0 1.2 GO:0060077 inhibitory synapse(GO:0060077)
0.0 1.2 GO:0005871 kinesin complex(GO:0005871)
0.0 1.0 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.9 GO:0005884 actin filament(GO:0005884)
0.0 0.8 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.8 GO:0005604 basement membrane(GO:0005604)
0.2 0.7 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.0 0.7 GO:0016459 myosin complex(GO:0016459)
0.0 0.7 GO:0042734 presynaptic membrane(GO:0042734)
0.2 0.6 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.1 0.6 GO:0043511 inhibin complex(GO:0043511)
0.1 0.6 GO:0031256 leading edge membrane(GO:0031256)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 94 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.2 GO:0005096 GTPase activator activity(GO:0005096)
0.9 2.6 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188)
0.1 2.2 GO:0030506 ankyrin binding(GO:0030506)
0.3 2.0 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.1 2.0 GO:0017091 AU-rich element binding(GO:0017091)
0.0 1.6 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 1.4 GO:0005522 profilin binding(GO:0005522)
0.0 1.4 GO:0031490 chromatin DNA binding(GO:0031490)
0.3 1.3 GO:0004104 cholinesterase activity(GO:0004104) choline binding(GO:0033265)
0.1 1.3 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 1.3 GO:0008565 protein transporter activity(GO:0008565)
0.2 1.2 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.2 1.2 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.1 1.2 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 1.2 GO:0003777 microtubule motor activity(GO:0003777)
0.0 1.2 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.2 1.1 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0 1.1 GO:0032452 histone demethylase activity(GO:0032452)
0.3 1.0 GO:0017153 sodium:dicarboxylate symporter activity(GO:0017153)
0.2 1.0 GO:0045545 syndecan binding(GO:0045545)