Motif ID: Zic4

Z-value: 1.154


Transcription factors associated with Zic4:

Gene SymbolEntrez IDGene Name
Zic4 ENSMUSG00000036972.8 Zic4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zic4mm10_v2_chr9_+_91378636_913786460.252.5e-01Click!


Activity profile for motif Zic4.

activity profile for motif Zic4


Sorted Z-values histogram for motif Zic4

Sorted Z-values for motif Zic4



Network of associatons between targets according to the STRING database.



First level regulatory network of Zic4

PNG image of the network

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Top targets:


Showing 1 to 20 of 182 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 7.513 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr12_+_112146187 3.796 ENSMUST00000128402.2
 Kif26a
kinesin family member 26A
chr19_+_47178820 3.245 ENSMUST00000111808.3
 Neurl1a
neuralized homolog 1A (Drosophila)
chr4_+_62965560 2.763 ENSMUST00000030043.6
ENSMUST00000107415.1
ENSMUST00000064814.5
 Zfp618


zinc finger protein 618


chrY_+_897782 2.733 ENSMUST00000055032.7
 Kdm5d
lysine (K)-specific demethylase 5D
chr4_-_72200833 2.606 ENSMUST00000102848.2
ENSMUST00000072695.6
ENSMUST00000107337.1
ENSMUST00000074216.7
 Tle1



transducin-like enhancer of split 1, homolog of Drosophila E(spl)



chr11_-_116335384 2.587 ENSMUST00000036215.7
 Foxj1
forkhead box J1
chr8_+_87473116 2.572 ENSMUST00000182650.1
ENSMUST00000182758.1
ENSMUST00000181898.1
 Gm2694


predicted gene 2694


chr19_+_48206025 2.497 ENSMUST00000078880.5
 Sorcs3
sortilin-related VPS10 domain containing receptor 3
chr7_-_17056669 2.377 ENSMUST00000037762.4
 Hif3a
hypoxia inducible factor 3, alpha subunit
chrX_-_49797700 2.376 ENSMUST00000033442.7
ENSMUST00000114891.1
 Igsf1

immunoglobulin superfamily, member 1

chr7_-_137314394 2.286 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr4_+_128883549 2.267 ENSMUST00000035667.8
 Trim62
tripartite motif-containing 62
chr2_+_180499893 2.122 ENSMUST00000029084.2
 Ntsr1
neurotensin receptor 1
chr1_+_153665666 2.001 ENSMUST00000111814.1
ENSMUST00000111810.1
 Rgs8

regulator of G-protein signaling 8

chr19_+_4099998 1.879 ENSMUST00000049658.7
 Pitpnm1
phosphatidylinositol transfer protein, membrane-associated 1
chr1_-_12991109 1.863 ENSMUST00000115403.2
ENSMUST00000115402.1
 Slco5a1

solute carrier organic anion transporter family, member 5A1

chr8_-_87959560 1.851 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr5_-_139325616 1.814 ENSMUST00000110865.1
 Adap1
ArfGAP with dual PH domains 1
chr1_+_153665274 1.812 ENSMUST00000152114.1
ENSMUST00000111812.1
 Rgs8

regulator of G-protein signaling 8


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 7.5 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.5 6.4 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 5.0 GO:0007179 transforming growth factor beta receptor signaling pathway(GO:0007179)
0.3 3.8 GO:0048484 enteric nervous system development(GO:0048484)
0.6 3.2 GO:2001025 positive regulation of response to drug(GO:2001025)
0.4 3.2 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.5 2.7 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.6 2.6 GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002924) negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.1 2.6 GO:2000811 negative regulation of anoikis(GO:2000811)
0.1 2.5 GO:1900452 regulation of long term synaptic depression(GO:1900452)
0.1 2.3 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.5 2.1 GO:1903802 positive regulation of arachidonic acid secretion(GO:0090238) L-glutamate(1-) import into cell(GO:1903802) L-glutamate import into cell(GO:1990123)
0.4 2.1 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.3 1.8 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.1 1.8 GO:0060065 uterus development(GO:0060065)
0.1 1.7 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.1 1.7 GO:1903861 regulation of dendrite extension(GO:1903859) positive regulation of dendrite extension(GO:1903861)
0.0 1.5 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.3 1.4 GO:0060838 lymphatic endothelial cell fate commitment(GO:0060838) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.3 1.2 GO:0097374 sensory neuron axon guidance(GO:0097374)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.7 GO:0005871 kinesin complex(GO:0005871)
0.1 4.2 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 3.7 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.5 3.2 GO:1990635 proximal dendrite(GO:1990635)
0.1 3.2 GO:0097440 apical dendrite(GO:0097440)
0.5 2.1 GO:0032280 symmetric synapse(GO:0032280)
0.0 2.1 GO:0005811 lipid particle(GO:0005811)
0.1 1.8 GO:0032590 dendrite membrane(GO:0032590)
0.0 1.8 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.8 GO:0016607 nuclear speck(GO:0016607)
0.1 1.2 GO:0005642 annulate lamellae(GO:0005642)
0.1 1.1 GO:0033391 chromatoid body(GO:0033391)
0.0 1.1 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 1.1 GO:0030286 dynein complex(GO:0030286)
0.0 1.0 GO:0005643 nuclear pore(GO:0005643)
0.0 0.8 GO:0001741 XY body(GO:0001741)
0.0 0.8 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.2 0.7 GO:0035061 interchromatin granule(GO:0035061)
0.0 0.7 GO:0030673 axolemma(GO:0030673)
0.1 0.5 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.4 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.2 6.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 4.1 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.1 3.8 GO:0003777 microtubule motor activity(GO:0003777)
0.0 3.3 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 3.1 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 3.0 GO:0045182 translation regulator activity(GO:0045182)
0.0 2.9 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 2.8 GO:0035064 methylated histone binding(GO:0035064)
0.4 2.7 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.1 2.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.3 2.4 GO:0034711 inhibin binding(GO:0034711)
0.1 2.1 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 1.8 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 1.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.5 1.5 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
0.2 1.4 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.2 1.4 GO:0001972 retinoic acid binding(GO:0001972)
0.0 1.3 GO:0071889 14-3-3 protein binding(GO:0071889)
0.4 1.2 GO:0035939 microsatellite binding(GO:0035939)