Motif ID: Zic4
Z-value: 1.154
Transcription factors associated with Zic4:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Zic4 | ENSMUSG00000036972.8 | Zic4 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Zic4 | mm10_v2_chr9_+_91378636_91378646 | 0.25 | 2.5e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.9 | 7.5 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
0.6 | 2.6 | GO:0002924 | negative regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002924) negative regulation of interleukin-6 biosynthetic process(GO:0045409) |
0.6 | 3.2 | GO:2001025 | positive regulation of response to drug(GO:2001025) |
0.5 | 2.7 | GO:0002457 | T cell antigen processing and presentation(GO:0002457) |
0.5 | 2.1 | GO:1903802 | positive regulation of arachidonic acid secretion(GO:0090238) L-glutamate(1-) import into cell(GO:1903802) L-glutamate import into cell(GO:1990123) |
0.5 | 6.4 | GO:0060159 | regulation of dopamine receptor signaling pathway(GO:0060159) |
0.4 | 2.1 | GO:0035093 | spermatogenesis, exchange of chromosomal proteins(GO:0035093) |
0.4 | 3.2 | GO:0048170 | positive regulation of long-term neuronal synaptic plasticity(GO:0048170) |
0.3 | 1.0 | GO:0097491 | trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491) neural crest cell migration involved in autonomic nervous system development(GO:1901166) |
0.3 | 3.8 | GO:0048484 | enteric nervous system development(GO:0048484) |
0.3 | 1.2 | GO:0097374 | sensory neuron axon guidance(GO:0097374) |
0.3 | 1.8 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) |
0.3 | 0.9 | GO:0017055 | negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055) |
0.3 | 1.4 | GO:0060838 | lymphatic endothelial cell fate commitment(GO:0060838) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849) |
0.2 | 0.9 | GO:0009957 | epidermal cell fate specification(GO:0009957) |
0.2 | 1.2 | GO:0003199 | endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) |
0.2 | 0.7 | GO:0021577 | hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589) |
0.2 | 0.4 | GO:0061743 | motor learning(GO:0061743) |
0.2 | 1.2 | GO:0006452 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
0.2 | 0.6 | GO:1900736 | regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900736) |
0.2 | 0.6 | GO:0021759 | globus pallidus development(GO:0021759) |
0.2 | 0.4 | GO:0061317 | canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:0061317) regulation of heart induction(GO:0090381) |
0.2 | 0.9 | GO:1902309 | negative regulation of peptidyl-serine dephosphorylation(GO:1902309) |
0.2 | 0.5 | GO:0002159 | desmosome assembly(GO:0002159) adherens junction maintenance(GO:0034334) intermediate filament bundle assembly(GO:0045110) maintenance of organ identity(GO:0048496) |
0.1 | 0.7 | GO:0002182 | cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248) |
0.1 | 0.8 | GO:0002317 | plasma cell differentiation(GO:0002317) negative regulation of amyloid precursor protein biosynthetic process(GO:0042985) |
0.1 | 0.4 | GO:0018199 | peptidyl-glutamine modification(GO:0018199) |
0.1 | 1.2 | GO:0031424 | keratinization(GO:0031424) establishment of skin barrier(GO:0061436) |
0.1 | 0.4 | GO:0060743 | epithelial cell maturation involved in prostate gland development(GO:0060743) alveolar secondary septum development(GO:0061144) |
0.1 | 0.4 | GO:0019065 | receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509) |
0.1 | 1.0 | GO:0097531 | mast cell migration(GO:0097531) |
0.1 | 0.4 | GO:0071930 | negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930) |
0.1 | 2.5 | GO:1900452 | regulation of long term synaptic depression(GO:1900452) |
0.1 | 2.3 | GO:0032897 | negative regulation of viral transcription(GO:0032897) |
0.1 | 0.8 | GO:0044027 | hypermethylation of CpG island(GO:0044027) |
0.1 | 2.6 | GO:2000811 | negative regulation of anoikis(GO:2000811) |
0.1 | 0.7 | GO:0070458 | detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458) |
0.1 | 1.7 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
0.1 | 1.8 | GO:0060065 | uterus development(GO:0060065) |
0.1 | 0.4 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
0.1 | 1.7 | GO:1903861 | regulation of dendrite extension(GO:1903859) positive regulation of dendrite extension(GO:1903861) |
0.1 | 0.2 | GO:0097274 | urea homeostasis(GO:0097274) |
0.1 | 0.2 | GO:0009838 | abscission(GO:0009838) positive regulation of viral budding via host ESCRT complex(GO:1903774) |
0.1 | 0.1 | GO:2000173 | negative regulation of branching morphogenesis of a nerve(GO:2000173) |
0.1 | 0.3 | GO:0010700 | negative regulation of norepinephrine secretion(GO:0010700) positive regulation of inositol trisphosphate biosynthetic process(GO:0032962) |
0.1 | 0.6 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) |
0.1 | 0.3 | GO:2000301 | negative regulation of synaptic vesicle exocytosis(GO:2000301) |
0.1 | 0.3 | GO:0060050 | positive regulation of protein glycosylation(GO:0060050) |
0.0 | 0.3 | GO:0006621 | protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437) |
0.0 | 1.0 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
0.0 | 1.5 | GO:0030513 | positive regulation of BMP signaling pathway(GO:0030513) |
0.0 | 0.2 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
0.0 | 0.7 | GO:0016188 | synaptic vesicle maturation(GO:0016188) |
0.0 | 0.6 | GO:0071392 | cellular response to estradiol stimulus(GO:0071392) |
0.0 | 0.2 | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377) |
0.0 | 0.2 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
0.0 | 0.3 | GO:0007042 | lysosomal lumen acidification(GO:0007042) |
0.0 | 5.0 | GO:0007179 | transforming growth factor beta receptor signaling pathway(GO:0007179) |
0.0 | 1.0 | GO:0042462 | eye photoreceptor cell development(GO:0042462) |
0.0 | 0.2 | GO:0003161 | cardiac conduction system development(GO:0003161) |
0.0 | 0.2 | GO:0070317 | negative regulation of G0 to G1 transition(GO:0070317) |
0.0 | 0.3 | GO:0042711 | maternal behavior(GO:0042711) |
0.0 | 0.1 | GO:0015920 | regulation of phosphatidylcholine catabolic process(GO:0010899) lipopolysaccharide transport(GO:0015920) |
0.0 | 0.3 | GO:0006337 | nucleosome disassembly(GO:0006337) protein-DNA complex disassembly(GO:0032986) |
0.0 | 0.3 | GO:0035646 | endosome to melanosome transport(GO:0035646) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757) |
0.0 | 0.2 | GO:0050957 | equilibrioception(GO:0050957) |
0.0 | 1.1 | GO:0006406 | mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427) |
0.0 | 0.5 | GO:0009299 | mRNA transcription(GO:0009299) |
0.0 | 0.4 | GO:0033235 | positive regulation of protein sumoylation(GO:0033235) |
0.0 | 0.5 | GO:2000279 | negative regulation of DNA biosynthetic process(GO:2000279) |
0.0 | 0.4 | GO:0035115 | embryonic forelimb morphogenesis(GO:0035115) |
0.0 | 1.1 | GO:0000380 | alternative mRNA splicing, via spliceosome(GO:0000380) |
0.0 | 0.5 | GO:0006301 | postreplication repair(GO:0006301) |
0.0 | 0.7 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
0.0 | 0.1 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
0.0 | 0.1 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
0.0 | 0.1 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
0.0 | 0.3 | GO:0007212 | dopamine receptor signaling pathway(GO:0007212) |
0.0 | 0.1 | GO:0007197 | adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 2.1 | GO:0032280 | symmetric synapse(GO:0032280) |
0.5 | 3.2 | GO:1990635 | proximal dendrite(GO:1990635) |
0.4 | 0.4 | GO:0044301 | climbing fiber(GO:0044301) |
0.2 | 0.7 | GO:0035061 | interchromatin granule(GO:0035061) |
0.1 | 3.7 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
0.1 | 1.1 | GO:0033391 | chromatoid body(GO:0033391) |
0.1 | 0.4 | GO:1990851 | Wnt-Frizzled-LRP5/6 complex(GO:1990851) |
0.1 | 1.2 | GO:0005642 | annulate lamellae(GO:0005642) |
0.1 | 4.2 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
0.1 | 0.5 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
0.1 | 0.4 | GO:0035189 | Rb-E2F complex(GO:0035189) |
0.1 | 3.2 | GO:0097440 | apical dendrite(GO:0097440) |
0.1 | 0.5 | GO:0001740 | Barr body(GO:0001740) |
0.1 | 4.7 | GO:0005871 | kinesin complex(GO:0005871) |
0.1 | 1.8 | GO:0032590 | dendrite membrane(GO:0032590) |
0.1 | 0.4 | GO:0005638 | lamin filament(GO:0005638) |
0.0 | 0.2 | GO:0090543 | Flemming body(GO:0090543) |
0.0 | 0.5 | GO:0030057 | desmosome(GO:0030057) |
0.0 | 0.8 | GO:0001741 | XY body(GO:0001741) |
0.0 | 0.2 | GO:0042382 | paraspeckles(GO:0042382) |
0.0 | 1.1 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
0.0 | 2.1 | GO:0005811 | lipid particle(GO:0005811) |
0.0 | 0.7 | GO:0030673 | axolemma(GO:0030673) |
0.0 | 0.8 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
0.0 | 1.1 | GO:0030286 | dynein complex(GO:0030286) |
0.0 | 0.4 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
0.0 | 0.3 | GO:0071564 | npBAF complex(GO:0071564) |
0.0 | 1.8 | GO:0031225 | anchored component of membrane(GO:0031225) |
0.0 | 0.2 | GO:0005905 | clathrin-coated pit(GO:0005905) |
0.0 | 0.1 | GO:0031315 | extrinsic component of mitochondrial outer membrane(GO:0031315) |
0.0 | 1.0 | GO:0005643 | nuclear pore(GO:0005643) |
0.0 | 1.8 | GO:0016607 | nuclear speck(GO:0016607) |
0.0 | 0.4 | GO:0016235 | aggresome(GO:0016235) |
0.0 | 0.1 | GO:0031045 | dense core granule(GO:0031045) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 1.5 | GO:0047179 | platelet-activating factor acetyltransferase activity(GO:0047179) |
0.4 | 1.2 | GO:0035939 | microsatellite binding(GO:0035939) |
0.4 | 2.7 | GO:0032453 | histone demethylase activity (H3-K4 specific)(GO:0032453) |
0.3 | 0.9 | GO:0005119 | smoothened binding(GO:0005119) hedgehog receptor activity(GO:0008158) hedgehog family protein binding(GO:0097108) |
0.3 | 0.9 | GO:0002153 | steroid receptor RNA activator RNA binding(GO:0002153) |
0.3 | 2.4 | GO:0034711 | inhibin binding(GO:0034711) |
0.2 | 1.4 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
0.2 | 1.4 | GO:0001972 | retinoic acid binding(GO:0001972) |
0.2 | 6.4 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
0.1 | 3.1 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
0.1 | 1.8 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
0.1 | 0.4 | GO:0005110 | frizzled-2 binding(GO:0005110) |
0.1 | 2.1 | GO:0008188 | neuropeptide receptor activity(GO:0008188) |
0.1 | 0.9 | GO:0050815 | phosphoserine binding(GO:0050815) |
0.1 | 0.5 | GO:0004427 | inorganic diphosphatase activity(GO:0004427) |
0.1 | 0.8 | GO:0051718 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718) |
0.1 | 1.0 | GO:0038191 | neuropilin binding(GO:0038191) |
0.1 | 1.2 | GO:0017070 | U6 snRNA binding(GO:0017070) |
0.1 | 0.3 | GO:0031686 | A1 adenosine receptor binding(GO:0031686) |
0.1 | 0.4 | GO:0015183 | L-aspartate transmembrane transporter activity(GO:0015183) |
0.1 | 0.3 | GO:0046923 | ER retention sequence binding(GO:0046923) |
0.1 | 0.9 | GO:0045294 | alpha-catenin binding(GO:0045294) |
0.1 | 2.6 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
0.1 | 3.0 | GO:0045182 | translation regulator activity(GO:0045182) |
0.1 | 1.7 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
0.1 | 0.3 | GO:0097642 | calcitonin family receptor activity(GO:0097642) |
0.1 | 3.8 | GO:0003777 | microtubule motor activity(GO:0003777) |
0.1 | 0.5 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
0.0 | 3.3 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
0.0 | 0.6 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) |
0.0 | 2.8 | GO:0035064 | methylated histone binding(GO:0035064) |
0.0 | 1.0 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
0.0 | 1.3 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
0.0 | 0.4 | GO:0016755 | transferase activity, transferring amino-acyl groups(GO:0016755) |
0.0 | 0.4 | GO:0031386 | protein tag(GO:0031386) |
0.0 | 0.8 | GO:0019706 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) |
0.0 | 0.7 | GO:0003746 | translation elongation factor activity(GO:0003746) |
0.0 | 0.6 | GO:0043274 | phospholipase binding(GO:0043274) |
0.0 | 0.7 | GO:1900750 | glutathione binding(GO:0043295) oligopeptide binding(GO:1900750) |
0.0 | 0.1 | GO:0001875 | lipopolysaccharide receptor activity(GO:0001875) |
0.0 | 0.9 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
0.0 | 1.0 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
0.0 | 0.8 | GO:0001540 | beta-amyloid binding(GO:0001540) |
0.0 | 0.1 | GO:0004719 | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719) |
0.0 | 1.2 | GO:0003774 | motor activity(GO:0003774) |
0.0 | 2.9 | GO:0003714 | transcription corepressor activity(GO:0003714) |
0.0 | 0.7 | GO:0036002 | pre-mRNA binding(GO:0036002) |
0.0 | 0.3 | GO:0050253 | prenylcysteine methylesterase activity(GO:0010296) 1-oxa-2-oxocycloheptane lactonase activity(GO:0018731) sulfolactone hydrolase activity(GO:0018732) butyrolactone hydrolase activity(GO:0018734) endosulfan lactone lactonase activity(GO:0034892) L-ascorbate 6-phosphate lactonase activity(GO:0035460) Ser-tRNA(Thr) hydrolase activity(GO:0043905) Ala-tRNA(Pro) hydrolase activity(GO:0043906) Cys-tRNA(Pro) hydrolase activity(GO:0043907) Ser(Gly)-tRNA(Ala) hydrolase activity(GO:0043908) all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity(GO:0047376) retinyl-palmitate esterase activity(GO:0050253) mannosyl-oligosaccharide 1,6-alpha-mannosidase activity(GO:0052767) mannosyl-oligosaccharide 1,3-alpha-mannosidase activity(GO:0052768) methyl indole-3-acetate esterase activity(GO:0080030) methyl salicylate esterase activity(GO:0080031) methyl jasmonate esterase activity(GO:0080032) |
0.0 | 0.7 | GO:0043548 | phosphatidylinositol 3-kinase binding(GO:0043548) |
0.0 | 1.2 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
0.0 | 1.2 | GO:0051219 | phosphoprotein binding(GO:0051219) |
0.0 | 4.1 | GO:0043774 | UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738) |
0.0 | 13.4 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
0.0 | 0.1 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) cobalt ion binding(GO:0050897) |
0.0 | 0.1 | GO:0016907 | G-protein coupled acetylcholine receptor activity(GO:0016907) |