Motif ID: Aire
Z-value: 0.687
Transcription factors associated with Aire:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Aire | ENSMUSG00000000731.9 | Aire |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 1.7 | GO:1990523 | bone regeneration(GO:1990523) |
| 0.5 | 2.3 | GO:0033762 | response to glucagon(GO:0033762) |
| 0.4 | 1.8 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
| 0.4 | 1.2 | GO:0034241 | positive regulation of macrophage fusion(GO:0034241) regulation of osteoclast proliferation(GO:0090289) |
| 0.4 | 1.2 | GO:0090526 | regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526) |
| 0.4 | 2.4 | GO:1904491 | protein localization to ciliary transition zone(GO:1904491) |
| 0.4 | 1.5 | GO:0072531 | pyrimidine-containing compound transmembrane transport(GO:0072531) |
| 0.3 | 3.1 | GO:0071372 | cellular response to follicle-stimulating hormone stimulus(GO:0071372) |
| 0.3 | 1.8 | GO:1990573 | potassium ion import across plasma membrane(GO:1990573) |
| 0.2 | 1.2 | GO:0090669 | telomerase RNA stabilization(GO:0090669) |
| 0.2 | 3.2 | GO:0070914 | UV-damage excision repair(GO:0070914) |
| 0.2 | 1.6 | GO:1903207 | neuron death in response to hydrogen peroxide(GO:0036476) regulation of hydrogen peroxide-induced neuron death(GO:1903207) negative regulation of hydrogen peroxide-induced neuron death(GO:1903208) |
| 0.1 | 0.4 | GO:0044837 | assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837) |
| 0.1 | 1.1 | GO:0060770 | negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770) |
| 0.1 | 0.4 | GO:0006550 | isoleucine catabolic process(GO:0006550) acetyl-CoA catabolic process(GO:0046356) ketone body catabolic process(GO:0046952) |
| 0.1 | 1.5 | GO:0000301 | retrograde transport, vesicle recycling within Golgi(GO:0000301) |
| 0.1 | 0.9 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.1 | 5.6 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
| 0.1 | 0.3 | GO:0002314 | germinal center B cell differentiation(GO:0002314) |
| 0.1 | 1.0 | GO:0021942 | radial glia guided migration of Purkinje cell(GO:0021942) |
| 0.1 | 0.7 | GO:1902414 | protein localization to cell junction(GO:1902414) |
| 0.1 | 0.2 | GO:0042726 | flavin-containing compound metabolic process(GO:0042726) |
| 0.1 | 0.3 | GO:0016340 | calcium-dependent cell-matrix adhesion(GO:0016340) |
| 0.1 | 1.7 | GO:0032288 | myelin assembly(GO:0032288) |
| 0.1 | 1.5 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.1 | 0.2 | GO:1900369 | negative regulation of RNA interference(GO:1900369) |
| 0.0 | 0.1 | GO:0030974 | thiamine pyrophosphate transport(GO:0030974) |
| 0.0 | 1.0 | GO:0045475 | locomotor rhythm(GO:0045475) |
| 0.0 | 0.6 | GO:0006465 | signal peptide processing(GO:0006465) |
| 0.0 | 0.1 | GO:0035552 | oxidative single-stranded DNA demethylation(GO:0035552) oxidative single-stranded RNA demethylation(GO:0035553) |
| 0.0 | 1.4 | GO:0061003 | positive regulation of dendritic spine morphogenesis(GO:0061003) |
| 0.0 | 0.2 | GO:0007168 | receptor guanylyl cyclase signaling pathway(GO:0007168) |
| 0.0 | 0.1 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.0 | 1.0 | GO:0030490 | maturation of SSU-rRNA(GO:0030490) |
| 0.0 | 0.2 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 0.0 | 0.1 | GO:0086023 | adrenergic receptor signaling pathway involved in heart process(GO:0086023) |
| 0.0 | 0.8 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 0.0 | 2.0 | GO:0017157 | regulation of exocytosis(GO:0017157) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 3.1 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.3 | 1.6 | GO:1990037 | Lewy body core(GO:1990037) |
| 0.2 | 2.3 | GO:0045275 | respiratory chain complex III(GO:0045275) |
| 0.2 | 1.0 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 0.2 | 2.1 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.2 | 2.4 | GO:0036038 | MKS complex(GO:0036038) |
| 0.1 | 1.5 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.1 | 1.7 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.1 | 6.1 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.1 | 1.3 | GO:0017119 | Golgi transport complex(GO:0017119) |
| 0.1 | 0.6 | GO:0005787 | signal peptidase complex(GO:0005787) |
| 0.1 | 1.6 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.1 | 3.3 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.0 | 0.3 | GO:0016011 | dystroglycan complex(GO:0016011) |
| 0.0 | 0.4 | GO:0090543 | Flemming body(GO:0090543) |
| 0.0 | 0.5 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.0 | 3.1 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 0.5 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 0.9 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.0 | 0.1 | GO:0071942 | XPC complex(GO:0071942) |
| 0.0 | 1.0 | GO:0032040 | small-subunit processome(GO:0032040) |
| 0.0 | 0.2 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 0.0 | 1.1 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.0 | 1.8 | GO:0030315 | T-tubule(GO:0030315) |
| 0.0 | 1.1 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 1.2 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 1.0 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 3.1 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
| 0.4 | 1.8 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.3 | 1.0 | GO:0004980 | melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980) |
| 0.3 | 2.3 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.2 | 1.7 | GO:0016308 | 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308) |
| 0.2 | 6.1 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.2 | 0.5 | GO:0070052 | collagen V binding(GO:0070052) |
| 0.2 | 1.2 | GO:0051880 | G-quadruplex DNA binding(GO:0051880) |
| 0.1 | 0.4 | GO:0031871 | proteinase activated receptor binding(GO:0031871) |
| 0.1 | 0.3 | GO:0035673 | oligopeptide transmembrane transporter activity(GO:0035673) |
| 0.1 | 2.0 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.1 | 1.7 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 1.5 | GO:0015215 | nucleotide transmembrane transporter activity(GO:0015215) |
| 0.1 | 0.4 | GO:0016453 | acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453) |
| 0.1 | 0.2 | GO:0003692 | left-handed Z-DNA binding(GO:0003692) |
| 0.0 | 3.2 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 0.0 | 1.0 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.0 | 0.1 | GO:0051747 | cytosine C-5 DNA demethylase activity(GO:0051747) |
| 0.0 | 1.2 | GO:0019789 | SUMO transferase activity(GO:0019789) |
| 0.0 | 2.1 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.0 | 1.8 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 0.3 | GO:0043237 | laminin-1 binding(GO:0043237) |
| 0.0 | 0.1 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
| 0.0 | 0.1 | GO:0015234 | thiamine transmembrane transporter activity(GO:0015234) |
| 0.0 | 0.1 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 0.0 | 0.7 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
| 0.0 | 1.1 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.0 | 0.2 | GO:0008106 | alcohol dehydrogenase (NADP+) activity(GO:0008106) |
| 0.0 | 1.6 | GO:0043130 | ubiquitin binding(GO:0043130) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.1 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.1 | 1.2 | PID_RANBP2_PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.1 | 1.7 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.1 | 2.2 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 0.9 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.7 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.1 | 0.9 | REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 2.0 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 0.6 | REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.0 | 1.2 | REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.0 | 1.7 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 1.0 | REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 0.0 | 1.0 | REACTOME_G_ALPHA_S_SIGNALLING_EVENTS | Genes involved in G alpha (s) signalling events |
| 0.0 | 0.4 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
