Motif ID: Alx4

Z-value: 0.637


Transcription factors associated with Alx4:

Gene SymbolEntrez IDGene Name
Alx4 ENSMUSG00000040310.6 Alx4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Alx4mm10_v2_chr2_+_93642307_93642388-0.161.6e-01Click!


Activity profile for motif Alx4.

activity profile for motif Alx4


Sorted Z-values histogram for motif Alx4

Sorted Z-values for motif Alx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Alx4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_73483602 5.185 ENSMUST00000033741.8
ENSMUST00000169489.1
 Bgn

biglycan

chr7_-_45103747 5.148 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter
chr10_+_97479470 5.015 ENSMUST00000105287.3
 Dcn
decorin
chr1_+_58210397 4.967 ENSMUST00000040442.5
 Aox4
aldehyde oxidase 4
chr6_-_136875794 3.704 ENSMUST00000032342.1
 Mgp
matrix Gla protein
chr5_+_13398688 3.499 ENSMUST00000125629.1
 Sema3a
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr13_+_44121167 3.441 ENSMUST00000163056.1
ENSMUST00000159595.1
 Gm5083

predicted gene 5083

chr7_-_46667375 3.103 ENSMUST00000107669.2
 Tph1
tryptophan hydroxylase 1
chr18_+_57468478 3.084 ENSMUST00000091892.2
 Ctxn3
cortexin 3
chr8_+_94152607 3.012 ENSMUST00000034211.8
 Mt3
metallothionein 3
chr6_+_116650674 2.929 ENSMUST00000067354.5
ENSMUST00000178241.1
 8430408G22Rik

RIKEN cDNA 8430408G22 gene

chr2_-_160619971 2.918 ENSMUST00000109473.1
 Gm14221
predicted gene 14221
chr5_-_43981757 2.826 ENSMUST00000061299.7
 Fgfbp1
fibroblast growth factor binding protein 1
chr1_-_163725123 2.818 ENSMUST00000159679.1
 Mettl11b
methyltransferase like 11B
chr3_-_57294880 2.761 ENSMUST00000171384.1
 Tm4sf1
transmembrane 4 superfamily member 1
chr2_+_125136692 2.657 ENSMUST00000099452.2
 Ctxn2
cortexin 2
chr4_-_14621805 2.569 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr1_-_152386589 2.544 ENSMUST00000162371.1
 Tsen15
tRNA splicing endonuclease 15 homolog (S. cerevisiae)
chr11_-_102946688 2.380 ENSMUST00000057849.5
 C1ql1
complement component 1, q subcomponent-like 1
chr1_-_152386675 2.346 ENSMUST00000015124.8
 Tsen15
tRNA splicing endonuclease 15 homolog (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 10.2 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
1.7 5.0 GO:0046110 xanthine metabolic process(GO:0046110)
0.3 4.9 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
1.2 4.8 GO:0072592 oxygen metabolic process(GO:0072592)
0.6 4.7 GO:1901162 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.4 4.2 GO:0015838 proline transport(GO:0015824) amino-acid betaine transport(GO:0015838)
0.3 3.7 GO:0051923 sulfation(GO:0051923)
0.1 3.7 GO:0030500 regulation of bone mineralization(GO:0030500)
0.7 3.5 GO:0021856 cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375)
0.8 3.4 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.3 3.2 GO:0045607 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.4 3.0 GO:0019532 oxalate transport(GO:0019532)
0.4 2.8 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.8 2.4 GO:0061743 motor learning(GO:0061743)
0.1 2.4 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.8 2.3 GO:1904956 regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.1 2.3 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 2.2 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.7 2.1 GO:0002940 tRNA N2-guanine methylation(GO:0002940)
0.7 2.1 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) olefin metabolic process(GO:1900673)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 5.6 GO:0005802 trans-Golgi network(GO:0005802)
0.3 5.0 GO:0098644 complex of collagen trimers(GO:0098644)
0.0 3.7 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 3.0 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 2.6 GO:0031012 extracellular matrix(GO:0031012)
0.0 2.6 GO:0016324 apical plasma membrane(GO:0016324)
0.5 2.4 GO:0044301 climbing fiber(GO:0044301)
0.0 2.2 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 2.1 GO:0042555 MCM complex(GO:0042555)
0.0 2.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 2.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.9 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.5 1.8 GO:0071438 invadopodium membrane(GO:0071438)
0.2 1.8 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 1.8 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 1.8 GO:0014704 intercalated disc(GO:0014704)
0.0 1.5 GO:0045171 intercellular bridge(GO:0045171)
0.1 1.4 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 1.4 GO:0031258 lamellipodium membrane(GO:0031258)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.5 GO:0050840 extracellular matrix binding(GO:0050840)
1.0 5.1 GO:0019770 IgG receptor activity(GO:0019770)
1.2 5.0 GO:0030151 molybdenum ion binding(GO:0030151)
0.8 4.9 GO:0000213 tRNA-intron endonuclease activity(GO:0000213) endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
1.6 4.7 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.5 4.2 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
1.2 3.7 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.1 3.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.3 3.5 GO:0038191 neuropilin binding(GO:0038191)
0.4 3.4 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.3 3.0 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.1 2.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 2.8 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 2.8 GO:0008276 protein methyltransferase activity(GO:0008276)
0.2 2.2 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.4 2.1 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.4 2.1 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.1 2.1 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.1 2.1 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.3 2.0 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 10.2 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 7.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.7 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 2.7 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 2.5 PID_ATR_PATHWAY ATR signaling pathway
0.0 2.3 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 1.9 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.8 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.8 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.8 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.8 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.8 PID_RAC1_PATHWAY RAC1 signaling pathway
0.1 1.5 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 1.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 1.4 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 1.2 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway
0.0 1.2 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.9 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.9 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 0.8 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 10.2 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.4 4.7 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.5 3.7 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.2 3.0 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 2.7 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 2.2 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 2.1 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 2.1 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 2.1 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 1.9 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.1 1.9 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.9 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 1.8 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.0 1.8 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 1.6 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 1.4 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.1 1.3 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 1.3 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 1.2 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis