Motif ID: Arnt2

Z-value: 0.311


Transcription factors associated with Arnt2:

Gene SymbolEntrez IDGene Name
Arnt2 ENSMUSG00000015709.8 Arnt2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Arnt2mm10_v2_chr7_-_84409959_844100020.208.8e-02Click!


Activity profile for motif Arnt2.

activity profile for motif Arnt2


Sorted Z-values histogram for motif Arnt2

Sorted Z-values for motif Arnt2



Network of associatons between targets according to the STRING database.



First level regulatory network of Arnt2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_46890405 2.532 ENSMUST00000086675.3
 A330017A19Rik
RIKEN cDNA A330017A19 gene
chr13_+_118714678 1.699 ENSMUST00000022246.8
 Fgf10
fibroblast growth factor 10
chr4_+_101496648 1.516 ENSMUST00000106930.1
ENSMUST00000154120.1
 Dnajc6

DnaJ (Hsp40) homolog, subfamily C, member 6

chr9_-_86695897 1.483 ENSMUST00000034989.8
 Me1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr13_+_13590402 1.463 ENSMUST00000110559.1
 Lyst
lysosomal trafficking regulator
chr7_+_130865756 1.432 ENSMUST00000120441.1
 Plekha1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr7_+_130865835 1.227 ENSMUST00000075181.4
ENSMUST00000048180.5
 Plekha1

pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1

chr1_+_87327008 1.149 ENSMUST00000172794.1
ENSMUST00000164992.2
 Gigyf2

GRB10 interacting GYF protein 2

chr4_+_137862270 1.142 ENSMUST00000130407.1
 Ece1
endothelin converting enzyme 1
chr2_-_54085542 1.116 ENSMUST00000100089.2
 Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr1_-_52817503 1.112 ENSMUST00000162576.1
 Inpp1
inositol polyphosphate-1-phosphatase
chr1_+_87327044 1.029 ENSMUST00000173173.1
 Gigyf2
GRB10 interacting GYF protein 2
chr5_-_135251209 0.953 ENSMUST00000062572.2
 Fzd9
frizzled homolog 9 (Drosophila)
chr1_+_87326997 0.818 ENSMUST00000027475.8
 Gigyf2
GRB10 interacting GYF protein 2
chr1_-_52817643 0.799 ENSMUST00000027271.2
 Inpp1
inositol polyphosphate-1-phosphatase
chr14_-_63543931 0.659 ENSMUST00000058679.5
 Mtmr9
myotubularin related protein 9
chr11_+_107547925 0.643 ENSMUST00000100305.1
ENSMUST00000075012.1
ENSMUST00000106746.1
 Helz


helicase with zinc finger domain


chr2_+_59160884 0.622 ENSMUST00000037903.8
 Pkp4
plakophilin 4
chr7_-_45370559 0.606 ENSMUST00000003971.7
 Lin7b
lin-7 homolog B (C. elegans)
chr12_-_59011996 0.571 ENSMUST00000021375.5
 Sec23a
SEC23A (S. cerevisiae)
chr2_-_33371400 0.559 ENSMUST00000113164.1
ENSMUST00000091039.2
ENSMUST00000042615.6
 Ralgps1


Ral GEF with PH domain and SH3 binding motif 1


chr18_+_31634368 0.548 ENSMUST00000178164.1
 Sap130
Sin3A associated protein
chr18_+_31634374 0.538 ENSMUST00000025109.7
 Sap130
Sin3A associated protein
chr4_-_123116686 0.501 ENSMUST00000166337.1
 Gm17244
predicted gene, 17244
chr2_-_33371486 0.485 ENSMUST00000113165.1
 Ralgps1
Ral GEF with PH domain and SH3 binding motif 1
chr2_+_5951440 0.480 ENSMUST00000060092.6
 Upf2
UPF2 regulator of nonsense transcripts homolog (yeast)
chr19_-_5098418 0.425 ENSMUST00000025805.6
 Cnih2
cornichon homolog 2 (Drosophila)
chr1_-_16619245 0.412 ENSMUST00000182984.1
ENSMUST00000182554.1
 Ube2w

ubiquitin-conjugating enzyme E2W (putative)

chr3_+_69721985 0.400 ENSMUST00000029358.8
 Nmd3
NMD3 homolog (S. cerevisiae)
chr1_+_59912972 0.379 ENSMUST00000036540.5
 Fam117b
family with sequence similarity 117, member B
chr4_-_48279544 0.337 ENSMUST00000030028.4
 Erp44
endoplasmic reticulum protein 44
chr1_-_58973421 0.326 ENSMUST00000173590.1
ENSMUST00000027186.5
 Trak2

trafficking protein, kinesin binding 2

chr2_+_19658055 0.298 ENSMUST00000052168.4
 Otud1
OTU domain containing 1
chr1_+_58973521 0.248 ENSMUST00000114296.1
ENSMUST00000027185.4
 Stradb

STE20-related kinase adaptor beta

chr8_+_83900706 0.243 ENSMUST00000045393.8
ENSMUST00000132500.1
ENSMUST00000152978.1
 Lphn1


latrophilin 1


chr6_+_4601124 0.223 ENSMUST00000181734.1
ENSMUST00000141359.1
 Casd1

CAS1 domain containing 1

chr19_+_43612299 0.176 ENSMUST00000057178.9
 Nkx2-3
NK2 homeobox 3
chr9_+_86695542 0.165 ENSMUST00000150367.2
 A330041J22Rik
RIKEN cDNA A330041J22 gene
chr18_-_10030017 0.161 ENSMUST00000116669.1
ENSMUST00000092096.6
 Usp14

ubiquitin specific peptidase 14

chr2_+_119208975 0.109 ENSMUST00000102519.4
 Zfyve19
zinc finger, FYVE domain containing 19
chr17_-_65613521 0.098 ENSMUST00000024897.8
 Vapa
vesicle-associated membrane protein, associated protein A
chr15_-_38078842 0.050 ENSMUST00000110336.2
 Ubr5
ubiquitin protein ligase E3 component n-recognin 5
chr4_-_41275091 0.046 ENSMUST00000030143.6
ENSMUST00000108068.1
 Ubap2

ubiquitin-associated protein 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0071336 white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338)
0.5 1.5 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.4 1.1 GO:0010814 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.3 1.0 GO:1990523 bone regeneration(GO:1990523)
0.3 1.5 GO:1902031 regulation of NADP metabolic process(GO:1902031)
0.3 1.5 GO:0072318 clathrin coat disassembly(GO:0072318)
0.2 1.0 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.2 2.7 GO:0033327 Leydig cell differentiation(GO:0033327)
0.1 0.4 GO:1901608 regulation of vesicle transport along microtubule(GO:1901608)
0.1 0.6 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.1 3.0 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.1 0.4 GO:1904751 positive regulation of protein localization to nucleolus(GO:1904751)
0.1 1.9 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.1 0.2 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
0.0 0.6 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.1 GO:0009838 abscission(GO:0009838)
0.0 0.3 GO:0098937 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937)
0.0 0.2 GO:0002317 plasma cell differentiation(GO:0002317)
0.0 0.5 GO:0031100 organ regeneration(GO:0031100)
0.0 0.6 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.1 GO:1902915 negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.0 0.1 GO:0044828 negative regulation by host of viral genome replication(GO:0044828) positive regulation by host of viral genome replication(GO:0044829)
0.0 0.4 GO:0071218 cellular response to misfolded protein(GO:0071218)
0.0 0.3 GO:0070536 protein K63-linked deubiquitination(GO:0070536)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0033093 Weibel-Palade body(GO:0033093)
0.2 3.0 GO:1990635 proximal dendrite(GO:1990635)
0.1 0.6 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.6 GO:0030057 desmosome(GO:0030057)
0.0 1.1 GO:0070822 Sin3-type complex(GO:0070822)
0.0 1.0 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.6 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 2.7 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.5 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.3 GO:0032839 dendrite cytoplasm(GO:0032839)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0004473 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.5 1.9 GO:0004441 inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441)
0.4 1.7 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.2 1.0 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 3.0 GO:0070064 proline-rich region binding(GO:0070064)
0.1 2.7 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 0.6 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.4 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 1.0 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.2 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.0 0.3 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.3 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 1.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.5 GO:0042162 telomeric DNA binding(GO:0042162)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.7 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.0 1.0 PID_WNT_SIGNALING_PATHWAY Wnt signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 1.5 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.6 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.2 REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 1.5 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 1.0 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)