Motif ID: Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

Z-value: 0.641

Transcription factors associated with Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec:

Gene SymbolEntrez IDGene Name
Arntl ENSMUSG00000055116.7 Arntl
Mitf ENSMUSG00000035158.9 Mitf
Mlx ENSMUSG00000017801.9 Mlx
Mlxipl ENSMUSG00000005373.7 Mlxipl
Tfe3 ENSMUSG00000000134.11 Tfe3
Tfec ENSMUSG00000029553.7 Tfec

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Arntlmm10_v2_chr7_+_113207465_113207595-0.489.2e-06Click!
Mlxmm10_v2_chr11_+_101087277_1010873230.446.8e-05Click!
Tfe3mm10_v2_chrX_+_7763943_77640870.361.3e-03Click!
Mlxiplmm10_v2_chr5_+_135106881_135106918-0.171.5e-01Click!
Mitfmm10_v2_chr6_+_97807014_97807067-0.019.3e-01Click!


Activity profile for motif Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec.

activity profile for motif Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec


Sorted Z-values histogram for motif Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

Sorted Z-values for motif Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec



Network of associatons between targets according to the STRING database.



First level regulatory network of Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_127063599 11.403 ENSMUST00000120226.1
ENSMUST00000133115.1
 Cdk4

cyclin-dependent kinase 4

chr10_+_127063527 11.018 ENSMUST00000006911.5
 Cdk4
cyclin-dependent kinase 4
chr11_+_70000578 10.912 ENSMUST00000019362.8
 Dvl2
dishevelled 2, dsh homolog (Drosophila)
chr4_+_148039097 10.574 ENSMUST00000141283.1
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr4_+_148039035 9.565 ENSMUST00000097788.4
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr6_+_128362919 7.287 ENSMUST00000073316.6
 Foxm1
forkhead box M1
chr13_+_108316332 5.931 ENSMUST00000051594.5
 Depdc1b
DEP domain containing 1B
chr17_-_12769605 5.524 ENSMUST00000024599.7
 Igf2r
insulin-like growth factor 2 receptor
chr1_-_82291370 5.478 ENSMUST00000069799.2
 Irs1
insulin receptor substrate 1
chr3_+_67582737 5.372 ENSMUST00000029344.8
 Mfsd1
major facilitator superfamily domain containing 1
chr3_+_137864573 5.356 ENSMUST00000174561.1
ENSMUST00000173790.1
 H2afz

H2A histone family, member Z

chr19_-_4201591 5.342 ENSMUST00000025740.6
 Rad9a
RAD9 homolog A
chr9_+_21368014 5.011 ENSMUST00000067646.4
ENSMUST00000115414.1
 Ilf3

interleukin enhancer binding factor 3

chr13_+_108316395 4.958 ENSMUST00000171178.1
 Depdc1b
DEP domain containing 1B
chrY_-_1245685 4.922 ENSMUST00000143286.1
ENSMUST00000137048.1
ENSMUST00000069309.7
ENSMUST00000139365.1
 Uty



ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome



chr10_+_41519493 4.784 ENSMUST00000019962.8
 Cd164
CD164 antigen
chr3_-_90052463 4.776 ENSMUST00000029553.9
ENSMUST00000064639.8
ENSMUST00000090908.6
 Ubap2l


ubiquitin associated protein 2-like


chr3_+_137864487 4.639 ENSMUST00000041045.7
 H2afz
H2A histone family, member Z
chr8_+_13159135 4.473 ENSMUST00000033824.6
 Lamp1
lysosomal-associated membrane protein 1
chr3_+_90052814 4.404 ENSMUST00000160640.1
ENSMUST00000029552.6
ENSMUST00000162114.1
ENSMUST00000068798.6
 4933434E20Rik



RIKEN cDNA 4933434E20 gene




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 576 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.6 22.4 GO:0010288 response to lead ion(GO:0010288)
5.0 20.1 GO:0070829 heterochromatin maintenance(GO:0070829)
2.2 10.9 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.5 10.7 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
2.0 10.2 GO:0090521 glomerular visceral epithelial cell migration(GO:0090521)
0.9 9.7 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.1 8.7 GO:0030177 positive regulation of Wnt signaling pathway(GO:0030177)
0.3 7.8 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.9 7.5 GO:0071557 histone H3-K27 demethylation(GO:0071557)
1.2 7.4 GO:1904715 negative regulation of chaperone-mediated autophagy(GO:1904715)
0.8 7.3 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
0.3 7.2 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
1.1 6.8 GO:0046502 uroporphyrinogen III metabolic process(GO:0046502)
0.9 6.5 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.6 6.3 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.3 5.9 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
1.1 5.5 GO:0090273 regulation of somatostatin secretion(GO:0090273)
1.3 5.2 GO:0015889 cobalamin transport(GO:0015889)
1.7 5.1 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.4 4.7 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 230 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.6 22.4 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.0 13.0 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.2 10.9 GO:0016235 aggresome(GO:0016235)
1.4 9.5 GO:0001740 Barr body(GO:0001740)
0.1 8.6 GO:0022626 cytosolic ribosome(GO:0022626)
1.0 7.9 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.1 7.5 GO:0072686 mitotic spindle(GO:0072686)
1.3 6.4 GO:0044611 nuclear pore inner ring(GO:0044611)
0.4 6.4 GO:0031083 BLOC-1 complex(GO:0031083)
2.0 5.9 GO:0033186 CAF-1 complex(GO:0033186)
1.8 5.5 GO:0005899 insulin receptor complex(GO:0005899)
0.9 5.4 GO:0030896 checkpoint clamp complex(GO:0030896)
0.2 5.3 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.2 4.9 GO:0000421 autophagosome membrane(GO:0000421)
0.2 4.9 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
1.2 4.7 GO:0031084 BLOC-2 complex(GO:0031084)
0.2 4.7 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 4.6 GO:0016607 nuclear speck(GO:0016607)
1.5 4.5 GO:0044194 cytolytic granule(GO:0044194)
0.1 4.5 GO:0017053 transcriptional repressor complex(GO:0017053)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 350 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 24.4 GO:0030332 cyclin binding(GO:0030332)
6.7 20.1 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.3 14.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.3 11.4 GO:0005109 frizzled binding(GO:0005109)
0.0 10.2 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987)
0.0 9.1 GO:0005096 GTPase activator activity(GO:0005096)
0.2 8.9 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 8.8 GO:0003735 structural constituent of ribosome(GO:0003735)
1.1 7.6 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.8 7.6 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
1.1 7.5 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.1 6.7 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
0.3 6.5 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.8 6.0 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.5 5.9 GO:0031386 protein tag(GO:0031386)
0.5 5.5 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
1.4 5.4 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.8 5.4 GO:0031419 cobalamin binding(GO:0031419)
0.6 5.1 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 4.9 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 24.5 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.4 10.7 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.1 9.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 8.9 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 8.6 PID_CMYB_PATHWAY C-MYB transcription factor network
0.2 7.7 PID_ATR_PATHWAY ATR signaling pathway
0.1 7.6 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.2 6.4 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.1 6.0 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.2 4.3 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.1 4.0 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 4.0 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 4.0 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.4 3.6 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 3.2 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.1 3.0 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 3.0 PID_PLK1_PATHWAY PLK1 signaling events
0.2 2.9 PID_CONE_PATHWAY Visual signal transduction: Cones
0.1 2.7 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 2.7 PID_ILK_PATHWAY Integrin-linked kinase signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 107 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 25.0 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 15.0 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.4 13.5 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 11.9 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.3 11.4 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 11.0 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.3 10.9 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.1 8.6 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2 8.3 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress
0.4 7.5 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.3 6.4 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.2 6.3 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 6.3 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 5.4 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 5.4 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.4 4.9 REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.2 4.7 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.4 4.1 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.2 3.6 REACTOME_ACYL_CHAIN_REMODELLING_OF_PC Genes involved in Acyl chain remodelling of PC
0.1 3.6 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)