Motif ID: Ascl2

Z-value: 0.639


Transcription factors associated with Ascl2:

Gene SymbolEntrez IDGene Name
Ascl2 ENSMUSG00000009248.5 Ascl2



Activity profile for motif Ascl2.

activity profile for motif Ascl2


Sorted Z-values histogram for motif Ascl2

Sorted Z-values for motif Ascl2



Network of associatons between targets according to the STRING database.



First level regulatory network of Ascl2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_28302238 8.024 ENSMUST00000108315.3
 Dll3
delta-like 3 (Drosophila)
chr5_-_106458440 7.696 ENSMUST00000086795.6
 Barhl2
BarH-like 2 (Drosophila)
chr15_-_78773452 6.753 ENSMUST00000018313.5
 Mfng
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr7_+_45216671 5.951 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr8_+_31091593 5.438 ENSMUST00000161713.1
 Dusp26
dual specificity phosphatase 26 (putative)
chr7_-_141443314 5.067 ENSMUST00000106005.2
 Lrdd
leucine-rich and death domain containing
chr6_+_56017489 4.724 ENSMUST00000052827.4
 Ppp1r17
protein phosphatase 1, regulatory subunit 17
chr8_+_105518736 4.643 ENSMUST00000034363.5
 Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
chr5_+_114568016 4.179 ENSMUST00000043650.7
 Fam222a
family with sequence similarity 222, member A
chr3_-_116253467 4.175 ENSMUST00000090473.5
 Gpr88
G-protein coupled receptor 88
chr8_-_105471481 3.725 ENSMUST00000014990.6
 Tppp3
tubulin polymerization-promoting protein family member 3
chr6_-_56362356 3.592 ENSMUST00000044505.7
ENSMUST00000166102.1
ENSMUST00000164037.1
ENSMUST00000114327.2
 Pde1c



phosphodiesterase 1C



chr9_-_43239816 3.550 ENSMUST00000034512.5
 Oaf
OAF homolog (Drosophila)
chr6_-_72235559 3.521 ENSMUST00000042646.7
 Atoh8
atonal homolog 8 (Drosophila)
chr19_+_25610533 3.516 ENSMUST00000048935.4
 Dmrt3
doublesex and mab-3 related transcription factor 3
chr12_+_53248677 3.480 ENSMUST00000101432.2
 Npas3
neuronal PAS domain protein 3
chr12_-_40038025 3.338 ENSMUST00000101472.3
 Arl4a
ADP-ribosylation factor-like 4A
chr11_+_117849223 3.260 ENSMUST00000081387.4
 Birc5
baculoviral IAP repeat-containing 5
chr1_-_84696182 3.243 ENSMUST00000049126.6
 Dner
delta/notch-like EGF-related receptor
chr7_+_142471838 3.217 ENSMUST00000038946.2
 Lsp1
lymphocyte specific 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 184 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 8.0 GO:0007386 compartment pattern specification(GO:0007386)
0.2 7.7 GO:0001709 cell fate determination(GO:0001709)
0.8 6.8 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.3 6.4 GO:0030903 notochord development(GO:0030903)
0.2 6.2 GO:0050873 brown fat cell differentiation(GO:0050873)
0.4 6.1 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.3 5.9 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.8 5.5 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
1.8 5.4 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.4 4.6 GO:0001977 renal system process involved in regulation of blood volume(GO:0001977)
1.0 4.2 GO:0061743 motor learning(GO:0061743)
0.0 4.0 GO:0010921 regulation of phosphatase activity(GO:0010921)
0.0 3.9 GO:0001764 neuron migration(GO:0001764)
0.0 3.7 GO:0001578 microtubule bundle formation(GO:0001578)
0.2 3.6 GO:0046069 cGMP catabolic process(GO:0046069)
0.2 3.6 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.3 3.5 GO:0090308 regulation of methylation-dependent chromatin silencing(GO:0090308)
0.3 3.5 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.2 3.5 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.2 3.5 GO:0042711 maternal behavior(GO:0042711)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.9 GO:0043235 receptor complex(GO:0043235)
0.1 6.8 GO:0030173 integral component of Golgi membrane(GO:0030173)
2.0 6.0 GO:0071149 TEAD-2-YAP complex(GO:0071149)
1.1 5.5 GO:0032133 interphase microtubule organizing center(GO:0031021) chromosome passenger complex(GO:0032133)
0.4 4.9 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 4.2 GO:0031225 anchored component of membrane(GO:0031225)
0.0 4.1 GO:0015629 actin cytoskeleton(GO:0015629)
0.4 3.7 GO:0097427 microtubule bundle(GO:0097427)
0.1 3.5 GO:0000791 euchromatin(GO:0000791)
0.0 3.2 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.5 3.1 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.1 3.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 2.3 GO:0005776 autophagosome(GO:0005776)
0.0 2.3 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.5 2.1 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.3 2.0 GO:0071817 MMXD complex(GO:0071817)
0.0 2.0 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 1.9 GO:0001520 outer dense fiber(GO:0001520)
0.2 1.7 GO:0097452 GAIT complex(GO:0097452)
0.1 1.7 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 125 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.7 GO:0003779 actin binding(GO:0003779)
0.0 12.7 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.3 11.9 GO:0005112 Notch binding(GO:0005112)
0.2 9.7 GO:0008536 Ran GTPase binding(GO:0008536)
2.3 6.8 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 6.5 GO:0003924 GTPase activity(GO:0003924)
0.3 6.0 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.7 5.9 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 5.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.4 5.5 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0033764)
1.8 5.4 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.6 4.7 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 4.6 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982)
0.6 4.5 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 4.3 GO:0015631 tubulin binding(GO:0015631)
0.1 4.2 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 4.2 GO:0003774 motor activity(GO:0003774)
0.1 3.7 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.5 3.6 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.2 3.6 GO:0005078 MAP-kinase scaffold activity(GO:0005078)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.2 PID_NOTCH_PATHWAY Notch signaling pathway
0.2 8.8 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 6.1 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 5.5 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 5.0 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 3.2 PID_ERBB4_PATHWAY ErbB4 signaling events
0.1 2.9 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.3 2.8 PID_ALK2_PATHWAY ALK2 signaling events
0.1 2.4 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 2.4 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.1 1.7 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 1.7 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 1.6 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 1.6 ST_ADRENERGIC Adrenergic Pathway
0.1 1.5 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 1.5 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.2 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 1.2 PID_FGF_PATHWAY FGF signaling pathway
0.2 1.1 PID_TNF_PATHWAY TNF receptor signaling pathway
0.1 1.1 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.2 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 5.8 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2 4.9 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.2 4.3 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.2 3.9 REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.0 3.8 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 3.6 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 3.2 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 2.6 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 2.4 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.1 2.0 REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.2 1.9 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.2 1.9 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.1 1.9 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.8 REACTOME_PHASE_II_CONJUGATION Genes involved in Phase II conjugation
0.1 1.5 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 1.5 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.2 1.4 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 1.4 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.1 1.3 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism