Motif ID: Atf1_Creb5

Z-value: 0.512

Transcription factors associated with Atf1_Creb5:

Gene SymbolEntrez IDGene Name
Atf1 ENSMUSG00000023027.6 Atf1
Creb5 ENSMUSG00000053007.6 Creb5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf1mm10_v2_chr15_+_100227819_1002278560.545.3e-07Click!
Creb5mm10_v2_chr6_+_53573364_535733940.351.8e-03Click!


Activity profile for motif Atf1_Creb5.

activity profile for motif Atf1_Creb5


Sorted Z-values histogram for motif Atf1_Creb5

Sorted Z-values for motif Atf1_Creb5



Network of associatons between targets according to the STRING database.



First level regulatory network of Atf1_Creb5

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_101468164 6.915 ENSMUST00000001347.6
 Rnd2
Rho family GTPase 2
chr3_+_135212557 5.235 ENSMUST00000062893.7
 Cenpe
centromere protein E
chr7_+_112679314 4.353 ENSMUST00000084705.5
ENSMUST00000059768.10
 Tead1

TEA domain family member 1

chr3_+_127553462 4.233 ENSMUST00000043108.4
 4930422G04Rik
RIKEN cDNA 4930422G04 gene
chr2_+_105668888 4.111 ENSMUST00000111086.4
ENSMUST00000111087.3
 Pax6

paired box gene 6

chr5_-_124032214 4.079 ENSMUST00000040967.7
 Vps37b
vacuolar protein sorting 37B (yeast)
chr11_+_113619318 3.804 ENSMUST00000146390.2
ENSMUST00000106630.1
 Sstr2

somatostatin receptor 2

chr2_+_109280738 3.717 ENSMUST00000028527.7
 Kif18a
kinesin family member 18A
chr7_+_79500081 3.372 ENSMUST00000181511.2
ENSMUST00000182937.1
 AI854517

expressed sequence AI854517

chr3_+_145118564 3.150 ENSMUST00000098538.2
ENSMUST00000106192.2
ENSMUST00000029920.8
ENSMUST00000098539.2
 Odf2l



outer dense fiber of sperm tails 2-like



chr2_+_105668935 2.987 ENSMUST00000142772.1
 Pax6
paired box gene 6
chr7_+_112679327 2.980 ENSMUST00000106638.2
 Tead1
TEA domain family member 1
chr14_+_47472547 2.945 ENSMUST00000168833.1
ENSMUST00000163324.1
ENSMUST00000043112.7
 Fbxo34


F-box protein 34


chr7_+_79500018 2.877 ENSMUST00000182495.1
ENSMUST00000183043.1
 AI854517

expressed sequence AI854517

chr14_+_47472628 2.687 ENSMUST00000095941.2
 Fbxo34
F-box protein 34
chr4_+_11704439 2.541 ENSMUST00000108304.2
 Gem
GTP binding protein (gene overexpressed in skeletal muscle)
chr4_-_107810948 2.399 ENSMUST00000097930.1
 B230314M03Rik
RIKEN cDNA B230314M03 gene
chr17_-_71526819 2.397 ENSMUST00000024851.9
 Ndc80
NDC80 homolog, kinetochore complex component (S. cerevisiae)
chr3_-_65958236 2.291 ENSMUST00000029416.7
 Ccnl1
cyclin L1
chr9_+_53850243 2.279 ENSMUST00000048485.5
 Sln
sarcolipin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 181 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 7.3 GO:0014883 transition between fast and slow fiber(GO:0014883)
1.4 7.1 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
0.5 6.9 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.9 5.2 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.6 4.4 GO:0098535 positive regulation of centriole replication(GO:0046601) de novo centriole assembly(GO:0098535)
1.4 4.1 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.3 3.8 GO:0030432 peristalsis(GO:0030432)
0.2 3.7 GO:0072520 seminiferous tubule development(GO:0072520)
0.1 3.4 GO:0009409 response to cold(GO:0009409)
0.4 3.2 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.1 3.1 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.3 3.0 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
0.7 2.8 GO:0051316 attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation(GO:0051316)
0.3 2.8 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.2 2.7 GO:0033327 Leydig cell differentiation(GO:0033327)
0.3 2.5 GO:1901386 negative regulation of voltage-gated calcium channel activity(GO:1901386)
0.2 2.5 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.3 2.4 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.2 2.4 GO:0035881 amacrine cell differentiation(GO:0035881)
0.6 2.3 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.1 GO:0005667 transcription factor complex(GO:0005667)
0.7 9.9 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
1.8 7.3 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.0 6.9 GO:0005815 microtubule organizing center(GO:0005815)
0.0 6.7 GO:0005769 early endosome(GO:0005769)
0.5 4.6 GO:0000813 ESCRT I complex(GO:0000813)
0.7 4.4 GO:0098536 deuterosome(GO:0098536)
0.5 3.7 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 3.0 GO:0016605 PML body(GO:0016605)
0.4 2.9 GO:0070652 HAUS complex(GO:0070652)
0.0 2.9 GO:0005844 polysome(GO:0005844)
0.0 2.8 GO:0032587 ruffle membrane(GO:0032587)
0.1 2.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 2.5 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.4 2.2 GO:0042583 chromaffin granule(GO:0042583)
0.1 2.2 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 2.2 GO:0097546 ciliary base(GO:0097546)
0.2 2.1 GO:0030478 actin cap(GO:0030478)
0.1 1.9 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 1.7 GO:0051233 spindle midzone(GO:0051233)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 118 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.4 7.3 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.4 7.1 GO:0003680 AT DNA binding(GO:0003680)
1.0 5.2 GO:0043515 kinetochore binding(GO:0043515)
0.0 4.1 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
1.3 3.8 GO:0004994 somatostatin receptor activity(GO:0004994)
0.3 3.8 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.2 3.8 GO:0051010 microtubule plus-end binding(GO:0051010)
0.2 3.7 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 3.2 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.0 3.1 GO:0047485 protein N-terminus binding(GO:0047485)
0.1 2.8 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.3 2.6 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.1 2.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 2.4 GO:0005109 frizzled binding(GO:0005109)
0.2 2.2 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 2.2 GO:0070182 DNA polymerase binding(GO:0070182)
0.2 2.1 GO:0016783 sulfurtransferase activity(GO:0016783)
0.0 2.1 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.2 2.0 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.8 PID_PLK1_PATHWAY PLK1 signaling events
0.1 6.6 PID_CDC42_PATHWAY CDC42 signaling events
0.1 4.3 PID_ATM_PATHWAY ATM pathway
0.1 2.9 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 2.3 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.0 2.3 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 2.1 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 1.9 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.6 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.2 1.4 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 1.4 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 1.4 PID_VEGFR1_PATHWAY VEGFR1 specific signals
0.0 1.1 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 0.9 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 0.8 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.7 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.7 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.6 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 0.6 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.6 PID_IL12_2PATHWAY IL12-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.3 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.5 7.1 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 5.2 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 4.5 REACTOME_KINESINS Genes involved in Kinesins
0.1 4.5 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.4 4.1 REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 4.1 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 3.9 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.3 2.2 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 1.9 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.9 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.6 REACTOME_ACYL_CHAIN_REMODELLING_OF_PC Genes involved in Acyl chain remodelling of PC
0.1 1.6 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 1.6 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 1.5 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 1.3 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 1.3 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.1 1.1 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 1.1 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 1.0 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening