Motif ID: Atf3

Z-value: 1.380


Transcription factors associated with Atf3:

Gene SymbolEntrez IDGene Name
Atf3 ENSMUSG00000026628.8 Atf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf3mm10_v2_chr1_-_191183244_191183340-0.412.4e-04Click!


Activity profile for motif Atf3.

activity profile for motif Atf3


Sorted Z-values histogram for motif Atf3

Sorted Z-values for motif Atf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Atf3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_113619318 18.575 ENSMUST00000146390.2
ENSMUST00000106630.1
 Sstr2

somatostatin receptor 2

chr11_-_84068766 15.006 ENSMUST00000018792.5
 Dusp14
dual specificity phosphatase 14
chr9_+_118478182 11.389 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr11_-_84069179 10.233 ENSMUST00000138208.1
 Dusp14
dual specificity phosphatase 14
chrX_+_134308084 9.866 ENSMUST00000081064.5
ENSMUST00000101251.1
ENSMUST00000129782.1
 Cenpi


centromere protein I


chr3_+_135212557 9.783 ENSMUST00000062893.7
 Cenpe
centromere protein E
chr3_+_159495408 9.686 ENSMUST00000120272.1
ENSMUST00000029825.7
ENSMUST00000106041.2
 Depdc1a


DEP domain containing 1a


chr15_-_10713537 9.507 ENSMUST00000090339.3
 Rai14
retinoic acid induced 14
chr5_-_124032214 9.452 ENSMUST00000040967.7
 Vps37b
vacuolar protein sorting 37B (yeast)
chr11_+_101468164 9.110 ENSMUST00000001347.6
 Rnd2
Rho family GTPase 2
chr14_-_47411666 9.048 ENSMUST00000111778.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr6_+_113531675 8.051 ENSMUST00000036340.5
ENSMUST00000101051.2
 Fancd2

Fanconi anemia, complementation group D2

chr3_+_127553462 7.784 ENSMUST00000043108.4
 4930422G04Rik
RIKEN cDNA 4930422G04 gene
chr9_+_118478344 7.650 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr15_+_99074968 7.418 ENSMUST00000039665.6
 Troap
trophinin associated protein
chr6_-_23248264 7.293 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr2_+_172549581 7.104 ENSMUST00000030391.2
 Tfap2c
transcription factor AP-2, gamma
chr14_+_65806066 6.744 ENSMUST00000139644.1
 Pbk
PDZ binding kinase
chr4_-_117182623 6.469 ENSMUST00000065896.2
 Kif2c
kinesin family member 2C
chr4_-_97584612 6.419 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 600 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 24.9 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.7 20.8 GO:0034508 centromere complex assembly(GO:0034508)
6.3 19.0 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
5.3 15.9 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
3.8 15.3 GO:1902724 positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
0.4 12.6 GO:0007140 male meiosis(GO:0007140)
2.4 11.9 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.5 11.9 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
1.0 10.9 GO:0030432 peristalsis(GO:0030432)
1.8 10.5 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.2 10.3 GO:0070527 platelet aggregation(GO:0070527)
1.7 10.1 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.7 9.9 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
1.4 9.8 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
3.2 9.7 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774)
1.4 9.6 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
1.4 9.6 GO:0036089 cleavage furrow formation(GO:0036089)
0.8 9.3 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.9 9.2 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
2.9 8.7 GO:0072382 minus-end-directed vesicle transport along microtubule(GO:0072382)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 237 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 27.7 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.2 22.7 GO:0000776 kinetochore(GO:0000776)
0.4 22.5 GO:0005871 kinesin complex(GO:0005871)
1.7 22.1 GO:1990023 mitotic spindle midzone(GO:1990023)
1.2 22.0 GO:0031616 spindle pole centrosome(GO:0031616)
0.3 17.0 GO:0005657 replication fork(GO:0005657)
0.1 13.8 GO:0017053 transcriptional repressor complex(GO:0017053)
0.6 11.1 GO:0051233 spindle midzone(GO:0051233)
1.1 10.0 GO:0000813 ESCRT I complex(GO:0000813)
1.4 9.8 GO:0001940 male pronucleus(GO:0001940)
1.2 9.3 GO:0072687 meiotic spindle(GO:0072687)
0.2 8.9 GO:0005844 polysome(GO:0005844)
1.2 8.7 GO:0008278 cohesin complex(GO:0008278)
2.2 8.6 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.7 8.6 GO:0008385 IkappaB kinase complex(GO:0008385)
0.6 8.5 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 8.0 GO:0000793 condensed chromosome(GO:0000793)
0.1 7.9 GO:0000922 spindle pole(GO:0000922)
0.6 7.5 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 7.0 GO:0005667 transcription factor complex(GO:0005667)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 404 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 27.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
7.9 23.6 GO:0004994 somatostatin receptor activity(GO:0004994)
1.6 23.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.5 15.6 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
1.7 15.5 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.9 15.0 GO:0051010 microtubule plus-end binding(GO:0051010)
0.7 14.2 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 13.8 GO:0003682 chromatin binding(GO:0003682)
0.5 13.6 GO:0070182 DNA polymerase binding(GO:0070182)
2.6 12.8 GO:0043515 kinetochore binding(GO:0043515)
0.3 12.1 GO:0005109 frizzled binding(GO:0005109)
0.8 11.6 GO:0003688 DNA replication origin binding(GO:0003688)
0.2 10.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.3 9.5 GO:0003777 microtubule motor activity(GO:0003777)
0.1 9.1 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.6 8.7 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.4 8.6 GO:0004697 protein kinase C activity(GO:0004697)
0.3 8.6 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.5 8.3 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.1 8.0 GO:0003714 transcription corepressor activity(GO:0003714)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 32.5 PID_AURORA_B_PATHWAY Aurora B signaling
0.5 26.2 PID_IL12_2PATHWAY IL12-mediated signaling events
0.8 15.2 ST_STAT3_PATHWAY STAT3 Pathway
0.3 14.9 PID_ATR_PATHWAY ATR signaling pathway
0.2 13.2 PID_E2F_PATHWAY E2F transcription factor network
0.2 12.5 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.3 12.3 PID_IL1_PATHWAY IL1-mediated signaling events
0.3 12.0 PID_PLK1_PATHWAY PLK1 signaling events
0.8 11.1 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
1.0 9.0 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 8.5 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.3 7.2 PID_AURORA_A_PATHWAY Aurora A signaling
0.2 7.0 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 6.5 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 5.9 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.2 5.1 PID_IGF1_PATHWAY IGF1 pathway
0.2 4.5 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.2 4.4 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.3 4.0 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.2 3.9 PID_BARD1_PATHWAY BARD1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 112 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 46.0 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
1.2 32.3 REACTOME_KINESINS Genes involved in Kinesins
0.6 15.9 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress
1.3 15.5 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.5 12.9 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.7 11.1 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.9 9.8 REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.4 9.0 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.3 8.8 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.3 8.6 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 8.2 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
1.2 8.1 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.2 8.0 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.4 7.6 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 7.2 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.5 7.0 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex
0.2 6.1 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.2 5.1 REACTOME_AMYLOIDS Genes involved in Amyloids
0.1 4.7 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 4.7 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases