• All motifs sorted by activity significance
• All samples sorted alphabetically
• Mean activities
• All promoters sorted by FOV

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
• Download the whole report

Motif ID: Atf4

Z-value: 1.069

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr1_-_71653162	15.867	ENSMUST00000055226.6	Fn1	fibronectin 1
chr19_-_12501996	14.957	ENSMUST00000045521.7	Dtx4	deltex 4 homolog (Drosophila)
chr2_+_119351222	10.433	ENSMUST00000028780.3	Chac1	ChaC, cation transport regulator 1
chr9_+_109931774	9.093	ENSMUST00000169851.2	Map4	microtubule-associated protein 4
chr1_-_22315792	7.875	ENSMUST00000164877.1	Rims1	regulating synaptic membrane exocytosis 1
chr4_+_43957678	7.748	ENSMUST00000107855.1	Glipr2	GLI pathogenesis-related 2
chr11_-_35798884	7.429	ENSMUST00000160726.2	Fbll1	fibrillarin-like 1
chrX_-_162565514	7.173	ENSMUST00000154424.1	Reps2	RALBP1 associated Eps domain containing protein 2
chr5_-_148399901	6.355	ENSMUST00000048116.8	Slc7a1	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr4_+_117835387	5.778	ENSMUST00000169885.1	Slc6a9	solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr11_-_20332689	5.152	ENSMUST00000109594.1	Slc1a4	solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr11_-_120643643	4.918	ENSMUST00000141254.1 ENSMUST00000170556.1 ENSMUST00000151876.1 ENSMUST00000026133.8 ENSMUST00000139706.1	Pycr1	pyrroline-5-carboxylate reductase 1
chr11_-_20332654	4.732	ENSMUST00000004634.6	Slc1a4	solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr12_+_85599047	4.254	ENSMUST00000177587.1	Jdp2	Jun dimerization protein 2
chr8_+_75093591	4.129	ENSMUST00000005548.6	Hmox1	heme oxygenase (decycling) 1
chr7_-_126566364	3.790	ENSMUST00000032992.5	Eif3c	eukaryotic translation initiation factor 3, subunit C
chr6_+_129533183	3.646	ENSMUST00000032264.6	Gabarapl1	gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1
chr18_-_64516547	3.644	ENSMUST00000025483.9	Nars	asparaginyl-tRNA synthetase
chr4_+_129189760	3.528	ENSMUST00000106054.2 ENSMUST00000001365.2	Yars	tyrosyl-tRNA synthetase
chr15_-_98953541	3.492	ENSMUST00000097014.5	Tuba1a	tubulin, alpha 1A
chr11_-_115276973	3.451	ENSMUST00000021078.2	Fdxr	ferredoxin reductase
chr12_+_85599388	3.399	ENSMUST00000050687.6	Jdp2	Jun dimerization protein 2
chr1_-_191183244	3.282	ENSMUST00000027941.8	Atf3	activating transcription factor 3
chr4_+_127021311	3.094	ENSMUST00000030623.7	Sfpq	splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)
chr7_-_143600049	2.946	ENSMUST00000105909.3 ENSMUST00000010899.7	Cars	cysteinyl-tRNA synthetase
chr3_-_127408986	2.903	ENSMUST00000182588.1 ENSMUST00000182959.1 ENSMUST00000182452.1	Ank2	ankyrin 2, brain
chr3_-_127409014	2.784	ENSMUST00000182008.1 ENSMUST00000182711.1 ENSMUST00000182547.1	Ank2	ankyrin 2, brain
chr14_-_66868572	2.784	ENSMUST00000022629.8	Dpysl2	dihydropyrimidinase-like 2
chr3_-_127409044	2.780	ENSMUST00000182704.1	Ank2	ankyrin 2, brain
chr5_-_90223923	2.774	ENSMUST00000118816.1 ENSMUST00000048363.7	Cox18	cytochrome c oxidase assembly protein 18
chrX_+_103422010	2.751	ENSMUST00000182089.1	Gm26992	predicted gene, 26992
chr4_-_129189600	2.745	ENSMUST00000117497.1 ENSMUST00000117350.1	S100pbp	S100P binding protein
chr9_+_109931458	2.645	ENSMUST00000072772.5 ENSMUST00000035055.8	Map4	microtubule-associated protein 4
chr4_-_129189512	2.642	ENSMUST00000117965.1 ENSMUST00000106061.2 ENSMUST00000072431.6	S100pbp	S100P binding protein
chr3_-_127408937	2.637	ENSMUST00000183095.1 ENSMUST00000182610.1	Ank2	ankyrin 2, brain
chr6_+_55037988	2.453	ENSMUST00000003572.8	Gars	glycyl-tRNA synthetase
chr10_-_83533383	2.400	ENSMUST00000146640.1	Aldh1l2	aldehyde dehydrogenase 1 family, member L2
chrX_+_94234594	2.399	ENSMUST00000153900.1	Klhl15	kelch-like 15
chr15_+_99393219	2.393	ENSMUST00000159209.1	Tmbim6	transmembrane BAX inhibitor motif containing 6
chr10_+_102158858	2.325	ENSMUST00000138522.1 ENSMUST00000163753.1 ENSMUST00000138016.1	Mgat4c	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr3_+_89715016	2.281	ENSMUST00000098924.2	Adar	adenosine deaminase, RNA-specific
chr2_-_3512746	2.278	ENSMUST00000027961.5 ENSMUST00000056700.7	Hspa14 Hspa14	heat shock protein 14 heat shock protein 14
chr10_-_68278713	2.253	ENSMUST00000020106.7	Arid5b	AT rich interactive domain 5B (MRF1-like)
chr6_-_129533267	2.221	ENSMUST00000181594.1	1700101I11Rik	RIKEN cDNA 1700101I11 gene
chr7_+_138846579	2.206	ENSMUST00000155672.1	Ppp2r2d	protein phosphatase 2, regulatory subunit B, delta isoform
chr9_+_109931863	2.157	ENSMUST00000165876.1	Map4	microtubule-associated protein 4
chr11_+_100320596	2.119	ENSMUST00000152521.1	Eif1	eukaryotic translation initiation factor 1
chr4_-_129189646	2.063	ENSMUST00000106059.1	S100pbp	S100P binding protein
chr1_-_78488846	2.050	ENSMUST00000068333.7 ENSMUST00000170217.1	Farsb	phenylalanyl-tRNA synthetase, beta subunit
chr2_+_163995503	2.023	ENSMUST00000131288.1	Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
chr10_+_121739915	1.994	ENSMUST00000065600.7 ENSMUST00000136432.1	BC048403	cDNA sequence BC048403
chr7_+_126565919	1.963	ENSMUST00000180459.1	G730046D07Rik	RIKEN cDNA G730046D07 gene
chr13_-_101692624	1.931	ENSMUST00000035532.6	Pik3r1	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr17_+_34187545	1.805	ENSMUST00000170086.1	Tap1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr4_+_41942037	1.801	ENSMUST00000181518.1	Gm20878	predicted gene, 20878
chr11_-_53430417	1.750	ENSMUST00000109019.1	Uqcrq	ubiquinol-cytochrome c reductase, complex III subunit VII
chr13_-_30545254	1.543	ENSMUST00000042834.3	Uqcrfs1	ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
chr17_+_34187789	1.508	ENSMUST00000041633.8	Tap1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr6_-_23248264	1.471	ENSMUST00000031709.5	Fezf1	Fez family zinc finger 1
chr7_-_126625676	1.400	ENSMUST00000032961.3	Nupr1	nuclear protein transcription regulator 1
chr5_-_145140238	1.400	ENSMUST00000031627.8	Pdap1	PDGFA associated protein 1
chr10_-_127311740	1.397	ENSMUST00000037290.5 ENSMUST00000171564.1	Mars	methionine-tRNA synthetase
chr8_+_105701624	1.316	ENSMUST00000093195.6	Pard6a	par-6 (partitioning defective 6,) homolog alpha (C. elegans)
chr4_-_41774097	1.308	ENSMUST00000108036.1 ENSMUST00000173865.1 ENSMUST00000108037.2 ENSMUST00000108032.2	Ccl27a	chemokine (C-C motif) ligand 27A
chr11_-_87826023	1.272	ENSMUST00000103177.3	Lpo	lactoperoxidase
chr7_-_126502094	1.216	ENSMUST00000179818.1	Atxn2l	ataxin 2-like
chr12_-_104865076	1.152	ENSMUST00000109937.1 ENSMUST00000109936.1	Clmn	calmin
chr11_-_118290188	1.117	ENSMUST00000106296.2 ENSMUST00000092382.3	Usp36	ubiquitin specific peptidase 36
chr15_-_83510861	1.072	ENSMUST00000109479.1 ENSMUST00000109480.1 ENSMUST00000016897.4	Ttll1	tubulin tyrosine ligase-like 1
chr11_-_53430779	1.058	ENSMUST00000061326.4 ENSMUST00000109021.3	Uqcrq	ubiquinol-cytochrome c reductase, complex III subunit VII
chr15_-_83510793	1.030	ENSMUST00000154401.1	Ttll1	tubulin tyrosine ligase-like 1
chr7_+_110018301	0.968	ENSMUST00000084731.3	Ipo7	importin 7
chr2_+_3513035	0.959	ENSMUST00000036350.2	Cdnf	cerebral dopamine neurotrophic factor
chr4_-_139380374	0.914	ENSMUST00000181556.1	2700016F22Rik	RIKEN cDNA 2700016F22 gene
chr1_-_36709904	0.872	ENSMUST00000043951.3	Actr1b	ARP1 actin-related protein 1B, centractin beta
chr11_-_118290167	0.774	ENSMUST00000144153.1	Usp36	ubiquitin specific peptidase 36
chr7_-_126502312	0.749	ENSMUST00000166682.2	Atxn2l	ataxin 2-like
chr11_+_58009064	0.733	ENSMUST00000071487.6 ENSMUST00000178636.1	Larp1	La ribonucleoprotein domain family, member 1
chr8_+_111033890	0.711	ENSMUST00000034441.7	Aars	alanyl-tRNA synthetase
chr15_+_99393574	0.697	ENSMUST00000162624.1	Tmbim6	transmembrane BAX inhibitor motif containing 6
chr13_-_118387224	0.655	ENSMUST00000022245.8	Mrps30	mitochondrial ribosomal protein S30
chr11_-_75422524	0.653	ENSMUST00000125982.1 ENSMUST00000137103.1	Serpinf1	serine (or cysteine) peptidase inhibitor, clade F, member 1
chr11_-_98400393	0.647	ENSMUST00000128897.1	Pgap3	post-GPI attachment to proteins 3
chr7_-_126502380	0.638	ENSMUST00000167759.1	Atxn2l	ataxin 2-like
chr19_-_43524462	0.634	ENSMUST00000026196.7	Got1	glutamate oxaloacetate transaminase 1, soluble
chr19_+_53140430	0.612	ENSMUST00000111741.2	Add3	adducin 3 (gamma)
chr4_+_124741844	0.598	ENSMUST00000094782.3 ENSMUST00000153837.1 ENSMUST00000154229.1	Inpp5b	inositol polyphosphate-5-phosphatase B
chr18_-_42262053	0.585	ENSMUST00000097590.3	Lars	leucyl-tRNA synthetase
chr17_-_34187219	0.582	ENSMUST00000173831.1	Psmb9	proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
chr16_-_34095983	0.556	ENSMUST00000114973.1 ENSMUST00000114964.1	Kalrn	kalirin, RhoGEF kinase
chr19_-_50678642	0.549	ENSMUST00000072685.6 ENSMUST00000164039.2	Sorcs1	VPS10 domain receptor protein SORCS 1
chr9_-_71771535	0.524	ENSMUST00000122065.1 ENSMUST00000121322.1 ENSMUST00000072899.2	Cgnl1	cingulin-like 1
chr4_-_118179628	0.479	ENSMUST00000097911.2	Kdm4a	lysine (K)-specific demethylase 4A
chr3_-_89998656	0.473	ENSMUST00000079724.4	Hax1	HCLS1 associated X-1
chr5_-_36695969	0.405	ENSMUST00000031091.9 ENSMUST00000140063.1	D5Ertd579e	DNA segment, Chr 5, ERATO Doi 579, expressed
chr11_-_75422586	0.397	ENSMUST00000138661.1 ENSMUST00000000769.7	Serpinf1	serine (or cysteine) peptidase inhibitor, clade F, member 1
chr8_-_92356103	0.333	ENSMUST00000034183.3	4933436C20Rik	RIKEN cDNA 4933436C20 gene
chr10_+_80141457	0.323	ENSMUST00000105367.1	Atp5d	ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
chr8_+_105701142	0.317	ENSMUST00000098444.2	Pard6a	par-6 (partitioning defective 6,) homolog alpha (C. elegans)
chr11_-_98400453	0.288	ENSMUST00000090827.5	Pgap3	post-GPI attachment to proteins 3
chr19_+_44203265	0.260	ENSMUST00000026220.5	Scd3	stearoyl-coenzyme A desaturase 3
chr12_-_108893197	0.258	ENSMUST00000161154.1 ENSMUST00000161410.1	Wars	tryptophanyl-tRNA synthetase
chr13_-_53473074	0.218	ENSMUST00000021922.8	Msx2	msh homeobox 2
chr8_-_105701077	0.173	ENSMUST00000042608.6	Acd	adrenocortical dysplasia
chr4_+_42735545	0.155	ENSMUST00000068158.3	4930578G10Rik	RIKEN cDNA 4930578G10 gene
chr3_-_138143352	0.148	ENSMUST00000098580.2	Mttp	microsomal triglyceride transfer protein
chr1_+_133131143	0.146	ENSMUST00000052529.3	Ppp1r15b	protein phosphatase 1, regulatory (inhibitor) subunit 15b
chr15_+_99393610	0.119	ENSMUST00000159531.1	Tmbim6	transmembrane BAX inhibitor motif containing 6
chr13_+_49682191	0.072	ENSMUST00000172254.1	Iars	isoleucine-tRNA synthetase
chr8_+_123477859	0.053	ENSMUST00000001520.7	Afg3l1	AFG3(ATPase family gene 3)-like 1 (yeast)
chr7_+_44468051	0.044	ENSMUST00000118493.1	Josd2	Josephin domain containing 2
chrX_+_106187100	0.037	ENSMUST00000081593.6	Pgk1	phosphoglycerate kinase 1

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
5.3	15.9	GO:0006931	substrate-dependent cell migration, cell attachment to substrate(GO:0006931) calcium-independent cell-matrix adhesion(GO:0007161) transforming growth factor-beta secretion(GO:0038044)
2.8	13.9	GO:0051012	microtubule sliding(GO:0051012)
2.6	10.4	GO:0006751	glutathione catabolic process(GO:0006751)
2.5	9.9	GO:0015825	L-serine transport(GO:0015825)
2.0	7.9	GO:0010808	positive regulation of synaptic vesicle priming(GO:0010808)
1.9	5.8	GO:0061537	glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
1.5	7.4	GO:0018364	peptidyl-glutamine methylation(GO:0018364)
1.2	11.1	GO:0036371	protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
1.0	4.1	GO:1904706	heme oxidation(GO:0006788) negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.9	3.6	GO:0006421	asparaginyl-tRNA aminoacylation(GO:0006421)
0.8	3.3	GO:0046967	cytosol to ER transport(GO:0046967)
0.8	3.3	GO:1903984	positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.8	2.4	GO:0042560	10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.8	2.3	GO:1900369	negative regulation of RNA interference(GO:1900369)
0.6	3.2	GO:1904721	regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.5	2.0	GO:0006432	phenylalanyl-tRNA aminoacylation(GO:0006432)
0.5	2.5	GO:0015960	diadenosine polyphosphate biosynthetic process(GO:0015960) diadenosine tetraphosphate metabolic process(GO:0015965) diadenosine tetraphosphate biosynthetic process(GO:0015966)
0.5	2.8	GO:0021539	subthalamus development(GO:0021539)
0.4	3.1	GO:0045876	positive regulation of sister chromatid cohesion(GO:0045876)
0.4	1.3	GO:0071677	positive regulation of mononuclear cell migration(GO:0071677)
0.4	1.3	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.4	6.4	GO:0015809	arginine transport(GO:0015809)
0.4	2.4	GO:0071630	nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.4	2.8	GO:0051204	protein insertion into mitochondrial membrane(GO:0051204)
0.4	3.8	GO:1902416	positive regulation of mRNA binding(GO:1902416)
0.3	3.6	GO:0006995	cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.3	3.5	GO:0070995	NADPH oxidation(GO:0070995)
0.3	7.7	GO:0031065	positive regulation of histone deacetylation(GO:0031065)
0.3	2.3	GO:0060613	fat pad development(GO:0060613)
0.2	1.5	GO:0021797	forebrain anterior/posterior pattern specification(GO:0021797)
0.2	0.7	GO:1901355	response to rapamycin(GO:1901355)
0.2	9.1	GO:0006418	tRNA aminoacylation for protein translation(GO:0006418)
0.2	2.1	GO:0018095	protein polyglutamylation(GO:0018095)
0.2	1.6	GO:0006561	proline biosynthetic process(GO:0006561)
0.2	0.6	GO:0006106	fumarate metabolic process(GO:0006106) aspartate biosynthetic process(GO:0006532) aspartate catabolic process(GO:0006533) alditol biosynthetic process(GO:0019401)
0.2	1.0	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.2	1.6	GO:1904781	positive regulation of protein localization to centrosome(GO:1904781)
0.2	1.9	GO:0010459	negative regulation of heart rate(GO:0010459)
0.2	1.4	GO:2000194	regulation of female gonad development(GO:2000194)
0.1	2.1	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.1	2.6	GO:0010603	regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.1	2.0	GO:1904262	negative regulation of TORC1 signaling(GO:1904262)
0.1	2.8	GO:0014049	positive regulation of glutamate secretion(GO:0014049)
0.1	2.4	GO:0070262	peptidyl-serine dephosphorylation(GO:0070262)
0.1	7.7	GO:0010718	positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.1	0.2	GO:0051795	positive regulation of catagen(GO:0051795)
0.1	0.5	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.1	15.0	GO:0007219	Notch signaling pathway(GO:0007219)
0.1	0.6	GO:0061368	maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.1	0.3	GO:1903966	monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.1	0.2	GO:1904742	regulation of telomeric DNA binding(GO:1904742)
0.0	0.5	GO:1900113	negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.0	2.0	GO:0051220	cytoplasmic sequestering of protein(GO:0051220)
0.0	1.4	GO:1903146	regulation of mitophagy(GO:1903146)
0.0	0.1	GO:0034196	acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.0	1.0	GO:0071542	dopaminergic neuron differentiation(GO:0071542)
0.0	0.6	GO:0046856	phosphatidylinositol dephosphorylation(GO:0046856)
0.0	1.4	GO:0048008	platelet-derived growth factor receptor signaling pathway(GO:0048008)
0.0	0.9	GO:0006506	GPI anchor biosynthetic process(GO:0006506)
0.0	0.6	GO:0042493	response to drug(GO:0042493)
0.0	0.3	GO:0015985	energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
5.3	15.9	GO:0005577	fibrinogen complex(GO:0005577)
1.6	7.9	GO:0098831	presynaptic active zone cytoplasmic component(GO:0098831)
1.1	7.4	GO:0031428	box C/D snoRNP complex(GO:0031428)
0.7	2.0	GO:0009328	phenylalanine-tRNA ligase complex(GO:0009328)
0.5	3.3	GO:0042825	TAP complex(GO:0042825)
0.4	4.4	GO:0005750	mitochondrial respiratory chain complex III(GO:0005750)
0.4	3.8	GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.4	11.1	GO:0031430	M band(GO:0031430)
0.4	3.1	GO:0042382	paraspeckles(GO:0042382)
0.4	2.3	GO:0044530	supraspliceosomal complex(GO:0044530)
0.3	5.2	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.2	3.6	GO:0000421	autophagosome membrane(GO:0000421)
0.1	9.9	GO:0005882	intermediate filament(GO:0005882)
0.1	0.6	GO:1990111	spermatoproteasome complex(GO:1990111)
0.1	13.9	GO:0072686	mitotic spindle(GO:0072686)
0.1	2.2	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.1	1.0	GO:0043203	axon hillock(GO:0043203)
0.1	2.8	GO:0031305	integral component of mitochondrial inner membrane(GO:0031305)
0.1	1.9	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.1	0.7	GO:0031931	TORC1 complex(GO:0031931)
0.1	0.9	GO:0005869	dynactin complex(GO:0005869)
0.1	1.6	GO:0034451	centriolar satellite(GO:0034451)
0.1	3.5	GO:0005881	cytoplasmic microtubule(GO:0005881)
0.0	10.4	GO:0005802	trans-Golgi network(GO:0005802)
0.0	4.1	GO:0005901	caveola(GO:0005901)
0.0	0.3	GO:0045261	mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0	2.5	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	7.7	GO:0000139	Golgi membrane(GO:0000139)
0.0	1.9	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0	9.6	GO:0016607	nuclear speck(GO:0016607)
0.0	8.6	GO:0098793	presynapse(GO:0098793)
0.0	0.2	GO:0070187	telosome(GO:0070187)
0.0	2.0	GO:0017053	transcriptional repressor complex(GO:0017053)
0.0	0.5	GO:0005721	pericentric heterochromatin(GO:0005721)
0.0	0.1	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.0	2.5	GO:0030141	secretory granule(GO:0030141)
0.0	3.3	GO:0005730	nucleolus(GO:0005730)
0.0	2.9	GO:0005840	ribosome(GO:0005840)
0.0	0.5	GO:0030136	clathrin-coated vesicle(GO:0030136)
0.0	0.5	GO:0016459	myosin complex(GO:0016459)
0.0	0.6	GO:0043679	axon terminus(GO:0043679)
0.0	0.1	GO:0031528	microvillus membrane(GO:0031528)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.6	15.9	GO:0045340	mercury ion binding(GO:0045340)
2.1	10.4	GO:0003839	gamma-glutamylcyclotransferase activity(GO:0003839)
1.2	9.9	GO:0015180	L-alanine transmembrane transporter activity(GO:0015180) L-proline transmembrane transporter activity(GO:0015193) alanine transmembrane transporter activity(GO:0022858)
1.2	4.9	GO:0004735	pyrroline-5-carboxylate reductase activity(GO:0004735)
1.2	3.6	GO:0004816	asparagine-tRNA ligase activity(GO:0004816)
1.0	4.1	GO:0004392	heme oxygenase (decyclizing) activity(GO:0004392)
0.8	3.3	GO:0015433	peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
0.8	2.4	GO:0016155	formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.8	6.4	GO:0015181	arginine transmembrane transporter activity(GO:0015181)
0.8	2.3	GO:0003692	left-handed Z-DNA binding(GO:0003692)
0.7	5.8	GO:0015187	glycine transmembrane transporter activity(GO:0015187)
0.5	4.4	GO:0008121	ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.5	3.2	GO:0060698	endoribonuclease inhibitor activity(GO:0060698)
0.5	2.1	GO:0070740	tubulin-glutamic acid ligase activity(GO:0070740)
0.5	1.9	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.5	2.3	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.5	7.4	GO:0008649	rRNA methyltransferase activity(GO:0008649)
0.4	2.0	GO:0004826	phenylalanine-tRNA ligase activity(GO:0004826)
0.3	11.5	GO:0016876	aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.2	3.6	GO:0030957	Tat protein binding(GO:0030957)
0.2	0.6	GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.2	0.6	GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.2	3.5	GO:0070402	NADPH binding(GO:0070402)
0.2	11.1	GO:0030507	spectrin binding(GO:0030507)
0.2	2.0	GO:0050815	phosphoserine binding(GO:0050815)
0.2	0.5	GO:0019966	interleukin-1 binding(GO:0019966)
0.1	0.7	GO:0008494	translation activator activity(GO:0008494)
0.1	1.4	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.1	5.9	GO:0003743	translation initiation factor activity(GO:0003743)
0.1	7.4	GO:0048306	calcium-dependent protein binding(GO:0048306)
0.1	0.3	GO:0032896	palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.1	11.9	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1	1.6	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.1	3.5	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.1	7.9	GO:0017137	Rab GTPase binding(GO:0017137)
0.0	13.2	GO:0008017	microtubule binding(GO:0008017)
0.0	3.1	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0	3.7	GO:0008565	protein transporter activity(GO:0008565)
0.0	2.2	GO:0004722	protein serine/threonine phosphatase activity(GO:0004722)
0.0	2.5	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0	1.3	GO:0004601	peroxidase activity(GO:0004601)
0.0	0.6	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.6	GO:0004298	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) proteasome binding(GO:0070628)
0.0	0.5	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454) histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	1.0	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.0	0.3	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0	1.5	GO:0004843	thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0	10.4	GO:0008270	zinc ion binding(GO:0008270)
0.0	6.4	GO:0005509	calcium ion binding(GO:0005509)
0.0	0.1	GO:0034185	apolipoprotein binding(GO:0034185)
0.0	1.3	GO:0005125	cytokine activity(GO:0005125)

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.9	15.9	PID_INTEGRIN5_PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2	4.1	PID_FRA_PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1	9.0	PID_ATF2_PATHWAY	ATF-2 transcription factor network
0.1	1.9	PID_IL5_PATHWAY	IL5-mediated signaling events
0.1	3.5	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.1	2.0	PID_P38_MK2_PATHWAY	p38 signaling mediated by MAPKAP kinases
0.1	3.5	PID_TAP63_PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.1	1.6	PID_NEPHRIN_NEPH1_PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.0	3.3	PID_P53_DOWNSTREAM_PATHWAY	Direct p53 effectors
0.0	0.6	PID_ARF6_DOWNSTREAM_PATHWAY	Arf6 downstream pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.1	15.9	REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.8	7.9	REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE	Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.6	5.8	REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.5	16.2	REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.5	13.6	REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.4	15.0	REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.2	3.5	REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.2	3.3	REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.2	1.9	REACTOME_IL_7_SIGNALING	Genes involved in Interleukin-7 signaling
0.1	2.8	REACTOME_CRMPS_IN_SEMA3A_SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.1	2.0	REACTOME_RAF_MAP_KINASE_CASCADE	Genes involved in RAF/MAP kinase cascade
0.1	2.3	REACTOME_N_GLYCAN_ANTENNAE_ELONGATION	Genes involved in N-Glycan antennae elongation
0.1	4.1	REACTOME_IRON_UPTAKE_AND_TRANSPORT	Genes involved in Iron uptake and transport
0.1	1.6	REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1	3.8	REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1	1.7	REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.1	4.4	REACTOME_RESPIRATORY_ELECTRON_TRANSPORT	Genes involved in Respiratory electron transport
0.1	2.3	REACTOME_INTERFERON_ALPHA_BETA_SIGNALING	Genes involved in Interferon alpha/beta signaling
0.0	0.3	REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.0	0.6	REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0	0.1	REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT	Genes involved in Chylomicron-mediated lipid transport

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