Motif ID: Atf4

Z-value: 1.069


Transcription factors associated with Atf4:

Gene SymbolEntrez IDGene Name
Atf4 ENSMUSG00000042406.7 Atf4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf4mm10_v2_chr15_+_80255184_80255263-0.132.8e-01Click!


Activity profile for motif Atf4.

activity profile for motif Atf4


Sorted Z-values histogram for motif Atf4

Sorted Z-values for motif Atf4



Network of associatons between targets according to the STRING database.



First level regulatory network of Atf4

PNG image of the network

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Top targets:


Showing 1 to 20 of 112 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_71653162 15.867 ENSMUST00000055226.6
 Fn1
fibronectin 1
chr19_-_12501996 14.957 ENSMUST00000045521.7
 Dtx4
deltex 4 homolog (Drosophila)
chr2_+_119351222 10.433 ENSMUST00000028780.3
 Chac1
ChaC, cation transport regulator 1
chr9_+_109931774 9.093 ENSMUST00000169851.2
 Map4
microtubule-associated protein 4
chr1_-_22315792 7.875 ENSMUST00000164877.1
 Rims1
regulating synaptic membrane exocytosis 1
chr4_+_43957678 7.748 ENSMUST00000107855.1
 Glipr2
GLI pathogenesis-related 2
chr11_-_35798884 7.429 ENSMUST00000160726.2
 Fbll1
fibrillarin-like 1
chrX_-_162565514 7.173 ENSMUST00000154424.1
 Reps2
RALBP1 associated Eps domain containing protein 2
chr5_-_148399901 6.355 ENSMUST00000048116.8
 Slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr4_+_117835387 5.778 ENSMUST00000169885.1
 Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr11_-_20332689 5.152 ENSMUST00000109594.1
 Slc1a4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr11_-_120643643 4.918 ENSMUST00000141254.1
ENSMUST00000170556.1
ENSMUST00000151876.1
ENSMUST00000026133.8
ENSMUST00000139706.1
 Pycr1




pyrroline-5-carboxylate reductase 1




chr11_-_20332654 4.732 ENSMUST00000004634.6
 Slc1a4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr12_+_85599047 4.254 ENSMUST00000177587.1
 Jdp2
Jun dimerization protein 2
chr8_+_75093591 4.129 ENSMUST00000005548.6
 Hmox1
heme oxygenase (decycling) 1
chr7_-_126566364 3.790 ENSMUST00000032992.5
 Eif3c
eukaryotic translation initiation factor 3, subunit C
chr6_+_129533183 3.646 ENSMUST00000032264.6
 Gabarapl1
gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1
chr18_-_64516547 3.644 ENSMUST00000025483.9
 Nars
asparaginyl-tRNA synthetase
chr4_+_129189760 3.528 ENSMUST00000106054.2
ENSMUST00000001365.2
 Yars

tyrosyl-tRNA synthetase

chr15_-_98953541 3.492 ENSMUST00000097014.5
 Tuba1a
tubulin, alpha 1A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.3 15.9 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931) calcium-independent cell-matrix adhesion(GO:0007161) transforming growth factor-beta secretion(GO:0038044)
0.1 15.0 GO:0007219 Notch signaling pathway(GO:0007219)
2.8 13.9 GO:0051012 microtubule sliding(GO:0051012)
1.2 11.1 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
2.6 10.4 GO:0006751 glutathione catabolic process(GO:0006751)
2.5 9.9 GO:0015825 L-serine transport(GO:0015825)
0.2 9.1 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
2.0 7.9 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.3 7.7 GO:0031065 positive regulation of histone deacetylation(GO:0031065)
0.1 7.7 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
1.5 7.4 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
0.4 6.4 GO:0015809 arginine transport(GO:0015809)
1.9 5.8 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
1.0 4.1 GO:1904706 heme oxidation(GO:0006788) negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.4 3.8 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.9 3.6 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.3 3.6 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.3 3.5 GO:0070995 NADPH oxidation(GO:0070995)
0.8 3.3 GO:0046967 cytosol to ER transport(GO:0046967)
0.8 3.3 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.3 15.9 GO:0005577 fibrinogen complex(GO:0005577)
0.1 13.9 GO:0072686 mitotic spindle(GO:0072686)
0.4 11.1 GO:0031430 M band(GO:0031430)
0.0 10.4 GO:0005802 trans-Golgi network(GO:0005802)
0.1 9.9 GO:0005882 intermediate filament(GO:0005882)
0.0 9.6 GO:0016607 nuclear speck(GO:0016607)
0.0 8.6 GO:0098793 presynapse(GO:0098793)
1.6 7.9 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.0 7.7 GO:0000139 Golgi membrane(GO:0000139)
1.1 7.4 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.3 5.2 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.4 4.4 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.0 4.1 GO:0005901 caveola(GO:0005901)
0.4 3.8 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.2 3.6 GO:0000421 autophagosome membrane(GO:0000421)
0.1 3.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.5 3.3 GO:0042825 TAP complex(GO:0042825)
0.0 3.3 GO:0005730 nucleolus(GO:0005730)
0.4 3.1 GO:0042382 paraspeckles(GO:0042382)
0.0 2.9 GO:0005840 ribosome(GO:0005840)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 15.9 GO:0045340 mercury ion binding(GO:0045340)
0.0 13.2 GO:0008017 microtubule binding(GO:0008017)
0.1 11.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3 11.5 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.2 11.1 GO:0030507 spectrin binding(GO:0030507)
2.1 10.4 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.0 10.4 GO:0008270 zinc ion binding(GO:0008270)
1.2 9.9 GO:0015180 L-alanine transmembrane transporter activity(GO:0015180) L-proline transmembrane transporter activity(GO:0015193) alanine transmembrane transporter activity(GO:0022858)
0.1 7.9 GO:0017137 Rab GTPase binding(GO:0017137)
0.5 7.4 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.1 7.4 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.8 6.4 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.0 6.4 GO:0005509 calcium ion binding(GO:0005509)
0.1 5.9 GO:0003743 translation initiation factor activity(GO:0003743)
0.7 5.8 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
1.2 4.9 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.5 4.4 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
1.0 4.1 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.0 3.7 GO:0008565 protein transporter activity(GO:0008565)
1.2 3.6 GO:0004816 asparagine-tRNA ligase activity(GO:0004816)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 15.9 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 9.0 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.2 4.1 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 3.5 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.1 3.5 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 3.3 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 2.0 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 1.9 PID_IL5_PATHWAY IL5-mediated signaling events
0.1 1.6 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.6 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 16.2 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
1.1 15.9 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.4 15.0 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.5 13.6 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.8 7.9 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.6 5.8 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 4.4 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 4.1 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport
0.1 3.8 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2 3.5 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.2 3.3 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 2.8 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 2.3 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.1 2.3 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 2.0 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade
0.2 1.9 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 1.7 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 1.6 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.6 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.3 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling