Motif ID: Atf5
Z-value: 0.839
Transcription factors associated with Atf5:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Atf5 | ENSMUSG00000038539.8 | Atf5 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Atf5 | mm10_v2_chr7_-_44816586_44816658 | -0.11 | 3.4e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 8.6 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 1.2 | 3.5 | GO:0018103 | protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406) |
| 0.7 | 2.2 | GO:1904339 | negative regulation of dopaminergic neuron differentiation(GO:1904339) |
| 0.7 | 6.5 | GO:0030035 | microspike assembly(GO:0030035) |
| 0.6 | 1.9 | GO:0016344 | meiotic chromosome movement towards spindle pole(GO:0016344) |
| 0.6 | 1.8 | GO:2000620 | positive regulation of histone H4-K16 acetylation(GO:2000620) |
| 0.6 | 5.6 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
| 0.6 | 2.2 | GO:0007113 | endomitotic cell cycle(GO:0007113) |
| 0.5 | 2.1 | GO:1902268 | negative regulation of polyamine transmembrane transport(GO:1902268) |
| 0.5 | 2.5 | GO:0034436 | glycoprotein transport(GO:0034436) |
| 0.4 | 4.4 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 0.4 | 3.8 | GO:0098700 | neurotransmitter loading into synaptic vesicle(GO:0098700) |
| 0.4 | 5.9 | GO:0007213 | G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) |
| 0.4 | 2.5 | GO:0099525 | presynaptic dense core granule exocytosis(GO:0099525) |
| 0.4 | 0.8 | GO:0003169 | coronary vein morphogenesis(GO:0003169) |
| 0.4 | 3.6 | GO:0010793 | regulation of mRNA export from nucleus(GO:0010793) |
| 0.4 | 19.1 | GO:0001919 | regulation of receptor recycling(GO:0001919) |
| 0.4 | 4.2 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
| 0.4 | 2.3 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.4 | 1.8 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.3 | 2.0 | GO:0035989 | tendon development(GO:0035989) |
| 0.3 | 1.0 | GO:0003219 | cardiac right ventricle formation(GO:0003219) |
| 0.3 | 0.8 | GO:0046340 | diacylglycerol catabolic process(GO:0046340) |
| 0.2 | 1.5 | GO:0046549 | retinal cone cell development(GO:0046549) |
| 0.2 | 0.7 | GO:1990743 | protein sialylation(GO:1990743) |
| 0.2 | 1.6 | GO:0031339 | negative regulation of vesicle fusion(GO:0031339) |
| 0.2 | 1.3 | GO:0048341 | paraxial mesoderm formation(GO:0048341) |
| 0.2 | 1.5 | GO:0010606 | positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606) |
| 0.2 | 1.9 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 0.2 | 1.1 | GO:0035754 | B cell chemotaxis(GO:0035754) |
| 0.1 | 4.9 | GO:0014912 | negative regulation of smooth muscle cell migration(GO:0014912) |
| 0.1 | 0.4 | GO:0002182 | cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248) |
| 0.1 | 2.0 | GO:0036120 | cellular response to platelet-derived growth factor stimulus(GO:0036120) |
| 0.1 | 1.3 | GO:0060536 | cartilage morphogenesis(GO:0060536) |
| 0.1 | 1.1 | GO:0070236 | negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 0.1 | 2.5 | GO:0039703 | viral RNA genome replication(GO:0039694) RNA replication(GO:0039703) |
| 0.1 | 0.7 | GO:0003431 | growth plate cartilage chondrocyte development(GO:0003431) |
| 0.1 | 0.5 | GO:0035720 | intraciliary anterograde transport(GO:0035720) |
| 0.1 | 0.3 | GO:0002314 | germinal center B cell differentiation(GO:0002314) |
| 0.1 | 1.6 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.1 | 0.2 | GO:0032632 | interleukin-3 production(GO:0032632) |
| 0.1 | 0.3 | GO:0042138 | meiotic DNA double-strand break formation(GO:0042138) |
| 0.1 | 0.4 | GO:2000271 | positive regulation of fibroblast apoptotic process(GO:2000271) |
| 0.0 | 2.0 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.0 | 0.6 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 0.0 | 0.1 | GO:0018298 | protein-chromophore linkage(GO:0018298) |
| 0.0 | 0.4 | GO:0006450 | regulation of translational fidelity(GO:0006450) |
| 0.0 | 0.9 | GO:0051205 | protein insertion into membrane(GO:0051205) |
| 0.0 | 1.8 | GO:0003170 | heart valve development(GO:0003170) |
| 0.0 | 0.7 | GO:0016558 | protein import into peroxisome matrix(GO:0016558) |
| 0.0 | 0.8 | GO:0042474 | middle ear morphogenesis(GO:0042474) |
| 0.0 | 2.3 | GO:0000422 | mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726) |
| 0.0 | 1.9 | GO:0060976 | coronary vasculature development(GO:0060976) |
| 0.0 | 4.9 | GO:0032869 | cellular response to insulin stimulus(GO:0032869) |
| 0.0 | 1.2 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.0 | 1.3 | GO:0046580 | negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058) |
| 0.0 | 2.8 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 0.0 | 1.2 | GO:0048024 | regulation of mRNA splicing, via spliceosome(GO:0048024) |
| 0.0 | 1.1 | GO:0030641 | regulation of cellular pH(GO:0030641) |
| 0.0 | 0.1 | GO:0021940 | positive regulation of cerebellar granule cell precursor proliferation(GO:0021940) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 19.1 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.4 | 2.5 | GO:0044308 | axonal spine(GO:0044308) |
| 0.4 | 8.6 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.4 | 3.6 | GO:0000347 | THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) |
| 0.3 | 1.8 | GO:0070531 | BRCA1-A complex(GO:0070531) |
| 0.2 | 4.0 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.2 | 2.5 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.2 | 2.5 | GO:0034361 | very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385) |
| 0.2 | 1.9 | GO:0030478 | actin cap(GO:0030478) |
| 0.2 | 2.2 | GO:1990909 | Wnt signalosome(GO:1990909) |
| 0.2 | 1.5 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
| 0.2 | 0.7 | GO:1990415 | Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429) |
| 0.2 | 2.5 | GO:0031045 | dense core granule(GO:0031045) |
| 0.2 | 3.8 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.2 | 5.9 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.1 | 1.3 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.1 | 1.3 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.1 | 4.4 | GO:0016592 | mediator complex(GO:0016592) |
| 0.1 | 1.2 | GO:1904949 | ATPase complex(GO:1904949) |
| 0.1 | 0.4 | GO:0032021 | NELF complex(GO:0032021) |
| 0.1 | 3.5 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.1 | 2.3 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.1 | 0.2 | GO:0070820 | tertiary granule(GO:0070820) |
| 0.1 | 1.0 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.0 | 0.5 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.0 | 4.3 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 0.8 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.0 | 0.4 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.0 | 0.4 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 3.5 | GO:0034399 | nuclear periphery(GO:0034399) |
| 0.0 | 5.6 | GO:0000775 | chromosome, centromeric region(GO:0000775) |
| 0.0 | 2.1 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 2.0 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.0 | 2.4 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
| 0.0 | 0.8 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 0.8 | GO:0005604 | basement membrane(GO:0005604) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 19.1 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.8 | 2.5 | GO:0034437 | very-low-density lipoprotein particle binding(GO:0034189) glycoprotein transporter activity(GO:0034437) |
| 0.5 | 2.1 | GO:0008073 | ornithine decarboxylase inhibitor activity(GO:0008073) |
| 0.5 | 1.5 | GO:0008502 | melatonin receptor activity(GO:0008502) |
| 0.3 | 0.8 | GO:0043183 | vascular endothelial growth factor receptor 1 binding(GO:0043183) |
| 0.3 | 1.8 | GO:0001515 | opioid peptide activity(GO:0001515) |
| 0.2 | 4.9 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.2 | 1.2 | GO:0017116 | single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116) |
| 0.2 | 8.6 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.2 | 3.8 | GO:0005313 | L-glutamate transmembrane transporter activity(GO:0005313) |
| 0.2 | 0.8 | GO:0042134 | rRNA primary transcript binding(GO:0042134) |
| 0.2 | 2.2 | GO:0008641 | small protein activating enzyme activity(GO:0008641) |
| 0.2 | 3.5 | GO:0000030 | mannosyltransferase activity(GO:0000030) |
| 0.1 | 2.5 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.1 | 5.9 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.1 | 1.1 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 0.1 | 4.4 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.1 | 0.7 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
| 0.1 | 2.2 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.1 | 0.3 | GO:0035673 | oligopeptide transmembrane transporter activity(GO:0035673) |
| 0.1 | 4.0 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.1 | 1.6 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.1 | 1.5 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.1 | 0.3 | GO:0061505 | DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505) |
| 0.1 | 2.5 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 3.9 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.1 | 1.3 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.1 | 2.0 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.1 | 1.2 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.1 | 5.8 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 0.9 | GO:0016594 | glycine binding(GO:0016594) |
| 0.0 | 0.1 | GO:0009881 | photoreceptor activity(GO:0009881) |
| 0.0 | 0.4 | GO:0016884 | carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884) |
| 0.0 | 2.5 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.0 | 1.8 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 0.0 | 0.5 | GO:0005326 | neurotransmitter transporter activity(GO:0005326) |
| 0.0 | 0.4 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
| 0.0 | 1.0 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.0 | 0.8 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.0 | 2.4 | GO:0008081 | phosphoric diester hydrolase activity(GO:0008081) |
| 0.0 | 1.9 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 1.3 | GO:0005179 | hormone activity(GO:0005179) |
| 0.0 | 0.2 | GO:0005384 | manganese ion transmembrane transporter activity(GO:0005384) |
| 0.0 | 0.7 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.0 | 6.9 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.0 | 0.6 | GO:0046875 | ephrin receptor binding(GO:0046875) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.4 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.2 | 2.2 | PID_ERB_GENOMIC_PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 3.8 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 5.6 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.1 | 2.8 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
| 0.1 | 2.5 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.1 | 2.5 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 3.9 | PID_RB_1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 1.5 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 4.9 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.8 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.0 | 1.3 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 1.3 | PID_AP1_PATHWAY | AP-1 transcription factor network |
| 0.0 | 2.8 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.0 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 18.2 | REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.3 | 8.8 | REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.2 | 4.9 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.2 | 1.1 | REACTOME_ENDOGENOUS_STEROLS | Genes involved in Endogenous sterols |
| 0.1 | 2.0 | REACTOME_PECAM1_INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.1 | 4.4 | REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.1 | 7.4 | REACTOME_MEIOTIC_SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.1 | 6.5 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 3.8 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.1 | 0.8 | REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 1.3 | REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.0 | 6.0 | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | Genes involved in G alpha (i) signalling events |
| 0.0 | 2.1 | REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.0 | 0.8 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 1.0 | REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 1.6 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.0 | 2.5 | REACTOME_TOLL_RECEPTOR_CASCADES | Genes involved in Toll Receptor Cascades |
| 0.0 | 0.3 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION | Genes involved in N-Glycan antennae elongation |
