Motif ID: Atf5

Z-value: 0.839


Transcription factors associated with Atf5:

Gene SymbolEntrez IDGene Name
Atf5 ENSMUSG00000038539.8 Atf5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf5mm10_v2_chr7_-_44816586_44816658-0.113.4e-01Click!


Activity profile for motif Atf5.

activity profile for motif Atf5


Sorted Z-values histogram for motif Atf5

Sorted Z-values for motif Atf5



Network of associatons between targets according to the STRING database.



First level regulatory network of Atf5

PNG image of the network

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Top targets:


Showing 1 to 20 of 109 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_82705735 8.628 ENSMUST00000155821.1
 Nfib
nuclear factor I/B
chrX_+_41401304 7.477 ENSMUST00000076349.5
 Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chrX_+_41401128 6.899 ENSMUST00000115103.2
 Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr2_+_124610573 4.892 ENSMUST00000103239.3
ENSMUST00000103240.2
 Sema6d

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D

chrX_+_41401476 4.697 ENSMUST00000165288.1
 Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr1_-_172057573 4.386 ENSMUST00000059794.3
 Nhlh1
nescient helix loop helix 1
chr6_-_144209448 4.193 ENSMUST00000077160.5
 Sox5
SRY-box containing gene 5
chr4_-_91376433 4.175 ENSMUST00000107109.2
ENSMUST00000107111.2
ENSMUST00000107120.1
 Elavl2


ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)


chrX_-_41911877 4.138 ENSMUST00000047037.8
 Thoc2
THO complex 2
chr4_+_86748526 4.004 ENSMUST00000082026.7
ENSMUST00000045512.8
 Dennd4c

DENN/MADD domain containing 4C

chr15_-_102529025 3.908 ENSMUST00000096143.1
 Atf7
activating transcription factor 7
chr7_+_51621830 3.809 ENSMUST00000032710.5
 Slc17a6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr4_-_11322109 3.546 ENSMUST00000084892.5
ENSMUST00000128024.1
 Dpy19l4

dpy-19-like 4 (C. elegans)

chr10_+_115384951 3.495 ENSMUST00000036044.8
 Zfc3h1
zinc finger, C3H1-type containing
chr16_-_16560201 3.315 ENSMUST00000162045.1
ENSMUST00000162124.1
ENSMUST00000161861.1
 Fgd4


FYVE, RhoGEF and PH domain containing 4


chrX_+_42151002 3.152 ENSMUST00000123245.1
 Stag2
stromal antigen 2
chr16_-_16560046 3.136 ENSMUST00000172181.2
 Fgd4
FYVE, RhoGEF and PH domain containing 4
chr16_-_46010212 3.017 ENSMUST00000130481.1
 Plcxd2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr13_+_104287855 2.765 ENSMUST00000065766.6
 Adamts6
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6
chr14_+_12284198 2.683 ENSMUST00000112669.3
ENSMUST00000163392.1
 3830406C13Rik

RIKEN cDNA 3830406C13 gene


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 19.1 GO:0001919 regulation of receptor recycling(GO:0001919)
2.2 8.6 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.7 6.5 GO:0030035 microspike assembly(GO:0030035)
0.4 5.9 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.6 5.6 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.1 4.9 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.0 4.9 GO:0032869 cellular response to insulin stimulus(GO:0032869)
0.4 4.4 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.4 4.2 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.4 3.8 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.4 3.6 GO:0010793 regulation of mRNA export from nucleus(GO:0010793)
1.2 3.5 GO:0018103 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0 2.8 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.5 2.5 GO:0034436 glycoprotein transport(GO:0034436)
0.4 2.5 GO:0099525 presynaptic dense core granule exocytosis(GO:0099525)
0.1 2.5 GO:0039703 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.4 2.3 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 2.3 GO:0000422 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.7 2.2 GO:1904339 negative regulation of dopaminergic neuron differentiation(GO:1904339)
0.6 2.2 GO:0007113 endomitotic cell cycle(GO:0007113)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 19.1 GO:0043083 synaptic cleft(GO:0043083)
0.4 8.6 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.2 5.9 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 5.6 GO:0000775 chromosome, centromeric region(GO:0000775)
0.1 4.4 GO:0016592 mediator complex(GO:0016592)
0.0 4.3 GO:0030175 filopodium(GO:0030175)
0.2 4.0 GO:0032593 insulin-responsive compartment(GO:0032593)
0.2 3.8 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.4 3.6 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1 3.5 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 3.5 GO:0034399 nuclear periphery(GO:0034399)
0.4 2.5 GO:0044308 axonal spine(GO:0044308)
0.2 2.5 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.2 2.5 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.2 2.5 GO:0031045 dense core granule(GO:0031045)
0.0 2.4 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.1 2.3 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.2 2.2 GO:1990909 Wnt signalosome(GO:1990909)
0.0 2.1 GO:0072562 blood microparticle(GO:0072562)
0.0 2.0 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 19.1 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.2 8.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 6.9 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 5.9 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 5.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 4.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 4.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 4.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 3.9 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.2 3.8 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.2 3.5 GO:0000030 mannosyltransferase activity(GO:0000030)
0.8 2.5 GO:0034437 very-low-density lipoprotein particle binding(GO:0034189) glycoprotein transporter activity(GO:0034437)
0.1 2.5 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 2.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 2.5 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 2.4 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.2 2.2 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.1 2.2 GO:0050321 tau-protein kinase activity(GO:0050321)
0.5 2.1 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.1 2.0 GO:0005154 epidermal growth factor receptor binding(GO:0005154)

Gene overrepresentation in C2:CP category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.4 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 5.6 PID_PLK1_PATHWAY PLK1 signaling events
0.0 4.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.9 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.1 3.8 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 2.8 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 2.8 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 2.5 NABA_COLLAGENS Genes encoding collagen proteins
0.2 2.2 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 1.5 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.3 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.3 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.0 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.8 PID_ARF6_PATHWAY Arf6 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 18.2 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.3 8.8 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 7.4 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.1 6.5 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 6.0 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.2 4.9 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 4.4 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.1 3.8 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 2.5 REACTOME_TOLL_RECEPTOR_CASCADES Genes involved in Toll Receptor Cascades
0.0 2.1 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.1 2.0 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.0 1.6 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 1.3 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.2 1.1 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.0 1.0 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 0.8 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.8 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.3 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation