Motif ID: Atf6

Z-value: 1.013


Transcription factors associated with Atf6:

Gene SymbolEntrez IDGene Name
Atf6 ENSMUSG00000026663.6 Atf6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf6mm10_v2_chr1_-_170867761_170867784-0.402.6e-04Click!


Activity profile for motif Atf6.

activity profile for motif Atf6


Sorted Z-values histogram for motif Atf6

Sorted Z-values for motif Atf6



Network of associatons between targets according to the STRING database.



First level regulatory network of Atf6

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_-_23988852 23.132 ENSMUST00000023151.5
 Bcl6
B cell leukemia/lymphoma 6
chr12_+_82616885 14.311 ENSMUST00000161801.1
 Rgs6
regulator of G-protein signaling 6
chr5_-_89883321 13.335 ENSMUST00000163159.1
ENSMUST00000061427.5
 Adamts3

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3

chr16_+_41532999 12.025 ENSMUST00000099761.3
 Lsamp
limbic system-associated membrane protein
chr8_+_125995102 11.887 ENSMUST00000046765.8
 Kcnk1
potassium channel, subfamily K, member 1
chr4_+_125490688 11.535 ENSMUST00000030676.7
 Grik3
glutamate receptor, ionotropic, kainate 3
chr6_-_136173492 11.380 ENSMUST00000111905.1
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr6_-_126740151 10.772 ENSMUST00000112242.1
 Kcna6
potassium voltage-gated channel, shaker-related, subfamily, member 6
chr3_+_123267445 10.727 ENSMUST00000047923.7
 Sec24d
Sec24 related gene family, member D (S. cerevisiae)
chr5_+_134986191 8.845 ENSMUST00000094245.2
 Cldn3
claudin 3
chr6_+_77242644 8.745 ENSMUST00000159616.1
 Lrrtm1
leucine rich repeat transmembrane neuronal 1
chr6_+_77242715 8.676 ENSMUST00000161677.1
 Lrrtm1
leucine rich repeat transmembrane neuronal 1
chr13_+_58807884 8.674 ENSMUST00000079828.5
 Ntrk2
neurotrophic tyrosine kinase, receptor, type 2
chr5_+_137288273 8.499 ENSMUST00000024099.4
ENSMUST00000085934.3
 Ache

acetylcholinesterase

chr16_+_41532851 7.574 ENSMUST00000078873.4
 Lsamp
limbic system-associated membrane protein
chr11_-_108343917 6.859 ENSMUST00000059595.4
 Prkca
protein kinase C, alpha
chrX_+_41401128 6.639 ENSMUST00000115103.2
 Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr13_-_92131494 6.376 ENSMUST00000099326.3
ENSMUST00000146492.1
 Rasgrf2

RAS protein-specific guanine nucleotide-releasing factor 2

chr13_-_105054895 6.310 ENSMUST00000063551.5
 Rgs7bp
regulator of G-protein signalling 7 binding protein
chr13_+_118714678 6.156 ENSMUST00000022246.8
 Fgf10
fibroblast growth factor 10

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 172 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 38.3 GO:0035640 exploration behavior(GO:0035640)
0.1 26.0 GO:0007186 G-protein coupled receptor signaling pathway(GO:0007186)
7.7 23.1 GO:0043379 memory T cell differentiation(GO:0043379) negative regulation of isotype switching to IgE isotypes(GO:0048294)
1.3 21.3 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
2.7 13.3 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
2.0 11.9 GO:0019695 choline metabolic process(GO:0019695)
2.8 11.4 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
1.9 11.4 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.7 10.8 GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion(GO:0010881)
0.4 10.4 GO:0043496 regulation of protein homodimerization activity(GO:0043496)
0.1 9.8 GO:0071805 potassium ion transmembrane transport(GO:0071805)
2.9 8.8 GO:0070343 white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350)
1.1 8.8 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.6 8.8 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
1.4 8.7 GO:0099550 trans-synaptic signalling, modulating synaptic transmission(GO:0099550)
0.2 8.0 GO:0007528 neuromuscular junction development(GO:0007528)
0.2 7.8 GO:0001919 regulation of receptor recycling(GO:0001919)
2.4 7.1 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.2 7.1 GO:0007094 mitotic spindle assembly checkpoint(GO:0007094) spindle assembly checkpoint(GO:0071173)
2.3 6.9 GO:0002159 desmosome assembly(GO:0002159)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 27.7 GO:0045211 postsynaptic membrane(GO:0045211)
1.8 26.5 GO:0043083 synaptic cleft(GO:0043083)
0.5 22.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.3 22.1 GO:0005657 replication fork(GO:0005657)
0.4 20.9 GO:0043034 costamere(GO:0043034)
0.2 13.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
3.0 11.9 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.2 11.0 GO:0048786 presynaptic active zone(GO:0048786)
1.3 9.4 GO:0005827 polar microtubule(GO:0005827)
0.6 9.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 9.1 GO:0031594 neuromuscular junction(GO:0031594)
0.4 8.8 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.2 8.4 GO:0031201 SNARE complex(GO:0031201)
0.3 7.1 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 6.9 GO:0030425 dendrite(GO:0030425)
0.6 6.6 GO:0005642 annulate lamellae(GO:0005642)
0.2 6.4 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 6.1 GO:0009986 cell surface(GO:0009986)
0.0 5.9 GO:0043209 myelin sheath(GO:0043209)
0.4 5.7 GO:0044754 autolysosome(GO:0044754)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 131 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 23.1 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.2 18.6 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 17.3 GO:0005096 GTPase activator activity(GO:0005096)
3.0 11.9 GO:0004104 cholinesterase activity(GO:0004104) choline binding(GO:0033265)
2.3 11.5 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
1.4 11.4 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
1.0 11.4 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.6 10.8 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 10.6 GO:0004175 endopeptidase activity(GO:0004175)
0.8 10.2 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.2 10.2 GO:0005158 insulin receptor binding(GO:0005158)
0.9 9.8 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
1.7 8.7 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.3 8.7 GO:0005246 calcium channel regulator activity(GO:0005246)
0.2 7.1 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
2.3 6.9 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
0.1 6.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
1.3 6.6 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.4 6.6 GO:0017070 U6 snRNA binding(GO:0017070)
1.5 6.2 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 25.4 PID_FOXO_PATHWAY FoxO family signaling
0.1 11.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 11.3 PID_ERBB4_PATHWAY ErbB4 signaling events
0.2 10.7 PID_SHP2_PATHWAY SHP2 signaling
0.1 7.0 PID_MTOR_4PATHWAY mTOR signaling pathway
0.4 6.5 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 5.5 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 5.3 PID_AP1_PATHWAY AP-1 transcription factor network
0.3 5.0 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 3.7 PID_LKB1_PATHWAY LKB1 signaling events
0.1 2.7 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 2.6 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 2.4 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.1 2.3 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.1 1.8 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.7 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 1.4 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 1.2 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 1.2 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 1.2 PID_RHOA_REG_PATHWAY Regulation of RhoA activity

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 18.0 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.2 14.5 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 14.1 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.3 12.9 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.5 11.7 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
1.6 11.4 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.3 10.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 10.5 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.5 10.4 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.3 10.3 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.3 7.3 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.9 6.9 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.8 6.4 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.5 6.2 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.4 6.0 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.6 5.5 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.4 5.1 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 4.7 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 3.7 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.2 3.4 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters