Motif ID: Atf7_E4f1

Z-value: 1.048

Transcription factors associated with Atf7_E4f1:

Gene SymbolEntrez IDGene Name
Atf7 ENSMUSG00000052414.9 Atf7
Atf7 ENSMUSG00000071584.1 Atf7
E4f1 ENSMUSG00000024137.8 E4f1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E4f1mm10_v2_chr17_-_24455265_24455345-0.281.3e-02Click!
Atf7mm10_v2_chr15_-_102529025_102529025-0.243.2e-02Click!


Activity profile for motif Atf7_E4f1.

activity profile for motif Atf7_E4f1


Sorted Z-values histogram for motif Atf7_E4f1

Sorted Z-values for motif Atf7_E4f1



Network of associatons between targets according to the STRING database.



First level regulatory network of Atf7_E4f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_113619318 24.705 ENSMUST00000146390.2
ENSMUST00000106630.1
 Sstr2

somatostatin receptor 2

chr3_+_135212557 18.282 ENSMUST00000062893.7
 Cenpe
centromere protein E
chr5_-_106458440 17.400 ENSMUST00000086795.6
 Barhl2
BarH-like 2 (Drosophila)
chr3_-_36571952 17.207 ENSMUST00000029270.3
 Ccna2
cyclin A2
chr15_+_99074968 17.075 ENSMUST00000039665.6
 Troap
trophinin associated protein
chr11_+_101468164 15.602 ENSMUST00000001347.6
 Rnd2
Rho family GTPase 2
chr6_-_23248264 14.831 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr17_-_71526819 14.494 ENSMUST00000024851.9
 Ndc80
NDC80 homolog, kinetochore complex component (S. cerevisiae)
chr5_-_124032214 14.193 ENSMUST00000040967.7
 Vps37b
vacuolar protein sorting 37B (yeast)
chr6_+_113531675 13.819 ENSMUST00000036340.5
ENSMUST00000101051.2
 Fancd2

Fanconi anemia, complementation group D2

chr2_+_105668888 13.738 ENSMUST00000111086.4
ENSMUST00000111087.3
 Pax6

paired box gene 6

chr8_+_116921735 13.505 ENSMUST00000034205.4
 Cenpn
centromere protein N
chr2_+_105668935 12.254 ENSMUST00000142772.1
 Pax6
paired box gene 6
chr1_+_74791516 11.754 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr17_+_72918298 11.489 ENSMUST00000024857.6
 Lbh
limb-bud and heart
chr4_+_11704439 10.628 ENSMUST00000108304.2
 Gem
GTP binding protein (gene overexpressed in skeletal muscle)
chr11_-_88718223 10.223 ENSMUST00000107909.1
 Msi2
musashi RNA-binding protein 2
chr2_+_109280738 10.220 ENSMUST00000028527.7
 Kif18a
kinesin family member 18A
chr3_+_40800054 8.969 ENSMUST00000168287.1
 Plk4
polo-like kinase 4
chr1_-_134079114 8.655 ENSMUST00000020692.6
 Btg2
B cell translocation gene 2, anti-proliferative

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 203 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.4 40.5 GO:0051315 attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
5.2 26.0 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
2.2 24.7 GO:0030432 peristalsis(GO:0030432)
4.7 19.0 GO:1902724 positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
0.5 17.4 GO:0001709 cell fate determination(GO:0001709)
0.6 16.2 GO:0034508 centromere complex assembly(GO:0034508)
0.5 16.0 GO:0016572 histone phosphorylation(GO:0016572)
1.0 15.6 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
2.5 14.8 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
4.7 14.2 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774)
2.0 13.8 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
1.9 13.1 GO:0098535 positive regulation of centriole replication(GO:0046601) de novo centriole assembly(GO:0098535)
2.1 12.8 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
1.4 12.7 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
1.3 11.8 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
2.3 11.5 GO:1904672 regulation of somatic stem cell population maintenance(GO:1904672)
1.0 11.4 GO:0014883 transition between fast and slow fiber(GO:0014883)
1.2 10.6 GO:1901386 negative regulation of voltage-gated calcium channel activity(GO:1901386)
0.6 10.2 GO:0072520 seminiferous tubule development(GO:0072520)
0.1 10.0 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 114 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 32.4 GO:0005667 transcription factor complex(GO:0005667)
2.6 26.4 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.2 24.4 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.2 17.7 GO:0005844 polysome(GO:0005844)
2.5 17.2 GO:0001940 male pronucleus(GO:0001940)
0.3 16.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.4 16.5 GO:0097546 ciliary base(GO:0097546)
0.1 14.7 GO:0000776 kinetochore(GO:0000776)
3.6 14.5 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
1.6 14.2 GO:0000813 ESCRT I complex(GO:0000813)
0.2 13.5 GO:0005871 kinesin complex(GO:0005871)
2.2 13.1 GO:0098536 deuterosome(GO:0098536)
0.8 12.8 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.7 11.7 GO:0030008 TRAPP complex(GO:0030008)
2.8 11.4 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.0 11.0 GO:0005769 early endosome(GO:0005769)
0.4 10.6 GO:0051233 spindle midzone(GO:0051233)
1.5 10.2 GO:0005828 kinetochore microtubule(GO:0005828)
0.1 9.5 GO:0000793 condensed chromosome(GO:0000793)
0.3 8.6 GO:0000788 nuclear nucleosome(GO:0000788)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 142 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 36.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 34.0 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
1.6 26.0 GO:0003680 AT DNA binding(GO:0003680)
8.2 24.7 GO:0004994 somatostatin receptor activity(GO:0004994)
0.4 20.9 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
3.7 18.3 GO:0043515 kinetochore binding(GO:0043515)
1.1 17.9 GO:0051010 microtubule plus-end binding(GO:0051010)
0.7 17.7 GO:0008266 poly(U) RNA binding(GO:0008266)
2.0 17.6 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.5 13.8 GO:0070182 DNA polymerase binding(GO:0070182)
0.9 12.8 GO:0001054 RNA polymerase I activity(GO:0001054)
0.6 10.6 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.2 9.3 GO:0005109 frizzled binding(GO:0005109)
0.1 9.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 8.4 GO:0047485 protein N-terminus binding(GO:0047485)
1.4 8.3 GO:1990932 5.8S rRNA binding(GO:1990932)
0.2 8.3 GO:0003684 damaged DNA binding(GO:0003684)
0.1 8.2 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 7.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.2 7.7 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 29.5 PID_AURORA_B_PATHWAY Aurora B signaling
0.7 26.2 PID_BARD1_PATHWAY BARD1 signaling events
1.7 23.2 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
1.2 21.4 ST_STAT3_PATHWAY STAT3 Pathway
0.3 14.6 PID_PLK1_PATHWAY PLK1 signaling events
0.1 14.6 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.2 14.4 PID_CDC42_PATHWAY CDC42 signaling events
0.1 7.4 PID_E2F_PATHWAY E2F transcription factor network
0.1 7.3 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 5.7 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.2 5.2 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.1 4.5 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.1 4.2 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.1 3.4 PID_LKB1_PATHWAY LKB1 signaling events
0.2 2.9 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 2.3 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.2 2.1 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 1.9 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 1.4 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 1.3 PID_MYC_PATHWAY C-MYC pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 26.3 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
1.9 26.0 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.9 23.4 REACTOME_KINESINS Genes involved in Kinesins
0.2 20.2 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
1.6 19.0 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.2 17.3 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
1.0 17.2 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.3 17.2 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
1.8 14.2 REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
1.4 13.8 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.2 12.6 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.4 11.4 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 9.5 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.3 8.6 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.5 7.6 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.1 7.3 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.4 6.5 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.2 5.7 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 4.8 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.3 4.7 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines