Motif ID: Atoh1_Bhlhe23

Z-value: 0.683

Transcription factors associated with Atoh1_Bhlhe23:

Gene SymbolEntrez IDGene Name
Atoh1 ENSMUSG00000073043.4 Atoh1
Bhlhe23 ENSMUSG00000045493.3 Bhlhe23

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bhlhe23mm10_v2_chr2_-_180776900_1807769000.342.2e-03Click!


Activity profile for motif Atoh1_Bhlhe23.

activity profile for motif Atoh1_Bhlhe23


Sorted Z-values histogram for motif Atoh1_Bhlhe23

Sorted Z-values for motif Atoh1_Bhlhe23



Network of associatons between targets according to the STRING database.



First level regulatory network of Atoh1_Bhlhe23

PNG image of the network

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Top targets:


Showing 1 to 20 of 95 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_91191733 19.657 ENSMUST00000069511.6
 Abcd2
ATP-binding cassette, sub-family D (ALD), member 2
chr2_-_79456750 13.389 ENSMUST00000041099.4
 Neurod1
neurogenic differentiation 1
chr10_-_92164666 12.877 ENSMUST00000183123.1
ENSMUST00000182033.1
 Rmst

rhabdomyosarcoma 2 associated transcript (non-coding RNA)

chr1_+_6730051 10.430 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
 St18



suppression of tumorigenicity 18



chr4_-_110292719 8.108 ENSMUST00000106601.1
 Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr16_+_43235856 6.939 ENSMUST00000146708.1
 Zbtb20
zinc finger and BTB domain containing 20
chr13_-_97747399 6.781 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr1_+_6730135 6.628 ENSMUST00000155921.1
 St18
suppression of tumorigenicity 18
chr13_-_97747373 6.520 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr1_-_155232710 5.781 ENSMUST00000035914.3
 BC034090
cDNA sequence BC034090
chr14_+_28511344 5.656 ENSMUST00000112272.1
 Wnt5a
wingless-related MMTV integration site 5A
chr19_+_7268296 4.900 ENSMUST00000066646.4
 Rcor2
REST corepressor 2
chr1_+_15287259 4.873 ENSMUST00000175681.1
 Kcnb2
potassium voltage gated channel, Shab-related subfamily, member 2
chr5_+_3343893 4.610 ENSMUST00000165117.1
 Cdk6
cyclin-dependent kinase 6
chr4_-_82850721 4.609 ENSMUST00000139401.1
 Zdhhc21
zinc finger, DHHC domain containing 21
chr1_+_42697146 4.593 ENSMUST00000054883.2
 Pou3f3
POU domain, class 3, transcription factor 3
chr4_+_11579647 4.327 ENSMUST00000180239.1
 Fsbp
fibrinogen silencer binding protein
chr5_+_124194894 4.206 ENSMUST00000159053.1
ENSMUST00000162577.1
 Gm16338

predicted gene 16338

chr11_+_117232254 4.132 ENSMUST00000106354.2
 Sept9
septin 9
chr9_-_71896047 4.117 ENSMUST00000184448.1
 Tcf12
transcription factor 12

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 19.7 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
1.4 17.1 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
3.3 13.4 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.2 9.8 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
1.9 5.7 GO:0061349 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) hypophysis morphogenesis(GO:0048850) cervix development(GO:0060067) planar cell polarity pathway involved in outflow tract morphogenesis(GO:0061347) planar cell polarity pathway involved in ventricular septum morphogenesis(GO:0061348) planar cell polarity pathway involved in cardiac right atrium morphogenesis(GO:0061349) planar cell polarity pathway involved in cardiac muscle tissue morphogenesis(GO:0061350) planar cell polarity pathway involved in pericardium morphogenesis(GO:0061354)
1.1 4.6 GO:0072236 DCT cell differentiation(GO:0072069) metanephric loop of Henle development(GO:0072236) metanephric DCT cell differentiation(GO:0072240)
0.7 4.6 GO:0044838 cell quiescence(GO:0044838)
0.4 4.6 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 4.6 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.2 4.1 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 4.1 GO:0007050 cell cycle arrest(GO:0007050)
0.0 3.9 GO:0051260 protein homooligomerization(GO:0051260)
0.1 3.7 GO:0021860 pyramidal neuron development(GO:0021860)
0.0 3.5 GO:0043488 regulation of mRNA stability(GO:0043488)
0.0 3.5 GO:0043010 camera-type eye development(GO:0043010)
0.3 3.2 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.0 2.7 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.3 2.3 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.1 2.1 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 2.0 GO:0097062 dendritic spine maintenance(GO:0097062)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 19.7 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 17.5 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 15.8 GO:0032993 protein-DNA complex(GO:0032993)
0.5 8.1 GO:0042788 polysomal ribosome(GO:0042788)
0.1 4.9 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 4.9 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 4.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.3 4.1 GO:0031105 septin complex(GO:0031105)
0.1 3.9 GO:0016459 myosin complex(GO:0016459)
0.7 3.7 GO:0097441 basilar dendrite(GO:0097441)
0.0 2.8 GO:0005802 trans-Golgi network(GO:0005802)
0.0 2.0 GO:0043679 axon terminus(GO:0043679)
0.1 1.8 GO:0031143 pseudopodium(GO:0031143)
0.1 1.8 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.3 1.7 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 1.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 1.1 GO:0042588 zymogen granule(GO:0042588)
0.2 1.0 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) Holliday junction resolvase complex(GO:0048476)
0.0 0.8 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.2 0.6 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 20.3 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.1 16.9 GO:0001047 core promoter binding(GO:0001047)
0.3 16.3 GO:0070888 E-box binding(GO:0070888)
0.1 9.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 8.1 GO:0003714 transcription corepressor activity(GO:0003714)
1.9 5.7 GO:0005110 frizzled-2 binding(GO:0005110)
0.3 4.9 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
1.5 4.6 GO:0098770 FBXO family protein binding(GO:0098770)
0.2 4.6 GO:0071837 HMG box domain binding(GO:0071837)
0.2 4.6 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 4.2 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 3.9 GO:0003774 motor activity(GO:0003774)
0.0 3.8 GO:0005525 GTP binding(GO:0005525)
0.2 3.7 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 3.6 GO:0017091 AU-rich element binding(GO:0017091)
0.0 3.1 GO:0003713 transcription coactivator activity(GO:0003713)
0.1 2.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 1.8 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 1.7 GO:0070840 dynein complex binding(GO:0070840)
0.3 1.6 GO:0008494 translation activator activity(GO:0008494)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.7 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 4.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 4.6 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 3.9 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.6 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 0.9 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.8 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 0.2 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 19.7 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.5 13.4 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 5.7 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 4.9 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 4.6 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.1 4.6 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 4.1 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 3.9 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 2.3 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 1.7 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 1.0 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.9 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 0.4 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 0.3 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.2 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1