Motif ID: Barhl1

Z-value: 0.386


Transcription factors associated with Barhl1:

Gene SymbolEntrez IDGene Name
Barhl1 ENSMUSG00000026805.8 Barhl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Barhl1mm10_v2_chr2_-_28916412_28916440-0.385.5e-04Click!


Activity profile for motif Barhl1.

activity profile for motif Barhl1


Sorted Z-values histogram for motif Barhl1

Sorted Z-values for motif Barhl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Barhl1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_10827921 3.545 ENSMUST00000181732.1
 Gm26822
predicted gene, 26822
chr16_+_92292380 3.101 ENSMUST00000047383.3
 Kcne2
potassium voltage-gated channel, Isk-related subfamily, gene 2
chr5_+_149678224 3.045 ENSMUST00000100404.3
 B3galtl
beta 1,3-galactosyltransferase-like
chr15_-_43869993 2.517 ENSMUST00000067469.4
 Tmem74
transmembrane protein 74
chr5_-_62766153 2.376 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr3_-_146770603 1.695 ENSMUST00000106138.1
 Prkacb
protein kinase, cAMP dependent, catalytic, beta
chr3_-_146770218 1.511 ENSMUST00000106137.1
 Prkacb
protein kinase, cAMP dependent, catalytic, beta
chr3_+_116008220 1.411 ENSMUST00000106502.1
 Extl2
exostoses (multiple)-like 2
chr11_+_102430315 1.301 ENSMUST00000049460.4
ENSMUST00000129997.1
 Grn

granulin

chr6_-_41636389 0.945 ENSMUST00000031902.5
 Trpv6
transient receptor potential cation channel, subfamily V, member 6
chr13_+_63014934 0.920 ENSMUST00000091560.4
 2010111I01Rik
RIKEN cDNA 2010111I01 gene
chr11_+_22971991 0.878 ENSMUST00000049506.5
 Zrsr1
zinc finger (CCCH type), RNA binding motif and serine/arginine rich 1
chr18_-_32559914 0.851 ENSMUST00000174000.1
ENSMUST00000174459.1
 Gypc

glycophorin C

chr6_+_125349699 0.850 ENSMUST00000032491.8
 Tnfrsf1a
tumor necrosis factor receptor superfamily, member 1a
chr6_+_72097561 0.843 ENSMUST00000069994.4
ENSMUST00000114112.1
 St3gal5

ST3 beta-galactoside alpha-2,3-sialyltransferase 5

chr17_+_55892184 0.799 ENSMUST00000054780.8
 Zfp959
zinc finger protein 959
chr18_+_37355271 0.785 ENSMUST00000051163.1
 Pcdhb8
protocadherin beta 8
chrX_+_112604274 0.770 ENSMUST00000071814.6
 Zfp711
zinc finger protein 711
chr5_-_23783700 0.758 ENSMUST00000119946.1
 Pus7
pseudouridylate synthase 7 homolog (S. cerevisiae)
chr2_+_83812567 0.715 ENSMUST00000051454.3
 Fam171b
family with sequence similarity 171, member B
chr17_-_25115905 0.667 ENSMUST00000024987.5
ENSMUST00000115181.2
 Telo2

TEL2, telomere maintenance 2, homolog (S. cerevisiae)

chr17_-_78418083 0.664 ENSMUST00000070039.7
ENSMUST00000112487.1
 Fez2

fasciculation and elongation protein zeta 2 (zygin II)

chr13_+_63015167 0.661 ENSMUST00000021911.8
 2010111I01Rik
RIKEN cDNA 2010111I01 gene
chr13_-_35027077 0.569 ENSMUST00000170538.1
ENSMUST00000163280.1
 Eci2

enoyl-Coenzyme A delta isomerase 2

chr7_+_127800604 0.542 ENSMUST00000046863.5
ENSMUST00000106272.1
ENSMUST00000139068.1
 Hsd3b7


hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7


chr15_+_25752860 0.490 ENSMUST00000022882.5
ENSMUST00000135173.1
 Myo10

myosin X

chr15_+_55112317 0.488 ENSMUST00000096433.3
 Deptor
DEP domain containing MTOR-interacting protein
chr2_-_45110336 0.463 ENSMUST00000028229.6
ENSMUST00000152232.1
 Zeb2

zinc finger E-box binding homeobox 2

chr16_-_91618986 0.436 ENSMUST00000143058.1
ENSMUST00000049244.8
ENSMUST00000169982.1
ENSMUST00000133731.1
 Dnajc28



DnaJ (Hsp40) homolog, subfamily C, member 28



chr16_+_33251415 0.402 ENSMUST00000023502.4
 Snx4
sorting nexin 4
chr1_+_115684727 0.375 ENSMUST00000043725.7
 Cntnap5a
contactin associated protein-like 5A
chr14_+_25980039 0.366 ENSMUST00000173155.1
 Duxbl1
double homeobox B-like 1
chr18_+_12972225 0.351 ENSMUST00000025290.5
 Impact
imprinted and ancient
chr11_+_116198853 0.280 ENSMUST00000021130.6
 Ten1
TEN1 telomerase capping complex subunit
chr7_+_12834743 0.277 ENSMUST00000004614.8
 Zfp110
zinc finger protein 110
chr8_-_22694061 0.250 ENSMUST00000131767.1
 Ikbkb
inhibitor of kappaB kinase beta
chr7_+_45896941 0.246 ENSMUST00000069772.7
ENSMUST00000107716.1
 Tmem143

transmembrane protein 143

chr5_-_62765618 0.214 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr6_-_59426279 0.193 ENSMUST00000051065.4
 Gprin3
GPRIN family member 3
chr16_-_32868325 0.182 ENSMUST00000089684.3
ENSMUST00000040986.8
ENSMUST00000115105.2
 1700021K19Rik


RIKEN cDNA 1700021K19 gene


chr14_+_63860290 0.132 ENSMUST00000022528.4
 Pinx1
PIN2/TERF1 interacting, telomerase inhibitor 1
chr3_+_75557530 0.126 ENSMUST00000161776.1
ENSMUST00000029423.8
 Serpini1

serine (or cysteine) peptidase inhibitor, clade I, member 1

chr15_+_81744848 0.092 ENSMUST00000109554.1
 Zc3h7b
zinc finger CCCH type containing 7B
chr3_-_19265007 0.086 ENSMUST00000091314.4
 Pde7a
phosphodiesterase 7A
chr18_+_56562443 0.078 ENSMUST00000130163.1
ENSMUST00000132628.1
 Phax

phosphorylated adaptor for RNA export

chr9_+_36832684 0.058 ENSMUST00000034630.8
 Fez1
fasciculation and elongation protein zeta 1 (zygin I)
chr12_-_54795698 0.052 ENSMUST00000005798.8
 Snx6
sorting nexin 6
chr17_+_45734506 0.048 ENSMUST00000180558.1
 F630040K05Rik
RIKEN cDNA F630040K05 gene
chr10_-_127030813 0.045 ENSMUST00000040560.4
 Tsfm
Ts translation elongation factor, mitochondrial
chr10_-_41303171 0.042 ENSMUST00000043814.3
 Fig4
FIG4 homolog (S. cerevisiae)
chr8_+_40307458 0.025 ENSMUST00000068999.7
 Micu3
mitochondrial calcium uptake family, member 3
chr4_-_117156144 0.025 ENSMUST00000102696.4
 Rps8
ribosomal protein S8
chr18_-_42262053 0.020 ENSMUST00000097590.3
 Lars
leucyl-tRNA synthetase
chr13_+_24802020 0.019 ENSMUST00000155575.1
 BC005537
cDNA sequence BC005537

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.1 GO:1901979 regulation of inward rectifier potassium channel activity(GO:1901979)
0.4 1.4 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.3 3.2 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.2 1.3 GO:0035188 blastocyst hatching(GO:0001835) hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.1 0.9 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.1 0.4 GO:0032058 positive regulation of translational initiation in response to stress(GO:0032058)
0.1 1.1 GO:1901550 regulation of endothelial cell development(GO:1901550) regulation of establishment of endothelial barrier(GO:1903140)
0.1 0.5 GO:0035754 B cell chemotaxis(GO:0035754)
0.1 0.5 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 0.7 GO:0038203 TORC2 signaling(GO:0038203)
0.1 0.4 GO:0002553 histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553)
0.1 0.7 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.0 1.6 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.1 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.0 0.3 GO:1990009 retinal cell apoptotic process(GO:1990009)
0.0 0.4 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 0.8 GO:0001522 pseudouridine synthesis(GO:0001522)
0.0 0.5 GO:0045792 negative regulation of cell size(GO:0045792)
0.0 0.1 GO:0051030 snRNA transport(GO:0051030)
0.0 1.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.8 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.3 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211)
0.0 2.5 GO:0016236 macroautophagy(GO:0016236)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.9 GO:0089701 U2AF(GO:0089701)
0.1 0.7 GO:0031931 TORC1 complex(GO:0031931)
0.0 3.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.1 GO:0031983 vesicle lumen(GO:0031983)
0.0 0.4 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.3 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.0 0.6 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.2 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.4 GO:0005868 cytoplasmic dynein complex(GO:0005868)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.1 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.5 1.4 GO:0001888 glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0001888)
0.3 3.2 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.3 0.9 GO:0043120 tumor necrosis factor binding(GO:0043120)
0.1 0.6 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.1 0.4 GO:1990460 leptin receptor binding(GO:1990460)
0.1 0.5 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.1 0.2 GO:0008384 IkappaB kinase activity(GO:0008384)
0.1 1.6 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 0.9 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.1 0.3 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.1 2.6 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.8 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.8 GO:0008373 sialyltransferase activity(GO:0008373)
0.0 0.4 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.1 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.0 0.7 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 1.3 GO:0005125 cytokine activity(GO:0005125)
0.0 0.5 GO:0070412 R-SMAD binding(GO:0070412)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.2 PID_IL3_PATHWAY IL3-mediated signaling events
0.1 0.9 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 2.6 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.9 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.0 0.2 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.2 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 0.5 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 0.9 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.2 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 2.6 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases