Motif ID: Barhl2

Z-value: 0.444


Transcription factors associated with Barhl2:

Gene SymbolEntrez IDGene Name
Barhl2 ENSMUSG00000034384.10 Barhl2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Barhl2mm10_v2_chr5_-_106458440_106458470-0.471.5e-05Click!


Activity profile for motif Barhl2.

activity profile for motif Barhl2


Sorted Z-values histogram for motif Barhl2

Sorted Z-values for motif Barhl2



Network of associatons between targets according to the STRING database.



First level regulatory network of Barhl2

PNG image of the network

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Top targets:


Showing 1 to 20 of 127 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_101377897 4.815 ENSMUST00000075994.6
 Pdzrn3
PDZ domain containing RING finger 3
chr3_-_80802789 3.733 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr16_-_22439719 3.541 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr12_-_34528844 3.093 ENSMUST00000110819.2
 Hdac9
histone deacetylase 9
chr5_-_110839575 2.559 ENSMUST00000145318.1
 Hscb
HscB iron-sulfur cluster co-chaperone homolog (E. coli)
chr3_-_49757257 2.316 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr1_+_165788681 1.972 ENSMUST00000161971.1
ENSMUST00000178336.1
ENSMUST00000005907.5
ENSMUST00000027849.4
 Cd247



CD247 antigen



chr16_-_22439570 1.945 ENSMUST00000170393.1
 Etv5
ets variant gene 5
chr6_+_125552948 1.879 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
 Vwf


Von Willebrand factor homolog


chr5_-_110839757 1.874 ENSMUST00000056937.5
 Hscb
HscB iron-sulfur cluster co-chaperone homolog (E. coli)
chr17_-_49564262 1.812 ENSMUST00000057610.6
 Daam2
dishevelled associated activator of morphogenesis 2
chr2_-_45112890 1.581 ENSMUST00000076836.6
 Zeb2
zinc finger E-box binding homeobox 2
chr14_-_88471396 1.580 ENSMUST00000061628.5
 Pcdh20
protocadherin 20
chr2_+_59612034 1.556 ENSMUST00000112568.1
ENSMUST00000037526.4
 Tanc1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr14_+_30825580 1.535 ENSMUST00000006701.5
 Tmem110
transmembrane protein 110
chr1_+_165788746 1.520 ENSMUST00000161559.2
 Cd247
CD247 antigen
chrX_+_71663665 1.454 ENSMUST00000070449.5
 Gpr50
G-protein-coupled receptor 50
chr18_-_78206408 1.435 ENSMUST00000163367.1
 Slc14a2
solute carrier family 14 (urea transporter), member 2
chr11_+_85832551 1.424 ENSMUST00000000095.6
 Tbx2
T-box 2
chr7_+_127841817 1.419 ENSMUST00000121705.1
 Stx4a
syntaxin 4A (placental)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 5.5 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.1 4.8 GO:0007528 neuromuscular junction development(GO:0007528)
0.6 4.4 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.1 3.5 GO:0070207 protein homotrimerization(GO:0070207)
0.3 3.1 GO:0034983 peptidyl-lysine deacetylation(GO:0034983) regulation of skeletal muscle fiber development(GO:0048742)
0.9 2.7 GO:0002447 eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308) regulation of eosinophil activation(GO:1902566)
0.1 2.7 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.8 2.3 GO:0072223 metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.1 2.3 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 1.9 GO:0030168 platelet activation(GO:0030168)
0.4 1.8 GO:0015825 L-serine transport(GO:0015825)
0.4 1.8 GO:0010025 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.1 1.8 GO:0007368 determination of left/right symmetry(GO:0007368)
0.3 1.6 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.2 1.6 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.1 1.6 GO:0097062 dendritic spine maintenance(GO:0097062)
0.5 1.4 GO:0071918 urea transmembrane transport(GO:0071918)
0.5 1.4 GO:0007521 muscle cell fate determination(GO:0007521) mammary placode formation(GO:0060596)
0.5 1.4 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.1 1.4 GO:0034453 microtubule anchoring(GO:0034453)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.8 GO:0031594 neuromuscular junction(GO:0031594)
0.5 3.7 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.2 3.7 GO:0032279 asymmetric synapse(GO:0032279)
0.9 3.5 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 3.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 2.3 GO:0000781 chromosome, telomeric region(GO:0000781)
0.0 2.2 GO:0005882 intermediate filament(GO:0005882)
0.4 1.9 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 1.8 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.2 1.6 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 1.4 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 1.1 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 0.8 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.7 GO:0000786 nucleosome(GO:0000786)
0.0 0.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.6 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 0.5 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.5 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.1 0.4 GO:0033269 internode region of axon(GO:0033269)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 3.7 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 3.6 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 3.5 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.1 3.4 GO:0001671 ATPase activator activity(GO:0001671)
0.1 3.1 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.7 2.7 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.2 1.9 GO:0019865 immunoglobulin binding(GO:0019865)
0.4 1.8 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.2 1.8 GO:0015180 L-alanine transmembrane transporter activity(GO:0015180) L-proline transmembrane transporter activity(GO:0015193) alanine transmembrane transporter activity(GO:0022858)
0.3 1.6 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 1.6 GO:0070412 R-SMAD binding(GO:0070412)
0.5 1.5 GO:0008502 melatonin receptor activity(GO:0008502)
0.2 1.4 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.1 1.4 GO:0002162 dystroglycan binding(GO:0002162)
0.0 1.4 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.3 1.3 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.0 1.3 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
0.0 1.2 GO:0008276 protein methyltransferase activity(GO:0008276)
0.1 1.1 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.2 1.0 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.0 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 3.7 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 3.1 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.1 2.0 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 0.9 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.6 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 0.4 PID_AR_NONGENOMIC_PATHWAY Nongenotropic Androgen signaling
0.0 0.3 PID_NECTIN_PATHWAY Nectin adhesion pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.7 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.2 3.7 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.6 3.5 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 3.5 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2 1.9 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.1 1.8 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 1.8 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 1.6 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 1.4 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 1.4 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.4 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.4 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction
0.0 1.3 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 0.9 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.1 0.9 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.9 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 0.7 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.1 0.6 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 0.5 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.5 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis