Motif ID: Bbx

Z-value: 0.289


Transcription factors associated with Bbx:

Gene SymbolEntrez IDGene Name
Bbx ENSMUSG00000022641.9 Bbx

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bbxmm10_v2_chr16_-_50330987_50331017-0.539.3e-07Click!


Activity profile for motif Bbx.

activity profile for motif Bbx


Sorted Z-values histogram for motif Bbx

Sorted Z-values for motif Bbx



Network of associatons between targets according to the STRING database.



First level regulatory network of Bbx

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_+_21111452 6.247 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr13_-_52530827 5.373 ENSMUST00000057442.6
 Diras2
DIRAS family, GTP-binding RAS-like 2
chr5_-_146585239 3.611 ENSMUST00000036211.6
 Gpr12
G-protein coupled receptor 12
chr18_+_37421418 3.387 ENSMUST00000053073.4
 Pcdhb11
protocadherin beta 11
chr10_+_86021961 2.182 ENSMUST00000130320.1
 Fbxo7
F-box protein 7
chr17_+_57358682 2.073 ENSMUST00000086763.5
ENSMUST00000004850.7
 Emr1

EGF-like module containing, mucin-like, hormone receptor-like sequence 1

chr8_+_70616816 1.549 ENSMUST00000052437.3
 Lrrc25
leucine rich repeat containing 25
chr13_+_49608030 1.500 ENSMUST00000021822.5
 Ogn
osteoglycin
chrX_+_140367494 1.433 ENSMUST00000141660.1
 Frmpd3
FERM and PDZ domain containing 3
chr6_+_124304646 1.041 ENSMUST00000112541.2
ENSMUST00000032234.2
 Cd163

CD163 antigen

chrX_+_159708593 0.667 ENSMUST00000080394.6
 Sh3kbp1
SH3-domain kinase binding protein 1
chr7_-_127708738 0.644 ENSMUST00000106282.1
 Bcl7c
B cell CLL/lymphoma 7C
chrX_-_150814265 0.499 ENSMUST00000026302.6
ENSMUST00000129768.1
ENSMUST00000112699.2
 Maged2


melanoma antigen, family D, 2


chr2_+_136892168 0.493 ENSMUST00000099311.2
 Slx4ip
SLX4 interacting protein
chr11_+_105146893 0.389 ENSMUST00000100338.1
 Gm10842
predicted gene 10842
chr1_-_13660476 0.317 ENSMUST00000027071.5
 Lactb2
lactamase, beta 2
chr17_+_40811089 0.255 ENSMUST00000024721.7
 Rhag
Rhesus blood group-associated A glycoprotein
chrX_-_107816238 0.250 ENSMUST00000120722.1
 2610002M06Rik
RIKEN cDNA 2610002M06 gene
chr7_-_127708886 0.206 ENSMUST00000061468.8
 Bcl7c
B cell CLL/lymphoma 7C
chr1_+_180111339 0.196 ENSMUST00000145181.1
 Cdc42bpa
CDC42 binding protein kinase alpha
chr14_+_48670147 0.143 ENSMUST00000183522.1
ENSMUST00000184869.1
 RP23-131O4.2

RP23-131O4.2

chr10_+_86022189 0.130 ENSMUST00000120344.1
ENSMUST00000117597.1
 Fbxo7

F-box protein 7

chr10_+_84622365 0.001 ENSMUST00000077175.5
 Polr3b
polymerase (RNA) III (DNA directed) polypeptide B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.3 GO:1903207 neuron death in response to hydrogen peroxide(GO:0036476) regulation of hydrogen peroxide-induced neuron death(GO:1903207) negative regulation of hydrogen peroxide-induced neuron death(GO:1903208)
0.1 0.3 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.1 0.5 GO:0070294 renal sodium ion absorption(GO:0070294)
0.1 6.2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 1.0 GO:0006953 acute-phase response(GO:0006953)
0.0 3.4 GO:0007416 synapse assembly(GO:0007416)
0.0 0.3 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.3 GO:1990037 Lewy body core(GO:1990037)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.6 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.0 1.0 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.3 GO:0022842 leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
0.0 2.2 GO:0043130 ubiquitin binding(GO:0043130)
0.0 5.4 GO:0003924 GTPase activity(GO:0003924)
0.0 1.4 GO:0008083 growth factor activity(GO:0008083)
0.0 6.2 GO:0005509 calcium ion binding(GO:0005509)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 6.2 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.5 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 1.9 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.7 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.3 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters