Motif ID: Bcl6
Z-value: 0.775
Transcription factors associated with Bcl6:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Bcl6 | ENSMUSG00000022508.5 | Bcl6 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Bcl6 | mm10_v2_chr16_-_23988852_23988852 | 0.46 | 2.3e-05 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 8.9 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
| 1.9 | 7.4 | GO:0014012 | peripheral nervous system axon regeneration(GO:0014012) |
| 1.5 | 4.6 | GO:0071492 | cellular response to UV-A(GO:0071492) |
| 1.3 | 5.3 | GO:0033024 | mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025) |
| 1.3 | 7.5 | GO:0097646 | calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647) |
| 1.1 | 5.6 | GO:0009449 | gamma-aminobutyric acid biosynthetic process(GO:0009449) |
| 1.0 | 4.0 | GO:0010890 | positive regulation of sequestering of triglyceride(GO:0010890) |
| 0.9 | 2.8 | GO:1903538 | meiotic cell cycle process involved in oocyte maturation(GO:1903537) regulation of meiotic cell cycle process involved in oocyte maturation(GO:1903538) |
| 0.9 | 4.7 | GO:0048245 | eosinophil chemotaxis(GO:0048245) |
| 0.9 | 2.8 | GO:0035585 | calcium-mediated signaling using extracellular calcium source(GO:0035585) |
| 0.9 | 3.6 | GO:1904457 | positive regulation of neuronal action potential(GO:1904457) |
| 0.9 | 3.6 | GO:0071726 | response to diacyl bacterial lipopeptide(GO:0071724) cellular response to diacyl bacterial lipopeptide(GO:0071726) |
| 0.9 | 4.3 | GO:0035356 | cellular triglyceride homeostasis(GO:0035356) |
| 0.8 | 9.3 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 0.7 | 2.2 | GO:0035604 | fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604) coronal suture morphogenesis(GO:0060365) squamous basal epithelial stem cell differentiation involved in prostate gland acinus development(GO:0060529) |
| 0.7 | 5.1 | GO:0015862 | uridine transport(GO:0015862) |
| 0.6 | 2.6 | GO:0010756 | positive regulation of plasminogen activation(GO:0010756) |
| 0.6 | 2.4 | GO:0006478 | peptidyl-tyrosine sulfation(GO:0006478) |
| 0.6 | 4.7 | GO:0008343 | adult feeding behavior(GO:0008343) |
| 0.5 | 6.0 | GO:0097421 | liver regeneration(GO:0097421) |
| 0.5 | 1.6 | GO:0070366 | regulation of hepatocyte differentiation(GO:0070366) |
| 0.5 | 1.4 | GO:0060217 | hemangioblast cell differentiation(GO:0060217) |
| 0.4 | 2.7 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.4 | 3.3 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
| 0.4 | 1.6 | GO:0072137 | condensed mesenchymal cell proliferation(GO:0072137) |
| 0.4 | 0.7 | GO:1905076 | regulation of interleukin-17 secretion(GO:1905076) |
| 0.4 | 2.1 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
| 0.3 | 3.4 | GO:0061470 | interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619) |
| 0.3 | 1.4 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 0.3 | 2.4 | GO:0090527 | actin filament reorganization(GO:0090527) |
| 0.3 | 1.4 | GO:0060709 | glycogen cell differentiation involved in embryonic placenta development(GO:0060709) |
| 0.3 | 5.1 | GO:0009312 | oligosaccharide biosynthetic process(GO:0009312) |
| 0.3 | 2.6 | GO:0005513 | detection of calcium ion(GO:0005513) |
| 0.3 | 1.3 | GO:0060332 | positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335) |
| 0.3 | 1.5 | GO:1900122 | positive regulation of receptor binding(GO:1900122) |
| 0.3 | 1.5 | GO:0072235 | distal convoluted tubule development(GO:0072025) metanephric distal convoluted tubule development(GO:0072221) metanephric distal tubule development(GO:0072235) |
| 0.3 | 2.1 | GO:0060923 | cardiac muscle cell fate commitment(GO:0060923) |
| 0.2 | 1.8 | GO:0071494 | cellular response to UV-C(GO:0071494) |
| 0.2 | 1.1 | GO:0019236 | response to pheromone(GO:0019236) |
| 0.2 | 6.6 | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030) |
| 0.2 | 0.7 | GO:0002408 | myeloid dendritic cell chemotaxis(GO:0002408) |
| 0.2 | 1.0 | GO:0090611 | ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611) |
| 0.2 | 7.5 | GO:0001937 | negative regulation of endothelial cell proliferation(GO:0001937) |
| 0.2 | 1.4 | GO:0032264 | IMP salvage(GO:0032264) |
| 0.2 | 0.6 | GO:0021529 | spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) |
| 0.2 | 0.6 | GO:2000331 | regulation of terminal button organization(GO:2000331) |
| 0.2 | 4.5 | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205) |
| 0.2 | 2.0 | GO:0045607 | regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980) |
| 0.2 | 0.9 | GO:0046684 | response to pyrethroid(GO:0046684) |
| 0.2 | 0.5 | GO:0002182 | cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248) |
| 0.2 | 1.2 | GO:0034638 | phosphatidylcholine catabolic process(GO:0034638) |
| 0.2 | 1.0 | GO:1903300 | negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300) |
| 0.2 | 8.5 | GO:0045744 | negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744) |
| 0.1 | 0.7 | GO:0038018 | Wnt receptor catabolic process(GO:0038018) |
| 0.1 | 0.5 | GO:0017183 | peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183) |
| 0.1 | 2.1 | GO:0090129 | positive regulation of synapse maturation(GO:0090129) |
| 0.1 | 4.0 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.1 | 7.5 | GO:0003073 | regulation of systemic arterial blood pressure(GO:0003073) |
| 0.1 | 0.8 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.1 | 0.2 | GO:0048014 | Tie signaling pathway(GO:0048014) |
| 0.1 | 0.6 | GO:0015868 | purine ribonucleotide transport(GO:0015868) |
| 0.1 | 0.5 | GO:0097428 | protein maturation by iron-sulfur cluster transfer(GO:0097428) |
| 0.1 | 0.3 | GO:0050812 | regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812) |
| 0.1 | 1.0 | GO:0032026 | response to magnesium ion(GO:0032026) |
| 0.1 | 0.2 | GO:0006436 | tryptophanyl-tRNA aminoacylation(GO:0006436) |
| 0.1 | 0.8 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.1 | 0.8 | GO:0044406 | adhesion of symbiont to host(GO:0044406) |
| 0.1 | 1.5 | GO:0007097 | nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023) |
| 0.0 | 0.6 | GO:0043653 | mitochondrial fragmentation involved in apoptotic process(GO:0043653) positive regulation of cell cycle checkpoint(GO:1901978) |
| 0.0 | 0.2 | GO:0014835 | myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) |
| 0.0 | 0.1 | GO:0097212 | cleavage furrow ingression(GO:0036090) lysosomal membrane organization(GO:0097212) |
| 0.0 | 0.1 | GO:1900060 | negative regulation of ceramide biosynthetic process(GO:1900060) |
| 0.0 | 0.1 | GO:1904154 | trimming of terminal mannose on B branch(GO:0036509) positive regulation of retrograde protein transport, ER to cytosol(GO:1904154) |
| 0.0 | 0.3 | GO:0032510 | endosome to lysosome transport via multivesicular body sorting pathway(GO:0032510) |
| 0.0 | 1.0 | GO:0046470 | phosphatidylcholine metabolic process(GO:0046470) |
| 0.0 | 0.1 | GO:1903028 | regulation of opsonization(GO:1903027) positive regulation of opsonization(GO:1903028) |
| 0.0 | 0.1 | GO:2000587 | negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587) |
| 0.0 | 0.2 | GO:0046415 | urate metabolic process(GO:0046415) |
| 0.0 | 0.6 | GO:0099517 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
| 0.0 | 0.5 | GO:0046688 | response to copper ion(GO:0046688) |
| 0.0 | 0.3 | GO:0019368 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 0.0 | 0.7 | GO:0046854 | phosphatidylinositol phosphorylation(GO:0046854) |
| 0.0 | 1.8 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.0 | 0.3 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.0 | 0.5 | GO:0048266 | behavioral response to pain(GO:0048266) |
| 0.0 | 0.1 | GO:0042730 | fibrinolysis(GO:0042730) |
| 0.0 | 0.1 | GO:0021562 | vestibulocochlear nerve development(GO:0021562) |
| 0.0 | 1.4 | GO:0042089 | cytokine biosynthetic process(GO:0042089) cytokine metabolic process(GO:0042107) |
| 0.0 | 3.5 | GO:0043547 | positive regulation of GTPase activity(GO:0043547) |
| 0.0 | 0.8 | GO:0051591 | response to cAMP(GO:0051591) |
| 0.0 | 1.5 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 0.0 | 2.8 | GO:0007416 | synapse assembly(GO:0007416) |
| 0.0 | 0.4 | GO:0035025 | positive regulation of Rho protein signal transduction(GO:0035025) |
| 0.0 | 0.8 | GO:0001541 | ovarian follicle development(GO:0001541) |
| 0.0 | 0.2 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 0.0 | 0.4 | GO:0009950 | dorsal/ventral axis specification(GO:0009950) |
| 0.0 | 1.1 | GO:0050680 | negative regulation of epithelial cell proliferation(GO:0050680) |
| 0.0 | 1.1 | GO:0006487 | protein N-linked glycosylation(GO:0006487) |
| 0.0 | 0.6 | GO:0042632 | cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092) |
| 0.0 | 0.6 | GO:0008214 | protein demethylation(GO:0006482) protein dealkylation(GO:0008214) |
| 0.0 | 0.6 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.0 | 0.9 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 7.5 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 1.7 | 10.5 | GO:0005796 | Golgi lumen(GO:0005796) |
| 1.5 | 7.5 | GO:1903440 | calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440) |
| 1.3 | 3.9 | GO:0044299 | C-fiber(GO:0044299) |
| 1.2 | 3.6 | GO:0005940 | septin ring(GO:0005940) |
| 0.7 | 3.6 | GO:0044316 | cone cell pedicle(GO:0044316) |
| 0.7 | 2.8 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
| 0.6 | 3.6 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.6 | 9.5 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.6 | 4.0 | GO:0042627 | chylomicron(GO:0042627) |
| 0.5 | 2.6 | GO:0001652 | granular component(GO:0001652) |
| 0.5 | 1.4 | GO:0033193 | Lsd1/2 complex(GO:0033193) |
| 0.4 | 2.7 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.2 | 3.5 | GO:0044292 | dendrite terminus(GO:0044292) |
| 0.2 | 2.1 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.1 | 4.0 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.1 | 1.0 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 0.1 | 1.3 | GO:0044754 | autolysosome(GO:0044754) |
| 0.1 | 0.3 | GO:0097433 | dense body(GO:0097433) |
| 0.1 | 1.1 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.1 | 2.0 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
| 0.1 | 1.0 | GO:0031011 | Ino80 complex(GO:0031011) |
| 0.1 | 2.8 | GO:0031672 | A band(GO:0031672) |
| 0.1 | 0.9 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.1 | 0.8 | GO:0020005 | symbiont-containing vacuole membrane(GO:0020005) |
| 0.1 | 0.3 | GO:0097447 | dendritic tree(GO:0097447) |
| 0.1 | 0.3 | GO:0001674 | female germ cell nucleus(GO:0001674) |
| 0.1 | 0.8 | GO:0042555 | MCM complex(GO:0042555) |
| 0.0 | 0.6 | GO:0030123 | AP-3 adaptor complex(GO:0030123) |
| 0.0 | 0.7 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.0 | 0.4 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
| 0.0 | 2.4 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 10.6 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 2.6 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 0.3 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
| 0.0 | 2.6 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.0 | 3.1 | GO:0005903 | brush border(GO:0005903) |
| 0.0 | 0.1 | GO:0035339 | SPOTS complex(GO:0035339) |
| 0.0 | 0.5 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 1.7 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 0.4 | GO:0036038 | MKS complex(GO:0036038) |
| 0.0 | 1.5 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 0.3 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 1.6 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 4.7 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 0.3 | GO:0005686 | U2 snRNP(GO:0005686) |
| 0.0 | 1.4 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.0 | 11.4 | GO:0005615 | extracellular space(GO:0005615) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 7.5 | GO:0097643 | amylin receptor activity(GO:0097643) |
| 1.5 | 8.9 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 1.3 | 9.3 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 1.2 | 7.4 | GO:0045545 | syndecan binding(GO:0045545) |
| 1.2 | 3.6 | GO:0071723 | lipopeptide binding(GO:0071723) |
| 1.0 | 3.9 | GO:0031727 | CCR2 chemokine receptor binding(GO:0031727) |
| 0.9 | 5.3 | GO:0005173 | stem cell factor receptor binding(GO:0005173) |
| 0.9 | 2.6 | GO:0003846 | 2-acylglycerol O-acyltransferase activity(GO:0003846) |
| 0.8 | 6.6 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.8 | 5.6 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
| 0.7 | 5.1 | GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665) |
| 0.6 | 2.4 | GO:0008476 | protein-tyrosine sulfotransferase activity(GO:0008476) |
| 0.5 | 2.4 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
| 0.4 | 6.5 | GO:0030247 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.3 | 3.5 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 0.3 | 4.0 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.3 | 0.9 | GO:0000099 | sulfur amino acid transmembrane transporter activity(GO:0000099) L-asparagine transmembrane transporter activity(GO:0015182) |
| 0.3 | 2.7 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.3 | 8.1 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.2 | 2.2 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.2 | 10.2 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.2 | 4.5 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.2 | 5.1 | GO:0005337 | nucleoside transmembrane transporter activity(GO:0005337) |
| 0.2 | 1.4 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.2 | 0.8 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
| 0.2 | 2.6 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.2 | 2.4 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.2 | 2.1 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
| 0.1 | 7.5 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.1 | 0.9 | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) |
| 0.1 | 1.2 | GO:0004622 | lysophospholipase activity(GO:0004622) |
| 0.1 | 4.2 | GO:0030546 | receptor activator activity(GO:0030546) |
| 0.1 | 0.5 | GO:0004322 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.1 | 3.6 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.1 | 1.1 | GO:0004576 | oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.1 | 1.4 | GO:0070403 | NAD+ binding(GO:0070403) |
| 0.1 | 1.4 | GO:0030235 | nitric-oxide synthase regulator activity(GO:0030235) |
| 0.1 | 1.6 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 2.8 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.1 | 0.7 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
| 0.1 | 1.4 | GO:0017110 | nucleoside-diphosphatase activity(GO:0017110) |
| 0.1 | 1.8 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.1 | 0.3 | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740) |
| 0.1 | 0.3 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.1 | 9.2 | GO:0008237 | metallopeptidase activity(GO:0008237) |
| 0.1 | 0.2 | GO:0015143 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
| 0.1 | 0.2 | GO:0004830 | tryptophan-tRNA ligase activity(GO:0004830) |
| 0.1 | 1.2 | GO:0035613 | RNA stem-loop binding(GO:0035613) |
| 0.1 | 2.6 | GO:0019210 | protein kinase inhibitor activity(GO:0004860) kinase inhibitor activity(GO:0019210) |
| 0.0 | 2.1 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.0 | 2.8 | GO:0043621 | protein self-association(GO:0043621) |
| 0.0 | 1.4 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 0.6 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.0 | 0.2 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.0 | 4.0 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.0 | 0.5 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.0 | 2.6 | GO:0008201 | heparin binding(GO:0008201) |
| 0.0 | 4.1 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 1.0 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.0 | 0.3 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.0 | 0.4 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.0 | 0.3 | GO:0009922 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.0 | 0.1 | GO:0008113 | peptide-methionine (S)-S-oxide reductase activity(GO:0008113) |
| 0.0 | 0.2 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 0.0 | 1.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 0.6 | GO:0051721 | protein phosphatase 2A binding(GO:0051721) |
| 0.0 | 1.5 | GO:0019842 | vitamin binding(GO:0019842) |
| 0.0 | 0.8 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.0 | 0.6 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.0 | 0.1 | GO:0015038 | glutathione disulfide oxidoreductase activity(GO:0015038) protein-disulfide reductase (glutathione) activity(GO:0019153) |
| 0.0 | 0.8 | GO:0001046 | core promoter sequence-specific DNA binding(GO:0001046) |
| 0.0 | 0.5 | GO:0008198 | ferrous iron binding(GO:0008198) |
| 0.0 | 1.5 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.0 | 2.5 | GO:0005057 | receptor signaling protein activity(GO:0005057) |
| 0.0 | 0.1 | GO:0016004 | phospholipase activator activity(GO:0016004) lipase activator activity(GO:0060229) |
| 0.0 | 0.6 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.0 | 4.8 | GO:0005525 | GTP binding(GO:0005525) |
| 0.0 | 0.1 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.0 | 0.1 | GO:0070181 | mRNA 5'-UTR binding(GO:0048027) small ribosomal subunit rRNA binding(GO:0070181) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 4.5 | ST_INTERFERON_GAMMA_PATHWAY | Interferon gamma pathway. |
| 0.3 | 6.0 | PID_INTEGRIN5_PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.3 | 7.4 | PID_INTEGRIN_A9B1_PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.3 | 4.5 | PID_SYNDECAN_3_PATHWAY | Syndecan-3-mediated signaling events |
| 0.2 | 5.4 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 7.3 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 3.6 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.1 | 11.8 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 3.6 | PID_ANGIOPOIETIN_RECEPTOR_PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.1 | 2.2 | PID_FGF_PATHWAY | FGF signaling pathway |
| 0.1 | 2.1 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 2.9 | PID_AJDISS_2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 1.5 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 0.8 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 3.4 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.8 | PID_IL4_2PATHWAY | IL4-mediated signaling events |
| 0.0 | 0.4 | PID_MAPK_TRK_PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 1.0 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
| 0.0 | 0.1 | SA_G1_AND_S_PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 8.1 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.3 | 3.6 | REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.3 | 4.4 | REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.2 | 5.6 | REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.2 | 2.9 | REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.2 | 3.3 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.2 | 18.4 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.2 | 2.2 | REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR2c ligand binding and activation |
| 0.2 | 3.1 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
| 0.2 | 3.9 | REACTOME_ACTIVATION_OF_GENES_BY_ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.1 | 6.1 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 8.2 | REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS | Genes involved in G alpha (z) signalling events |
| 0.1 | 5.1 | REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.1 | 7.6 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 2.6 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
| 0.1 | 2.6 | REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.1 | 1.4 | REACTOME_PURINE_SALVAGE | Genes involved in Purine salvage |
| 0.0 | 0.8 | REACTOME_UNWINDING_OF_DNA | Genes involved in Unwinding of DNA |
| 0.0 | 2.1 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 3.5 | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | Genes involved in G alpha (i) signalling events |
| 0.0 | 7.3 | REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES | Genes involved in Transmission across Chemical Synapses |
| 0.0 | 2.8 | REACTOME_TRIGLYCERIDE_BIOSYNTHESIS | Genes involved in Triglyceride Biosynthesis |
| 0.0 | 0.7 | REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.0 | 0.2 | REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP | Genes involved in Destabilization of mRNA by KSRP |
| 0.0 | 1.0 | REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.0 | 0.6 | REACTOME_SYNTHESIS_OF_PC | Genes involved in Synthesis of PC |
| 0.0 | 0.8 | REACTOME_INTERFERON_GAMMA_SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 0.6 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 0.3 | REACTOME_GAP_JUNCTION_ASSEMBLY | Genes involved in Gap junction assembly |
| 0.0 | 0.3 | REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.0 | 0.2 | REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.0 | 0.5 | REACTOME_METAL_ION_SLC_TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.0 | 0.5 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 1.2 | REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION | Genes involved in Asparagine N-linked glycosylation |
