Motif ID: Bcl6

Z-value: 0.775


Transcription factors associated with Bcl6:

Gene SymbolEntrez IDGene Name
Bcl6 ENSMUSG00000022508.5 Bcl6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bcl6mm10_v2_chr16_-_23988852_239888520.462.3e-05Click!


Activity profile for motif Bcl6.

activity profile for motif Bcl6


Sorted Z-values histogram for motif Bcl6

Sorted Z-values for motif Bcl6



Network of associatons between targets according to the STRING database.



First level regulatory network of Bcl6

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_169747634 10.204 ENSMUST00000027991.5
ENSMUST00000111357.1
 Rgs4

regulator of G-protein signaling 4

chr11_+_101245996 7.543 ENSMUST00000129680.1
 Ramp2
receptor (calcitonin) activity modifying protein 2
chr11_-_55419898 7.478 ENSMUST00000108858.1
ENSMUST00000141530.1
 Sparc

secreted acidic cysteine rich glycoprotein

chr4_-_64046925 7.424 ENSMUST00000107377.3
 Tnc
tenascin C
chr11_+_78499087 6.010 ENSMUST00000017488.4
 Vtn
vitronectin
chr10_+_100015817 5.335 ENSMUST00000130190.1
ENSMUST00000020129.7
 Kitl

kit ligand

chr3_-_152982240 5.062 ENSMUST00000044278.5
 St6galnac5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr15_-_8710734 4.834 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr19_+_34217588 4.615 ENSMUST00000119603.1
 Stambpl1
STAM binding protein like 1
chr3_+_63295815 4.569 ENSMUST00000029400.1
 Mme
membrane metallo endopeptidase
chr8_-_105568298 4.475 ENSMUST00000005849.5
 Agrp
agouti related protein
chr10_+_58813359 4.223 ENSMUST00000135526.2
ENSMUST00000153031.1
 Sh3rf3

SH3 domain containing ring finger 3

chr18_+_37484955 4.223 ENSMUST00000053856.4
 Pcdhb17
protocadherin beta 17
chr15_-_37459327 4.217 ENSMUST00000119730.1
ENSMUST00000120746.1
 Ncald

neurocalcin delta

chr4_+_144892813 4.127 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr15_-_8710409 4.096 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr8_+_68880491 3.971 ENSMUST00000015712.8
 Lpl
lipoprotein lipase
chr9_+_20868628 3.955 ENSMUST00000043911.7
 A230050P20Rik
RIKEN cDNA A230050P20 gene
chr15_-_37458523 3.870 ENSMUST00000116445.2
 Ncald
neurocalcin delta
chr11_+_82035569 3.853 ENSMUST00000000193.5
 Ccl2
chemokine (C-C motif) ligand 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 9.3 GO:0042572 retinol metabolic process(GO:0042572)
2.2 8.9 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.2 8.5 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
1.3 7.5 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.2 7.5 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.1 7.5 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
1.9 7.4 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.2 6.6 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.5 6.0 GO:0097421 liver regeneration(GO:0097421)
1.1 5.6 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
1.3 5.3 GO:0033024 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.7 5.1 GO:0015862 uridine transport(GO:0015862)
0.3 5.1 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.9 4.7 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.6 4.7 GO:0008343 adult feeding behavior(GO:0008343)
1.5 4.6 GO:0071492 cellular response to UV-A(GO:0071492)
0.2 4.5 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.9 4.3 GO:0035356 cellular triglyceride homeostasis(GO:0035356)
1.0 4.0 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.1 4.0 GO:0045071 negative regulation of viral genome replication(GO:0045071)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 11.4 GO:0005615 extracellular space(GO:0005615)
0.0 10.6 GO:0016323 basolateral plasma membrane(GO:0016323)
1.7 10.5 GO:0005796 Golgi lumen(GO:0005796)
0.6 9.5 GO:0005614 interstitial matrix(GO:0005614)
1.9 7.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
1.5 7.5 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.0 4.7 GO:0000139 Golgi membrane(GO:0000139)
0.6 4.0 GO:0042627 chylomicron(GO:0042627)
0.1 4.0 GO:0060077 inhibitory synapse(GO:0060077)
1.3 3.9 GO:0044299 C-fiber(GO:0044299)
1.2 3.6 GO:0005940 septin ring(GO:0005940)
0.7 3.6 GO:0044316 cone cell pedicle(GO:0044316)
0.6 3.6 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.2 3.5 GO:0044292 dendrite terminus(GO:0044292)
0.0 3.1 GO:0005903 brush border(GO:0005903)
0.7 2.8 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.1 2.8 GO:0031672 A band(GO:0031672)
0.4 2.7 GO:0097512 cardiac myofibril(GO:0097512)
0.5 2.6 GO:0001652 granular component(GO:0001652)
0.0 2.6 GO:0005811 lipid particle(GO:0005811)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.2 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
1.3 9.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 9.2 GO:0008237 metallopeptidase activity(GO:0008237)
1.5 8.9 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.3 8.1 GO:0043014 alpha-tubulin binding(GO:0043014)
1.5 7.5 GO:0097643 amylin receptor activity(GO:0097643)
0.1 7.5 GO:0050840 extracellular matrix binding(GO:0050840)
1.2 7.4 GO:0045545 syndecan binding(GO:0045545)
0.8 6.6 GO:0097322 7SK snRNA binding(GO:0097322)
0.4 6.5 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.8 5.6 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.9 5.3 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.7 5.1 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.2 5.1 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 4.8 GO:0005525 GTP binding(GO:0005525)
0.2 4.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 4.2 GO:0030546 receptor activator activity(GO:0030546)
0.0 4.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.3 4.0 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 4.0 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)

Gene overrepresentation in C2:CP category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 7.4 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 7.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.3 6.0 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2 5.4 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.4 4.5 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.3 4.5 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.1 3.6 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 3.6 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 3.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.9 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 2.2 PID_FGF_PATHWAY FGF signaling pathway
0.1 2.1 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.0 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 0.8 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.8 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 0.4 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.1 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 18.4 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 8.2 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.4 8.1 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 7.6 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 7.3 REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES Genes involved in Transmission across Chemical Synapses
0.1 6.1 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 5.6 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 5.1 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.3 4.4 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.2 3.9 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.3 3.6 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 3.5 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.2 3.3 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 3.1 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.2 2.9 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 2.8 REACTOME_TRIGLYCERIDE_BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.1 2.6 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 2.6 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.2 2.2 REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.0 2.1 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis