Motif ID: Bcl6b

Z-value: 0.599


Transcription factors associated with Bcl6b:

Gene SymbolEntrez IDGene Name
Bcl6b ENSMUSG00000000317.5 Bcl6b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bcl6bmm10_v2_chr11_-_70229677_70229761-0.161.5e-01Click!


Activity profile for motif Bcl6b.

activity profile for motif Bcl6b


Sorted Z-values histogram for motif Bcl6b

Sorted Z-values for motif Bcl6b



Network of associatons between targets according to the STRING database.



First level regulatory network of Bcl6b

PNG image of the network

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Top targets:


Showing 1 to 20 of 79 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_5797410 4.911 ENSMUST00000173314.1
Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr13_-_98815408 3.828 ENSMUST00000040340.8
ENSMUST00000099277.4
ENSMUST00000179563.1
ENSMUST00000109403.1
Fcho2



FCH domain only 2



chr1_-_173942445 3.753 ENSMUST00000042228.8
ENSMUST00000081216.5
ENSMUST00000129829.1
ENSMUST00000123708.1
ENSMUST00000111210.2
Ifi203



Mndal
interferon activated gene 203



myeloid nuclear differentiation antigen like
chr6_+_149309391 3.419 ENSMUST00000130664.1
ENSMUST00000046689.6
2810474O19Rik

RIKEN cDNA 2810474O19 gene

chr6_+_149309444 3.241 ENSMUST00000100765.4
2810474O19Rik
RIKEN cDNA 2810474O19 gene
chr16_-_74411776 2.846 ENSMUST00000116586.2
Robo2
roundabout homolog 2 (Drosophila)
chr10_-_86705485 2.756 ENSMUST00000020238.7
Hsp90b1
heat shock protein 90, beta (Grp94), member 1
chr1_+_139454747 2.704 ENSMUST00000053364.8
ENSMUST00000097554.3
Aspm

asp (abnormal spindle)-like, microcephaly associated (Drosophila)

chr16_-_74411292 2.645 ENSMUST00000117200.1
Robo2
roundabout homolog 2 (Drosophila)
chr2_+_119594288 2.319 ENSMUST00000147425.1
ENSMUST00000153581.1
1700020I14Rik

RIKEN cDNA 1700020I14 gene

chr10_-_95417099 2.296 ENSMUST00000135822.1
Socs2
suppressor of cytokine signaling 2
chr10_+_57794335 2.282 ENSMUST00000151623.1
ENSMUST00000020022.7
Smpdl3a

sphingomyelin phosphodiesterase, acid-like 3A

chr5_-_150665560 2.088 ENSMUST00000118316.1
N4bp2l2
NEDD4 binding protein 2-like 2
chr10_-_95416850 2.078 ENSMUST00000020215.9
Socs2
suppressor of cytokine signaling 2
chr15_+_25752860 1.945 ENSMUST00000022882.5
ENSMUST00000135173.1
Myo10

myosin X

chrX_+_151344171 1.933 ENSMUST00000073364.5
Fam120c
family with sequence similarity 120, member C
chr16_-_34263179 1.929 ENSMUST00000114949.1
ENSMUST00000114954.1
Kalrn

kalirin, RhoGEF kinase

chr12_-_40134175 1.892 ENSMUST00000078481.7
ENSMUST00000002640.5
Scin

scinderin

chr16_-_34262830 1.806 ENSMUST00000114947.1
Kalrn
kalirin, RhoGEF kinase
chr6_+_34598500 1.747 ENSMUST00000079391.3
ENSMUST00000142512.1
Cald1

caldesmon 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 5.5 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.7 5.3 GO:0061368 maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
1.0 4.9 GO:0035063 nuclear speck organization(GO:0035063)
0.2 4.4 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.1 3.8 GO:0048268 clathrin coat assembly(GO:0048268)
0.1 3.8 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.1 3.4 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
0.7 2.9 GO:1902037 negative regulation of hematopoietic stem cell differentiation(GO:1902037)
0.3 2.8 GO:0071318 cellular response to ATP(GO:0071318)
0.5 2.7 GO:0051661 maintenance of centrosome location(GO:0051661)
0.2 2.6 GO:0048194 Golgi vesicle budding(GO:0048194)
0.5 2.3 GO:0046684 response to pyrethroid(GO:0046684)
0.3 2.3 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.3 1.9 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.0 1.9 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 1.5 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.1 1.4 GO:0030322 stabilization of membrane potential(GO:0030322)
0.4 1.3 GO:0090646 mitochondrial tRNA processing(GO:0090646)
0.0 1.3 GO:0015914 phospholipid transport(GO:0015914)
0.4 1.1 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.5 GO:0030673 axolemma(GO:0030673)
0.0 5.3 GO:0014069 postsynaptic density(GO:0014069)
0.0 4.9 GO:0016607 nuclear speck(GO:0016607)
1.3 3.8 GO:0098835 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835)
0.4 3.4 GO:0030478 actin cap(GO:0030478)
0.0 3.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 2.8 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.5 2.7 GO:0036449 microtubule minus-end(GO:0036449)
0.0 2.6 GO:0031985 Golgi cisterna(GO:0031985)
0.5 2.1 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.0 1.9 GO:0016459 myosin complex(GO:0016459)
0.0 1.6 GO:0005903 brush border(GO:0005903)
0.0 1.3 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 1.1 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.1 0.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.8 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 0.6 GO:0030991 intraciliary transport particle A(GO:0030991)
0.1 0.6 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.0 0.6 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 5.5 GO:0008046 axon guidance receptor activity(GO:0008046)
0.2 5.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.9 4.4 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 3.8 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 3.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 2.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.3 2.8 GO:0046790 virion binding(GO:0046790)
0.1 2.6 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.3 2.3 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 2.3 GO:0031402 sodium ion binding(GO:0031402)
0.0 1.9 GO:0030507 spectrin binding(GO:0030507)
0.0 1.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 1.4 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.4 1.3 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.1 1.3 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 1.0 GO:0008173 RNA methyltransferase activity(GO:0008173)
0.2 0.8 GO:0045545 syndecan binding(GO:0045545)
0.2 0.6 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.0 0.6 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.2 GO:0050816 phosphothreonine binding(GO:0050816)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.3 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 2.6 PID_IL2_1PATHWAY IL2-mediated signaling events
0.1 2.0 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 1.9 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.8 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.5 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 5.3 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 3.4 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.3 2.8 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 2.6 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.0 1.9 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.2 1.4 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 1.0 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.4 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG