Motif ID: Brca1

Z-value: 0.558


Transcription factors associated with Brca1:

Gene SymbolEntrez IDGene Name
Brca1 ENSMUSG00000017146.6 Brca1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Brca1mm10_v2_chr11_-_101551837_1015518930.243.7e-02Click!


Activity profile for motif Brca1.

activity profile for motif Brca1


Sorted Z-values histogram for motif Brca1

Sorted Z-values for motif Brca1



Network of associatons between targets according to the STRING database.



First level regulatory network of Brca1

PNG image of the network

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Top targets:


Showing 1 to 20 of 186 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 15.405 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr11_+_44617310 4.849 ENSMUST00000081265.5
ENSMUST00000101326.3
ENSMUST00000109268.1
 Ebf1


early B cell factor 1


chr1_-_75278345 3.012 ENSMUST00000039534.4
 Resp18
regulated endocrine-specific protein 18
chr7_-_144939823 2.789 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr18_-_47333311 2.674 ENSMUST00000126684.1
ENSMUST00000156422.1
 Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr11_-_98625661 2.414 ENSMUST00000104933.1
 Gm12355
predicted gene 12355
chr17_-_70853482 2.400 ENSMUST00000118283.1
 Tgif1
TGFB-induced factor homeobox 1
chr3_+_87906321 2.242 ENSMUST00000005017.8
 Hdgf
hepatoma-derived growth factor
chr11_-_106998483 2.155 ENSMUST00000124541.1
 Kpna2
karyopherin (importin) alpha 2
chr2_-_105399286 2.140 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr14_-_67715585 2.021 ENSMUST00000163100.1
ENSMUST00000132705.1
ENSMUST00000124045.1
 Cdca2


cell division cycle associated 2


chr1_+_74791516 1.932 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr11_-_101171302 1.906 ENSMUST00000164474.1
ENSMUST00000043397.7
 Plekhh3

pleckstrin homology domain containing, family H (with MyTH4 domain) member 3

chr7_+_51878967 1.904 ENSMUST00000051912.6
 Gas2
growth arrest specific 2
chr8_-_70700070 1.887 ENSMUST00000116172.1
 Gm11175
predicted gene 11175
chr19_-_24225015 1.780 ENSMUST00000099558.4
 Tjp2
tight junction protein 2
chr9_-_37657189 1.670 ENSMUST00000117654.1
 Tbrg1
transforming growth factor beta regulated gene 1
chr7_-_102100227 1.651 ENSMUST00000106937.1
 Art5
ADP-ribosyltransferase 5
chr17_-_6655939 1.641 ENSMUST00000179554.1
 Dynlt1f
dynein light chain Tctex-type 1F
chr12_+_52097737 1.620 ENSMUST00000040090.9
 Nubpl
nucleotide binding protein-like

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 15.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.3 3.0 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.4 2.8 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.1 2.7 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.1 2.6 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.2 2.4 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.1 2.4 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 2.2 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.2 1.9 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.6 1.8 GO:1903011 negative regulation of bone development(GO:1903011)
0.1 1.6 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.1 1.6 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 1.6 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.5 1.5 GO:1904578 response to thapsigargin(GO:1904578) cellular response to thapsigargin(GO:1904579)
0.3 1.5 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.3 1.5 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.2 1.5 GO:0009235 cobalamin metabolic process(GO:0009235)
0.2 1.5 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 1.5 GO:0051382 kinetochore assembly(GO:0051382)
0.0 1.5 GO:0070527 platelet aggregation(GO:0070527)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 3.0 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.4 3.0 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 3.0 GO:0005643 nuclear pore(GO:0005643)
0.1 2.9 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 2.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 2.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 1.8 GO:0005921 gap junction(GO:0005921)
0.2 1.6 GO:0001739 sex chromatin(GO:0001739)
0.0 1.6 GO:0034399 nuclear periphery(GO:0034399)
0.5 1.5 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.1 1.5 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 1.5 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 1.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 1.5 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.5 GO:0000776 kinetochore(GO:0000776)
0.2 1.3 GO:0000125 PCAF complex(GO:0000125)
0.0 1.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 1.2 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 1.2 GO:0031941 filamentous actin(GO:0031941)
0.1 1.1 GO:0031083 BLOC-1 complex(GO:0031083)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.4 6.1 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.2 4.6 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 3.1 GO:0003735 structural constituent of ribosome(GO:0003735)
0.4 3.0 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.1 2.7 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 2.6 GO:0005109 frizzled binding(GO:0005109)
0.8 2.4 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.1 2.4 GO:0070410 co-SMAD binding(GO:0070410)
0.1 2.3 GO:0070064 proline-rich region binding(GO:0070064)
0.1 2.2 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 1.6 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.3 1.5 GO:0043515 kinetochore binding(GO:0043515)
0.3 1.5 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.3 1.5 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.2 1.5 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.1 1.5 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 1.4 GO:0070491 repressing transcription factor binding(GO:0070491)
0.3 1.3 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.1 1.3 GO:0031681 G-protein beta-subunit binding(GO:0031681)

Gene overrepresentation in C2:CP category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.7 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.2 2.8 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 2.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.2 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 2.1 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 1.8 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.7 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.3 PID_MYC_PATHWAY C-MYC pathway
0.0 1.1 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 0.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.8 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.7 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.6 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.6 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.6 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 0.4 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.3 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.2 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.0 0.2 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.8 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 4.1 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 4.0 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 2.8 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 2.8 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 2.7 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 2.6 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 2.4 REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.1 2.4 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 2.2 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 1.9 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.3 1.8 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 1.6 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.5 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 1.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.5 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 1.3 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 1.3 REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.1 1.2 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 1.1 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis