Motif ID: Cbfb

Z-value: 0.474


Transcription factors associated with Cbfb:

Gene SymbolEntrez IDGene Name
Cbfb ENSMUSG00000031885.7 Cbfb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Cbfbmm10_v2_chr8_+_105170668_105170686-0.271.6e-02Click!


Activity profile for motif Cbfb.

activity profile for motif Cbfb


Sorted Z-values histogram for motif Cbfb

Sorted Z-values for motif Cbfb



Network of associatons between targets according to the STRING database.



First level regulatory network of Cbfb

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_66801577 13.425 ENSMUST00000168589.1
 Sla
src-like adaptor
chr14_+_101729907 7.851 ENSMUST00000100337.3
 Lmo7
LIM domain only 7
chr11_-_83649349 6.632 ENSMUST00000001008.5
 Ccl3
chemokine (C-C motif) ligand 3
chr4_-_6990774 4.083 ENSMUST00000039987.3
 Tox
thymocyte selection-associated high mobility group box
chr14_-_101729690 3.986 ENSMUST00000066461.3
 Gm9922
predicted gene 9922
chr12_+_95692212 3.937 ENSMUST00000057324.3
 Flrt2
fibronectin leucine rich transmembrane protein 2
chr5_+_104435112 2.718 ENSMUST00000031243.8
ENSMUST00000086833.6
ENSMUST00000112748.1
ENSMUST00000112746.1
ENSMUST00000145084.1
ENSMUST00000132457.1
 Spp1





secreted phosphoprotein 1





chr8_+_27260327 2.082 ENSMUST00000033880.5
 Eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
chr2_+_164948219 1.908 ENSMUST00000017881.2
 Mmp9
matrix metallopeptidase 9
chr7_-_90129339 1.890 ENSMUST00000181189.1
 2310010J17Rik
RIKEN cDNA 2310010J17 gene
chr1_-_174921813 1.865 ENSMUST00000055294.3
 Grem2
gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis)
chr17_-_64331817 1.788 ENSMUST00000172733.1
ENSMUST00000172818.1
 Pja2

praja 2, RING-H2 motif containing

chr10_+_69925954 1.192 ENSMUST00000181974.1
ENSMUST00000182795.1
ENSMUST00000182437.1
 Ank3


ankyrin 3, epithelial


chr2_+_32721055 1.117 ENSMUST00000074248.4
 Sh2d3c
SH2 domain containing 3C
chr1_-_16656843 1.064 ENSMUST00000115352.3
 Tceb1
transcription elongation factor B (SIII), polypeptide 1
chr5_+_24364804 1.052 ENSMUST00000030834.4
ENSMUST00000115090.1
 Nos3

nitric oxide synthase 3, endothelial cell

chr4_+_108847827 0.931 ENSMUST00000102738.2
 Kti12
KTI12 homolog, chromatin associated (S. cerevisiae)
chr15_+_99393219 0.864 ENSMUST00000159209.1
 Tmbim6
transmembrane BAX inhibitor motif containing 6
chr15_+_99392948 0.815 ENSMUST00000161250.1
ENSMUST00000160635.1
ENSMUST00000161778.1
 Tmbim6


transmembrane BAX inhibitor motif containing 6


chr17_+_12119274 0.694 ENSMUST00000024594.2
 Agpat4
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chr1_+_151755339 0.676 ENSMUST00000059498.5
 Edem3
ER degradation enhancer, mannosidase alpha-like 3
chr1_+_63176818 0.630 ENSMUST00000129339.1
 Eef1b2
eukaryotic translation elongation factor 1 beta 2
chr19_-_50678485 0.466 ENSMUST00000111756.3
 Sorcs1
VPS10 domain receptor protein SORCS 1
chr11_-_74724670 0.457 ENSMUST00000021091.8
 Pafah1b1
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
chr4_-_117891994 0.190 ENSMUST00000030265.3
 Dph2
DPH2 homolog (S. cerevisiae)
chr1_-_63176653 0.163 ENSMUST00000027111.8
ENSMUST00000168099.2
 Ndufs1

NADH dehydrogenase (ubiquinone) Fe-S protein 1

chr3_+_121291725 0.110 ENSMUST00000039442.7
 Alg14
asparagine-linked glycosylation 14
chr15_+_99393574 0.001 ENSMUST00000162624.1
 Tmbim6
transmembrane BAX inhibitor motif containing 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 6.6 GO:0043615 astrocyte cell migration(GO:0043615)
0.7 2.7 GO:0035937 androgen catabolic process(GO:0006710) estrogen secretion(GO:0035937) estradiol secretion(GO:0035938) regulation of estrogen secretion(GO:2000861) regulation of estradiol secretion(GO:2000864)
0.4 3.9 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.4 1.9 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.4 1.1 GO:0003100 regulation of systemic arterial blood pressure by endothelin(GO:0003100) regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
0.3 2.1 GO:1990928 response to amino acid starvation(GO:1990928)
0.3 1.5 GO:1904721 regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.3 1.9 GO:1900116 sequestering of extracellular ligand from receptor(GO:0035581) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.2 13.4 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.1 0.7 GO:0036508 protein deglycosylation involved in glycoprotein catabolic process(GO:0035977) protein demannosylation(GO:0036507) protein alpha-1,2-demannosylation(GO:0036508) glycoprotein ERAD pathway(GO:0097466) mannose trimming involved in glycoprotein ERAD pathway(GO:1904382)
0.1 1.2 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 0.5 GO:0051661 maintenance of centrosome location(GO:0051661)
0.1 1.8 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 0.2 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.6 GO:0045471 response to ethanol(GO:0045471)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 13.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 0.5 GO:0000235 astral microtubule(GO:0000235)
0.1 7.9 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 1.2 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 5.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 1.8 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 0.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.1 GO:0005901 caveola(GO:0005901)
0.0 11.2 GO:0005615 extracellular space(GO:0005615)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 14.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.4 1.1 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.2 1.5 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.2 3.9 GO:0045499 chemorepellent activity(GO:0045499)
0.2 6.6 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.2 7.9 GO:0042805 actinin binding(GO:0042805)
0.2 1.9 GO:0036122 BMP binding(GO:0036122)
0.2 2.1 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.1 1.8 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.1 0.7 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1 1.9 GO:0001968 fibronectin binding(GO:0001968)
0.1 2.7 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.7 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 1.2 GO:0030507 spectrin binding(GO:0030507)
0.0 0.5 GO:0045505 dynein intermediate chain binding(GO:0045505)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.6 PID_AVB3_OPN_PATHWAY Osteopontin-mediated events
0.1 6.6 PID_IL12_2PATHWAY IL12-mediated signaling events
0.1 13.4 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.0 1.1 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 2.1 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.1 PID_VEGFR1_PATHWAY VEGFR1 specific signals
0.0 0.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 6.6 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 2.1 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 1.9 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 1.9 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 1.1 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 0.7 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 1.1 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 1.2 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 2.7 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.7 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA