Motif ID: Cdx2
Z-value: 0.601
Transcription factors associated with Cdx2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Cdx2 | ENSMUSG00000029646.3 | Cdx2 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 6.5 | GO:1902256 | endocardial cushion fusion(GO:0003274) apoptotic process involved in outflow tract morphogenesis(GO:0003275) atrial septum primum morphogenesis(GO:0003289) positive regulation of catagen(GO:0051795) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256) |
| 1.8 | 7.3 | GO:0014012 | peripheral nervous system axon regeneration(GO:0014012) |
| 0.7 | 7.3 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 0.5 | 3.7 | GO:0070494 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
| 0.5 | 1.5 | GO:0070488 | neutrophil aggregation(GO:0070488) |
| 0.4 | 2.0 | GO:0021856 | cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375) |
| 0.4 | 7.1 | GO:0035994 | response to muscle stretch(GO:0035994) |
| 0.3 | 2.0 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) |
| 0.3 | 1.2 | GO:0046368 | GDP-L-fucose metabolic process(GO:0046368) |
| 0.3 | 2.7 | GO:0071285 | cellular response to lithium ion(GO:0071285) |
| 0.2 | 1.1 | GO:0038018 | Wnt receptor catabolic process(GO:0038018) |
| 0.2 | 1.1 | GO:0035590 | purinergic nucleotide receptor signaling pathway(GO:0035590) |
| 0.1 | 0.9 | GO:0021913 | regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913) |
| 0.1 | 0.3 | GO:0001692 | histamine metabolic process(GO:0001692) imidazole-containing compound catabolic process(GO:0052805) |
| 0.1 | 0.4 | GO:0002674 | negative regulation of acute inflammatory response(GO:0002674) |
| 0.1 | 0.7 | GO:0048664 | neuron fate determination(GO:0048664) |
| 0.1 | 2.8 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.1 | 0.4 | GO:0030263 | apoptotic chromosome condensation(GO:0030263) |
| 0.1 | 2.5 | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading(GO:1900026) |
| 0.1 | 1.6 | GO:0043171 | peptide catabolic process(GO:0043171) |
| 0.0 | 0.5 | GO:0010839 | negative regulation of keratinocyte proliferation(GO:0010839) |
| 0.0 | 0.8 | GO:0032291 | central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291) |
| 0.0 | 0.3 | GO:0060693 | regulation of branching involved in salivary gland morphogenesis(GO:0060693) |
| 0.0 | 0.1 | GO:0021546 | rhombomere development(GO:0021546) |
| 0.0 | 0.3 | GO:0060391 | positive regulation of SMAD protein import into nucleus(GO:0060391) |
| 0.0 | 0.1 | GO:1903071 | positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 7.1 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.5 | 7.3 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.2 | 2.5 | GO:0042581 | specific granule(GO:0042581) |
| 0.1 | 1.2 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.1 | 6.5 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 3.5 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 0.4 | GO:0061574 | ASAP complex(GO:0061574) |
| 0.0 | 3.2 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 0.1 | GO:1990037 | Lewy body core(GO:1990037) |
| 0.0 | 0.3 | GO:0005685 | U1 snRNP(GO:0005685) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 6.5 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
| 1.2 | 7.3 | GO:0045545 | syndecan binding(GO:0045545) |
| 1.0 | 7.3 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 0.9 | 3.7 | GO:0005008 | hepatocyte growth factor-activated receptor activity(GO:0005008) |
| 0.3 | 1.5 | GO:0050786 | arachidonic acid binding(GO:0050544) RAGE receptor binding(GO:0050786) |
| 0.2 | 7.1 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.2 | 2.0 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.2 | 1.1 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.1 | 1.2 | GO:0008417 | fucosyltransferase activity(GO:0008417) |
| 0.1 | 0.4 | GO:0046975 | histone methyltransferase activity (H3-K36 specific)(GO:0046975) |
| 0.1 | 2.7 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.1 | 1.6 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.1 | 0.4 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 0.1 | 0.3 | GO:0035614 | snRNA stem-loop binding(GO:0035614) |
| 0.0 | 2.0 | GO:0016860 | intramolecular oxidoreductase activity(GO:0016860) |
| 0.0 | 0.7 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.0 | 1.1 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 2.6 | GO:0030674 | protein binding, bridging(GO:0030674) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 6.5 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.4 | 7.1 | PID_TCR_RAS_PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.3 | 7.3 | PID_INTEGRIN_A9B1_PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 7.0 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 3.7 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.1 | 1.5 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.0 | 2.7 | PID_AP1_PATHWAY | AP-1 transcription factor network |
| 0.0 | 2.0 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.1 | PID_P73PATHWAY | p73 transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 7.1 | REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.1 | 1.8 | REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.1 | 2.0 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.1 | 2.7 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 3.7 | REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.1 | 7.3 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 6.5 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 1.2 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI | Genes involved in N-glycan antennae elongation in the medial/trans-Golgi |
