Motif ID: Cebpa_Cebpg

Z-value: 0.884

Transcription factors associated with Cebpa_Cebpg:

Gene SymbolEntrez IDGene Name
Cebpa ENSMUSG00000034957.9 Cebpa
Cebpg ENSMUSG00000056216.8 Cebpg

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Cebpgmm10_v2_chr7_-_35056467_35056556-0.503.3e-06Click!
Cebpamm10_v2_chr7_+_35119285_351193010.252.6e-02Click!


Activity profile for motif Cebpa_Cebpg.

activity profile for motif Cebpa_Cebpg


Sorted Z-values histogram for motif Cebpa_Cebpg

Sorted Z-values for motif Cebpa_Cebpg



Network of associatons between targets according to the STRING database.



First level regulatory network of Cebpa_Cebpg

PNG image of the network

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Top targets:


Showing 1 to 20 of 162 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_57239310 17.388 ENSMUST00000111559.1
 Ablim1
actin-binding LIM protein 1
chr7_-_103813913 11.341 ENSMUST00000098192.3
 Hbb-bt
hemoglobin, beta adult t chain
chr6_+_17463749 10.992 ENSMUST00000115443.1
 Met
met proto-oncogene
chrX_-_162565514 8.737 ENSMUST00000154424.1
 Reps2
RALBP1 associated Eps domain containing protein 2
chr4_-_15149051 7.760 ENSMUST00000041606.7
 Necab1
N-terminal EF-hand calcium binding protein 1
chr1_-_22315792 7.368 ENSMUST00000164877.1
 Rims1
regulating synaptic membrane exocytosis 1
chr14_+_65970610 7.237 ENSMUST00000127387.1
 Clu
clusterin
chr13_-_117025505 7.113 ENSMUST00000022239.6
 Parp8
poly (ADP-ribose) polymerase family, member 8
chr14_+_65971049 6.984 ENSMUST00000128539.1
 Clu
clusterin
chr9_-_121495678 6.619 ENSMUST00000035120.4
 Cck
cholecystokinin
chr12_+_74297474 6.463 ENSMUST00000072100.3
 Dbpht2
DNA binding protein with his-thr domain
chr4_-_15149755 6.222 ENSMUST00000108273.1
 Necab1
N-terminal EF-hand calcium binding protein 1
chr1_-_38821215 6.138 ENSMUST00000039612.4
 Lonrf2
LON peptidase N-terminal domain and ring finger 2
chr1_+_169655493 5.756 ENSMUST00000027997.3
 Rgs5
regulator of G-protein signaling 5
chr2_-_129371131 5.442 ENSMUST00000028881.7
 Il1b
interleukin 1 beta
chr13_-_49309217 5.400 ENSMUST00000110087.2
 Fgd3
FYVE, RhoGEF and PH domain containing 3
chr1_-_71653162 4.946 ENSMUST00000055226.6
 Fn1
fibronectin 1
chr2_-_45117349 4.885 ENSMUST00000176438.2
 Zeb2
zinc finger E-box binding homeobox 2
chr14_+_65970804 4.726 ENSMUST00000138191.1
 Clu
clusterin
chr14_+_65971164 4.479 ENSMUST00000144619.1
 Clu
clusterin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.9 23.4 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
1.6 11.0 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
1.2 9.2 GO:0017085 response to insecticide(GO:0017085)
0.1 7.5 GO:0030032 lamellipodium assembly(GO:0030032)
1.8 7.4 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.7 6.6 GO:0051901 positive regulation of mitochondrial depolarization(GO:0051901)
1.6 6.3 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.1 6.1 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
1.8 5.4 GO:0045410 positive regulation of interleukin-6 biosynthetic process(GO:0045410)
1.6 4.9 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931) calcium-independent cell-matrix adhesion(GO:0007161) transforming growth factor-beta secretion(GO:0038044)
0.8 4.9 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0 4.8 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
1.4 4.2 GO:0002586 positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588) detection of peptidoglycan(GO:0032499)
0.1 4.0 GO:0046847 filopodium assembly(GO:0046847)
0.7 3.6 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.4 3.5 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.7 3.4 GO:0033140 negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140)
0.4 3.3 GO:0005513 detection of calcium ion(GO:0005513)
0.3 3.2 GO:0061470 interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619)
0.8 3.1 GO:2000182 regulation of progesterone biosynthetic process(GO:2000182)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.3 23.4 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.2 17.5 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
2.8 11.3 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 9.7 GO:0009925 basal plasma membrane(GO:0009925)
1.5 7.4 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.5 6.6 GO:0043203 axon hillock(GO:0043203)
1.6 4.9 GO:0005577 fibrinogen complex(GO:0005577)
0.3 4.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 4.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 3.9 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.0 3.7 GO:0043679 axon terminus(GO:0043679)
0.0 3.5 GO:0005901 caveola(GO:0005901)
0.0 3.2 GO:0030141 secretory granule(GO:0030141)
0.1 3.1 GO:0097440 apical dendrite(GO:0097440)
0.0 3.1 GO:0005769 early endosome(GO:0005769)
0.0 2.8 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.2 2.7 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 2.7 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 2.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.3 2.3 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 23.4 GO:0051787 misfolded protein binding(GO:0051787)
0.0 21.7 GO:0005509 calcium ion binding(GO:0005509)
0.0 11.6 GO:0003779 actin binding(GO:0003779)
2.8 11.3 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
2.7 11.0 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.5 9.0 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 8.9 GO:0044325 ion channel binding(GO:0044325)
0.3 7.1 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.7 6.3 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 5.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.4 5.4 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.8 4.9 GO:0045340 mercury ion binding(GO:0045340)
0.1 4.9 GO:0070412 R-SMAD binding(GO:0070412)
0.2 4.8 GO:0031402 sodium ion binding(GO:0031402)
0.0 4.6 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 4.5 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 4.4 GO:0035259 glucocorticoid receptor binding(GO:0035259)
1.1 4.2 GO:0070891 peptidoglycan binding(GO:0042834) lipoteichoic acid binding(GO:0070891)
0.0 3.7 GO:0005096 GTPase activator activity(GO:0005096)
0.5 3.6 GO:0008429 phosphatidylethanolamine binding(GO:0008429)

Gene overrepresentation in C2:CP category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 23.3 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.2 11.0 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.1 6.0 PID_BMP_PATHWAY BMP receptor signaling
0.5 5.4 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.3 4.9 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 4.4 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 3.1 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 3.0 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 2.3 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 2.2 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.0 0.9 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.1 0.8 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.7 PID_ATM_PATHWAY ATM pathway
0.0 0.4 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.2 PID_FOXO_PATHWAY FoxO family signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 23.7 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.4 12.1 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.3 11.0 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 8.4 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.7 7.4 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.2 6.0 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 5.4 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.4 4.9 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.2 4.4 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 4.3 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.2 4.2 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 3.3 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 3.1 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 3.0 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.2 2.7 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 2.6 REACTOME_TRANSLATION Genes involved in Translation
0.1 2.4 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.1 2.3 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 2.1 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 2.0 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs