Motif ID: Cebpb

Z-value: 1.169


Transcription factors associated with Cebpb:

Gene SymbolEntrez IDGene Name
Cebpb ENSMUSG00000056501.3 Cebpb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Cebpbmm10_v2_chr2_+_167688915_1676889730.741.4e-14Click!


Activity profile for motif Cebpb.

activity profile for motif Cebpb


Sorted Z-values histogram for motif Cebpb

Sorted Z-values for motif Cebpb



Network of associatons between targets according to the STRING database.



First level regulatory network of Cebpb

PNG image of the network

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Top targets:


Showing 1 to 20 of 163 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_57358682 15.863 ENSMUST00000086763.5
ENSMUST00000004850.7
 Emr1

EGF-like module containing, mucin-like, hormone receptor-like sequence 1

chr19_-_57239310 14.024 ENSMUST00000111559.1
 Ablim1
actin-binding LIM protein 1
chr17_+_48346465 13.361 ENSMUST00000113237.3
 Trem2
triggering receptor expressed on myeloid cells 2
chr17_+_48346401 12.954 ENSMUST00000024791.8
 Trem2
triggering receptor expressed on myeloid cells 2
chrX_-_162565514 12.587 ENSMUST00000154424.1
 Reps2
RALBP1 associated Eps domain containing protein 2
chr19_+_12460749 12.420 ENSMUST00000081035.7
 Mpeg1
macrophage expressed gene 1
chr11_-_83649349 10.697 ENSMUST00000001008.5
 Ccl3
chemokine (C-C motif) ligand 3
chr15_-_37459327 10.523 ENSMUST00000119730.1
ENSMUST00000120746.1
 Ncald

neurocalcin delta

chr1_+_169655493 10.100 ENSMUST00000027997.3
 Rgs5
regulator of G-protein signaling 5
chr6_+_17463749 9.896 ENSMUST00000115443.1
 Met
met proto-oncogene
chr1_-_38821215 9.644 ENSMUST00000039612.4
 Lonrf2
LON peptidase N-terminal domain and ring finger 2
chr8_+_75093591 9.521 ENSMUST00000005548.6
 Hmox1
heme oxygenase (decycling) 1
chr13_+_16011851 9.363 ENSMUST00000042603.6
 Inhba
inhibin beta-A
chr1_-_71653162 8.833 ENSMUST00000055226.6
 Fn1
fibronectin 1
chr3_+_123446913 8.606 ENSMUST00000029603.8
 Prss12
protease, serine, 12 neurotrypsin (motopsin)
chr18_-_36726730 8.238 ENSMUST00000061829.6
 Cd14
CD14 antigen
chr1_-_191183244 8.201 ENSMUST00000027941.8
 Atf3
activating transcription factor 3
chr19_+_6401675 8.154 ENSMUST00000113471.1
ENSMUST00000113469.2
 Rasgrp2

RAS, guanyl releasing protein 2

chr12_+_74297474 8.017 ENSMUST00000072100.3
 Dbpht2
DNA binding protein with his-thr domain
chr15_-_37458523 7.818 ENSMUST00000116445.2
 Ncald
neurocalcin delta

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
8.8 26.3 GO:0002586 positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588) detection of peptidoglycan(GO:0032499)
3.8 22.7 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.2 18.3 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.2 13.2 GO:0030032 lamellipodium assembly(GO:0030032)
1.2 10.7 GO:0043615 astrocyte cell migration(GO:0043615)
0.2 10.1 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
1.4 9.9 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
2.4 9.5 GO:1904706 heme oxidation(GO:0006788) negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
1.9 9.4 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
2.9 8.8 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931) calcium-independent cell-matrix adhesion(GO:0007161) transforming growth factor-beta secretion(GO:0038044)
0.1 8.6 GO:0031638 zymogen activation(GO:0031638)
2.1 8.2 GO:0071220 response to bacterial lipopeptide(GO:0070339) cellular response to bacterial lipoprotein(GO:0071220) cellular response to bacterial lipopeptide(GO:0071221) response to diacyl bacterial lipopeptide(GO:0071724) cellular response to diacyl bacterial lipopeptide(GO:0071726)
2.1 8.2 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.0 8.2 GO:0043547 positive regulation of GTPase activity(GO:0043547)
2.4 7.3 GO:0032430 positive regulation of phospholipase A2 activity(GO:0032430)
0.8 7.3 GO:0044539 long-chain fatty acid import(GO:0044539)
0.2 7.3 GO:0071353 cellular response to interleukin-4(GO:0071353)
1.4 7.2 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
1.0 7.2 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.5 7.0 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.2 22.7 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.1 11.4 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 10.8 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
3.3 9.8 GO:0005577 fibrinogen complex(GO:0005577)
0.1 9.5 GO:0005901 caveola(GO:0005901)
3.1 9.4 GO:0043512 inhibin A complex(GO:0043512)
0.6 8.6 GO:0043083 synaptic cleft(GO:0043083)
0.1 8.4 GO:0009925 basal plasma membrane(GO:0009925)
1.4 8.2 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 7.7 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.4 7.5 GO:0098644 complex of collagen trimers(GO:0098644)
2.4 7.3 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.2 7.0 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 6.8 GO:0005902 microvillus(GO:0005902)
1.2 6.1 GO:0001533 cornified envelope(GO:0001533)
1.2 5.8 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.7 4.9 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 4.9 GO:0005925 focal adhesion(GO:0005925)
0.1 4.6 GO:0005581 collagen trimer(GO:0005581)
0.3 4.5 GO:0043203 axon hillock(GO:0043203)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 87 entries
Log-likelihood per target Total log-likelihoodTermDescription
8.9 35.6 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.9 22.7 GO:0051787 misfolded protein binding(GO:0051787)
0.6 18.3 GO:0043014 alpha-tubulin binding(GO:0043014)
0.2 11.7 GO:0005518 collagen binding(GO:0005518)
0.1 11.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.4 10.7 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 10.1 GO:0005096 GTPase activator activity(GO:0005096)
2.5 9.9 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
2.4 9.5 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
1.6 9.4 GO:0070699 type II activin receptor binding(GO:0070699)
1.5 8.8 GO:0045340 mercury ion binding(GO:0045340)
0.4 8.6 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 8.2 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
2.4 7.3 GO:0043758 acetate-CoA ligase (ADP-forming) activity(GO:0043758)
0.2 7.3 GO:0005507 copper ion binding(GO:0005507)
1.8 7.2 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
1.4 6.8 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.5 6.3 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 6.2 GO:0005509 calcium ion binding(GO:0005509)
0.2 6.0 GO:0042287 MHC protein binding(GO:0042287)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 19.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.5 17.0 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.2 14.6 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.3 13.9 PID_IL12_2PATHWAY IL12-mediated signaling events
0.2 9.9 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.3 9.7 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.2 9.5 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.3 9.4 PID_ALK1_PATHWAY ALK1 signaling events
0.3 9.3 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.5 8.8 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2 7.9 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.3 6.8 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.6 6.3 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 6.1 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 4.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 4.2 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 2.9 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway
0.0 2.6 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.2 1.8 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 1.8 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 30.0 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
1.0 26.3 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.2 17.1 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 16.9 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.5 14.7 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.8 14.4 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.5 12.0 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.3 11.8 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.4 10.7 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.3 9.9 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
2.3 9.4 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.8 9.3 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.3 8.2 REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING Genes involved in Integrin alphaIIb beta3 signaling
0.5 7.5 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.3 7.3 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.1 6.8 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction
0.3 6.6 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.2 6.3 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.1 6.2 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.6 5.8 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle