Motif ID: Cenpb
Z-value: 1.285
Transcription factors associated with Cenpb:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Cenpb | ENSMUSG00000068267.4 | Cenpb |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Cenpb | mm10_v2_chr2_-_131179985_131180092 | -0.34 | 2.5e-03 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.4 | 22.2 | GO:0060598 | dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598) |
| 2.1 | 10.4 | GO:0035262 | gonad morphogenesis(GO:0035262) |
| 1.2 | 3.6 | GO:0036388 | pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) DNA replication preinitiation complex assembly(GO:0071163) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299) |
| 1.1 | 2.2 | GO:0072076 | nephrogenic mesenchyme development(GO:0072076) |
| 1.0 | 3.0 | GO:0098974 | postsynaptic actin cytoskeleton organization(GO:0098974) |
| 1.0 | 4.0 | GO:2000546 | positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546) |
| 1.0 | 3.0 | GO:0032474 | otolith morphogenesis(GO:0032474) |
| 0.9 | 6.2 | GO:1903715 | regulation of aerobic respiration(GO:1903715) |
| 0.9 | 2.6 | GO:0001978 | regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978) |
| 0.9 | 2.6 | GO:0003219 | atrioventricular node development(GO:0003162) cardiac right ventricle formation(GO:0003219) |
| 0.9 | 3.5 | GO:0055099 | response to high density lipoprotein particle(GO:0055099) |
| 0.8 | 2.5 | GO:2000620 | positive regulation of histone H4-K16 acetylation(GO:2000620) |
| 0.8 | 4.1 | GO:0060266 | negative regulation of respiratory burst involved in inflammatory response(GO:0060266) |
| 0.8 | 6.5 | GO:0035542 | regulation of SNARE complex assembly(GO:0035542) |
| 0.8 | 3.3 | GO:0010940 | positive regulation of necrotic cell death(GO:0010940) |
| 0.8 | 2.3 | GO:1903334 | positive regulation of protein folding(GO:1903334) |
| 0.8 | 2.3 | GO:0051105 | regulation of DNA ligation(GO:0051105) positive regulation of DNA ligation(GO:0051106) |
| 0.7 | 7.0 | GO:1903298 | regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903297) negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903298) |
| 0.7 | 6.3 | GO:0090267 | positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) |
| 0.7 | 1.4 | GO:0042726 | flavin-containing compound metabolic process(GO:0042726) |
| 0.7 | 2.0 | GO:0002669 | positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913) |
| 0.6 | 1.8 | GO:1903630 | regulation of aminoacyl-tRNA ligase activity(GO:1903630) positive regulation of aminoacyl-tRNA ligase activity(GO:1903632) regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435) |
| 0.6 | 0.6 | GO:2000830 | vacuolar phosphate transport(GO:0007037) vitamin D3 metabolic process(GO:0070640) positive regulation of parathyroid hormone secretion(GO:2000830) |
| 0.5 | 1.5 | GO:0000720 | pyrimidine dimer repair by nucleotide-excision repair(GO:0000720) |
| 0.5 | 2.5 | GO:0060242 | contact inhibition(GO:0060242) |
| 0.5 | 1.9 | GO:0044330 | canonical Wnt signaling pathway involved in positive regulation of wound healing(GO:0044330) lactic acid secretion(GO:0046722) regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096) |
| 0.5 | 6.4 | GO:0060052 | neurofilament cytoskeleton organization(GO:0060052) |
| 0.4 | 4.1 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
| 0.4 | 7.9 | GO:0042711 | maternal behavior(GO:0042711) |
| 0.4 | 1.2 | GO:2000850 | protein-chromophore linkage(GO:0018298) negative regulation of corticosteroid hormone secretion(GO:2000847) negative regulation of glucocorticoid secretion(GO:2000850) |
| 0.4 | 2.5 | GO:2001225 | cellular hypotonic response(GO:0071476) regulation of chloride transport(GO:2001225) |
| 0.3 | 1.3 | GO:1903237 | negative regulation of leukocyte tethering or rolling(GO:1903237) |
| 0.3 | 1.3 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 0.3 | 2.9 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.3 | 1.6 | GO:0070459 | prolactin secretion(GO:0070459) |
| 0.3 | 1.6 | GO:2001184 | regulation of interleukin-12 secretion(GO:2001182) positive regulation of interleukin-12 secretion(GO:2001184) |
| 0.3 | 3.4 | GO:0070445 | oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445) |
| 0.3 | 15.4 | GO:0070303 | negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303) |
| 0.2 | 4.2 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.2 | 1.2 | GO:0014022 | neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007) |
| 0.2 | 1.8 | GO:0006975 | DNA damage induced protein phosphorylation(GO:0006975) |
| 0.2 | 1.1 | GO:0007603 | phototransduction, visible light(GO:0007603) |
| 0.2 | 0.9 | GO:0015744 | succinate transport(GO:0015744) |
| 0.2 | 2.9 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
| 0.2 | 0.8 | GO:0060741 | prostate gland stromal morphogenesis(GO:0060741) |
| 0.2 | 0.6 | GO:0002572 | pro-T cell differentiation(GO:0002572) ureter maturation(GO:0035799) cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) regulation of DNA demethylation(GO:1901535) negative regulation of DNA demethylation(GO:1901536) |
| 0.2 | 3.6 | GO:0045653 | negative regulation of megakaryocyte differentiation(GO:0045653) |
| 0.2 | 0.7 | GO:0019087 | transformation of host cell by virus(GO:0019087) |
| 0.2 | 0.6 | GO:0033615 | mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615) |
| 0.2 | 3.7 | GO:0006999 | nuclear pore organization(GO:0006999) |
| 0.2 | 1.3 | GO:0048793 | pronephros development(GO:0048793) |
| 0.2 | 2.0 | GO:2000628 | regulation of miRNA metabolic process(GO:2000628) |
| 0.2 | 0.7 | GO:0061623 | glycolytic process from galactose(GO:0061623) |
| 0.2 | 0.3 | GO:2001206 | positive regulation of osteoclast development(GO:2001206) |
| 0.2 | 6.6 | GO:0030513 | positive regulation of BMP signaling pathway(GO:0030513) |
| 0.2 | 6.2 | GO:0006879 | cellular iron ion homeostasis(GO:0006879) |
| 0.2 | 2.0 | GO:0031274 | positive regulation of pseudopodium assembly(GO:0031274) |
| 0.2 | 2.8 | GO:0016226 | iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163) |
| 0.2 | 0.8 | GO:0030397 | membrane disassembly(GO:0030397) nuclear envelope disassembly(GO:0051081) positive regulation of microtubule nucleation(GO:0090063) |
| 0.1 | 0.6 | GO:0002035 | brain renin-angiotensin system(GO:0002035) positive regulation of arachidonic acid secretion(GO:0090238) |
| 0.1 | 2.7 | GO:0022027 | interkinetic nuclear migration(GO:0022027) |
| 0.1 | 2.4 | GO:1902187 | negative regulation of viral release from host cell(GO:1902187) |
| 0.1 | 1.6 | GO:0006995 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 0.1 | 1.1 | GO:0010815 | bradykinin catabolic process(GO:0010815) |
| 0.1 | 1.3 | GO:0042135 | neurotransmitter catabolic process(GO:0042135) |
| 0.1 | 2.0 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
| 0.1 | 1.8 | GO:0016973 | poly(A)+ mRNA export from nucleus(GO:0016973) |
| 0.1 | 2.1 | GO:0032515 | negative regulation of phosphoprotein phosphatase activity(GO:0032515) |
| 0.1 | 6.6 | GO:0005978 | glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250) |
| 0.1 | 1.5 | GO:1900119 | positive regulation of execution phase of apoptosis(GO:1900119) |
| 0.1 | 0.4 | GO:0097494 | regulation of vesicle size(GO:0097494) |
| 0.1 | 3.3 | GO:0097320 | membrane tubulation(GO:0097320) |
| 0.1 | 1.1 | GO:0033089 | positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400) |
| 0.1 | 2.9 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.1 | 1.5 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.1 | 0.3 | GO:0031038 | meiotic chromosome movement towards spindle pole(GO:0016344) myosin II filament organization(GO:0031038) regulation of myosin II filament organization(GO:0043519) regulation of bleb assembly(GO:1904170) |
| 0.1 | 1.0 | GO:0021942 | radial glia guided migration of Purkinje cell(GO:0021942) |
| 0.1 | 1.1 | GO:0034244 | negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244) positive regulation of histone H3-K4 methylation(GO:0051571) |
| 0.1 | 1.2 | GO:0071712 | ER-associated misfolded protein catabolic process(GO:0071712) |
| 0.1 | 0.9 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
| 0.1 | 1.8 | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205) |
| 0.1 | 0.5 | GO:0046600 | negative regulation of centriole replication(GO:0046600) |
| 0.1 | 1.3 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.1 | 0.6 | GO:0010764 | negative regulation of fibroblast migration(GO:0010764) negative regulation of cytokine production involved in inflammatory response(GO:1900016) |
| 0.1 | 0.8 | GO:0006228 | UTP biosynthetic process(GO:0006228) |
| 0.1 | 0.4 | GO:0051697 | protein delipidation(GO:0051697) |
| 0.1 | 1.0 | GO:0010216 | maintenance of DNA methylation(GO:0010216) |
| 0.1 | 0.5 | GO:0006348 | chromatin silencing at telomere(GO:0006348) |
| 0.1 | 0.4 | GO:0031053 | primary miRNA processing(GO:0031053) |
| 0.1 | 1.5 | GO:0097150 | neuronal stem cell population maintenance(GO:0097150) |
| 0.1 | 0.3 | GO:1904751 | positive regulation of protein localization to nucleolus(GO:1904751) |
| 0.1 | 0.4 | GO:1903690 | astral microtubule organization(GO:0030953) negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 0.1 | 0.2 | GO:0070343 | white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350) |
| 0.1 | 0.2 | GO:2000189 | fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540) positive regulation of cholesterol homeostasis(GO:2000189) |
| 0.1 | 1.4 | GO:0044342 | type B pancreatic cell proliferation(GO:0044342) |
| 0.1 | 2.3 | GO:0001947 | heart looping(GO:0001947) |
| 0.1 | 2.5 | GO:2001222 | regulation of neuron migration(GO:2001222) |
| 0.1 | 3.9 | GO:0007043 | cell-cell junction assembly(GO:0007043) |
| 0.1 | 2.9 | GO:0009060 | aerobic respiration(GO:0009060) |
| 0.1 | 3.3 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) |
| 0.0 | 0.5 | GO:0048742 | regulation of skeletal muscle fiber development(GO:0048742) |
| 0.0 | 0.5 | GO:0031936 | negative regulation of chromatin silencing(GO:0031936) |
| 0.0 | 2.9 | GO:0032543 | mitochondrial translation(GO:0032543) |
| 0.0 | 0.7 | GO:2000114 | regulation of establishment of cell polarity(GO:2000114) |
| 0.0 | 0.7 | GO:2000251 | positive regulation of actin cytoskeleton reorganization(GO:2000251) |
| 0.0 | 0.3 | GO:0016242 | negative regulation of macroautophagy(GO:0016242) |
| 0.0 | 2.3 | GO:0048015 | phosphatidylinositol-mediated signaling(GO:0048015) inositol lipid-mediated signaling(GO:0048017) |
| 0.0 | 1.2 | GO:0061157 | mRNA destabilization(GO:0061157) |
| 0.0 | 0.3 | GO:2000507 | positive regulation of energy homeostasis(GO:2000507) |
| 0.0 | 2.8 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.0 | 1.3 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 0.0 | 3.7 | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway(GO:2001237) |
| 0.0 | 0.4 | GO:0010667 | negative regulation of cardiac muscle cell apoptotic process(GO:0010667) |
| 0.0 | 0.9 | GO:0051123 | RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123) |
| 0.0 | 0.8 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.0 | 0.2 | GO:0061002 | negative regulation of dendritic spine morphogenesis(GO:0061002) |
| 0.0 | 0.1 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 0.0 | 2.1 | GO:0072164 | ureteric bud development(GO:0001657) mesonephric epithelium development(GO:0072163) mesonephric tubule development(GO:0072164) |
| 0.0 | 0.6 | GO:1903077 | negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376) |
| 0.0 | 0.9 | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184) |
| 0.0 | 0.1 | GO:0046133 | pyrimidine ribonucleoside catabolic process(GO:0046133) |
| 0.0 | 2.1 | GO:0043484 | regulation of RNA splicing(GO:0043484) |
| 0.0 | 0.2 | GO:2000786 | positive regulation of autophagosome assembly(GO:2000786) |
| 0.0 | 0.4 | GO:0009299 | mRNA transcription(GO:0009299) |
| 0.0 | 0.0 | GO:0006407 | rRNA export from nucleus(GO:0006407) |
| 0.0 | 1.1 | GO:0006635 | fatty acid beta-oxidation(GO:0006635) |
| 0.0 | 0.2 | GO:1902231 | positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231) |
| 0.0 | 0.9 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
| 0.0 | 0.6 | GO:0033045 | regulation of sister chromatid segregation(GO:0033045) |
| 0.0 | 3.9 | GO:0007283 | spermatogenesis(GO:0007283) |
| 0.0 | 0.1 | GO:0007099 | centriole replication(GO:0007099) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 3.6 | GO:0036387 | nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387) |
| 1.1 | 4.6 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.8 | 2.5 | GO:0071149 | TEAD-2-YAP complex(GO:0071149) |
| 0.8 | 7.1 | GO:0005883 | neurofilament(GO:0005883) |
| 0.7 | 9.4 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.6 | 2.8 | GO:0097361 | CIA complex(GO:0097361) |
| 0.5 | 2.6 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
| 0.5 | 9.2 | GO:0000145 | exocyst(GO:0000145) |
| 0.3 | 1.1 | GO:0031983 | vesicle lumen(GO:0031983) |
| 0.3 | 1.1 | GO:0032021 | NELF complex(GO:0032021) |
| 0.2 | 0.7 | GO:0005899 | insulin receptor complex(GO:0005899) |
| 0.2 | 3.1 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.2 | 4.1 | GO:0097470 | ribbon synapse(GO:0097470) |
| 0.2 | 2.9 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.2 | 2.9 | GO:0042555 | MCM complex(GO:0042555) |
| 0.2 | 5.8 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.2 | 3.5 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.1 | 0.9 | GO:0097504 | Gemini of coiled bodies(GO:0097504) |
| 0.1 | 0.9 | GO:0070847 | core mediator complex(GO:0070847) |
| 0.1 | 3.3 | GO:0030137 | COPI-coated vesicle(GO:0030137) |
| 0.1 | 2.3 | GO:0000800 | lateral element(GO:0000800) |
| 0.1 | 3.0 | GO:0043189 | NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562) |
| 0.1 | 10.1 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.1 | 1.8 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.1 | 3.6 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.1 | 1.8 | GO:0000346 | transcription export complex(GO:0000346) |
| 0.1 | 1.1 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.1 | 0.9 | GO:0036157 | outer dynein arm(GO:0036157) |
| 0.1 | 2.2 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.1 | 0.4 | GO:0030981 | cortical microtubule cytoskeleton(GO:0030981) |
| 0.1 | 2.9 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.1 | 1.2 | GO:0036513 | Derlin-1 retrotranslocation complex(GO:0036513) |
| 0.1 | 0.4 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.1 | 0.8 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.1 | 0.6 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 0.1 | 1.1 | GO:0005686 | U2 snRNP(GO:0005686) |
| 0.1 | 3.0 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.0 | 6.2 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 4.5 | GO:0016234 | inclusion body(GO:0016234) |
| 0.0 | 2.5 | GO:0000791 | euchromatin(GO:0000791) |
| 0.0 | 0.3 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.0 | 0.5 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.0 | 1.3 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 0.7 | GO:0033276 | transcription factor TFTC complex(GO:0033276) |
| 0.0 | 0.1 | GO:0020018 | ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018) |
| 0.0 | 3.1 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 0.0 | 0.7 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.0 | 0.3 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.0 | 2.6 | GO:0030315 | T-tubule(GO:0030315) |
| 0.0 | 3.3 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 1.8 | GO:0005657 | replication fork(GO:0005657) |
| 0.0 | 1.9 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 1.7 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 2.6 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 0.3 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.0 | 3.5 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 0.1 | GO:0098536 | deuterosome(GO:0098536) |
| 0.0 | 0.6 | GO:0035869 | ciliary transition zone(GO:0035869) |
| 0.0 | 4.5 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 1.1 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 0.6 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 0.4 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 4.0 | GO:0005105 | type 1 fibroblast growth factor receptor binding(GO:0005105) |
| 1.2 | 3.5 | GO:0034437 | glycoprotein transporter activity(GO:0034437) |
| 1.0 | 3.0 | GO:0098973 | structural constituent of synapse(GO:0098918) structural constituent of postsynaptic actin cytoskeleton(GO:0098973) |
| 0.9 | 2.6 | GO:0004936 | alpha-adrenergic receptor activity(GO:0004936) |
| 0.7 | 6.6 | GO:0035251 | UDP-glucosyltransferase activity(GO:0035251) |
| 0.6 | 2.5 | GO:0004692 | cGMP-dependent protein kinase activity(GO:0004692) |
| 0.6 | 1.8 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
| 0.6 | 4.2 | GO:0048101 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.6 | 9.9 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.6 | 2.3 | GO:0046920 | alpha-(1->3)-fucosyltransferase activity(GO:0046920) |
| 0.5 | 3.2 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.5 | 4.1 | GO:0016618 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
| 0.5 | 4.6 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.5 | 1.5 | GO:0004140 | dephospho-CoA kinase activity(GO:0004140) |
| 0.4 | 3.1 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 0.4 | 1.2 | GO:0009881 | photoreceptor activity(GO:0009881) |
| 0.3 | 1.3 | GO:0031735 | CCR10 chemokine receptor binding(GO:0031735) |
| 0.3 | 2.3 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.3 | 4.1 | GO:0048273 | mitogen-activated protein kinase p38 binding(GO:0048273) |
| 0.3 | 0.9 | GO:0015140 | malate transmembrane transporter activity(GO:0015140) |
| 0.3 | 1.4 | GO:0004165 | dodecenoyl-CoA delta-isomerase activity(GO:0004165) |
| 0.3 | 3.6 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.3 | 1.8 | GO:1990948 | ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948) |
| 0.2 | 0.7 | GO:0051425 | PTB domain binding(GO:0051425) |
| 0.2 | 0.7 | GO:0005128 | erythropoietin receptor binding(GO:0005128) |
| 0.2 | 22.2 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
| 0.2 | 2.2 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.2 | 1.3 | GO:0008242 | omega peptidase activity(GO:0008242) |
| 0.2 | 3.4 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.2 | 1.9 | GO:0015037 | peptide disulfide oxidoreductase activity(GO:0015037) |
| 0.2 | 2.3 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.2 | 3.7 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.1 | 1.9 | GO:0004576 | oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.1 | 2.0 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.1 | 0.8 | GO:0016300 | tRNA (uracil) methyltransferase activity(GO:0016300) |
| 0.1 | 0.8 | GO:1901612 | phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612) |
| 0.1 | 0.6 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 0.1 | 2.0 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.1 | 1.3 | GO:0043495 | protein anchor(GO:0043495) |
| 0.1 | 1.1 | GO:0047391 | alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391) |
| 0.1 | 2.9 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.1 | 2.2 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.1 | 2.5 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.1 | 1.6 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.1 | 0.4 | GO:0004719 | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719) |
| 0.1 | 0.3 | GO:0016971 | flavin-linked sulfhydryl oxidase activity(GO:0016971) |
| 0.1 | 1.3 | GO:0070403 | NAD+ binding(GO:0070403) |
| 0.1 | 3.2 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.1 | 2.7 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 0.1 | 0.6 | GO:0016863 | intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863) |
| 0.1 | 0.6 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
| 0.1 | 0.4 | GO:0043515 | kinetochore binding(GO:0043515) |
| 0.1 | 2.6 | GO:0005112 | Notch binding(GO:0005112) |
| 0.1 | 1.5 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.1 | 0.6 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.1 | 1.2 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
| 0.1 | 0.4 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 0.1 | 1.1 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 0.1 | 0.3 | GO:0019841 | retinol binding(GO:0019841) |
| 0.1 | 2.6 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 2.0 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.1 | 0.2 | GO:0016309 | 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309) |
| 0.1 | 0.9 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.1 | 1.2 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.0 | 1.9 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 0.6 | GO:0015299 | solute:proton antiporter activity(GO:0015299) |
| 0.0 | 1.3 | GO:0000149 | SNARE binding(GO:0000149) |
| 0.0 | 0.4 | GO:0031685 | adenosine receptor binding(GO:0031685) |
| 0.0 | 0.2 | GO:0035514 | DNA demethylase activity(GO:0035514) oxidative RNA demethylase activity(GO:0035515) |
| 0.0 | 0.7 | GO:0016857 | racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857) |
| 0.0 | 0.9 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.0 | 1.9 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 0.2 | GO:0016401 | palmitoyl-CoA oxidase activity(GO:0016401) |
| 0.0 | 0.3 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
| 0.0 | 0.8 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.0 | 1.6 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.0 | 1.1 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.0 | 0.8 | GO:0070840 | dynein complex binding(GO:0070840) |
| 0.0 | 0.1 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
| 0.0 | 0.2 | GO:0035033 | histone deacetylase regulator activity(GO:0035033) |
| 0.0 | 1.1 | GO:0030145 | manganese ion binding(GO:0030145) |
| 0.0 | 0.3 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.0 | 1.3 | GO:0043022 | ribosome binding(GO:0043022) |
| 0.0 | 2.4 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.0 | 0.9 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) |
| 0.0 | 4.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 1.8 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 4.9 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.0 | 0.4 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 0.4 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
| 0.0 | 6.2 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
| 0.0 | 0.9 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.0 | 0.5 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 3.7 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.0 | 0.5 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
| 0.0 | 3.0 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 20.4 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.3 | 1.8 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.2 | 7.4 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
| 0.2 | 2.2 | PID_ALK2_PATHWAY | ALK2 signaling events |
| 0.2 | 5.9 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 1.8 | ST_INTERFERON_GAMMA_PATHWAY | Interferon gamma pathway. |
| 0.2 | 3.2 | PID_PDGFRA_PATHWAY | PDGFR-alpha signaling pathway |
| 0.1 | 5.5 | PID_CD40_PATHWAY | CD40/CD40L signaling |
| 0.1 | 6.3 | PID_ERBB4_PATHWAY | ErbB4 signaling events |
| 0.1 | 4.1 | PID_P38_ALPHA_BETA_PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.1 | 1.1 | PID_RHODOPSIN_PATHWAY | Visual signal transduction: Rods |
| 0.1 | 3.5 | PID_ATR_PATHWAY | ATR signaling pathway |
| 0.1 | 4.5 | PID_FGF_PATHWAY | FGF signaling pathway |
| 0.1 | 1.2 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
| 0.1 | 7.2 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.1 | 2.1 | PID_AURORA_A_PATHWAY | Aurora A signaling |
| 0.0 | 2.8 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.0 | 1.1 | ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.0 | 0.8 | PID_NCADHERIN_PATHWAY | N-cadherin signaling events |
| 0.0 | 2.9 | PID_NOTCH_PATHWAY | Notch signaling pathway |
| 0.0 | 1.3 | PID_IL4_2PATHWAY | IL4-mediated signaling events |
| 0.0 | 2.5 | PID_MTOR_4PATHWAY | mTOR signaling pathway |
| 0.0 | 1.8 | PID_P53_REGULATION_PATHWAY | p53 pathway |
| 0.0 | 2.6 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 0.6 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 0.2 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.0 | 0.2 | PID_ERBB2_ERBB3_PATHWAY | ErbB2/ErbB3 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 4.5 | REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR4 ligand binding and activation |
| 0.4 | 6.4 | REACTOME_UNWINDING_OF_DNA | Genes involved in Unwinding of DNA |
| 0.3 | 6.3 | REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 0.3 | 3.5 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.2 | 1.1 | REACTOME_OLFACTORY_SIGNALING_PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.2 | 3.0 | REACTOME_SIGNALING_BY_EGFR_IN_CANCER | Genes involved in Signaling by EGFR in Cancer |
| 0.2 | 2.6 | REACTOME_AMINE_LIGAND_BINDING_RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.2 | 1.8 | REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.2 | 3.6 | REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP | Genes involved in Destabilization of mRNA by KSRP |
| 0.2 | 2.5 | REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.2 | 3.1 | REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.1 | 2.3 | REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.1 | 7.8 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 3.1 | REACTOME_SULFUR_AMINO_ACID_METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 3.9 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 3.7 | REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.1 | 1.5 | REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.1 | 3.6 | REACTOME_PACKAGING_OF_TELOMERE_ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.1 | 3.0 | REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
| 0.1 | 1.4 | REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.1 | 2.5 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.1 | 1.9 | REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_ | Genes involved in Cyclin E associated events during G1/S transition |
| 0.1 | 4.1 | REACTOME_ER_PHAGOSOME_PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.1 | 2.3 | REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.1 | 5.0 | REACTOME_GLUCOSE_METABOLISM | Genes involved in Glucose metabolism |
| 0.1 | 2.0 | REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.1 | 0.7 | REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.1 | 1.3 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 0.7 | REACTOME_SIGNAL_ATTENUATION | Genes involved in Signal attenuation |
| 0.0 | 1.3 | REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 0.0 | 1.4 | REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 0.9 | REACTOME_METABOLISM_OF_NON_CODING_RNA | Genes involved in Metabolism of non-coding RNA |
| 0.0 | 3.7 | REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.0 | 1.1 | REACTOME_MRNA_SPLICING_MINOR_PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.0 | 0.9 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
| 0.0 | 0.5 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 0.9 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
