Motif ID: Cenpb

Z-value: 1.285


Transcription factors associated with Cenpb:

Gene SymbolEntrez IDGene Name
Cenpb ENSMUSG00000068267.4 Cenpb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Cenpbmm10_v2_chr2_-_131179985_131180092-0.342.5e-03Click!


Activity profile for motif Cenpb.

activity profile for motif Cenpb


Sorted Z-values histogram for motif Cenpb

Sorted Z-values for motif Cenpb



Network of associatons between targets according to the STRING database.



First level regulatory network of Cenpb

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_98662227 71.608 ENSMUST00000099684.3
 Gm10801
predicted gene 10801
chr2_+_172550991 22.240 ENSMUST00000170744.1
 Tfap2c
transcription factor AP-2, gamma
chr1_-_138848576 10.405 ENSMUST00000112030.2
 Lhx9
LIM homeobox protein 9
chr8_-_87959560 9.763 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr7_-_137314394 9.551 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr14_+_65805832 8.538 ENSMUST00000022612.3
 Pbk
PDZ binding kinase
chr4_-_68954351 7.857 ENSMUST00000030036.5
 Brinp1
bone morphogenic protein/retinoic acid inducible neural specific 1
chr10_+_50895651 7.059 ENSMUST00000020071.3
 Sim1
single-minded homolog 1 (Drosophila)
chr19_+_47014672 7.059 ENSMUST00000037636.3
 Ina
internexin neuronal intermediate filament protein, alpha
chr14_+_65806066 6.979 ENSMUST00000139644.1
 Pbk
PDZ binding kinase
chr16_-_17125106 6.372 ENSMUST00000093336.6
 2610318N02Rik
RIKEN cDNA 2610318N02 gene
chr6_+_66535418 6.317 ENSMUST00000101343.1
 Mad2l1
MAD2 mitotic arrest deficient-like 1
chr8_-_122678653 6.198 ENSMUST00000134045.1
 Cbfa2t3
core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)
chr4_-_119232661 6.168 ENSMUST00000141112.1
 AU022252
expressed sequence AU022252
chr17_+_87282880 6.167 ENSMUST00000041110.5
ENSMUST00000125875.1
 Ttc7

tetratricopeptide repeat domain 7

chr11_-_4746778 5.548 ENSMUST00000009219.2
 Cabp7
calcium binding protein 7
chr10_+_67979709 4.969 ENSMUST00000117086.1
 Rtkn2
rhotekin 2
chr12_-_45074112 4.937 ENSMUST00000120531.1
ENSMUST00000143376.1
 Stxbp6

syntaxin binding protein 6 (amisyn)

chr16_+_81200697 4.764 ENSMUST00000067602.3
ENSMUST00000037785.7
 Ncam2

neural cell adhesion molecule 2

chr11_+_101316917 4.552 ENSMUST00000151385.1
 Psme3
proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 131 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.4 22.2 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.3 15.4 GO:0070303 negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303)
2.1 10.4 GO:0035262 gonad morphogenesis(GO:0035262)
0.4 7.9 GO:0042711 maternal behavior(GO:0042711)
0.7 7.0 GO:1903298 regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903297) negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903298)
0.2 6.6 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.1 6.6 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.8 6.5 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.5 6.4 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.7 6.3 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.9 6.2 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.2 6.2 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.2 4.2 GO:0046069 cGMP catabolic process(GO:0046069)
0.8 4.1 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.4 4.1 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
1.0 4.0 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.1 3.9 GO:0007043 cell-cell junction assembly(GO:0007043)
0.0 3.9 GO:0007283 spermatogenesis(GO:0007283)
0.2 3.7 GO:0006999 nuclear pore organization(GO:0006999)
0.0 3.7 GO:2001237 negative regulation of extrinsic apoptotic signaling pathway(GO:2001237)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.1 GO:0005643 nuclear pore(GO:0005643)
0.7 9.4 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.5 9.2 GO:0000145 exocyst(GO:0000145)
0.8 7.1 GO:0005883 neurofilament(GO:0005883)
0.0 6.2 GO:0031225 anchored component of membrane(GO:0031225)
0.2 5.8 GO:0032588 trans-Golgi network membrane(GO:0032588)
1.1 4.6 GO:0008537 proteasome activator complex(GO:0008537)
0.0 4.5 GO:0016234 inclusion body(GO:0016234)
0.0 4.5 GO:0016607 nuclear speck(GO:0016607)
0.2 4.1 GO:0097470 ribbon synapse(GO:0097470)
1.2 3.6 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.1 3.6 GO:0000788 nuclear nucleosome(GO:0000788)
0.2 3.5 GO:0000421 autophagosome membrane(GO:0000421)
0.0 3.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 3.3 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 3.3 GO:0005913 cell-cell adherens junction(GO:0005913)
0.2 3.1 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 3.1 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.1 3.0 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.1 3.0 GO:0005876 spindle microtubule(GO:0005876)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 22.2 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.6 9.9 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.7 6.6 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 6.2 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.0 4.9 GO:0003682 chromatin binding(GO:0003682)
0.5 4.6 GO:0061133 endopeptidase activator activity(GO:0061133)
0.6 4.2 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.5 4.1 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.3 4.1 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.0 4.1 GO:0003735 structural constituent of ribosome(GO:0003735)
1.3 4.0 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.2 3.7 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 3.7 GO:0005198 structural molecule activity(GO:0005198)
0.3 3.6 GO:0003688 DNA replication origin binding(GO:0003688)
1.2 3.5 GO:0034437 glycoprotein transporter activity(GO:0034437)
0.2 3.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.5 3.2 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 3.2 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.4 3.1 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
1.0 3.0 GO:0098973 structural constituent of synapse(GO:0098918) structural constituent of postsynaptic actin cytoskeleton(GO:0098973)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 20.4 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.2 7.4 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 7.2 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 6.3 PID_ERBB4_PATHWAY ErbB4 signaling events
0.2 5.9 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 5.5 PID_CD40_PATHWAY CD40/CD40L signaling
0.1 4.5 PID_FGF_PATHWAY FGF signaling pathway
0.1 4.1 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.1 3.5 PID_ATR_PATHWAY ATR signaling pathway
0.2 3.2 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 2.9 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 2.8 PID_LKB1_PATHWAY LKB1 signaling events
0.0 2.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.5 PID_MTOR_4PATHWAY mTOR signaling pathway
0.2 2.2 PID_ALK2_PATHWAY ALK2 signaling events
0.1 2.1 PID_AURORA_A_PATHWAY Aurora A signaling
0.3 1.8 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 1.8 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.0 1.8 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 1.3 PID_IL4_2PATHWAY IL4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.8 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.4 6.4 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.3 6.3 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.1 5.0 REACTOME_GLUCOSE_METABOLISM Genes involved in Glucose metabolism
0.6 4.5 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 4.1 REACTOME_ER_PHAGOSOME_PATHWAY Genes involved in ER-Phagosome pathway
0.1 3.9 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 3.7 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 3.7 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.2 3.6 REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP Genes involved in Destabilization of mRNA by KSRP
0.1 3.6 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.3 3.5 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.2 3.1 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 3.1 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.2 3.0 REACTOME_SIGNALING_BY_EGFR_IN_CANCER Genes involved in Signaling by EGFR in Cancer
0.1 3.0 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.2 2.6 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.2 2.5 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1 2.5 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 2.3 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks