Motif ID: Chd1_Pml

Z-value: 4.114

Transcription factors associated with Chd1_Pml:

Gene SymbolEntrez IDGene Name
Chd1 ENSMUSG00000023852.7 Chd1
Pml ENSMUSG00000036986.10 Pml

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pmlmm10_v2_chr9_-_58249660_58249672-0.561.6e-07Click!
Chd1mm10_v2_chr17_+_15704963_157049940.342.2e-03Click!


Activity profile for motif Chd1_Pml.

activity profile for motif Chd1_Pml


Sorted Z-values histogram for motif Chd1_Pml

Sorted Z-values for motif Chd1_Pml



Network of associatons between targets according to the STRING database.



First level regulatory network of Chd1_Pml

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_36698002 59.523 ENSMUST00000021641.6
 Tshz3
teashirt zinc finger family member 3
chr14_-_39472825 56.644 ENSMUST00000168810.2
ENSMUST00000173780.1
ENSMUST00000166968.2
 Nrg3


neuregulin 3


chr16_-_67620880 42.498 ENSMUST00000114292.1
ENSMUST00000120898.1
 Cadm2

cell adhesion molecule 2

chr7_+_123982799 40.907 ENSMUST00000106437.1
 Hs3st4
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr7_-_74554474 38.866 ENSMUST00000134539.1
ENSMUST00000026897.7
ENSMUST00000098371.2
 Slco3a1


solute carrier organic anion transporter family, member 3a1


chr6_-_148444336 36.360 ENSMUST00000060095.8
ENSMUST00000100772.3
 Tmtc1

transmembrane and tetratricopeptide repeat containing 1

chr16_-_67620805 35.409 ENSMUST00000120594.1
 Cadm2
cell adhesion molecule 2
chrX_-_162643575 34.178 ENSMUST00000101102.1
 Reps2
RALBP1 associated Eps domain containing protein 2
chr13_-_107890059 34.004 ENSMUST00000105097.2
 Zswim6
zinc finger SWIM-type containing 6
chr1_-_3671498 33.492 ENSMUST00000070533.4
 Xkr4
X Kell blood group precursor related family member 4
chr5_+_30588078 32.448 ENSMUST00000066295.2
 Kcnk3
potassium channel, subfamily K, member 3
chr10_-_43174521 32.419 ENSMUST00000040275.7
 Sobp
sine oculis-binding protein homolog (Drosophila)
chr11_-_67922136 32.399 ENSMUST00000021288.3
ENSMUST00000108677.1
 Usp43

ubiquitin specific peptidase 43

chr10_+_39732099 31.309 ENSMUST00000019986.6
 Rev3l
REV3-like, catalytic subunit of DNA polymerase zeta RAD54 like (S. cerevisiae)
chr18_-_58209926 31.175 ENSMUST00000025497.6
 Fbn2
fibrillin 2
chr3_+_136670076 30.494 ENSMUST00000070198.7
 Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chrX_-_162643629 28.627 ENSMUST00000112334.1
 Reps2
RALBP1 associated Eps domain containing protein 2
chr11_-_33147400 28.528 ENSMUST00000020507.7
 Fgf18
fibroblast growth factor 18
chr2_-_163918683 28.368 ENSMUST00000044734.2
 Rims4
regulating synaptic membrane exocytosis 4
chr19_+_27217357 28.209 ENSMUST00000047645.6
ENSMUST00000167487.1
 Vldlr

very low density lipoprotein receptor


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,042 entries
Log-likelihood per target Total log-likelihoodTermDescription
18.5 111.3 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.8 109.5 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
5.9 95.2 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.8 91.9 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
5.1 86.2 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
23.6 70.8 GO:0050975 sensory perception of touch(GO:0050975)
5.3 69.3 GO:0015732 prostaglandin transport(GO:0015732)
5.6 67.1 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
2.3 65.5 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
4.1 62.0 GO:0048681 negative regulation of axon regeneration(GO:0048681)
3.3 60.2 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
19.8 59.4 GO:0060596 mammary placode formation(GO:0060596)
4.9 58.5 GO:0045634 regulation of melanocyte differentiation(GO:0045634)
5.5 55.4 GO:0061470 T follicular helper cell differentiation(GO:0061470)
13.3 53.4 GO:2000705 regulation of dense core granule biogenesis(GO:2000705)
13.2 52.9 GO:0051643 endoplasmic reticulum localization(GO:0051643)
0.8 51.8 GO:0016579 protein deubiquitination(GO:0016579)
17.0 51.1 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
9.9 49.5 GO:0034436 glycoprotein transport(GO:0034436)
1.3 48.6 GO:0034243 regulation of transcription elongation from RNA polymerase II promoter(GO:0034243)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 397 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 382.8 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 361.4 GO:0016021 integral component of membrane(GO:0016021)
1.2 212.7 GO:0099572 postsynaptic specialization(GO:0099572)
3.2 140.4 GO:0048786 presynaptic active zone(GO:0048786)
3.2 135.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
1.9 133.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 122.7 GO:0005886 plasma membrane(GO:0005886)
1.8 119.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
3.0 118.7 GO:0032809 neuronal cell body membrane(GO:0032809)
17.5 104.9 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.4 99.0 GO:0000139 Golgi membrane(GO:0000139)
1.7 81.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
1.1 69.7 GO:0043195 terminal bouton(GO:0043195)
10.9 65.4 GO:0005955 calcineurin complex(GO:0005955)
2.1 64.3 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
2.2 63.7 GO:0033268 node of Ranvier(GO:0033268)
1.3 60.2 GO:0009925 basal plasma membrane(GO:0009925)
9.6 57.5 GO:0042025 host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094)
3.1 56.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
3.8 56.3 GO:1902711 GABA-A receptor complex(GO:1902711)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 591 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 153.1 GO:0061659 ubiquitin-like protein ligase activity(GO:0061659)
1.5 150.4 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.5 129.9 GO:0005096 GTPase activator activity(GO:0005096)
2.3 98.6 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.5 91.4 GO:0008017 microtubule binding(GO:0008017)
2.0 89.8 GO:0046875 ephrin receptor binding(GO:0046875)
1.9 82.9 GO:0001786 phosphatidylserine binding(GO:0001786)
4.6 74.0 GO:0045499 chemorepellent activity(GO:0045499)
6.5 71.3 GO:0002151 G-quadruplex RNA binding(GO:0002151)
4.0 71.2 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
4.2 70.9 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.7 68.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
8.9 62.6 GO:0015198 oligopeptide transporter activity(GO:0015198)
2.3 62.6 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.9 62.1 GO:0048365 Rac GTPase binding(GO:0048365)
3.8 61.1 GO:0043008 ATP-dependent protein binding(GO:0043008)
10.0 59.7 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
4.6 59.2 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
1.0 59.1 GO:0032947 protein complex scaffold(GO:0032947)
2.9 55.3 GO:0005245 voltage-gated calcium channel activity(GO:0005245)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 105 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.4 147.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
2.4 137.2 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
6.7 113.8 PID_LPA4_PATHWAY LPA4-mediated signaling events
1.0 101.4 PID_ERBB1_DOWNSTREAM_PATHWAY ErbB1 downstream signaling
6.5 98.1 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
2.5 96.3 PID_RAS_PATHWAY Regulation of Ras family activation
2.7 82.2 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
4.0 71.4 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
1.3 64.8 PID_BMP_PATHWAY BMP receptor signaling
1.6 47.5 PID_EPHA_FWDPATHWAY EPHA forward signaling
1.0 44.4 PID_FGF_PATHWAY FGF signaling pathway
1.5 43.5 PID_ARF_3PATHWAY Arf1 pathway
1.1 40.6 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
3.0 35.9 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
1.1 35.3 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
1.9 35.2 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
1.2 34.3 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.5 32.8 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.8 30.7 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.2 26.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 180 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.8 161.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
3.9 136.1 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.8 99.8 REACTOME_NEURONAL_SYSTEM Genes involved in Neuronal System
2.5 89.7 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
2.8 87.4 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
3.5 84.5 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
6.9 83.0 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
2.5 81.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
3.6 79.1 REACTOME_ARMS_MEDIATED_ACTIVATION Genes involved in ARMS-mediated activation
2.2 66.0 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
3.2 64.8 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.8 64.5 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
1.6 62.7 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
1.6 61.2 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
7.5 60.3 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
3.6 57.8 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
4.0 52.5 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.7 49.7 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.8 49.1 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
1.3 44.8 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis