Motif ID: Clock

Z-value: 0.549


Transcription factors associated with Clock:

Gene SymbolEntrez IDGene Name
Clock ENSMUSG00000029238.8 Clock

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Clockmm10_v2_chr5_-_76304474_763045480.403.2e-04Click!


Activity profile for motif Clock.

activity profile for motif Clock


Sorted Z-values histogram for motif Clock

Sorted Z-values for motif Clock



Network of associatons between targets according to the STRING database.



First level regulatory network of Clock

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_164769892 4.047 ENSMUST00000088248.6
ENSMUST00000001439.6
Ube2c

ubiquitin-conjugating enzyme E2C

chr16_+_32608973 3.298 ENSMUST00000120680.1
Tfrc
transferrin receptor
chr5_+_139543889 3.265 ENSMUST00000174792.1
ENSMUST00000031523.8
Uncx

UNC homeobox

chr7_-_144939823 2.987 ENSMUST00000093962.4
Ccnd1
cyclin D1
chr12_+_59131473 2.954 ENSMUST00000177162.1
Ctage5
CTAGE family, member 5
chr12_+_59131286 2.892 ENSMUST00000176464.1
ENSMUST00000170992.2
ENSMUST00000176322.1
Ctage5


CTAGE family, member 5


chr1_-_75219245 2.806 ENSMUST00000079464.6
Tuba4a
tubulin, alpha 4A
chr4_-_97778042 2.756 ENSMUST00000146447.1
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr2_+_160645881 2.717 ENSMUST00000109468.2
Top1
topoisomerase (DNA) I
chr11_-_100759942 2.637 ENSMUST00000107363.2
Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr1_-_12991109 2.441 ENSMUST00000115403.2
ENSMUST00000115402.1
Slco5a1

solute carrier organic anion transporter family, member 5A1

chr8_+_90828820 2.415 ENSMUST00000109614.2
ENSMUST00000048665.6
Chd9

chromodomain helicase DNA binding protein 9

chr11_-_100759740 2.373 ENSMUST00000107361.2
Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr17_-_90455872 2.341 ENSMUST00000174337.1
ENSMUST00000172466.1
Nrxn1

neurexin I

chr1_-_82291370 2.323 ENSMUST00000069799.2
Irs1
insulin receptor substrate 1
chr6_-_49214954 2.184 ENSMUST00000031838.7
Igf2bp3
insulin-like growth factor 2 mRNA binding protein 3
chr2_+_83644435 2.162 ENSMUST00000081591.6
Zc3h15
zinc finger CCCH-type containing 15
chr15_-_10714612 2.073 ENSMUST00000169385.1
Rai14
retinoic acid induced 14
chr5_+_93093428 2.027 ENSMUST00000074733.7
Sept11
septin 11
chr1_+_59684949 2.002 ENSMUST00000027174.3
Nop58
NOP58 ribonucleoprotein
chr5_+_146231211 2.000 ENSMUST00000161181.1
ENSMUST00000161652.1
ENSMUST00000031640.8
ENSMUST00000159467.1
Cdk8



cyclin-dependent kinase 8



chr14_-_20181773 1.942 ENSMUST00000024011.8
Kcnk5
potassium channel, subfamily K, member 5
chr4_-_133756769 1.790 ENSMUST00000008024.6
Arid1a
AT rich interactive domain 1A (SWI-like)
chr8_+_58912257 1.768 ENSMUST00000160055.1
BC030500
cDNA sequence BC030500
chr4_-_97584605 1.748 ENSMUST00000107067.1
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_-_97584612 1.719 ENSMUST00000107068.2
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr16_+_43889896 1.643 ENSMUST00000122014.1
ENSMUST00000178400.1
2610015P09Rik

RIKEN cDNA 2610015P09 gene

chr12_+_71136848 1.586 ENSMUST00000149564.1
ENSMUST00000045907.8
2700049A03Rik

RIKEN cDNA 2700049A03 gene

chr4_+_44756609 1.508 ENSMUST00000143385.1
Zcchc7
zinc finger, CCHC domain containing 7
chr19_-_29812952 1.487 ENSMUST00000099525.3
Ranbp6
RAN binding protein 6
chr17_-_35000848 1.487 ENSMUST00000166828.3
D17H6S56E-5
DNA segment, Chr 17, human D6S56E 5
chr4_+_44756553 1.470 ENSMUST00000107824.2
Zcchc7
zinc finger, CCHC domain containing 7
chr16_+_43889800 1.468 ENSMUST00000132859.1
2610015P09Rik
RIKEN cDNA 2610015P09 gene
chr5_-_76951560 1.455 ENSMUST00000140076.1
Ppat
phosphoribosyl pyrophosphate amidotransferase
chr3_+_41564880 1.361 ENSMUST00000168086.1
Phf17
PHD finger protein 17
chr2_+_18055203 1.312 ENSMUST00000028076.8
Mllt10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
chr16_+_43889936 1.307 ENSMUST00000151183.1
2610015P09Rik
RIKEN cDNA 2610015P09 gene
chr5_-_45857473 1.306 ENSMUST00000016026.7
ENSMUST00000067997.6
ENSMUST00000045586.6
Lcorl


ligand dependent nuclear receptor corepressor-like


chr11_-_51756378 1.306 ENSMUST00000109092.1
ENSMUST00000064297.4
ENSMUST00000109097.2
Sec24a


Sec24 related gene family, member A (S. cerevisiae)


chr10_+_36974558 1.276 ENSMUST00000105510.1
Hdac2
histone deacetylase 2
chr10_+_22158566 1.268 ENSMUST00000181645.1
ENSMUST00000105522.2
Raet1e
H60b
retinoic acid early transcript 1E
histocompatibility 60b
chr6_-_47813512 1.209 ENSMUST00000077290.7
Pdia4
protein disulfide isomerase associated 4
chr19_-_29805507 1.193 ENSMUST00000175726.1
9930021J03Rik
RIKEN cDNA 9930021J03 gene
chr15_+_39076885 1.183 ENSMUST00000067072.3
Cthrc1
collagen triple helix repeat containing 1
chr11_+_106789235 1.131 ENSMUST00000103068.3
ENSMUST00000018516.4
Cep95

centrosomal protein 95

chr3_-_95882193 1.127 ENSMUST00000159863.1
ENSMUST00000159739.1
ENSMUST00000036418.3
Gm129


predicted gene 129


chr17_-_35000746 1.102 ENSMUST00000163360.1
D17H6S56E-5
DNA segment, Chr 17, human D6S56E 5
chr15_+_72913357 1.028 ENSMUST00000166418.2
Gm3150
predicted gene 3150
chrX_+_36328353 0.985 ENSMUST00000016383.3
Lonrf3
LON peptidase N-terminal domain and ring finger 3
chr4_+_97777780 0.976 ENSMUST00000107062.2
ENSMUST00000052018.5
ENSMUST00000107057.1
Nfia


nuclear factor I/A


chr1_-_52499980 0.972 ENSMUST00000164747.1
Nab1
Ngfi-A binding protein 1
chr9_+_58134017 0.951 ENSMUST00000134955.1
ENSMUST00000147134.1
ENSMUST00000170397.1
Stra6


stimulated by retinoic acid gene 6


chr13_-_75943812 0.951 ENSMUST00000022078.5
ENSMUST00000109606.1
Rhobtb3

Rho-related BTB domain containing 3

chr11_-_106216318 0.948 ENSMUST00000002043.3
Ccdc47
coiled-coil domain containing 47
chr11_-_106789157 0.922 ENSMUST00000129585.1
Ddx5
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
chr3_-_95882232 0.898 ENSMUST00000161866.1
Gm129
predicted gene 129
chr4_+_21848039 0.898 ENSMUST00000098238.2
ENSMUST00000108229.1
Sfrs18

serine/arginine-rich splicing factor 18

chr4_+_32657107 0.885 ENSMUST00000071642.4
ENSMUST00000178134.1
Mdn1

midasin homolog (yeast)

chrX_-_95444789 0.877 ENSMUST00000084535.5
Amer1
APC membrane recruitment 1
chr6_+_125096145 0.872 ENSMUST00000112390.1
Chd4
chromodomain helicase DNA binding protein 4
chr10_+_36974536 0.870 ENSMUST00000019911.7
Hdac2
histone deacetylase 2
chr10_+_17723220 0.868 ENSMUST00000038107.7
Cited2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr11_+_101316200 0.860 ENSMUST00000142640.1
ENSMUST00000019470.7
Psme3

proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki)

chr18_+_42511496 0.858 ENSMUST00000025375.7
Tcerg1
transcription elongation regulator 1 (CA150)
chr9_-_106891401 0.828 ENSMUST00000069036.7
Manf
mesencephalic astrocyte-derived neurotrophic factor
chr12_+_69372112 0.828 ENSMUST00000050063.7
Arf6
ADP-ribosylation factor 6
chr2_-_130906338 0.799 ENSMUST00000146975.1
4930402H24Rik
RIKEN cDNA 4930402H24 gene
chr4_+_107968332 0.788 ENSMUST00000106713.3
Slc1a7
solute carrier family 1 (glutamate transporter), member 7
chr11_+_101316917 0.760 ENSMUST00000151385.1
Psme3
proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki)
chr11_-_106788845 0.760 ENSMUST00000123339.1
Ddx5
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
chr11_-_47379405 0.756 ENSMUST00000077221.5
Sgcd
sarcoglycan, delta (dystrophin-associated glycoprotein)
chr4_-_132075250 0.754 ENSMUST00000105970.1
ENSMUST00000105975.1
Epb4.1

erythrocyte protein band 4.1

chr10_-_127522428 0.735 ENSMUST00000026470.4
Shmt2
serine hydroxymethyltransferase 2 (mitochondrial)
chr1_-_55088156 0.708 ENSMUST00000127861.1
ENSMUST00000144077.1
Hspd1

heat shock protein 1 (chaperonin)

chr1_-_55088024 0.678 ENSMUST00000027123.8
Hspd1
heat shock protein 1 (chaperonin)
chr5_-_74702891 0.675 ENSMUST00000117388.1
Lnx1
ligand of numb-protein X 1
chr9_-_110654161 0.674 ENSMUST00000133191.1
ENSMUST00000167320.1
Nbeal2

neurobeachin-like 2

chr9_-_114781986 0.674 ENSMUST00000035009.8
ENSMUST00000084867.7
Cmtm7

CKLF-like MARVEL transmembrane domain containing 7

chr11_+_74830920 0.652 ENSMUST00000000291.2
Mnt
max binding protein
chr6_-_23839137 0.649 ENSMUST00000166458.2
ENSMUST00000142913.2
ENSMUST00000115357.1
ENSMUST00000069074.7
ENSMUST00000115361.2
ENSMUST00000018122.7
ENSMUST00000115355.1
ENSMUST00000115356.2
Cadps2







Ca2+-dependent activator protein for secretion 2







chr12_+_16653470 0.644 ENSMUST00000111064.1
Ntsr2
neurotensin receptor 2
chr4_-_82705735 0.643 ENSMUST00000155821.1
Nfib
nuclear factor I/B
chr16_-_43889669 0.639 ENSMUST00000023387.7
Qtrtd1
queuine tRNA-ribosyltransferase domain containing 1
chr19_+_45015168 0.636 ENSMUST00000039016.6
Lzts2
leucine zipper, putative tumor suppressor 2
chr4_-_57143437 0.634 ENSMUST00000095076.3
ENSMUST00000030142.3
Epb4.1l4b

erythrocyte protein band 4.1-like 4b

chr10_+_69534039 0.630 ENSMUST00000182557.1
Ank3
ankyrin 3, epithelial
chr11_+_17211912 0.624 ENSMUST00000046955.6
Wdr92
WD repeat domain 92
chr7_+_46796088 0.622 ENSMUST00000006774.4
ENSMUST00000165031.1
Gtf2h1

general transcription factor II H, polypeptide 1

chr12_-_31950170 0.610 ENSMUST00000176520.1
Hbp1
high mobility group box transcription factor 1
chr14_-_118706180 0.595 ENSMUST00000036554.6
ENSMUST00000166646.1
Abcc4

ATP-binding cassette, sub-family C (CFTR/MRP), member 4

chr9_-_48480540 0.555 ENSMUST00000034524.3
Rexo2
REX2, RNA exonuclease 2 homolog (S. cerevisiae)
chr11_+_94629741 0.537 ENSMUST00000021239.6
Lrrc59
leucine rich repeat containing 59
chr9_+_44326804 0.536 ENSMUST00000054708.3
Dpagt1
dolichyl-phosphate (UDP-N-acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
chr12_-_31950210 0.522 ENSMUST00000176084.1
ENSMUST00000176103.1
ENSMUST00000167458.2
Hbp1


high mobility group box transcription factor 1


chr7_-_46795881 0.507 ENSMUST00000107653.1
ENSMUST00000107654.1
ENSMUST00000014562.7
ENSMUST00000152759.1
Hps5



Hermansky-Pudlak syndrome 5 homolog (human)



chr4_-_124693568 0.506 ENSMUST00000030738.7
Utp11l
UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast)
chr2_-_38926217 0.505 ENSMUST00000076275.4
ENSMUST00000142130.1
Nr6a1

nuclear receptor subfamily 6, group A, member 1

chr7_-_46795661 0.504 ENSMUST00000123725.1
Hps5
Hermansky-Pudlak syndrome 5 homolog (human)
chr9_+_58134535 0.496 ENSMUST00000128378.1
ENSMUST00000150820.1
ENSMUST00000167479.1
ENSMUST00000134450.1
Stra6



stimulated by retinoic acid gene 6



chr18_+_76241580 0.496 ENSMUST00000168423.1
ENSMUST00000091831.6
Smad2

SMAD family member 2

chr11_+_106216926 0.495 ENSMUST00000021046.5
Ddx42
DEAD (Asp-Glu-Ala-Asp) box polypeptide 42
chr3_+_88532314 0.491 ENSMUST00000172699.1
Mex3a
mex3 homolog A (C. elegans)
chr15_-_38078842 0.488 ENSMUST00000110336.2
Ubr5
ubiquitin protein ligase E3 component n-recognin 5
chr4_+_123282778 0.456 ENSMUST00000106243.1
ENSMUST00000106241.1
ENSMUST00000080178.6
Pabpc4


poly(A) binding protein, cytoplasmic 4


chr5_+_76951307 0.445 ENSMUST00000031160.9
ENSMUST00000120912.1
ENSMUST00000117536.1
Paics


phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase


chr11_-_99089296 0.417 ENSMUST00000017751.2
Tns4
tensin 4
chr16_+_94085226 0.414 ENSMUST00000072182.7
Sim2
single-minded homolog 2 (Drosophila)
chr4_+_132274385 0.406 ENSMUST00000105963.1
Taf12
TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr9_-_57606234 0.395 ENSMUST00000045068.8
Cplx3
complexin 3
chr4_+_57568144 0.395 ENSMUST00000102904.3
Palm2
paralemmin 2
chr5_+_76974683 0.394 ENSMUST00000101087.3
ENSMUST00000120550.1
Srp72

signal recognition particle 72

chr11_-_52000432 0.385 ENSMUST00000020657.6
Ube2b
ubiquitin-conjugating enzyme E2B
chr3_+_145576196 0.368 ENSMUST00000098534.4
Znhit6
zinc finger, HIT type 6
chr12_-_31950535 0.361 ENSMUST00000172314.2
Hbp1
high mobility group box transcription factor 1
chr12_+_8674681 0.359 ENSMUST00000168361.1
ENSMUST00000169750.1
ENSMUST00000163730.1
Pum2


pumilio 2 (Drosophila)


chr11_-_17211504 0.335 ENSMUST00000020317.7
Pno1
partner of NOB1 homolog (S. cerevisiae)
chrX_-_36864238 0.335 ENSMUST00000115249.3
ENSMUST00000115248.3
C330007P06Rik

RIKEN cDNA C330007P06 gene

chr4_-_155863362 0.324 ENSMUST00000030949.3
Tas1r3
taste receptor, type 1, member 3
chr19_+_6975048 0.315 ENSMUST00000070850.6
Ppp1r14b
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr1_-_166409773 0.310 ENSMUST00000135673.1
ENSMUST00000079972.6
ENSMUST00000169324.1
ENSMUST00000111411.2
ENSMUST00000128861.1
Pogk




pogo transposable element with KRAB domain




chr17_-_87265866 0.288 ENSMUST00000145895.1
ENSMUST00000129616.1
ENSMUST00000155904.1
ENSMUST00000151155.1
ENSMUST00000144236.1
ENSMUST00000024963.3
Mcfd2





multiple coagulation factor deficiency 2





chr11_+_74649462 0.288 ENSMUST00000092915.5
ENSMUST00000117818.1
Cluh

clustered mitochondria (cluA/CLU1) homolog

chr10_+_44268328 0.284 ENSMUST00000039286.4
Atg5
autophagy related 5
chr4_+_132274369 0.282 ENSMUST00000030731.4
Taf12
TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chrX_+_6047453 0.271 ENSMUST00000103007.3
Nudt11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr12_+_90738201 0.260 ENSMUST00000181874.1
Gm26512
predicted gene, 26512
chr3_-_108210438 0.255 ENSMUST00000117784.1
ENSMUST00000119650.1
ENSMUST00000117409.1
Atxn7l2


ataxin 7-like 2


chr19_+_41981709 0.243 ENSMUST00000026170.1
Ubtd1
ubiquitin domain containing 1
chr2_+_115581667 0.215 ENSMUST00000166472.1
ENSMUST00000110918.2
BC052040

cDNA sequence BC052040

chr17_-_45573253 0.214 ENSMUST00000165127.1
ENSMUST00000166469.1
ENSMUST00000024739.7
Hsp90ab1


heat shock protein 90 alpha (cytosolic), class B member 1


chr4_-_11386757 0.208 ENSMUST00000108313.1
ENSMUST00000108311.2
Esrp1

epithelial splicing regulatory protein 1

chr15_-_43170809 0.168 ENSMUST00000063492.6
Rspo2
R-spondin 2 homolog (Xenopus laevis)
chrX_-_7572843 0.168 ENSMUST00000132788.1
Ppp1r3f
protein phosphatase 1, regulatory (inhibitor) subunit 3F
chr9_+_95637601 0.150 ENSMUST00000015498.8
Pcolce2
procollagen C-endopeptidase enhancer 2
chr11_+_78178651 0.137 ENSMUST00000092880.7
ENSMUST00000127587.1
ENSMUST00000108338.1
Tlcd1


TLC domain containing 1


chr1_-_186705980 0.131 ENSMUST00000045288.8
Tgfb2
transforming growth factor, beta 2
chr8_-_45999860 0.125 ENSMUST00000053558.9
Ankrd37
ankyrin repeat domain 37
chr18_+_32837225 0.125 ENSMUST00000166214.1
ENSMUST00000053663.9
Wdr36

WD repeat domain 36

chr16_+_4036942 0.113 ENSMUST00000137748.1
ENSMUST00000006136.4
ENSMUST00000157044.1
ENSMUST00000120009.1
Dnase1



deoxyribonuclease I



chr8_+_123186235 0.113 ENSMUST00000019422.4
Dpep1
dipeptidase 1 (renal)
chr11_-_76217490 0.102 ENSMUST00000102500.4
Gemin4
gem (nuclear organelle) associated protein 4
chr5_+_76951382 0.096 ENSMUST00000141687.1
Paics
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase
chr11_-_52000748 0.093 ENSMUST00000109086.1
Ube2b
ubiquitin-conjugating enzyme E2B
chr11_-_72215592 0.082 ENSMUST00000021157.8
Med31
mediator of RNA polymerase II transcription, subunit 31 homolog (yeast)
chr9_+_44067072 0.078 ENSMUST00000177054.1
Usp2
ubiquitin specific peptidase 2
chr13_-_100015562 0.077 ENSMUST00000022148.6
Mccc2
methylcrotonoyl-Coenzyme A carboxylase 2 (beta)
chr9_+_40801235 0.063 ENSMUST00000117870.1
ENSMUST00000117557.1
Hspa8

heat shock protein 8

chr3_-_108085346 0.058 ENSMUST00000078912.5
Ampd2
adenosine monophosphate deaminase 2
chr14_-_89898466 0.057 ENSMUST00000081204.4
Gm10110
predicted gene 10110
chr11_+_102189620 0.042 ENSMUST00000070334.3
ENSMUST00000078975.7
G6pc3

glucose 6 phosphatase, catalytic, 3

chr4_-_148444744 0.015 ENSMUST00000051633.2
Ubiad1
UbiA prenyltransferase domain containing 1
chr7_-_126695731 0.011 ENSMUST00000144897.1
Slx1b
SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)
chr2_-_147186389 0.011 ENSMUST00000109970.3
ENSMUST00000067075.5
Nkx2-2

NK2 homeobox 2

chr5_-_22344690 0.005 ENSMUST00000062372.7
ENSMUST00000161356.1
Reln

reelin


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.0 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.6 4.4 GO:0006344 maintenance of chromatin silencing(GO:0006344)
0.6 2.3 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.5 2.3 GO:0090273 regulation of somatostatin secretion(GO:0090273)
0.5 1.4 GO:0002842 positive regulation of T cell mediated immune response to tumor cell(GO:0002842) protein import into mitochondrial intermembrane space(GO:0045041)
0.4 3.0 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.4 1.3 GO:1903334 positive regulation of protein folding(GO:1903334)
0.4 3.3 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.4 2.4 GO:0048254 snoRNA localization(GO:0048254)
0.3 2.7 GO:0006265 DNA topological change(GO:0006265)
0.3 1.5 GO:0006543 glutamine catabolic process(GO:0006543)
0.3 1.4 GO:0046864 retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) alveolar primary septum development(GO:0061143)
0.3 1.3 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.2 3.3 GO:0033572 transferrin transport(GO:0033572)
0.2 0.7 GO:0070889 platelet alpha granule organization(GO:0070889)
0.2 0.9 GO:0061428 embryonic heart tube left/right pattern formation(GO:0060971) negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.2 0.6 GO:0002014 vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure(GO:0002014)
0.2 1.9 GO:0030322 stabilization of membrane potential(GO:0030322)
0.2 2.4 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.2 0.7 GO:0006545 glycine biosynthetic process(GO:0006545)
0.2 0.7 GO:0002337 B-1a B cell differentiation(GO:0002337)
0.2 1.7 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.2 2.0 GO:0090209 negative regulation of triglyceride metabolic process(GO:0090209)
0.2 1.5 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.2 0.5 GO:1902915 negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.2 0.6 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.1 0.9 GO:2001012 mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.1 1.5 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.1 0.9 GO:0072553 terminal button organization(GO:0072553)
0.1 0.5 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352) positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)
0.1 0.5 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.1 1.2 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.1 0.9 GO:0006983 ER overload response(GO:0006983)
0.1 0.3 GO:0035973 aggrephagy(GO:0035973)
0.1 0.6 GO:1990504 dense core granule exocytosis(GO:1990504)
0.1 1.0 GO:0072189 ureter development(GO:0072189)
0.1 0.5 GO:0019348 dolichol metabolic process(GO:0019348)
0.1 0.8 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.1 0.2 GO:0097278 transforming growth factor beta activation(GO:0036363) complement-dependent cytotoxicity(GO:0097278)
0.1 0.4 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.1 0.3 GO:0050912 detection of chemical stimulus involved in sensory perception(GO:0050907) detection of chemical stimulus involved in sensory perception of taste(GO:0050912)
0.1 0.4 GO:1900246 positive regulation of RIG-I signaling pathway(GO:1900246)
0.1 0.6 GO:0006855 drug transmembrane transport(GO:0006855)
0.1 0.8 GO:0034143 regulation of toll-like receptor 4 signaling pathway(GO:0034143)
0.1 0.6 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 1.3 GO:0001913 T cell mediated cytotoxicity(GO:0001913)
0.0 0.3 GO:1901911 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.0 0.1 GO:1902256 endocardial cushion fusion(GO:0003274) apoptotic process involved in outflow tract morphogenesis(GO:0003275) apoptotic process involved in heart morphogenesis(GO:0003278) atrial septum primum morphogenesis(GO:0003289) negative regulation of macrophage cytokine production(GO:0010936) positive regulation of catagen(GO:0051795) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
0.0 0.2 GO:0060535 trachea cartilage morphogenesis(GO:0060535)
0.0 0.6 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 0.7 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.9 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 1.0 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 0.3 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 2.2 GO:0051028 mRNA transport(GO:0051028)
0.0 0.0 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.2 GO:2000465 regulation of glycogen (starch) synthase activity(GO:2000465)
0.0 2.0 GO:0051291 protein heterooligomerization(GO:0051291)
0.0 0.5 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.9 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 2.6 GO:0061136 regulation of proteasomal protein catabolic process(GO:0061136)
0.0 0.6 GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0005899 insulin receptor complex(GO:0005899)
0.7 2.7 GO:0001651 dense fibrillar component(GO:0001651)
0.4 1.6 GO:0008537 proteasome activator complex(GO:0008537)
0.3 2.0 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.3 3.3 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.3 1.3 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.3 2.1 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.3 2.3 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.3 1.0 GO:0031084 BLOC-2 complex(GO:0031084)
0.2 1.4 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.2 2.2 GO:0071141 SMAD protein complex(GO:0071141)
0.2 0.6 GO:0031088 platelet dense granule membrane(GO:0031088)
0.2 0.8 GO:0016012 sarcoglycan complex(GO:0016012)
0.2 0.7 GO:0070552 BRISC complex(GO:0070552)
0.2 4.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 0.7 GO:0000125 PCAF complex(GO:0000125)
0.1 0.3 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.1 1.2 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 1.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 0.8 GO:0090543 Flemming body(GO:0090543)
0.1 0.4 GO:0070761 pre-snoRNP complex(GO:0070761)
0.1 0.6 GO:0000439 core TFIIH complex(GO:0000439)
0.1 0.5 GO:0033503 HULC complex(GO:0033503)
0.1 3.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.4 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.0 0.2 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 1.5 GO:0016592 mediator complex(GO:0016592)
0.0 0.9 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545) nuclear transcriptional repressor complex(GO:0090568)
0.0 0.6 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.6 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.1 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.1 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 0.3 GO:0071564 npBAF complex(GO:0071564)
0.0 1.2 GO:0005581 collagen trimer(GO:0005581)
0.0 1.7 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 2.3 GO:0034399 nuclear periphery(GO:0034399)
0.0 1.6 GO:0005814 centriole(GO:0005814)
0.0 0.8 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.9 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.1 GO:0032797 SMN complex(GO:0032797)
0.0 0.5 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 1.1 GO:0000922 spindle pole(GO:0000922)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 GO:0004998 transferrin receptor activity(GO:0004998)
0.7 2.7 GO:0097100 supercoiled DNA binding(GO:0097100)
0.6 1.7 GO:0035500 MH2 domain binding(GO:0035500)
0.5 2.1 GO:0035851 histone deacetylase activity (H4-K16 specific)(GO:0034739) Krueppel-associated box domain binding(GO:0035851)
0.3 2.4 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.2 0.7 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.2 2.3 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.2 1.4 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.2 2.4 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.2 2.3 GO:0097109 neuroligin family protein binding(GO:0097109)
0.2 1.6 GO:0061133 endopeptidase activator activity(GO:0061133)
0.2 1.9 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.2 1.3 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.1 3.8 GO:0070064 proline-rich region binding(GO:0070064)
0.1 0.5 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.1 2.6 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 0.3 GO:0008527 taste receptor activity(GO:0008527)
0.1 0.5 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.1 4.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 0.2 GO:0019776 Atg8 ligase activity(GO:0019776)
0.1 2.2 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 0.8 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037)
0.1 0.9 GO:0050693 LBD domain binding(GO:0050693)
0.1 0.8 GO:0031996 thioesterase binding(GO:0031996)
0.1 5.0 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.1 0.6 GO:0015245 fatty acid transporter activity(GO:0015245)
0.1 0.4 GO:0005047 signal recognition particle binding(GO:0005047) 7S RNA binding(GO:0008312)
0.1 1.8 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 1.5 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 1.4 GO:0051183 vitamin transporter activity(GO:0051183)
0.0 0.3 GO:0000298 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.0 0.2 GO:2001069 glycogen binding(GO:2001069)
0.0 3.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.5 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.8 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 1.2 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.2 GO:0002135 CTP binding(GO:0002135) sulfonylurea receptor binding(GO:0017098)
0.0 1.0 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.1 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.6 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 0.1 GO:0070573 metallodipeptidase activity(GO:0070573)
0.0 0.9 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.7 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.4 GO:0005326 neurotransmitter transporter activity(GO:0005326)
0.0 0.1 GO:0031686 A1 adenosine receptor binding(GO:0031686)
0.0 0.4 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.6 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.8 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.0 0.9 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.1 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.0 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 2.3 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.1 3.3 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 2.2 PID_MYC_PATHWAY C-MYC pathway
0.1 1.4 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 2.7 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.2 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.6 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 2.1 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.8 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.5 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.1 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.9 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.0 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.2 2.8 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 2.0 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 3.3 REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING Genes involved in Transferrin endocytosis and recycling
0.1 5.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.3 REACTOME_SOS_MEDIATED_SIGNALLING Genes involved in SOS-mediated signalling
0.1 3.0 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 4.1 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 1.3 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.8 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.2 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.6 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 1.3 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.5 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 0.6 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.6 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.5 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein