Motif ID: Clock

Z-value: 0.549


Transcription factors associated with Clock:

Gene SymbolEntrez IDGene Name
Clock ENSMUSG00000029238.8 Clock

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Clockmm10_v2_chr5_-_76304474_763045480.403.2e-04Click!


Activity profile for motif Clock.

activity profile for motif Clock


Sorted Z-values histogram for motif Clock

Sorted Z-values for motif Clock



Network of associatons between targets according to the STRING database.



First level regulatory network of Clock

PNG image of the network

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Top targets:


Showing 1 to 20 of 154 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_164769892 4.047 ENSMUST00000088248.6
ENSMUST00000001439.6
 Ube2c

ubiquitin-conjugating enzyme E2C

chr16_+_32608973 3.298 ENSMUST00000120680.1
 Tfrc
transferrin receptor
chr5_+_139543889 3.265 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr7_-_144939823 2.987 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr12_+_59131473 2.954 ENSMUST00000177162.1
 Ctage5
CTAGE family, member 5
chr12_+_59131286 2.892 ENSMUST00000176464.1
ENSMUST00000170992.2
ENSMUST00000176322.1
 Ctage5


CTAGE family, member 5


chr1_-_75219245 2.806 ENSMUST00000079464.6
 Tuba4a
tubulin, alpha 4A
chr4_-_97778042 2.756 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr2_+_160645881 2.717 ENSMUST00000109468.2
 Top1
topoisomerase (DNA) I
chr11_-_100759942 2.637 ENSMUST00000107363.2
 Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr1_-_12991109 2.441 ENSMUST00000115403.2
ENSMUST00000115402.1
 Slco5a1

solute carrier organic anion transporter family, member 5A1

chr8_+_90828820 2.415 ENSMUST00000109614.2
ENSMUST00000048665.6
 Chd9

chromodomain helicase DNA binding protein 9

chr11_-_100759740 2.373 ENSMUST00000107361.2
 Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr17_-_90455872 2.341 ENSMUST00000174337.1
ENSMUST00000172466.1
 Nrxn1

neurexin I

chr1_-_82291370 2.323 ENSMUST00000069799.2
 Irs1
insulin receptor substrate 1
chr6_-_49214954 2.184 ENSMUST00000031838.7
 Igf2bp3
insulin-like growth factor 2 mRNA binding protein 3
chr2_+_83644435 2.162 ENSMUST00000081591.6
 Zc3h15
zinc finger CCCH-type containing 15
chr15_-_10714612 2.073 ENSMUST00000169385.1
 Rai14
retinoic acid induced 14
chr5_+_93093428 2.027 ENSMUST00000074733.7
 Sept11
septin 11
chr1_+_59684949 2.002 ENSMUST00000027174.3
 Nop58
NOP58 ribonucleoprotein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 4.4 GO:0006344 maintenance of chromatin silencing(GO:0006344)
0.8 4.0 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.4 3.3 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.2 3.3 GO:0033572 transferrin transport(GO:0033572)
0.4 3.0 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.3 2.7 GO:0006265 DNA topological change(GO:0006265)
0.0 2.6 GO:0061136 regulation of proteasomal protein catabolic process(GO:0061136)
0.4 2.4 GO:0048254 snoRNA localization(GO:0048254)
0.2 2.4 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.6 2.3 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.5 2.3 GO:0090273 regulation of somatostatin secretion(GO:0090273)
0.0 2.2 GO:0051028 mRNA transport(GO:0051028)
0.2 2.0 GO:0090209 negative regulation of triglyceride metabolic process(GO:0090209)
0.0 2.0 GO:0051291 protein heterooligomerization(GO:0051291)
0.2 1.9 GO:0030322 stabilization of membrane potential(GO:0030322)
0.2 1.7 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.3 1.5 GO:0006543 glutamine catabolic process(GO:0006543)
0.2 1.5 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.1 1.5 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.5 1.4 GO:0002842 positive regulation of T cell mediated immune response to tumor cell(GO:0002842) protein import into mitochondrial intermembrane space(GO:0045041)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.3 3.3 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 3.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.7 2.7 GO:0001651 dense fibrillar component(GO:0001651)
0.8 2.3 GO:0005899 insulin receptor complex(GO:0005899)
0.3 2.3 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 2.3 GO:0034399 nuclear periphery(GO:0034399)
0.2 2.2 GO:0071141 SMAD protein complex(GO:0071141)
0.3 2.1 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.3 2.0 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 1.7 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.4 1.6 GO:0008537 proteasome activator complex(GO:0008537)
0.0 1.6 GO:0005814 centriole(GO:0005814)
0.0 1.5 GO:0016592 mediator complex(GO:0016592)
0.2 1.4 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.3 1.3 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.1 1.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 1.2 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 1.2 GO:0005581 collagen trimer(GO:0005581)
0.0 1.1 GO:0000922 spindle pole(GO:0000922)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.0 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.1 4.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 3.8 GO:0070064 proline-rich region binding(GO:0070064)
0.0 3.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
1.1 3.3 GO:0004998 transferrin receptor activity(GO:0004998)
0.7 2.7 GO:0097100 supercoiled DNA binding(GO:0097100)
0.1 2.6 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.3 2.4 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.2 2.4 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.2 2.3 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.2 2.3 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 2.2 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.5 2.1 GO:0035851 histone deacetylase activity (H4-K16 specific)(GO:0034739) Krueppel-associated box domain binding(GO:0035851)
0.2 1.9 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 1.8 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.6 1.7 GO:0035500 MH2 domain binding(GO:0035500)
0.2 1.6 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 1.5 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.2 1.4 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.0 1.4 GO:0051183 vitamin transporter activity(GO:0051183)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 3.0 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 2.7 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 2.3 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.1 2.2 PID_MYC_PATHWAY C-MYC pathway
0.0 2.1 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.6 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 1.4 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.2 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.9 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 0.8 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.5 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.1 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 4.1 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2 4.0 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 3.3 REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING Genes involved in Transferrin endocytosis and recycling
0.1 3.0 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.2 2.8 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 2.3 REACTOME_SOS_MEDIATED_SIGNALLING Genes involved in SOS-mediated signalling
0.1 2.0 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 1.3 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 1.3 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.8 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.6 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.6 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.6 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.5 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 0.5 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.2 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome