Motif ID: Cpeb1
Z-value: 2.061
Transcription factors associated with Cpeb1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Cpeb1 | ENSMUSG00000025586.10 | Cpeb1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Cpeb1 | mm10_v2_chr7_-_81454751_81454764 | 0.01 | 9.0e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.8 | 105.9 | GO:2001269 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269) |
| 7.7 | 31.0 | GO:0046552 | eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) |
| 7.5 | 37.5 | GO:0035262 | gonad morphogenesis(GO:0035262) |
| 7.0 | 28.0 | GO:0045091 | regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091) |
| 6.0 | 18.0 | GO:0060023 | soft palate development(GO:0060023) |
| 5.6 | 27.8 | GO:0061073 | ciliary body morphogenesis(GO:0061073) |
| 5.0 | 15.0 | GO:0090425 | hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979) |
| 4.6 | 37.1 | GO:0048625 | myoblast fate commitment(GO:0048625) |
| 4.4 | 22.0 | GO:0021905 | pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937) |
| 3.7 | 18.3 | GO:0097476 | spinal cord motor neuron migration(GO:0097476) |
| 3.3 | 9.9 | GO:0021546 | rhombomere development(GO:0021546) |
| 3.2 | 15.9 | GO:0015671 | oxygen transport(GO:0015671) |
| 3.1 | 15.5 | GO:0035426 | extracellular matrix-cell signaling(GO:0035426) |
| 3.1 | 6.1 | GO:1900220 | semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220) |
| 2.9 | 8.6 | GO:0071649 | negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865) regulation of chemokine (C-C motif) ligand 5 production(GO:0071649) positive regulation of somatostatin secretion(GO:0090274) |
| 2.8 | 8.5 | GO:0002191 | cap-dependent translational initiation(GO:0002191) |
| 2.8 | 8.4 | GO:0042320 | regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938) |
| 2.8 | 30.8 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 2.7 | 8.1 | GO:0097155 | fasciculation of sensory neuron axon(GO:0097155) |
| 2.6 | 39.6 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
| 2.4 | 7.1 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
| 2.3 | 9.2 | GO:0070537 | histone H2A K63-linked deubiquitination(GO:0070537) |
| 2.2 | 11.1 | GO:1900147 | Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147) |
| 2.1 | 4.1 | GO:0060399 | positive regulation of growth hormone receptor signaling pathway(GO:0060399) |
| 1.9 | 9.7 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 1.9 | 7.7 | GO:0033087 | negative regulation of immature T cell proliferation(GO:0033087) |
| 1.9 | 5.7 | GO:0046098 | regulation of primitive erythrocyte differentiation(GO:0010725) guanine metabolic process(GO:0046098) |
| 1.8 | 3.6 | GO:0010908 | regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) |
| 1.8 | 7.1 | GO:0055099 | response to high density lipoprotein particle(GO:0055099) platelet dense granule organization(GO:0060155) |
| 1.7 | 8.7 | GO:2000325 | regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327) |
| 1.7 | 5.1 | GO:0048687 | positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) |
| 1.7 | 21.7 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
| 1.6 | 16.5 | GO:1901386 | negative regulation of voltage-gated calcium channel activity(GO:1901386) |
| 1.6 | 4.9 | GO:0035928 | RNA 5'-end processing(GO:0000966) rRNA import into mitochondrion(GO:0035928) |
| 1.6 | 11.1 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
| 1.6 | 25.1 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 1.4 | 15.9 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
| 1.4 | 24.3 | GO:0031987 | locomotion involved in locomotory behavior(GO:0031987) |
| 1.4 | 9.8 | GO:0007296 | vitellogenesis(GO:0007296) |
| 1.4 | 12.5 | GO:0030259 | lipid glycosylation(GO:0030259) |
| 1.4 | 15.0 | GO:1990001 | inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001) |
| 1.2 | 4.9 | GO:0036091 | positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091) |
| 1.1 | 4.5 | GO:0035470 | positive regulation of vascular wound healing(GO:0035470) |
| 1.1 | 7.4 | GO:0021780 | oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780) |
| 1.0 | 3.1 | GO:0035989 | tendon development(GO:0035989) |
| 1.0 | 44.3 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 1.0 | 15.5 | GO:0060736 | prostate gland growth(GO:0060736) |
| 1.0 | 8.7 | GO:0090166 | Golgi disassembly(GO:0090166) regulation of chaperone-mediated autophagy(GO:1904714) |
| 1.0 | 2.9 | GO:0050689 | negative regulation of defense response to virus by host(GO:0050689) |
| 0.9 | 1.8 | GO:0060455 | negative regulation of gastric acid secretion(GO:0060455) |
| 0.9 | 4.5 | GO:0097475 | motor neuron migration(GO:0097475) |
| 0.8 | 15.2 | GO:2001224 | positive regulation of neuron migration(GO:2001224) |
| 0.8 | 5.6 | GO:1900029 | positive regulation of ruffle assembly(GO:1900029) |
| 0.8 | 17.3 | GO:0060009 | Sertoli cell development(GO:0060009) |
| 0.8 | 8.5 | GO:0009404 | toxin metabolic process(GO:0009404) |
| 0.8 | 3.9 | GO:0006842 | tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746) |
| 0.8 | 8.5 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.8 | 4.5 | GO:0006570 | tyrosine metabolic process(GO:0006570) |
| 0.8 | 4.5 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
| 0.7 | 11.8 | GO:0045723 | positive regulation of fatty acid biosynthetic process(GO:0045723) |
| 0.7 | 5.1 | GO:0071699 | olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699) |
| 0.7 | 2.2 | GO:0031660 | regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662) positive regulation of calcium-transporting ATPase activity(GO:1901896) |
| 0.7 | 8.7 | GO:0090394 | negative regulation of excitatory postsynaptic potential(GO:0090394) |
| 0.7 | 2.9 | GO:0060040 | retinal bipolar neuron differentiation(GO:0060040) |
| 0.7 | 3.3 | GO:1903566 | positive regulation of protein localization to cilium(GO:1903566) |
| 0.7 | 6.6 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
| 0.7 | 3.9 | GO:0007253 | cytoplasmic sequestering of NF-kappaB(GO:0007253) |
| 0.6 | 0.6 | GO:1902338 | negative regulation of apoptotic process involved in morphogenesis(GO:1902338) negative regulation of apoptotic process involved in development(GO:1904746) |
| 0.6 | 4.2 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.6 | 5.4 | GO:0010758 | regulation of macrophage chemotaxis(GO:0010758) |
| 0.6 | 8.2 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.6 | 1.7 | GO:0007171 | activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210) Tie signaling pathway(GO:0048014) |
| 0.5 | 4.3 | GO:0010587 | miRNA catabolic process(GO:0010587) |
| 0.5 | 8.9 | GO:1902459 | positive regulation of stem cell population maintenance(GO:1902459) |
| 0.5 | 2.6 | GO:0050858 | negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860) |
| 0.5 | 2.0 | GO:0007113 | endomitotic cell cycle(GO:0007113) |
| 0.5 | 10.2 | GO:0040034 | regulation of development, heterochronic(GO:0040034) |
| 0.5 | 2.4 | GO:0035720 | intraciliary anterograde transport(GO:0035720) |
| 0.5 | 1.4 | GO:0050957 | equilibrioception(GO:0050957) |
| 0.5 | 3.3 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.5 | 7.4 | GO:0045653 | negative regulation of megakaryocyte differentiation(GO:0045653) |
| 0.4 | 8.3 | GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482) |
| 0.4 | 1.3 | GO:1904798 | positive regulation of core promoter binding(GO:1904798) |
| 0.4 | 3.9 | GO:0048664 | neuron fate determination(GO:0048664) |
| 0.4 | 6.2 | GO:0097034 | mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034) |
| 0.4 | 3.8 | GO:0006527 | arginine catabolic process(GO:0006527) |
| 0.4 | 3.7 | GO:0090557 | establishment of endothelial intestinal barrier(GO:0090557) |
| 0.4 | 5.2 | GO:0033572 | transferrin transport(GO:0033572) |
| 0.4 | 2.2 | GO:0035878 | nail development(GO:0035878) |
| 0.4 | 1.8 | GO:0045654 | positive regulation of megakaryocyte differentiation(GO:0045654) |
| 0.3 | 1.7 | GO:0033762 | response to glucagon(GO:0033762) |
| 0.3 | 5.2 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.3 | 2.4 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
| 0.3 | 6.6 | GO:2000144 | positive regulation of DNA-templated transcription, initiation(GO:2000144) |
| 0.3 | 5.6 | GO:0038063 | collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) |
| 0.3 | 1.6 | GO:0046684 | response to pyrethroid(GO:0046684) |
| 0.3 | 1.3 | GO:1902268 | negative regulation of polyamine transmembrane transport(GO:1902268) |
| 0.3 | 2.6 | GO:0014807 | regulation of somitogenesis(GO:0014807) |
| 0.3 | 0.9 | GO:0048162 | preantral ovarian follicle growth(GO:0001546) multi-layer follicle stage(GO:0048162) |
| 0.3 | 6.0 | GO:0050728 | negative regulation of inflammatory response(GO:0050728) |
| 0.3 | 6.5 | GO:0001967 | suckling behavior(GO:0001967) |
| 0.3 | 14.5 | GO:1901998 | toxin transport(GO:1901998) |
| 0.3 | 0.9 | GO:0002314 | germinal center B cell differentiation(GO:0002314) |
| 0.3 | 0.9 | GO:0051604 | protein maturation(GO:0051604) |
| 0.3 | 4.2 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.3 | 4.9 | GO:2001014 | regulation of skeletal muscle cell differentiation(GO:2001014) |
| 0.3 | 1.1 | GO:0046898 | response to cycloheximide(GO:0046898) |
| 0.3 | 2.0 | GO:0097152 | mesenchymal cell apoptotic process(GO:0097152) regulation of mesenchymal cell apoptotic process(GO:2001053) negative regulation of mesenchymal cell apoptotic process(GO:2001054) |
| 0.3 | 4.1 | GO:0051382 | kinetochore assembly(GO:0051382) |
| 0.2 | 1.2 | GO:0090292 | nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292) |
| 0.2 | 2.7 | GO:0016445 | somatic diversification of immunoglobulins(GO:0016445) |
| 0.2 | 2.4 | GO:2001214 | positive regulation of vasculogenesis(GO:2001214) |
| 0.2 | 3.6 | GO:0051457 | maintenance of protein location in nucleus(GO:0051457) |
| 0.2 | 10.5 | GO:0045599 | negative regulation of fat cell differentiation(GO:0045599) |
| 0.2 | 10.3 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.2 | 8.2 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.2 | 3.4 | GO:0006336 | DNA replication-independent nucleosome assembly(GO:0006336) |
| 0.2 | 4.6 | GO:0006825 | copper ion transport(GO:0006825) |
| 0.2 | 27.5 | GO:0048015 | phosphatidylinositol-mediated signaling(GO:0048015) inositol lipid-mediated signaling(GO:0048017) |
| 0.2 | 10.4 | GO:0031122 | cytoplasmic microtubule organization(GO:0031122) |
| 0.2 | 27.2 | GO:0006261 | DNA-dependent DNA replication(GO:0006261) |
| 0.2 | 11.3 | GO:0051384 | response to glucocorticoid(GO:0051384) |
| 0.2 | 1.7 | GO:0090527 | actin filament reorganization(GO:0090527) |
| 0.2 | 8.9 | GO:0006493 | protein O-linked glycosylation(GO:0006493) |
| 0.2 | 0.8 | GO:0021631 | optic nerve morphogenesis(GO:0021631) |
| 0.2 | 3.0 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
| 0.2 | 1.0 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.2 | 3.1 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.2 | 1.7 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
| 0.1 | 2.0 | GO:0034142 | toll-like receptor 4 signaling pathway(GO:0034142) |
| 0.1 | 7.3 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity(GO:0032088) |
| 0.1 | 2.5 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 0.1 | 3.0 | GO:0006625 | protein targeting to peroxisome(GO:0006625) peroxisomal transport(GO:0043574) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663) |
| 0.1 | 1.3 | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440) |
| 0.1 | 2.1 | GO:0007097 | nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023) |
| 0.1 | 0.6 | GO:0007320 | insemination(GO:0007320) |
| 0.1 | 1.5 | GO:0006817 | phosphate ion transport(GO:0006817) |
| 0.1 | 1.3 | GO:0009048 | dosage compensation by inactivation of X chromosome(GO:0009048) |
| 0.1 | 1.8 | GO:1901522 | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522) |
| 0.1 | 0.2 | GO:0035864 | response to potassium ion(GO:0035864) cellular response to potassium ion(GO:0035865) |
| 0.1 | 0.3 | GO:0071921 | establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922) |
| 0.1 | 5.8 | GO:0035904 | aorta development(GO:0035904) |
| 0.1 | 12.8 | GO:0000910 | cytokinesis(GO:0000910) |
| 0.1 | 0.7 | GO:0034638 | phosphatidylcholine catabolic process(GO:0034638) |
| 0.1 | 5.3 | GO:0042475 | odontogenesis of dentin-containing tooth(GO:0042475) |
| 0.1 | 3.6 | GO:0021680 | cerebellar Purkinje cell layer development(GO:0021680) |
| 0.1 | 14.5 | GO:0060348 | bone development(GO:0060348) |
| 0.1 | 3.3 | GO:1902653 | cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653) |
| 0.1 | 1.9 | GO:0033194 | response to hydroperoxide(GO:0033194) |
| 0.1 | 2.4 | GO:0006303 | double-strand break repair via nonhomologous end joining(GO:0006303) |
| 0.1 | 0.7 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.1 | 0.5 | GO:0000395 | mRNA 5'-splice site recognition(GO:0000395) |
| 0.1 | 2.8 | GO:0006940 | regulation of smooth muscle contraction(GO:0006940) |
| 0.1 | 0.1 | GO:0070944 | neutrophil mediated killing of bacterium(GO:0070944) |
| 0.1 | 0.6 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
| 0.1 | 4.0 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 0.1 | 3.8 | GO:0030433 | ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) |
| 0.0 | 2.9 | GO:0051225 | spindle assembly(GO:0051225) |
| 0.0 | 0.5 | GO:1904321 | response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322) |
| 0.0 | 2.5 | GO:0070936 | protein K48-linked ubiquitination(GO:0070936) |
| 0.0 | 2.8 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 1.6 | GO:0010507 | negative regulation of autophagy(GO:0010507) |
| 0.0 | 0.3 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 0.0 | 0.3 | GO:0042573 | retinoic acid metabolic process(GO:0042573) |
| 0.0 | 2.6 | GO:0030307 | positive regulation of cell growth(GO:0030307) |
| 0.0 | 2.7 | GO:0016579 | protein deubiquitination(GO:0016579) |
| 0.0 | 0.6 | GO:0060706 | cell differentiation involved in embryonic placenta development(GO:0060706) |
| 0.0 | 0.6 | GO:0032330 | regulation of chondrocyte differentiation(GO:0032330) |
| 0.0 | 0.1 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
| 0.0 | 1.5 | GO:0015807 | L-amino acid transport(GO:0015807) |
| 0.0 | 1.0 | GO:0071479 | cellular response to ionizing radiation(GO:0071479) |
| 0.0 | 4.3 | GO:0007059 | chromosome segregation(GO:0007059) |
| 0.0 | 0.3 | GO:0003309 | type B pancreatic cell differentiation(GO:0003309) |
| 0.0 | 0.4 | GO:0001522 | pseudouridine synthesis(GO:0001522) |
| 0.0 | 1.3 | GO:0042742 | defense response to bacterium(GO:0042742) |
| 0.0 | 0.6 | GO:0090263 | positive regulation of canonical Wnt signaling pathway(GO:0090263) |
| 0.0 | 3.0 | GO:0006281 | DNA repair(GO:0006281) |
| 0.0 | 1.0 | GO:0008637 | apoptotic mitochondrial changes(GO:0008637) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.9 | 35.8 | GO:0008623 | CHRAC(GO:0008623) |
| 7.9 | 15.9 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 4.5 | 40.7 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
| 2.8 | 11.1 | GO:0045098 | type III intermediate filament(GO:0045098) |
| 2.4 | 7.1 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 2.3 | 9.2 | GO:0070552 | BRISC complex(GO:0070552) |
| 2.2 | 8.9 | GO:0071148 | TEAD-1-YAP complex(GO:0071148) |
| 1.7 | 10.2 | GO:0000444 | MIS12/MIND type complex(GO:0000444) |
| 1.7 | 5.1 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
| 1.6 | 9.7 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 1.1 | 6.8 | GO:0001674 | female germ cell nucleus(GO:0001674) |
| 1.1 | 5.6 | GO:0005587 | collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651) |
| 1.0 | 25.1 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 1.0 | 11.0 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 1.0 | 13.9 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 1.0 | 7.7 | GO:0098554 | cytoplasmic side of endoplasmic reticulum membrane(GO:0098554) |
| 0.8 | 7.6 | GO:0030478 | actin cap(GO:0030478) |
| 0.7 | 7.3 | GO:0032982 | myosin filament(GO:0032982) |
| 0.7 | 2.2 | GO:0036128 | CatSper complex(GO:0036128) |
| 0.7 | 8.5 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.6 | 2.6 | GO:0001652 | granular component(GO:0001652) |
| 0.6 | 109.7 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.5 | 2.0 | GO:0071942 | XPC complex(GO:0071942) |
| 0.5 | 16.5 | GO:0051233 | spindle midzone(GO:0051233) |
| 0.5 | 2.4 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 0.5 | 16.5 | GO:1990391 | DNA repair complex(GO:1990391) |
| 0.5 | 3.7 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.5 | 3.2 | GO:0005664 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.4 | 1.7 | GO:0005694 | chromosome(GO:0005694) |
| 0.4 | 2.0 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.4 | 7.1 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.4 | 2.9 | GO:0070652 | HAUS complex(GO:0070652) |
| 0.3 | 3.1 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.3 | 1.6 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.3 | 33.7 | GO:0005814 | centriole(GO:0005814) |
| 0.3 | 4.9 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.3 | 2.7 | GO:0000974 | Prp19 complex(GO:0000974) |
| 0.3 | 1.6 | GO:0071141 | SMAD protein complex(GO:0071141) |
| 0.3 | 3.3 | GO:0043596 | nuclear replication fork(GO:0043596) |
| 0.3 | 3.3 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.2 | 17.2 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.2 | 6.6 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.2 | 31.8 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.2 | 2.2 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.2 | 4.1 | GO:0010369 | chromocenter(GO:0010369) |
| 0.2 | 1.2 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.2 | 0.6 | GO:0034673 | inhibin-betaglycan-ActRII complex(GO:0034673) |
| 0.2 | 3.0 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.2 | 17.1 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.2 | 0.9 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.2 | 9.2 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.2 | 1.7 | GO:0045275 | respiratory chain complex III(GO:0045275) |
| 0.1 | 3.1 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 2.4 | GO:0005849 | mRNA cleavage factor complex(GO:0005849) |
| 0.1 | 0.6 | GO:1990357 | terminal web(GO:1990357) |
| 0.1 | 39.0 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 1.5 | GO:0043189 | NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562) |
| 0.1 | 7.7 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.1 | 60.0 | GO:0005912 | adherens junction(GO:0005912) |
| 0.1 | 1.6 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.1 | 1.1 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.1 | 0.6 | GO:0034388 | Pwp2p-containing subcomplex of 90S preribosome(GO:0034388) |
| 0.1 | 0.8 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.1 | 0.8 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.1 | 2.2 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.1 | 7.9 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.1 | 4.6 | GO:0030118 | clathrin coat(GO:0030118) |
| 0.1 | 2.3 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.1 | 3.0 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 10.2 | GO:0005813 | centrosome(GO:0005813) |
| 0.1 | 6.1 | GO:0005795 | Golgi stack(GO:0005795) |
| 0.1 | 3.6 | GO:0005769 | early endosome(GO:0005769) |
| 0.1 | 1.7 | GO:0005902 | microvillus(GO:0005902) |
| 0.1 | 4.0 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.1 | 10.0 | GO:0000775 | chromosome, centromeric region(GO:0000775) |
| 0.1 | 0.5 | GO:0000243 | commitment complex(GO:0000243) |
| 0.1 | 5.1 | GO:0034399 | nuclear periphery(GO:0034399) |
| 0.1 | 4.2 | GO:0036126 | sperm flagellum(GO:0036126) |
| 0.0 | 5.4 | GO:0070382 | exocytic vesicle(GO:0070382) |
| 0.0 | 1.6 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.0 | 0.7 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.0 | 14.0 | GO:0005774 | vacuolar membrane(GO:0005774) |
| 0.0 | 7.0 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 1.7 | GO:0030427 | site of polarized growth(GO:0030427) |
| 0.0 | 6.8 | GO:0005764 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.0 | 23.1 | GO:0005794 | Golgi apparatus(GO:0005794) |
| 0.0 | 0.3 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.0 | 0.0 | GO:0030981 | cortical microtubule cytoskeleton(GO:0030981) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.0 | 28.0 | GO:0061505 | DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505) |
| 4.8 | 28.6 | GO:0019841 | retinol binding(GO:0019841) |
| 3.8 | 26.9 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
| 3.5 | 10.5 | GO:0036132 | 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522) |
| 3.4 | 20.5 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 3.2 | 15.9 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 2.8 | 11.1 | GO:1990254 | keratin filament binding(GO:1990254) |
| 2.4 | 7.1 | GO:0030226 | apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556) |
| 2.2 | 41.8 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 2.1 | 12.5 | GO:0047276 | N-acetyllactosaminide 3-alpha-galactosyltransferase activity(GO:0047276) |
| 1.9 | 15.0 | GO:0050693 | LBD domain binding(GO:0050693) |
| 1.7 | 15.5 | GO:0043237 | laminin-1 binding(GO:0043237) |
| 1.7 | 8.5 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 1.7 | 35.0 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 1.5 | 24.0 | GO:0003680 | AT DNA binding(GO:0003680) |
| 1.5 | 4.5 | GO:0016494 | C-X-C chemokine receptor activity(GO:0016494) |
| 1.4 | 8.5 | GO:0071074 | eukaryotic initiation factor eIF2 binding(GO:0071074) |
| 1.4 | 20.5 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 1.2 | 8.3 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915) |
| 1.1 | 5.7 | GO:0034648 | histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648) |
| 1.1 | 11.0 | GO:0005167 | neurotrophin TRK receptor binding(GO:0005167) |
| 1.1 | 3.3 | GO:0004769 | steroid delta-isomerase activity(GO:0004769) |
| 1.1 | 8.6 | GO:0051393 | alpha-actinin binding(GO:0051393) |
| 1.1 | 8.6 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
| 1.0 | 5.2 | GO:0004594 | pantothenate kinase activity(GO:0004594) |
| 1.0 | 9.9 | GO:0004445 | inositol-polyphosphate 5-phosphatase activity(GO:0004445) inositol trisphosphate phosphatase activity(GO:0046030) |
| 0.9 | 4.6 | GO:0004322 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.9 | 4.3 | GO:0050265 | RNA uridylyltransferase activity(GO:0050265) |
| 0.8 | 10.2 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 0.8 | 5.1 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 0.8 | 3.9 | GO:0015142 | citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142) |
| 0.8 | 27.7 | GO:0005112 | Notch binding(GO:0005112) |
| 0.8 | 15.2 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.7 | 2.1 | GO:0016716 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716) |
| 0.7 | 21.7 | GO:0032452 | histone demethylase activity(GO:0032452) |
| 0.6 | 3.8 | GO:0016813 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813) |
| 0.6 | 5.6 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.6 | 4.9 | GO:0034046 | poly(G) binding(GO:0034046) |
| 0.6 | 131.4 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.6 | 8.9 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.6 | 1.8 | GO:0004886 | 9-cis retinoic acid receptor activity(GO:0004886) |
| 0.6 | 4.1 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 0.6 | 10.9 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.6 | 2.3 | GO:0071532 | ankyrin repeat binding(GO:0071532) |
| 0.6 | 8.9 | GO:0001134 | transcription factor activity, transcription factor recruiting(GO:0001134) |
| 0.5 | 15.9 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.5 | 1.6 | GO:0035500 | MH2 domain binding(GO:0035500) |
| 0.5 | 9.6 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.5 | 13.6 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
| 0.5 | 4.2 | GO:0032564 | dATP binding(GO:0032564) |
| 0.5 | 6.0 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.5 | 8.2 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
| 0.5 | 4.5 | GO:0016863 | intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863) |
| 0.4 | 2.2 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.4 | 6.1 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.4 | 9.7 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.4 | 3.7 | GO:0071253 | connexin binding(GO:0071253) |
| 0.4 | 31.7 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.4 | 1.5 | GO:0000832 | inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724) |
| 0.4 | 7.3 | GO:0000146 | microfilament motor activity(GO:0000146) |
| 0.3 | 2.9 | GO:0039706 | co-receptor binding(GO:0039706) |
| 0.3 | 3.9 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.3 | 3.0 | GO:0004679 | AMP-activated protein kinase activity(GO:0004679) |
| 0.3 | 0.9 | GO:0035673 | oligopeptide transmembrane transporter activity(GO:0035673) |
| 0.3 | 0.9 | GO:0032896 | palmitoyl-CoA 9-desaturase activity(GO:0032896) |
| 0.3 | 2.0 | GO:0032795 | heterotrimeric G-protein binding(GO:0032795) |
| 0.3 | 8.5 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.3 | 4.2 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.2 | 35.7 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.2 | 12.2 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.2 | 7.3 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.2 | 3.2 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.2 | 4.8 | GO:0001221 | transcription cofactor binding(GO:0001221) |
| 0.2 | 3.7 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.2 | 9.0 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.2 | 1.7 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.2 | 15.1 | GO:0002039 | p53 binding(GO:0002039) |
| 0.2 | 8.2 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.2 | 131.3 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.2 | 56.1 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.2 | 2.2 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.2 | 9.5 | GO:0005179 | hormone activity(GO:0005179) |
| 0.2 | 5.8 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.2 | 4.9 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.2 | 0.8 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
| 0.1 | 1.9 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.1 | 2.0 | GO:0008641 | small protein activating enzyme activity(GO:0008641) |
| 0.1 | 2.0 | GO:0001530 | lipopolysaccharide binding(GO:0001530) |
| 0.1 | 1.1 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 0.1 | 14.7 | GO:0016779 | nucleotidyltransferase activity(GO:0016779) |
| 0.1 | 2.5 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.1 | 2.2 | GO:0051861 | glycolipid binding(GO:0051861) |
| 0.1 | 3.8 | GO:0031690 | adrenergic receptor binding(GO:0031690) |
| 0.1 | 25.9 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 1.7 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 0.1 | 2.5 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.1 | 4.6 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.1 | 1.2 | GO:0043560 | insulin receptor substrate binding(GO:0043560) |
| 0.1 | 2.4 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.1 | 1.6 | GO:0031402 | sodium ion binding(GO:0031402) |
| 0.1 | 0.8 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
| 0.1 | 4.3 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.1 | 0.9 | GO:0042923 | neuropeptide binding(GO:0042923) |
| 0.1 | 50.9 | GO:0019904 | protein domain specific binding(GO:0019904) |
| 0.1 | 4.4 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.1 | 1.2 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.1 | 0.3 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.1 | 2.0 | GO:0042054 | histone methyltransferase activity(GO:0042054) |
| 0.1 | 0.3 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.0 | 2.5 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.0 | 17.8 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.0 | 6.1 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 0.0 | 11.9 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 1.6 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.0 | 2.7 | GO:0036459 | thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005) |
| 0.0 | 1.5 | GO:0015175 | neutral amino acid transmembrane transporter activity(GO:0015175) |
| 0.0 | 0.3 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.0 | 0.3 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
| 0.0 | 0.7 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 2.2 | GO:0051117 | ATPase binding(GO:0051117) |
| 0.0 | 0.6 | GO:0030515 | snoRNA binding(GO:0030515) |
| 0.0 | 0.6 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 0.4 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 0.0 | 4.9 | GO:0008233 | peptidase activity(GO:0008233) |
| 0.0 | 0.1 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.0 | 1.3 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.0 | 0.3 | GO:0004029 | aldehyde dehydrogenase (NAD) activity(GO:0004029) |
| 0.0 | 0.1 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.0 | 0.1 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 2.2 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.8 | 30.8 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.6 | 11.1 | PID_EPHA2_FWD_PATHWAY | EPHA2 forward signaling |
| 0.6 | 21.7 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.6 | 20.7 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.6 | 27.8 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.6 | 8.3 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
| 0.5 | 24.7 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.5 | 34.7 | PID_AP1_PATHWAY | AP-1 transcription factor network |
| 0.5 | 18.3 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.5 | 11.3 | SA_B_CELL_RECEPTOR_COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.5 | 21.9 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.4 | 24.2 | PID_CDC42_PATHWAY | CDC42 signaling events |
| 0.3 | 12.2 | PID_NEPHRIN_NEPH1_PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.3 | 8.1 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.3 | 6.0 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
| 0.3 | 4.8 | PID_HIF1A_PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.2 | 8.9 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.2 | 7.6 | PID_IL6_7_PATHWAY | IL6-mediated signaling events |
| 0.2 | 5.6 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.2 | 7.5 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.2 | 21.5 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 4.2 | PID_ATF2_PATHWAY | ATF-2 transcription factor network |
| 0.2 | 8.2 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 2.0 | PID_ERB_GENOMIC_PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 6.6 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.1 | 5.0 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 3.1 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 2.4 | PID_DNA_PK_PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.1 | 3.3 | SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.1 | 1.9 | PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 1.0 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.1 | 1.7 | PID_ANGIOPOIETIN_RECEPTOR_PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.1 | 3.0 | PID_VEGFR1_2_PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.1 | 1.0 | PID_AR_NONGENOMIC_PATHWAY | Nongenotropic Androgen signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 7.7 | REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS | Genes involved in Hormone ligand-binding receptors |
| 2.0 | 27.8 | REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 1.6 | 22.0 | REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 1.1 | 7.4 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.7 | 11.3 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.7 | 26.9 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.6 | 8.5 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
| 0.5 | 14.3 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.5 | 7.1 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.5 | 11.1 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.4 | 8.5 | REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 0.4 | 5.2 | REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.4 | 11.1 | REACTOME_IL_RECEPTOR_SHC_SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.3 | 8.4 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.3 | 3.2 | REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.3 | 2.5 | REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.3 | 9.1 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.3 | 17.6 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.3 | 4.2 | REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.3 | 4.1 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.3 | 4.8 | REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.3 | 8.2 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.3 | 2.9 | REACTOME_ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 0.3 | 6.7 | REACTOME_SIGNALING_BY_ROBO_RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.2 | 17.0 | REACTOME_MEIOTIC_SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.2 | 7.6 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.2 | 3.0 | REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.2 | 4.5 | REACTOME_EARLY_PHASE_OF_HIV_LIFE_CYCLE | Genes involved in Early Phase of HIV Life Cycle |
| 0.2 | 6.1 | REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.2 | 8.9 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.2 | 5.7 | REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.2 | 12.6 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.2 | 8.6 | REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS | Genes involved in Glucagon-type ligand receptors |
| 0.2 | 1.0 | REACTOME_REGULATION_OF_COMPLEMENT_CASCADE | Genes involved in Regulation of Complement cascade |
| 0.2 | 1.7 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
| 0.2 | 1.3 | REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.2 | 4.6 | REACTOME_METAL_ION_SLC_TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.2 | 5.2 | REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |
| 0.2 | 16.6 | REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS | Genes involved in G alpha (q) signalling events |
| 0.1 | 1.3 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.1 | 2.4 | REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.1 | 3.3 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.1 | 1.6 | REACTOME_MUSCLE_CONTRACTION | Genes involved in Muscle contraction |
| 0.1 | 3.9 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 0.9 | REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR4 ligand binding and activation |
| 0.1 | 10.2 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 0.9 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.1 | 2.5 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 1.1 | REACTOME_INFLAMMASOMES | Genes involved in Inflammasomes |
| 0.1 | 1.9 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
| 0.1 | 1.0 | REACTOME_DEADENYLATION_OF_MRNA | Genes involved in Deadenylation of mRNA |
| 0.1 | 1.7 | REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.0 | 1.0 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 3.0 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 1.5 | REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 1.5 | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 1.3 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 1.3 | REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.0 | 7.4 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 2.0 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
