Motif ID: Creb1

Z-value: 1.633


Transcription factors associated with Creb1:

Gene SymbolEntrez IDGene Name
Creb1 ENSMUSG00000025958.8 Creb1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Creb1mm10_v2_chr1_+_64532790_645328150.471.6e-05Click!


Activity profile for motif Creb1.

activity profile for motif Creb1


Sorted Z-values histogram for motif Creb1

Sorted Z-values for motif Creb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Creb1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_4907705 17.158 ENSMUST00000020962.5
 Ubxn2a
UBX domain protein 2A
chr19_+_6084983 12.539 ENSMUST00000025704.2
 Cdca5
cell division cycle associated 5
chr12_-_4907229 11.727 ENSMUST00000142867.1
 Ubxn2a
UBX domain protein 2A
chr3_+_135212557 9.728 ENSMUST00000062893.7
 Cenpe
centromere protein E
chr9_-_66919646 9.353 ENSMUST00000041139.7
 Rab8b
RAB8B, member RAS oncogene family
chr11_+_43528759 9.215 ENSMUST00000050574.6
 Ccnjl
cyclin J-like
chr7_-_47008397 8.844 ENSMUST00000061639.7
 Spty2d1
SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)
chr2_+_156840966 8.766 ENSMUST00000109564.1
 Tgif2
TGFB-induced factor homeobox 2
chr6_+_113531675 8.703 ENSMUST00000036340.5
ENSMUST00000101051.2
 Fancd2

Fanconi anemia, complementation group D2

chr2_+_119047116 8.635 ENSMUST00000152380.1
ENSMUST00000099542.2
 Casc5

cancer susceptibility candidate 5

chr12_-_98901478 8.396 ENSMUST00000065716.6
 Eml5
echinoderm microtubule associated protein like 5
chr9_+_122951051 8.042 ENSMUST00000040717.5
 Kif15
kinesin family member 15
chr13_-_29984219 7.583 ENSMUST00000146092.1
 E2f3
E2F transcription factor 3
chr8_+_57511833 7.200 ENSMUST00000067925.6
 Hmgb2
high mobility group box 2
chr2_+_119047129 6.982 ENSMUST00000153300.1
ENSMUST00000028799.5
 Casc5

cancer susceptibility candidate 5

chr12_+_73286868 6.020 ENSMUST00000153941.1
ENSMUST00000122920.1
ENSMUST00000101313.3
 Slc38a6


solute carrier family 38, member 6


chr7_-_118533298 5.988 ENSMUST00000098090.3
ENSMUST00000032887.3
 Coq7

demethyl-Q 7

chr15_-_76710486 5.706 ENSMUST00000036852.7
 Recql4
RecQ protein-like 4
chr17_-_56476462 5.706 ENSMUST00000067538.5
 Ptprs
protein tyrosine phosphatase, receptor type, S
chr10_-_31609184 5.607 ENSMUST00000081989.6
 Rnf217
ring finger protein 217

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 164 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 28.9 GO:0031468 nuclear envelope reassembly(GO:0031468)
3.4 13.5 GO:0010847 regulation of chromatin assembly(GO:0010847)
4.2 12.5 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
1.6 11.5 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
1.6 9.7 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
1.3 9.4 GO:0051461 regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
2.3 9.3 GO:0072365 regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072365)
0.4 9.3 GO:0038092 nodal signaling pathway(GO:0038092)
2.9 8.8 GO:0072554 arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) endothelial cell fate specification(GO:0060847) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) blood vessel lumenization(GO:0072554) blood vessel endothelial cell fate specification(GO:0097101) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) positive regulation of heart induction(GO:1901321) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)
0.3 8.8 GO:0030488 tRNA methylation(GO:0030488)
2.1 8.5 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.7 8.2 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.5 8.1 GO:0015693 magnesium ion transport(GO:0015693)
0.1 8.1 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.2 7.4 GO:0003333 amino acid transmembrane transport(GO:0003333)
1.0 7.2 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.1 6.7 GO:0007098 centrosome cycle(GO:0007098)
0.9 6.4 GO:0006344 maintenance of chromatin silencing(GO:0006344)
0.6 6.4 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
3.0 6.0 GO:1903722 regulation of centriole elongation(GO:1903722)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 108 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 31.0 GO:0005801 cis-Golgi network(GO:0005801)
0.3 17.2 GO:0005871 kinesin complex(GO:0005871)
0.2 16.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 13.0 GO:0000793 condensed chromosome(GO:0000793)
1.8 12.5 GO:0008278 cohesin complex(GO:0008278)
0.7 9.7 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778) mitotic spindle midzone(GO:1990023)
0.6 9.4 GO:0051286 cell tip(GO:0051286)
1.8 8.8 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.6 8.6 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 8.6 GO:0005643 nuclear pore(GO:0005643)
0.1 8.5 GO:0043198 dendritic shaft(GO:0043198)
0.0 8.1 GO:0005769 early endosome(GO:0005769)
0.7 6.1 GO:0000813 ESCRT I complex(GO:0000813)
0.1 6.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 6.1 GO:0000151 ubiquitin ligase complex(GO:0000151)
1.5 6.0 GO:0031084 BLOC-2 complex(GO:0031084)
0.6 6.0 GO:0090543 Flemming body(GO:0090543)
0.1 5.9 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.2 5.7 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 5.6 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 124 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 28.9 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 14.6 GO:0003682 chromatin binding(GO:0003682)
0.3 12.8 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.3 12.8 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 11.3 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 10.3 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
1.9 9.7 GO:0043515 kinetochore binding(GO:0043515)
1.2 9.4 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
1.2 9.4 GO:0030911 TPR domain binding(GO:0030911)
0.2 8.7 GO:0003777 microtubule motor activity(GO:0003777)
1.2 8.5 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.3 8.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 8.4 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 8.4 GO:0008017 microtubule binding(GO:0008017)
0.0 7.8 GO:0042393 histone binding(GO:0042393)
0.1 7.4 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
1.2 7.2 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 6.7 GO:0042623 ATPase activity, coupled(GO:0042623)
0.3 6.6 GO:0070182 DNA polymerase binding(GO:0070182)
0.2 6.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 19.6 PID_BARD1_PATHWAY BARD1 signaling events
0.3 16.7 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.2 13.9 PID_E2F_PATHWAY E2F transcription factor network
0.2 12.8 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.2 9.7 PID_PLK1_PATHWAY PLK1 signaling events
0.2 8.5 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 8.2 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.2 7.6 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.3 5.2 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 3.5 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 3.3 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.1 3.3 PID_FAS_PATHWAY FAS (CD95) signaling pathway
0.1 3.3 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 3.2 PID_AVB3_INTEGRIN_PATHWAY Integrins in angiogenesis
0.3 2.9 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 2.8 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.1 2.8 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.3 2.2 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 2.0 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 1.9 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 18.7 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.3 15.6 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
1.4 14.2 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 9.2 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.5 8.5 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.3 8.0 REACTOME_KINESINS Genes involved in Kinesins
0.6 7.6 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 7.5 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.5 7.2 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.4 6.5 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.8 6.1 REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.2 6.1 REACTOME_TRANSPORT_OF_RIBONUCLEOPROTEINS_INTO_THE_HOST_NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.1 6.1 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.3 5.7 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.2 5.4 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 5.0 REACTOME_PIP3_ACTIVATES_AKT_SIGNALING Genes involved in PIP3 activates AKT signaling
0.2 4.9 REACTOME_DOUBLE_STRAND_BREAK_REPAIR Genes involved in Double-Strand Break Repair
0.2 4.8 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_2_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.3 4.5 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 4.5 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants