Motif ID: Creb3

Z-value: 0.684


Transcription factors associated with Creb3:

Gene SymbolEntrez IDGene Name
Creb3 ENSMUSG00000028466.9 Creb3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Creb3mm10_v2_chr4_+_43562672_435629470.342.5e-03Click!


Activity profile for motif Creb3.

activity profile for motif Creb3


Sorted Z-values histogram for motif Creb3

Sorted Z-values for motif Creb3



Network of associatons between targets according to the STRING database.



First level regulatory network of Creb3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_45092130 7.097 ENSMUST00000148175.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr7_-_45091713 6.563 ENSMUST00000141576.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr4_-_117182623 5.401 ENSMUST00000065896.2
 Kif2c
kinesin family member 2C
chrX_-_60893430 5.022 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr3_-_36571952 4.823 ENSMUST00000029270.3
 Ccna2
cyclin A2
chr15_+_79892436 3.891 ENSMUST00000175752.1
ENSMUST00000176325.1
 Apobec3

apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3

chr4_+_47474652 3.805 ENSMUST00000065678.5
ENSMUST00000137461.1
ENSMUST00000125622.1
 Sec61b


Sec61 beta subunit


chr7_-_45092198 3.738 ENSMUST00000140449.1
ENSMUST00000117546.1
ENSMUST00000019683.3
 Rcn3


reticulocalbin 3, EF-hand calcium binding domain


chr11_+_70000578 3.671 ENSMUST00000019362.8
 Dvl2
dishevelled 2, dsh homolog (Drosophila)
chr15_+_79892397 3.607 ENSMUST00000175714.1
ENSMUST00000109620.3
ENSMUST00000165537.1
 Apobec3


apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3


chr10_+_41519493 3.593 ENSMUST00000019962.8
 Cd164
CD164 antigen
chr1_+_74791516 3.567 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr2_-_105399286 3.428 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr6_-_108185552 3.347 ENSMUST00000167338.1
ENSMUST00000172188.1
ENSMUST00000032191.9
 Sumf1


sulfatase modifying factor 1


chr5_-_124352233 3.088 ENSMUST00000111472.1
 Cdk2ap1
CDK2 (cyclin-dependent kinase 2)-associated protein 1
chr4_+_3938888 2.684 ENSMUST00000121110.1
ENSMUST00000108386.1
ENSMUST00000149544.1
 Chchd7


coiled-coil-helix-coiled-coil-helix domain containing 7


chr11_-_94653964 2.631 ENSMUST00000039949.4
 Eme1
essential meiotic endonuclease 1 homolog 1 (S. pombe)
chr4_+_148039097 2.547 ENSMUST00000141283.1
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr9_+_44379490 2.519 ENSMUST00000066601.6
 Hyou1
hypoxia up-regulated 1
chr10_+_19356558 2.511 ENSMUST00000053225.5
 Olig3
oligodendrocyte transcription factor 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 118 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 7.5 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
0.7 7.0 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.1 5.5 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
1.1 5.4 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.5 5.0 GO:1903298 regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903297) negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903298)
0.3 5.0 GO:0007530 sex determination(GO:0007530)
1.2 4.8 GO:0070829 heterochromatin maintenance(GO:0070829)
1.3 3.8 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.7 3.7 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.3 3.6 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
1.1 3.3 GO:0070476 rRNA (guanine-N7)-methylation(GO:0070476)
0.1 3.3 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.1 3.1 GO:0060325 face morphogenesis(GO:0060325)
0.5 2.6 GO:0072429 response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.3 2.6 GO:0018158 protein oxidation(GO:0018158)
0.5 2.5 GO:0097476 spinal cord motor neuron migration(GO:0097476)
0.8 2.4 GO:0051105 regulation of DNA ligation(GO:0051105) positive regulation of DNA ligation(GO:0051106)
0.2 2.3 GO:0002227 innate immune response in mucosa(GO:0002227)
0.4 2.2 GO:0006621 protein retention in ER lumen(GO:0006621)
0.2 2.2 GO:0033234 negative regulation of protein sumoylation(GO:0033234)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.4 GO:0035371 microtubule plus-end(GO:0035371)
0.4 5.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.7 4.8 GO:0001940 male pronucleus(GO:0001940)
0.1 4.6 GO:0016235 aggresome(GO:0016235)
1.3 3.8 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.1 3.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 3.1 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 3.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.5 2.6 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.1 2.4 GO:0000800 lateral element(GO:0000800)
0.1 2.2 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 2.2 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 2.1 GO:0005811 lipid particle(GO:0005811)
0.0 2.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 2.0 GO:0032587 ruffle membrane(GO:0032587)
0.0 2.0 GO:0008021 synaptic vesicle(GO:0008021)
0.2 1.9 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.1 1.9 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 1.9 GO:0031902 late endosome membrane(GO:0031902)
0.0 1.9 GO:0005759 mitochondrial matrix(GO:0005759)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.9 GO:0005509 calcium ion binding(GO:0005509)
0.2 8.0 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
1.9 7.5 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.2 7.5 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 7.2 GO:0005109 frizzled binding(GO:0005109)
0.1 6.0 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
0.3 5.4 GO:0051010 microtubule plus-end binding(GO:0051010)
1.6 4.8 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.0 4.7 GO:0003735 structural constituent of ribosome(GO:0003735)
1.0 3.8 GO:0048408 epidermal growth factor binding(GO:0048408)
0.0 3.3 GO:0008276 protein methyltransferase activity(GO:0008276)
0.1 3.1 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 2.9 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 2.8 GO:0019789 SUMO transferase activity(GO:0019789)
0.4 2.6 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.3 2.4 GO:0000150 recombinase activity(GO:0000150)
0.6 2.2 GO:0046923 ER retention sequence binding(GO:0046923)
0.2 2.2 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.2 2.0 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.1 2.0 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 6.8 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 5.4 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 4.7 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 4.1 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway
0.1 3.7 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.1 3.1 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 3.0 PID_ARF_3PATHWAY Arf1 pathway
0.1 2.4 PID_ATR_PATHWAY ATR signaling pathway
0.2 2.2 ST_JAK_STAT_PATHWAY Jak-STAT Pathway
0.1 2.0 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 2.0 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.7 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 1.6 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.3 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.1 1.2 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 1.2 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 1.0 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.9 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.9 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.8 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.6 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.2 5.4 REACTOME_KINESINS Genes involved in Kinesins
0.0 5.4 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.3 4.8 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 4.8 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 4.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 4.1 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 3.5 REACTOME_ER_PHAGOSOME_PATHWAY Genes involved in ER-Phagosome pathway
0.1 3.1 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.3 2.6 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 2.2 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 2.0 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.5 1.9 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 1.9 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.2 1.7 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 1.3 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 1.2 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 1.2 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 1.1 REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.1 1.1 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks