Motif ID: Creb3l2

Z-value: 0.578


Transcription factors associated with Creb3l2:

Gene SymbolEntrez IDGene Name
Creb3l2 ENSMUSG00000038648.5 Creb3l2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Creb3l2mm10_v2_chr6_-_37442095_37442154-0.123.0e-01Click!


Activity profile for motif Creb3l2.

activity profile for motif Creb3l2


Sorted Z-values histogram for motif Creb3l2

Sorted Z-values for motif Creb3l2



Network of associatons between targets according to the STRING database.



First level regulatory network of Creb3l2

PNG image of the network

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Top targets:


Showing 1 to 20 of 142 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_148591482 7.528 ENSMUST00000006611.8
 Srm
spermidine synthase
chr13_-_92131494 6.095 ENSMUST00000099326.3
ENSMUST00000146492.1
 Rasgrf2

RAS protein-specific guanine nucleotide-releasing factor 2

chr3_+_123267445 5.385 ENSMUST00000047923.7
 Sec24d
Sec24 related gene family, member D (S. cerevisiae)
chr6_-_22356068 4.856 ENSMUST00000163963.1
ENSMUST00000165576.1
 Fam3c

family with sequence similarity 3, member C

chr6_-_22356176 4.565 ENSMUST00000081288.7
 Fam3c
family with sequence similarity 3, member C
chr5_-_30945393 4.441 ENSMUST00000031051.6
 Cgref1
cell growth regulator with EF hand domain 1
chrX_+_8271133 4.198 ENSMUST00000127103.1
ENSMUST00000115591.1
 Slc38a5

solute carrier family 38, member 5

chr19_-_6840590 4.137 ENSMUST00000170516.2
ENSMUST00000025903.5
 Rps6ka4

ribosomal protein S6 kinase, polypeptide 4

chr5_+_107331157 3.962 ENSMUST00000031215.8
ENSMUST00000112677.3
 Brdt

bromodomain, testis-specific

chr6_-_8778439 3.544 ENSMUST00000115520.1
ENSMUST00000038403.5
ENSMUST00000115518.1
 Ica1


islet cell autoantigen 1


chr18_+_75018709 3.464 ENSMUST00000039608.7
 Dym
dymeclin
chr6_-_8778106 3.161 ENSMUST00000151758.1
ENSMUST00000115519.1
ENSMUST00000153390.1
 Ica1


islet cell autoantigen 1


chr11_-_55033398 3.104 ENSMUST00000108883.3
ENSMUST00000102727.2
 Anxa6

annexin A6

chr9_+_89909775 2.887 ENSMUST00000034912.4
ENSMUST00000034909.4
 Rasgrf1

RAS protein-specific guanine nucleotide-releasing factor 1

chr15_-_102136225 2.833 ENSMUST00000154032.1
 Spryd3
SPRY domain containing 3
chr15_-_75678732 2.662 ENSMUST00000000958.8
 Top1mt
DNA topoisomerase 1, mitochondrial
chr10_-_20725023 2.471 ENSMUST00000020165.7
 Pde7b
phosphodiesterase 7B
chr6_-_13871459 2.400 ENSMUST00000155856.1
 2610001J05Rik
RIKEN cDNA 2610001J05 gene
chrX_+_153139941 2.251 ENSMUST00000039720.4
ENSMUST00000144175.2
 Rragb

Ras-related GTP binding B

chr3_-_20155069 2.235 ENSMUST00000184552.1
ENSMUST00000178328.1
 Gyg

glycogenin


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.0 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
1.9 7.5 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.3 6.5 GO:0043496 regulation of protein homodimerization activity(GO:0043496)
0.0 4.4 GO:0007050 cell cycle arrest(GO:0007050)
0.3 4.2 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.3 4.2 GO:0015816 glycine transport(GO:0015816)
1.4 4.1 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.3 4.0 GO:0007141 male meiosis I(GO:0007141)
0.0 3.8 GO:0007030 Golgi organization(GO:0007030)
0.1 3.6 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 3.3 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.1 3.1 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.3 2.7 GO:0006265 DNA topological change(GO:0006265)
0.0 2.4 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.2 2.3 GO:1990253 cellular response to leucine starvation(GO:1990253)
0.0 2.2 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.2 2.1 GO:0051103 DNA ligation involved in DNA repair(GO:0051103)
0.0 2.1 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.7 2.0 GO:1990523 bone regeneration(GO:1990523)
0.1 1.9 GO:0006465 signal peptide processing(GO:0006465)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.7 GO:0030667 secretory granule membrane(GO:0030667)
0.3 4.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.2 3.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.5 3.0 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807)
0.1 2.9 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 2.7 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.5 2.3 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 2.2 GO:0014704 intercalated disc(GO:0014704)
0.1 2.0 GO:0031527 filopodium membrane(GO:0031527)
0.2 1.9 GO:0005787 signal peptidase complex(GO:0005787)
0.1 1.6 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 1.6 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 1.6 GO:0005905 clathrin-coated pit(GO:0005905)
0.5 1.5 GO:0005927 muscle tendon junction(GO:0005927)
0.1 1.3 GO:1990635 proximal dendrite(GO:1990635)
0.0 1.3 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2 0.8 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.2 0.8 GO:0097574 lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795)
0.1 0.8 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 0.8 GO:0005796 Golgi lumen(GO:0005796)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 7.5 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.3 5.7 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 5.7 GO:0000149 SNARE binding(GO:0000149)
0.0 5.1 GO:0008236 serine-type peptidase activity(GO:0008236)
0.4 4.2 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.2 4.0 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.2 3.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 3.1 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.5 3.0 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.5 2.7 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.1 2.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.2 2.2 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 2.1 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.1 2.0 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.3 1.8 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 1.8 GO:0008378 galactosyltransferase activity(GO:0008378)
0.6 1.7 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.4 1.7 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.1 1.7 GO:0005154 epidermal growth factor receptor binding(GO:0005154)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.9 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 4.1 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 3.0 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 2.9 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 2.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.0 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 2.0 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 1.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.6 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 1.4 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 0.7 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.6 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.5 PID_BMP_PATHWAY BMP receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.0 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.4 5.9 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.3 5.2 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 4.1 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.2 3.3 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.2 3.0 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus
0.1 2.6 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 2.5 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.0 2.0 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.9 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.2 1.8 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 1.8 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 1.7 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 1.6 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 1.6 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.1 1.5 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 1.5 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 1.2 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.9 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 0.8 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE