Motif ID: Crx_Gsc

Z-value: 0.523

Transcription factors associated with Crx_Gsc:

Gene SymbolEntrez IDGene Name
Crx ENSMUSG00000041578.9 Crx
Gsc ENSMUSG00000021095.4 Gsc

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Crxmm10_v2_chr7_-_15879844_15879968-0.056.5e-01Click!


Activity profile for motif Crx_Gsc.

activity profile for motif Crx_Gsc


Sorted Z-values histogram for motif Crx_Gsc

Sorted Z-values for motif Crx_Gsc



Network of associatons between targets according to the STRING database.



First level regulatory network of Crx_Gsc

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_74013442 6.261 ENSMUST00000098006.2
ENSMUST00000084474.5
 Frmd3

FERM domain containing 3

chr11_+_104231390 5.602 ENSMUST00000106992.3
 Mapt
microtubule-associated protein tau
chr6_-_59426279 5.218 ENSMUST00000051065.4
 Gprin3
GPRIN family member 3
chr14_+_65968483 5.113 ENSMUST00000022616.6
 Clu
clusterin
chr13_+_110395041 5.041 ENSMUST00000022212.7
 Plk2
polo-like kinase 2
chr10_+_90576872 4.531 ENSMUST00000182550.1
ENSMUST00000099364.5
 Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B

chr14_-_19977249 4.339 ENSMUST00000160013.1
 Gng2
guanine nucleotide binding protein (G protein), gamma 2
chr14_-_19977151 3.595 ENSMUST00000055100.7
ENSMUST00000162425.1
 Gng2

guanine nucleotide binding protein (G protein), gamma 2

chr14_-_19977040 3.408 ENSMUST00000159028.1
 Gng2
guanine nucleotide binding protein (G protein), gamma 2
chr4_+_120854786 3.373 ENSMUST00000071093.2
 Rims3
regulating synaptic membrane exocytosis 3
chr1_-_154725920 3.369 ENSMUST00000004214.8
 Cacna1e
calcium channel, voltage-dependent, R type, alpha 1E subunit
chr11_+_6658510 3.242 ENSMUST00000045374.7
 Ramp3
receptor (calcitonin) activity modifying protein 3
chr7_-_140082246 3.151 ENSMUST00000166758.2
 Caly
calcyon neuron-specific vesicular protein
chr4_-_138396438 3.033 ENSMUST00000105032.2
 Fam43b
family with sequence similarity 43, member B
chr4_-_14621494 3.009 ENSMUST00000149633.1
 Slc26a7
solute carrier family 26, member 7
chr12_+_81631369 2.845 ENSMUST00000036116.5
 Ttc9
tetratricopeptide repeat domain 9
chr1_-_152625212 2.824 ENSMUST00000027760.7
 Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chr9_-_53975246 2.819 ENSMUST00000048409.7
 Elmod1
ELMO/CED-12 domain containing 1
chr19_+_26605106 2.728 ENSMUST00000025862.7
ENSMUST00000176030.1
 Smarca2

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

chr9_+_109051090 2.720 ENSMUST00000059097.8
 Shisa5
shisa homolog 5 (Xenopus laevis)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 125 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.4 GO:0007186 G-protein coupled receptor signaling pathway(GO:0007186)
1.1 6.5 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.6 5.6 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.9 5.1 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.4 5.0 GO:0032486 Rap protein signal transduction(GO:0032486)
0.0 4.8 GO:0031032 actomyosin structure organization(GO:0031032)
0.4 4.5 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 4.3 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.2 4.0 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.1 3.7 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.7 3.4 GO:0090273 regulation of somatostatin secretion(GO:0090273)
0.1 3.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 3.2 GO:0048268 clathrin coat assembly(GO:0048268)
0.4 3.0 GO:0019532 oxalate transport(GO:0019532)
0.3 2.7 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.4 2.5 GO:0061718 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.2 2.5 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.5 2.2 GO:2000705 regulation of dense core granule biogenesis(GO:2000705)
0.1 2.2 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.2 2.1 GO:0042756 drinking behavior(GO:0042756)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 10.7 GO:0097418 neurofibrillary tangle(GO:0097418)
0.2 9.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
1.3 6.5 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.1 5.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 5.1 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 3.4 GO:0048786 presynaptic active zone(GO:0048786)
0.0 3.4 GO:0005814 centriole(GO:0005814)
0.1 2.7 GO:0071564 npBAF complex(GO:0071564)
0.1 2.5 GO:0097228 sperm principal piece(GO:0097228)
0.0 2.5 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 2.1 GO:0043034 costamere(GO:0043034)
0.0 2.1 GO:0031225 anchored component of membrane(GO:0031225)
0.1 1.9 GO:0031143 pseudopodium(GO:0031143)
0.0 1.8 GO:0002102 podosome(GO:0002102)
0.0 1.7 GO:0000502 proteasome complex(GO:0000502)
0.1 1.6 GO:0042581 specific granule(GO:0042581)
0.0 1.6 GO:0060170 ciliary membrane(GO:0060170)
0.0 1.3 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.2 1.2 GO:0005955 calcineurin complex(GO:0005955)
0.3 1.1 GO:0031092 platelet alpha granule membrane(GO:0031092)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 10.7 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 6.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
1.3 6.5 GO:0097643 amylin receptor activity(GO:0097643)
0.8 5.6 GO:0099609 microtubule lateral binding(GO:0099609)
0.1 5.6 GO:0001786 phosphatidylserine binding(GO:0001786)
0.4 5.4 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 5.4 GO:0044325 ion channel binding(GO:0044325)
0.3 5.0 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.2 4.9 GO:0051787 misfolded protein binding(GO:0051787)
0.1 4.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.4 3.2 GO:0032051 clathrin light chain binding(GO:0032051)
0.3 3.0 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.5 2.8 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 2.7 GO:0050699 WW domain binding(GO:0050699)
0.5 2.5 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 2.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 2.2 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.1 2.2 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.2 2.1 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 2.1 GO:0004222 metalloendopeptidase activity(GO:0004222)

Gene overrepresentation in C2:CP category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 11.3 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.1 6.9 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.3 5.6 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 4.3 PID_IL12_2PATHWAY IL12-mediated signaling events
0.1 3.2 PID_ARF6_PATHWAY Arf6 signaling events
0.0 2.7 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 2.5 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 1.8 PID_ARF_3PATHWAY Arf1 pathway
0.0 1.0 PID_EPO_PATHWAY EPO signaling pathway
0.0 1.0 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 0.9 PID_IL23_PATHWAY IL23-mediated signaling events
0.0 0.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 0.7 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.5 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.4 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.4 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 0.3 PID_CD40_PATHWAY CD40/CD40L signaling
0.0 0.2 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 0.2 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 11.5 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.1 6.1 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 5.6 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 4.2 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 3.9 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.4 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.1 2.1 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 1.9 REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.2 1.5 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 1.3 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 1.2 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 1.1 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 0.8 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 0.8 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 0.8 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.7 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.6 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.6 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.6 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.4 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters