Motif ID: Ctcfl_Ctcf

Z-value: 0.889

Transcription factors associated with Ctcfl_Ctcf:

Gene SymbolEntrez IDGene Name
Ctcf ENSMUSG00000005698.9 Ctcf
Ctcfl ENSMUSG00000070495.5 Ctcfl

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ctcflmm10_v2_chr2_-_173119402_173119525-0.262.2e-02Click!
Ctcfmm10_v2_chr8_+_105636509_105636589-0.234.6e-02Click!


Activity profile for motif Ctcfl_Ctcf.

activity profile for motif Ctcfl_Ctcf


Sorted Z-values histogram for motif Ctcfl_Ctcf

Sorted Z-values for motif Ctcfl_Ctcf



Network of associatons between targets according to the STRING database.



First level regulatory network of Ctcfl_Ctcf

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_34486125 17.706 ENSMUST00000115148.2
ENSMUST00000183580.1
 Kirrel3
RP24-225I21.1
kin of IRRE like 3 (Drosophila)
RP24-225I21.1
chr13_-_54055650 15.588 ENSMUST00000021932.5
 Drd1a
dopamine receptor D1A
chr18_-_66291770 12.260 ENSMUST00000130300.1
 Ccbe1
collagen and calcium binding EGF domains 1
chr15_-_44788016 10.906 ENSMUST00000090057.4
ENSMUST00000110269.1
 Sybu

syntabulin (syntaxin-interacting)

chr6_-_136173492 10.766 ENSMUST00000111905.1
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr16_-_26371828 10.620 ENSMUST00000023154.2
 Cldn1
claudin 1
chr5_-_123132651 10.555 ENSMUST00000031401.5
 Rhof
ras homolog gene family, member f
chr11_-_109298066 10.095 ENSMUST00000106706.1
 Rgs9
regulator of G-protein signaling 9
chr2_+_65620829 9.418 ENSMUST00000028377.7
 Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr11_-_109298121 9.274 ENSMUST00000020920.3
 Rgs9
regulator of G-protein signaling 9
chr14_+_62555737 8.937 ENSMUST00000039064.7
 Fam124a
family with sequence similarity 124, member A
chr9_-_102354685 8.699 ENSMUST00000035129.7
ENSMUST00000085169.5
 Ephb1

Eph receptor B1

chr18_+_36952621 8.693 ENSMUST00000115661.2
 Pcdha2
protocadherin alpha 2
chr11_+_32286946 8.628 ENSMUST00000101387.3
 Hbq1b
hemoglobin, theta 1B
chr2_-_32353283 8.271 ENSMUST00000091089.5
ENSMUST00000113350.1
 Dnm1

dynamin 1

chr2_-_32353247 8.124 ENSMUST00000078352.5
ENSMUST00000113352.2
ENSMUST00000113365.1
 Dnm1


dynamin 1


chr7_+_121392266 7.869 ENSMUST00000084628.3
 Hs3st2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr11_-_76577701 7.715 ENSMUST00000176179.1
 Abr
active BCR-related gene
chr11_+_103103051 7.532 ENSMUST00000152971.1
 Acbd4
acyl-Coenzyme A binding domain containing 4
chr11_-_95514570 7.094 ENSMUST00000058866.7
 Nxph3
neurexophilin 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 197 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 25.4 GO:0007416 synapse assembly(GO:0007416)
0.5 23.6 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
2.1 19.1 GO:1900034 regulation of cellular response to heat(GO:1900034)
3.5 17.7 GO:0002121 inter-male aggressive behavior(GO:0002121)
2.3 16.4 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
3.1 12.3 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
3.1 12.3 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
2.7 10.8 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
3.5 10.6 GO:1903348 positive regulation of bicellular tight junction assembly(GO:1903348)
1.7 8.7 GO:2001015 negative regulation of skeletal muscle cell differentiation(GO:2001015)
0.1 8.6 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
2.7 8.2 GO:0016256 N-glycan processing to lysosome(GO:0016256)
2.6 7.9 GO:0043181 vacuolar sequestering(GO:0043181)
1.5 7.7 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313)
1.1 6.7 GO:0032439 endosome localization(GO:0032439)
0.8 6.6 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
1.6 6.5 GO:0044268 multicellular organismal protein metabolic process(GO:0044268)
0.8 6.4 GO:0051549 positive regulation of keratinocyte migration(GO:0051549)
2.1 6.3 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
1.4 5.6 GO:0014846 esophagus smooth muscle contraction(GO:0014846)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 121 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 25.4 GO:0005887 integral component of plasma membrane(GO:0005887)
1.4 22.5 GO:0043196 varicosity(GO:0043196)
0.2 22.3 GO:0043198 dendritic shaft(GO:0043198)
0.6 21.9 GO:0001917 photoreceptor inner segment(GO:0001917)
1.9 19.1 GO:0045298 tubulin complex(GO:0045298)
0.1 18.7 GO:0070382 exocytic vesicle(GO:0070382)
0.1 11.7 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 11.4 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
1.4 10.9 GO:0097433 dense body(GO:0097433)
0.2 10.9 GO:0005581 collagen trimer(GO:0005581)
0.7 10.8 GO:0043083 synaptic cleft(GO:0043083)
0.0 9.5 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.5 9.0 GO:0032433 filopodium tip(GO:0032433)
0.1 7.0 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 7.0 GO:0001650 fibrillar center(GO:0001650)
0.0 6.9 GO:0000139 Golgi membrane(GO:0000139)
1.3 6.6 GO:0005683 U7 snRNP(GO:0005683)
1.1 5.5 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 5.4 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 5.2 GO:0032281 AMPA glutamate receptor complex(GO:0032281)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 137 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 27.8 GO:0005096 GTPase activator activity(GO:0005096)
2.7 27.2 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.1 21.1 GO:0030165 PDZ domain binding(GO:0030165)
2.7 19.1 GO:0099609 microtubule lateral binding(GO:0099609)
0.1 13.1 GO:0051117 ATPase binding(GO:0051117)
0.4 10.9 GO:0017075 syntaxin-1 binding(GO:0017075)
0.8 10.6 GO:0001618 virus receptor activity(GO:0001618)
0.1 10.2 GO:0005518 collagen binding(GO:0005518)
2.1 8.2 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
2.6 7.9 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.4 7.9 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
1.9 7.5 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
2.2 6.6 GO:0071209 U7 snRNA binding(GO:0071209)
2.2 6.5 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
1.0 6.3 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.2 5.7 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.1 5.7 GO:0005158 insulin receptor binding(GO:0005158)
0.1 5.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
1.1 5.6 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.6 5.4 GO:0035374 chondroitin sulfate binding(GO:0035374)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 25.1 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
2.0 21.9 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
1.0 19.1 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.4 12.0 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.1 11.8 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 11.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 9.5 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.2 9.1 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 8.7 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 7.2 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.4 6.4 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 4.6 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 4.3 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 4.3 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 3.3 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 3.1 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 2.7 PID_CMYB_PATHWAY C-MYB transcription factor network
0.1 2.6 PID_RAC1_PATHWAY RAC1 signaling pathway
0.1 2.5 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 2.2 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 24.6 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 21.0 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.8 19.1 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.9 17.0 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.5 15.1 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.5 12.3 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.4 10.8 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.3 10.6 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 9.0 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.5 8.6 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 8.4 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.2 7.9 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 6.8 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.2 6.5 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.3 6.4 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.3 5.7 REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.1 5.1 REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH Genes involved in NCAM signaling for neurite out-growth
0.4 4.7 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.2 4.5 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 4.5 REACTOME_GLYCOLYSIS Genes involved in Glycolysis