Motif ID: Cux1
Z-value: 1.079
Transcription factors associated with Cux1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Cux1 | ENSMUSG00000029705.11 | Cux1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Cux1 | mm10_v2_chr5_-_136567242_136567287 | 0.75 | 4.3e-15 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.9 | 20.7 | GO:0061075 | cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871) |
| 4.8 | 14.3 | GO:1903002 | regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002) |
| 3.3 | 10.0 | GO:0016998 | cell wall macromolecule catabolic process(GO:0016998) |
| 3.0 | 6.1 | GO:0034372 | very-low-density lipoprotein particle remodeling(GO:0034372) |
| 2.4 | 7.1 | GO:0099548 | drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by nitric oxide(GO:0099548) |
| 2.3 | 6.8 | GO:0045110 | intermediate filament bundle assembly(GO:0045110) |
| 2.1 | 23.4 | GO:0097421 | liver regeneration(GO:0097421) |
| 1.6 | 6.4 | GO:1904425 | negative regulation of GTP binding(GO:1904425) |
| 1.6 | 7.9 | GO:0002677 | negative regulation of chronic inflammatory response(GO:0002677) |
| 1.6 | 4.7 | GO:2001180 | negative regulation of interleukin-18 production(GO:0032701) negative regulation of interleukin-10 secretion(GO:2001180) |
| 1.3 | 11.9 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 1.3 | 5.0 | GO:0045054 | constitutive secretory pathway(GO:0045054) |
| 1.0 | 3.1 | GO:1990705 | cholangiocyte proliferation(GO:1990705) |
| 1.0 | 3.0 | GO:1900369 | negative regulation of RNA interference(GO:1900369) |
| 1.0 | 3.0 | GO:0002447 | eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308) |
| 0.9 | 2.8 | GO:0061744 | motor behavior(GO:0061744) |
| 0.9 | 3.6 | GO:0001692 | histamine metabolic process(GO:0001692) imidazole-containing compound catabolic process(GO:0052805) |
| 0.9 | 2.7 | GO:0090403 | oxidative stress-induced premature senescence(GO:0090403) |
| 0.9 | 6.3 | GO:0016127 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
| 0.9 | 2.6 | GO:0046900 | tetrahydrofolylpolyglutamate metabolic process(GO:0046900) |
| 0.8 | 3.4 | GO:0001920 | negative regulation of receptor recycling(GO:0001920) |
| 0.7 | 3.6 | GO:0015803 | branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820) |
| 0.7 | 4.1 | GO:1902261 | positive regulation of delayed rectifier potassium channel activity(GO:1902261) |
| 0.7 | 2.7 | GO:0072737 | response to diamide(GO:0072737) cellular response to diamide(GO:0072738) |
| 0.7 | 2.0 | GO:0071639 | positive regulation of immature T cell proliferation in thymus(GO:0033092) positive regulation of interleukin-6 biosynthetic process(GO:0045410) positive regulation of monocyte chemotactic protein-1 production(GO:0071639) |
| 0.7 | 1.3 | GO:0048294 | negative regulation of isotype switching to IgE isotypes(GO:0048294) |
| 0.6 | 11.0 | GO:1902259 | regulation of delayed rectifier potassium channel activity(GO:1902259) |
| 0.6 | 1.9 | GO:0009174 | UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049) |
| 0.6 | 1.7 | GO:1902938 | regulation of intracellular calcium activated chloride channel activity(GO:1902938) |
| 0.6 | 3.4 | GO:0007144 | female meiosis I(GO:0007144) |
| 0.6 | 1.7 | GO:2000850 | protein-chromophore linkage(GO:0018298) negative regulation of corticosteroid hormone secretion(GO:2000847) negative regulation of glucocorticoid secretion(GO:2000850) |
| 0.6 | 2.2 | GO:0007412 | axon target recognition(GO:0007412) |
| 0.6 | 4.4 | GO:0016114 | terpenoid biosynthetic process(GO:0016114) |
| 0.5 | 1.6 | GO:0098886 | modification of dendritic spine(GO:0098886) |
| 0.5 | 4.3 | GO:0060346 | bone trabecula formation(GO:0060346) |
| 0.5 | 3.2 | GO:0006072 | glycerol-3-phosphate metabolic process(GO:0006072) |
| 0.5 | 2.7 | GO:0010636 | positive regulation of mitochondrial fusion(GO:0010636) |
| 0.5 | 1.6 | GO:0009182 | purine deoxyribonucleoside diphosphate metabolic process(GO:0009182) dGDP metabolic process(GO:0046066) GDP metabolic process(GO:0046710) |
| 0.5 | 5.9 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
| 0.5 | 0.5 | GO:0050955 | thermoception(GO:0050955) |
| 0.5 | 1.5 | GO:0002940 | tRNA N2-guanine methylation(GO:0002940) |
| 0.5 | 4.5 | GO:0035269 | protein O-linked mannosylation(GO:0035269) |
| 0.5 | 4.4 | GO:0098700 | neurotransmitter loading into synaptic vesicle(GO:0098700) |
| 0.5 | 2.4 | GO:0021508 | floor plate formation(GO:0021508) floor plate morphogenesis(GO:0033505) |
| 0.5 | 1.5 | GO:0016561 | protein import into peroxisome matrix, translocation(GO:0016561) |
| 0.5 | 22.8 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.5 | 4.3 | GO:1902669 | positive regulation of axon guidance(GO:1902669) |
| 0.5 | 2.8 | GO:0030422 | production of siRNA involved in RNA interference(GO:0030422) |
| 0.5 | 1.4 | GO:1902396 | protein localization to bicellular tight junction(GO:1902396) |
| 0.4 | 1.3 | GO:0035844 | positive regulation of polarized epithelial cell differentiation(GO:0030862) cloaca development(GO:0035844) |
| 0.4 | 3.9 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 0.4 | 1.3 | GO:0006435 | threonyl-tRNA aminoacylation(GO:0006435) |
| 0.4 | 3.4 | GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743) |
| 0.4 | 1.3 | GO:1904431 | positive regulation of t-circle formation(GO:1904431) |
| 0.4 | 0.8 | GO:0090370 | negative regulation of cholesterol efflux(GO:0090370) |
| 0.4 | 3.6 | GO:2000467 | positive regulation of glycogen (starch) synthase activity(GO:2000467) |
| 0.4 | 3.5 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 0.4 | 1.2 | GO:0016132 | brassinosteroid metabolic process(GO:0016131) brassinosteroid biosynthetic process(GO:0016132) |
| 0.4 | 1.5 | GO:2000323 | negative regulation of glucocorticoid receptor signaling pathway(GO:2000323) |
| 0.4 | 1.5 | GO:0006121 | mitochondrial electron transport, succinate to ubiquinone(GO:0006121) |
| 0.4 | 1.5 | GO:0072344 | rescue of stalled ribosome(GO:0072344) |
| 0.4 | 1.1 | GO:1903279 | regulation of calcium:sodium antiporter activity(GO:1903279) |
| 0.4 | 1.1 | GO:0019659 | fermentation(GO:0006113) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661) |
| 0.4 | 2.5 | GO:0005981 | regulation of glycogen catabolic process(GO:0005981) |
| 0.4 | 2.8 | GO:0033089 | positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400) |
| 0.4 | 9.5 | GO:0022401 | desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401) |
| 0.4 | 1.8 | GO:0019236 | response to pheromone(GO:0019236) |
| 0.3 | 1.0 | GO:0032497 | detection of lipopolysaccharide(GO:0032497) |
| 0.3 | 3.0 | GO:0071569 | protein ufmylation(GO:0071569) |
| 0.3 | 1.3 | GO:0010796 | regulation of multivesicular body size(GO:0010796) |
| 0.3 | 1.3 | GO:2000525 | regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525) |
| 0.3 | 0.9 | GO:0006556 | S-adenosylmethionine biosynthetic process(GO:0006556) |
| 0.3 | 5.5 | GO:0031340 | positive regulation of vesicle fusion(GO:0031340) |
| 0.3 | 1.5 | GO:1904721 | regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721) |
| 0.3 | 1.8 | GO:0001927 | exocyst assembly(GO:0001927) |
| 0.3 | 0.9 | GO:0006030 | chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032) |
| 0.3 | 1.5 | GO:1904717 | positive regulation of synapse structural plasticity(GO:0051835) regulation of AMPA glutamate receptor clustering(GO:1904717) |
| 0.3 | 1.2 | GO:0010873 | positive regulation of cholesterol esterification(GO:0010873) |
| 0.3 | 0.9 | GO:0046416 | D-amino acid metabolic process(GO:0046416) |
| 0.3 | 1.1 | GO:1903542 | negative regulation of exosomal secretion(GO:1903542) |
| 0.3 | 1.1 | GO:0051541 | elastin metabolic process(GO:0051541) |
| 0.3 | 1.9 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
| 0.3 | 3.7 | GO:0034497 | protein localization to pre-autophagosomal structure(GO:0034497) |
| 0.3 | 2.9 | GO:1990173 | protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173) |
| 0.3 | 1.3 | GO:0032534 | regulation of microvillus assembly(GO:0032534) |
| 0.3 | 2.1 | GO:0019388 | galactose catabolic process(GO:0019388) |
| 0.3 | 2.6 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.2 | 1.5 | GO:0060576 | intestinal epithelial cell development(GO:0060576) |
| 0.2 | 0.7 | GO:0035963 | response to interleukin-13(GO:0035962) cellular response to interleukin-13(GO:0035963) |
| 0.2 | 5.0 | GO:0008210 | estrogen metabolic process(GO:0008210) |
| 0.2 | 0.5 | GO:2000016 | negative regulation of determination of dorsal identity(GO:2000016) |
| 0.2 | 3.7 | GO:0042407 | cristae formation(GO:0042407) |
| 0.2 | 1.1 | GO:0035590 | purinergic nucleotide receptor signaling pathway(GO:0035590) |
| 0.2 | 2.3 | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440) |
| 0.2 | 0.7 | GO:0032474 | otolith morphogenesis(GO:0032474) |
| 0.2 | 2.2 | GO:0042989 | sequestering of actin monomers(GO:0042989) |
| 0.2 | 4.3 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.2 | 5.2 | GO:0007614 | short-term memory(GO:0007614) |
| 0.2 | 1.8 | GO:0070813 | hydrogen sulfide metabolic process(GO:0070813) |
| 0.2 | 2.0 | GO:0018095 | protein polyglutamylation(GO:0018095) |
| 0.2 | 1.7 | GO:0006390 | transcription from mitochondrial promoter(GO:0006390) |
| 0.2 | 1.9 | GO:2000786 | positive regulation of autophagosome assembly(GO:2000786) |
| 0.2 | 1.9 | GO:0035095 | behavioral response to nicotine(GO:0035095) |
| 0.2 | 1.9 | GO:2000650 | negative regulation of sodium ion transmembrane transporter activity(GO:2000650) |
| 0.2 | 6.9 | GO:0061014 | positive regulation of mRNA catabolic process(GO:0061014) |
| 0.2 | 1.2 | GO:2000210 | positive regulation of anoikis(GO:2000210) |
| 0.2 | 2.2 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.2 | 3.5 | GO:0051085 | chaperone mediated protein folding requiring cofactor(GO:0051085) |
| 0.2 | 0.9 | GO:0034214 | protein hexamerization(GO:0034214) |
| 0.2 | 0.4 | GO:1902527 | positive regulation of protein monoubiquitination(GO:1902527) |
| 0.2 | 1.3 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.2 | 4.7 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) |
| 0.2 | 2.7 | GO:0033234 | negative regulation of protein sumoylation(GO:0033234) |
| 0.2 | 2.8 | GO:0000338 | protein deneddylation(GO:0000338) |
| 0.2 | 2.5 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.2 | 5.3 | GO:2000310 | regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310) |
| 0.2 | 0.7 | GO:0015744 | succinate transport(GO:0015744) |
| 0.2 | 3.0 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.2 | 0.5 | GO:0009186 | deoxyribonucleoside diphosphate metabolic process(GO:0009186) |
| 0.2 | 0.9 | GO:0006689 | ganglioside catabolic process(GO:0006689) |
| 0.2 | 3.1 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) |
| 0.2 | 1.9 | GO:0045187 | regulation of circadian sleep/wake cycle(GO:0042749) regulation of circadian sleep/wake cycle, sleep(GO:0045187) |
| 0.2 | 0.7 | GO:0045113 | regulation of integrin biosynthetic process(GO:0045113) |
| 0.2 | 2.9 | GO:0060252 | positive regulation of glial cell proliferation(GO:0060252) |
| 0.1 | 2.4 | GO:0016558 | protein import into peroxisome matrix(GO:0016558) |
| 0.1 | 11.4 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 3.9 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.1 | 0.7 | GO:1901341 | activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341) |
| 0.1 | 0.3 | GO:0072488 | ammonium transmembrane transport(GO:0072488) |
| 0.1 | 1.7 | GO:0030431 | sleep(GO:0030431) |
| 0.1 | 0.5 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
| 0.1 | 1.1 | GO:0048752 | semicircular canal morphogenesis(GO:0048752) |
| 0.1 | 1.3 | GO:0046688 | response to copper ion(GO:0046688) |
| 0.1 | 4.3 | GO:0010614 | negative regulation of cardiac muscle hypertrophy(GO:0010614) |
| 0.1 | 1.4 | GO:0061179 | negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179) |
| 0.1 | 0.6 | GO:0007386 | compartment pattern specification(GO:0007386) |
| 0.1 | 0.9 | GO:0071763 | nuclear membrane organization(GO:0071763) |
| 0.1 | 4.5 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.1 | 1.3 | GO:0014002 | astrocyte development(GO:0014002) |
| 0.1 | 1.8 | GO:0071157 | negative regulation of cell cycle arrest(GO:0071157) |
| 0.1 | 1.1 | GO:1902902 | negative regulation of autophagosome assembly(GO:1902902) |
| 0.1 | 0.7 | GO:0034551 | respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033) |
| 0.1 | 5.8 | GO:0003073 | regulation of systemic arterial blood pressure(GO:0003073) |
| 0.1 | 1.3 | GO:0060394 | negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394) |
| 0.1 | 0.7 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.1 | 2.4 | GO:2000300 | regulation of synaptic vesicle exocytosis(GO:2000300) |
| 0.1 | 17.5 | GO:0031032 | actomyosin structure organization(GO:0031032) |
| 0.1 | 0.4 | GO:0033140 | negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140) |
| 0.1 | 0.7 | GO:0031848 | protection from non-homologous end joining at telomere(GO:0031848) |
| 0.1 | 0.3 | GO:0000733 | DNA strand renaturation(GO:0000733) |
| 0.1 | 0.9 | GO:0034983 | peptidyl-lysine deacetylation(GO:0034983) |
| 0.1 | 0.6 | GO:0033299 | secretion of lysosomal enzymes(GO:0033299) |
| 0.1 | 5.0 | GO:0035914 | skeletal muscle cell differentiation(GO:0035914) |
| 0.1 | 0.5 | GO:0036444 | calcium ion transmembrane import into mitochondrion(GO:0036444) |
| 0.1 | 0.4 | GO:0090070 | positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234) |
| 0.1 | 1.5 | GO:0099517 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
| 0.1 | 0.4 | GO:1990928 | response to amino acid starvation(GO:1990928) |
| 0.1 | 0.5 | GO:0090315 | negative regulation of protein targeting to membrane(GO:0090315) |
| 0.1 | 0.3 | GO:0003097 | renal water transport(GO:0003097) renal water absorption(GO:0070295) |
| 0.1 | 7.9 | GO:0007416 | synapse assembly(GO:0007416) |
| 0.1 | 0.6 | GO:0007000 | nucleolus organization(GO:0007000) |
| 0.1 | 0.7 | GO:0090435 | protein localization to nuclear envelope(GO:0090435) |
| 0.1 | 1.2 | GO:0042755 | eating behavior(GO:0042755) |
| 0.1 | 0.7 | GO:0034244 | negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244) |
| 0.1 | 0.7 | GO:0070914 | UV-damage excision repair(GO:0070914) |
| 0.1 | 0.8 | GO:0035455 | response to interferon-alpha(GO:0035455) |
| 0.1 | 0.2 | GO:1900126 | negative regulation of hyaluronan biosynthetic process(GO:1900126) |
| 0.0 | 0.2 | GO:1904751 | positive regulation of protein localization to nucleolus(GO:1904751) |
| 0.0 | 1.4 | GO:2000249 | regulation of actin cytoskeleton reorganization(GO:2000249) |
| 0.0 | 0.9 | GO:0016226 | iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163) |
| 0.0 | 0.1 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 0.0 | 3.5 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 0.0 | 0.7 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.0 | 0.8 | GO:0006359 | regulation of transcription from RNA polymerase III promoter(GO:0006359) |
| 0.0 | 0.4 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.0 | 0.4 | GO:1900113 | negative regulation of histone H3-K9 trimethylation(GO:1900113) |
| 0.0 | 0.3 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
| 0.0 | 1.4 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.0 | 0.9 | GO:0071480 | cellular response to gamma radiation(GO:0071480) |
| 0.0 | 0.3 | GO:0010667 | negative regulation of cardiac muscle cell apoptotic process(GO:0010667) |
| 0.0 | 0.2 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 0.0 | 0.7 | GO:0071108 | protein K48-linked deubiquitination(GO:0071108) |
| 0.0 | 1.5 | GO:0061077 | chaperone-mediated protein folding(GO:0061077) |
| 0.0 | 1.8 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 0.0 | 0.9 | GO:0034314 | Arp2/3 complex-mediated actin nucleation(GO:0034314) |
| 0.0 | 0.3 | GO:0000244 | spliceosomal tri-snRNP complex assembly(GO:0000244) |
| 0.0 | 0.4 | GO:0060707 | trophoblast giant cell differentiation(GO:0060707) |
| 0.0 | 0.7 | GO:0008277 | regulation of G-protein coupled receptor protein signaling pathway(GO:0008277) |
| 0.0 | 0.4 | GO:0009083 | branched-chain amino acid catabolic process(GO:0009083) |
| 0.0 | 1.1 | GO:0030317 | sperm motility(GO:0030317) |
| 0.0 | 1.1 | GO:0006399 | tRNA metabolic process(GO:0006399) tRNA processing(GO:0008033) |
| 0.0 | 0.5 | GO:0006656 | phosphatidylcholine biosynthetic process(GO:0006656) |
| 0.0 | 0.1 | GO:0090202 | transcriptional activation by promoter-enhancer looping(GO:0071733) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899) gene looping(GO:0090202) dsDNA loop formation(GO:0090579) |
| 0.0 | 0.2 | GO:0036265 | RNA (guanine-N7)-methylation(GO:0036265) |
| 0.0 | 0.4 | GO:0046928 | regulation of neurotransmitter secretion(GO:0046928) |
| 0.0 | 0.5 | GO:0032467 | positive regulation of cytokinesis(GO:0032467) |
| 0.0 | 0.2 | GO:0060253 | negative regulation of glial cell proliferation(GO:0060253) |
| 0.0 | 0.4 | GO:0071425 | hematopoietic stem cell proliferation(GO:0071425) |
| 0.0 | 0.4 | GO:0045026 | plasma membrane fusion(GO:0045026) |
| 0.0 | 0.2 | GO:0019321 | pentose metabolic process(GO:0019321) |
| 0.0 | 1.0 | GO:0002028 | regulation of sodium ion transport(GO:0002028) |
| 0.0 | 2.5 | GO:0048839 | inner ear development(GO:0048839) |
| 0.0 | 0.2 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 0.0 | 1.9 | GO:0006626 | protein targeting to mitochondrion(GO:0006626) |
| 0.0 | 0.2 | GO:0006383 | transcription from RNA polymerase III promoter(GO:0006383) |
| 0.0 | 1.1 | GO:0035308 | negative regulation of protein dephosphorylation(GO:0035308) |
| 0.0 | 0.3 | GO:0071391 | cellular response to estrogen stimulus(GO:0071391) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.7 | 33.3 | GO:0048237 | rough endoplasmic reticulum lumen(GO:0048237) |
| 5.3 | 21.2 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 4.8 | 14.3 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 2.3 | 6.8 | GO:0033596 | TSC1-TSC2 complex(GO:0033596) |
| 1.5 | 6.1 | GO:0042627 | chylomicron(GO:0042627) |
| 1.1 | 4.5 | GO:0033185 | dolichol-phosphate-mannose synthase complex(GO:0033185) |
| 0.9 | 2.8 | GO:1903095 | microprocessor complex(GO:0070877) ribonuclease III complex(GO:1903095) |
| 0.9 | 4.4 | GO:0044316 | cone cell pedicle(GO:0044316) |
| 0.8 | 11.9 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.8 | 3.0 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) |
| 0.7 | 7.4 | GO:0045298 | tubulin complex(GO:0045298) |
| 0.7 | 8.0 | GO:0042582 | primary lysosome(GO:0005766) azurophil granule(GO:0042582) |
| 0.6 | 3.2 | GO:0009331 | glycerol-3-phosphate dehydrogenase complex(GO:0009331) |
| 0.5 | 3.0 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 0.5 | 1.4 | GO:0034657 | GID complex(GO:0034657) |
| 0.4 | 2.7 | GO:0031314 | extrinsic component of mitochondrial inner membrane(GO:0031314) |
| 0.4 | 2.6 | GO:1990393 | 3M complex(GO:1990393) |
| 0.3 | 2.7 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.3 | 4.6 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.3 | 4.8 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.3 | 0.9 | GO:0048269 | methionine adenosyltransferase complex(GO:0048269) |
| 0.3 | 1.5 | GO:0099524 | region of cytosol(GO:0099522) postsynaptic cytosol(GO:0099524) |
| 0.3 | 2.5 | GO:0042587 | glycogen granule(GO:0042587) |
| 0.3 | 1.3 | GO:0048476 | Holliday junction resolvase complex(GO:0048476) |
| 0.2 | 2.2 | GO:0061617 | MICOS complex(GO:0061617) |
| 0.2 | 2.9 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 0.2 | 1.4 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.2 | 1.9 | GO:0000836 | ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836) |
| 0.2 | 1.8 | GO:0044233 | ER-mitochondrion membrane contact site(GO:0044233) |
| 0.2 | 9.0 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.2 | 1.8 | GO:0002177 | manchette(GO:0002177) |
| 0.2 | 2.0 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.2 | 2.9 | GO:0042405 | nuclear inclusion body(GO:0042405) |
| 0.2 | 1.3 | GO:0005828 | kinetochore microtubule(GO:0005828) |
| 0.2 | 2.9 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.2 | 3.0 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.2 | 0.5 | GO:0016939 | kinesin II complex(GO:0016939) |
| 0.2 | 2.8 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
| 0.2 | 1.9 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.2 | 0.7 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.2 | 4.3 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.2 | 3.9 | GO:0098839 | postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634) |
| 0.1 | 3.3 | GO:0001741 | XY body(GO:0001741) |
| 0.1 | 0.9 | GO:0036195 | muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195) |
| 0.1 | 3.4 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.1 | 5.0 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.1 | 1.5 | GO:0098799 | outer mitochondrial membrane protein complex(GO:0098799) |
| 0.1 | 1.1 | GO:0090533 | cation-transporting ATPase complex(GO:0090533) |
| 0.1 | 1.5 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.1 | 0.5 | GO:1990246 | uniplex complex(GO:1990246) |
| 0.1 | 10.4 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 1.5 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.1 | 1.3 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.1 | 1.5 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.1 | 1.8 | GO:0000145 | exocyst(GO:0000145) |
| 0.1 | 6.5 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.1 | 1.3 | GO:0036038 | MKS complex(GO:0036038) |
| 0.1 | 0.7 | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting(GO:0005786) |
| 0.1 | 1.0 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.1 | 1.1 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.1 | 2.4 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.1 | 1.5 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 0.1 | 4.1 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.1 | 3.9 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.1 | 1.0 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.1 | 0.4 | GO:0070531 | BRCA1-A complex(GO:0070531) |
| 0.1 | 6.5 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 0.9 | GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex(GO:0031464) |
| 0.1 | 0.6 | GO:0061574 | ASAP complex(GO:0061574) |
| 0.1 | 0.2 | GO:0031673 | H zone(GO:0031673) |
| 0.0 | 3.7 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.0 | 3.6 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 1.4 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 2.2 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.0 | 0.3 | GO:0031315 | extrinsic component of mitochondrial outer membrane(GO:0031315) |
| 0.0 | 5.1 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 1.9 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 0.5 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.0 | 1.3 | GO:0031985 | Golgi cisterna(GO:0031985) |
| 0.0 | 1.9 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 3.6 | GO:0044306 | neuron projection terminus(GO:0044306) |
| 0.0 | 3.2 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.0 | 0.6 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.0 | 10.6 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 0.1 | GO:0036156 | inner dynein arm(GO:0036156) |
| 0.0 | 0.8 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.0 | 0.4 | GO:0072669 | tRNA-splicing ligase complex(GO:0072669) |
| 0.0 | 3.8 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 1.9 | GO:0005776 | autophagosome(GO:0005776) |
| 0.0 | 2.1 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 0.2 | GO:0043527 | tRNA methyltransferase complex(GO:0043527) |
| 0.0 | 0.1 | GO:0070876 | SOSS complex(GO:0070876) |
| 0.0 | 1.2 | GO:0030119 | AP-type membrane coat adaptor complex(GO:0030119) |
| 0.0 | 2.6 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.0 | 6.5 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 0.2 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) |
| 0.0 | 1.6 | GO:0019867 | mitochondrial outer membrane(GO:0005741) outer membrane(GO:0019867) organelle outer membrane(GO:0031968) |
| 0.0 | 2.0 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 0.3 | GO:0031011 | Ino80 complex(GO:0031011) |
| 0.0 | 0.2 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.0 | 0.4 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.0 | 1.5 | GO:0005840 | ribosome(GO:0005840) |
| 0.0 | 0.3 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
| 0.0 | 2.7 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 1.0 | GO:0030139 | endocytic vesicle(GO:0030139) |
| 0.0 | 0.3 | GO:0046540 | U4/U6 x U5 tri-snRNP complex(GO:0046540) |
| 0.0 | 0.1 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.3 | 21.2 | GO:0031720 | haptoglobin binding(GO:0031720) |
| 4.8 | 14.3 | GO:0046911 | hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 3.3 | 10.0 | GO:0003796 | lysozyme activity(GO:0003796) |
| 2.4 | 7.1 | GO:0004517 | nitric-oxide synthase activity(GO:0004517) |
| 2.0 | 11.9 | GO:1904315 | GABA-gated chloride ion channel activity(GO:0022851) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315) |
| 1.6 | 7.9 | GO:0019960 | C-X3-C chemokine binding(GO:0019960) |
| 1.5 | 4.4 | GO:0005280 | hydrogen:amino acid symporter activity(GO:0005280) |
| 1.3 | 23.2 | GO:0030247 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 1.1 | 4.5 | GO:0003836 | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836) |
| 1.1 | 4.5 | GO:0004582 | dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582) |
| 1.1 | 3.2 | GO:0016901 | glycerol-3-phosphate dehydrogenase activity(GO:0004368) oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901) |
| 1.0 | 3.0 | GO:0003692 | left-handed Z-DNA binding(GO:0003692) |
| 0.8 | 5.9 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 0.7 | 4.4 | GO:0004311 | farnesyltranstransferase activity(GO:0004311) |
| 0.6 | 1.9 | GO:0016309 | 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309) |
| 0.6 | 3.6 | GO:0015193 | L-proline transmembrane transporter activity(GO:0015193) |
| 0.6 | 2.8 | GO:0004525 | ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296) |
| 0.6 | 1.7 | GO:0009881 | photoreceptor activity(GO:0009881) |
| 0.6 | 2.2 | GO:0031694 | alpha-2A adrenergic receptor binding(GO:0031694) |
| 0.5 | 1.6 | GO:0044715 | 8-oxo-dGDP phosphatase activity(GO:0044715) |
| 0.5 | 0.5 | GO:0051379 | epinephrine binding(GO:0051379) |
| 0.5 | 6.1 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.5 | 2.0 | GO:0070740 | tubulin-glutamic acid ligase activity(GO:0070740) |
| 0.5 | 1.9 | GO:0004706 | JUN kinase kinase kinase activity(GO:0004706) |
| 0.5 | 2.9 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
| 0.4 | 7.9 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.4 | 1.7 | GO:0008332 | low voltage-gated calcium channel activity(GO:0008332) |
| 0.4 | 1.7 | GO:0000179 | rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) |
| 0.4 | 1.7 | GO:1903135 | cupric ion binding(GO:1903135) |
| 0.4 | 1.3 | GO:0004829 | threonine-tRNA ligase activity(GO:0004829) |
| 0.4 | 3.8 | GO:0001025 | RNA polymerase III transcription factor binding(GO:0001025) |
| 0.4 | 1.3 | GO:0004658 | propionyl-CoA carboxylase activity(GO:0004658) |
| 0.4 | 3.2 | GO:0070290 | N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290) |
| 0.4 | 1.2 | GO:0009918 | sterol delta7 reductase activity(GO:0009918) 7-dehydrocholesterol reductase activity(GO:0047598) |
| 0.4 | 1.2 | GO:0022865 | transmembrane electron transfer carrier(GO:0022865) |
| 0.4 | 2.7 | GO:1901612 | phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612) |
| 0.4 | 1.5 | GO:0030160 | GKAP/Homer scaffold activity(GO:0030160) |
| 0.4 | 4.3 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
| 0.4 | 7.8 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.4 | 2.1 | GO:0033691 | sialic acid binding(GO:0033691) |
| 0.3 | 6.6 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
| 0.3 | 3.1 | GO:0034046 | poly(G) binding(GO:0034046) |
| 0.3 | 1.0 | GO:0001875 | lipopolysaccharide receptor activity(GO:0001875) |
| 0.3 | 1.4 | GO:0005459 | UDP-galactose transmembrane transporter activity(GO:0005459) |
| 0.3 | 1.9 | GO:0050694 | galactose 3-O-sulfotransferase activity(GO:0050694) |
| 0.3 | 1.5 | GO:0004809 | tRNA (guanine-N2-)-methyltransferase activity(GO:0004809) |
| 0.3 | 5.1 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.3 | 1.2 | GO:0004045 | aminoacyl-tRNA hydrolase activity(GO:0004045) |
| 0.3 | 2.1 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
| 0.3 | 0.9 | GO:0004568 | chitinase activity(GO:0004568) |
| 0.3 | 1.2 | GO:0032896 | palmitoyl-CoA 9-desaturase activity(GO:0032896) |
| 0.3 | 0.9 | GO:0036361 | racemase and epimerase activity, acting on amino acids and derivatives(GO:0016855) racemase activity, acting on amino acids and derivatives(GO:0036361) amino-acid racemase activity(GO:0047661) |
| 0.3 | 1.1 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
| 0.3 | 6.8 | GO:0043274 | phospholipase binding(GO:0043274) |
| 0.3 | 2.7 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.3 | 0.8 | GO:0001032 | RNA polymerase III type 3 promoter DNA binding(GO:0001032) |
| 0.3 | 1.3 | GO:0004322 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.3 | 1.5 | GO:0060698 | endoribonuclease inhibitor activity(GO:0060698) |
| 0.3 | 1.3 | GO:0017108 | 5'-flap endonuclease activity(GO:0017108) |
| 0.2 | 7.9 | GO:0017046 | peptide hormone binding(GO:0017046) |
| 0.2 | 3.9 | GO:0005242 | inward rectifier potassium channel activity(GO:0005242) |
| 0.2 | 0.7 | GO:0017153 | sodium:dicarboxylate symporter activity(GO:0017153) |
| 0.2 | 1.9 | GO:0019870 | potassium channel inhibitor activity(GO:0019870) |
| 0.2 | 2.6 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.2 | 0.7 | GO:0030171 | voltage-gated proton channel activity(GO:0030171) |
| 0.2 | 3.0 | GO:0004551 | nucleotide diphosphatase activity(GO:0004551) |
| 0.2 | 4.1 | GO:0016208 | AMP binding(GO:0016208) |
| 0.2 | 0.6 | GO:0033829 | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829) |
| 0.2 | 2.5 | GO:0097371 | MDM2/MDM4 family protein binding(GO:0097371) |
| 0.2 | 1.1 | GO:0035381 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.2 | 1.9 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
| 0.2 | 1.5 | GO:0042500 | aspartic endopeptidase activity, intramembrane cleaving(GO:0042500) |
| 0.2 | 1.1 | GO:1990932 | 5.8S rRNA binding(GO:1990932) |
| 0.2 | 7.6 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.2 | 0.5 | GO:0009041 | uridylate kinase activity(GO:0009041) |
| 0.2 | 0.9 | GO:0004563 | beta-N-acetylhexosaminidase activity(GO:0004563) |
| 0.2 | 13.2 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.2 | 2.0 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.2 | 1.1 | GO:0004303 | estradiol 17-beta-dehydrogenase activity(GO:0004303) |
| 0.1 | 1.8 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
| 0.1 | 1.8 | GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 0.1 | 2.0 | GO:0099604 | calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604) |
| 0.1 | 0.4 | GO:0008192 | RNA guanylyltransferase activity(GO:0008192) |
| 0.1 | 3.7 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.1 | 2.2 | GO:0070403 | NAD+ binding(GO:0070403) |
| 0.1 | 1.1 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
| 0.1 | 3.9 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.1 | 0.7 | GO:0030942 | endoplasmic reticulum signal peptide binding(GO:0030942) |
| 0.1 | 0.8 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 0.1 | 1.8 | GO:0003988 | acetyl-CoA C-acyltransferase activity(GO:0003988) |
| 0.1 | 2.3 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.1 | 0.5 | GO:0005093 | Rab GDP-dissociation inhibitor activity(GO:0005093) |
| 0.1 | 2.6 | GO:0016881 | acid-amino acid ligase activity(GO:0016881) |
| 0.1 | 0.3 | GO:0000386 | second spliceosomal transesterification activity(GO:0000386) |
| 0.1 | 3.6 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.1 | 4.7 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.1 | 1.9 | GO:0008200 | ion channel inhibitor activity(GO:0008200) |
| 0.1 | 2.7 | GO:0032183 | SUMO binding(GO:0032183) |
| 0.1 | 1.1 | GO:0015037 | peptide disulfide oxidoreductase activity(GO:0015037) |
| 0.1 | 3.1 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.1 | 1.8 | GO:0034185 | apolipoprotein binding(GO:0034185) |
| 0.1 | 1.9 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.1 | 0.3 | GO:0022842 | leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842) |
| 0.1 | 3.5 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 0.1 | 1.4 | GO:0034713 | type I transforming growth factor beta receptor binding(GO:0034713) |
| 0.1 | 0.3 | GO:0034481 | chondroitin sulfotransferase activity(GO:0034481) |
| 0.1 | 2.7 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.1 | 0.4 | GO:0047631 | ADP-ribose diphosphatase activity(GO:0047631) |
| 0.1 | 1.8 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.1 | 15.7 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.1 | 2.2 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.1 | 0.7 | GO:0035312 | 5'-3' exodeoxyribonuclease activity(GO:0035312) |
| 0.1 | 2.7 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.1 | 6.3 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.1 | 2.2 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.1 | 0.7 | GO:0008097 | 5S rRNA binding(GO:0008097) |
| 0.1 | 4.0 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.1 | 2.7 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.1 | 1.6 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.1 | 0.2 | GO:0008176 | tRNA (guanine-N7-)-methyltransferase activity(GO:0008176) |
| 0.1 | 2.0 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
| 0.1 | 1.0 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.1 | 1.1 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.0 | 0.7 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 0.0 | 1.9 | GO:0016763 | transferase activity, transferring pentosyl groups(GO:0016763) |
| 0.0 | 0.6 | GO:0005537 | mannose binding(GO:0005537) |
| 0.0 | 0.3 | GO:0042609 | CD4 receptor binding(GO:0042609) |
| 0.0 | 0.2 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.0 | 0.3 | GO:0015288 | porin activity(GO:0015288) |
| 0.0 | 5.3 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.0 | 1.5 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 0.4 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
| 0.0 | 0.7 | GO:0005521 | lamin binding(GO:0005521) |
| 0.0 | 0.6 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
| 0.0 | 0.8 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
| 0.0 | 1.5 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 2.2 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.0 | 4.7 | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981) |
| 0.0 | 2.4 | GO:0008170 | N-methyltransferase activity(GO:0008170) |
| 0.0 | 0.4 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.0 | 0.4 | GO:0003995 | acyl-CoA dehydrogenase activity(GO:0003995) |
| 0.0 | 0.6 | GO:0008483 | transaminase activity(GO:0008483) |
| 0.0 | 0.3 | GO:0036310 | annealing helicase activity(GO:0036310) |
| 0.0 | 1.1 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.0 | 2.8 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 0.0 | 0.5 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 0.8 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 1.4 | GO:0009055 | electron carrier activity(GO:0009055) |
| 0.0 | 1.1 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.0 | 1.9 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 0.6 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.0 | 0.6 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
| 0.0 | 3.3 | GO:0008237 | metallopeptidase activity(GO:0008237) |
| 0.0 | 0.5 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.0 | 0.2 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.0 | 1.2 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |
| 0.0 | 0.1 | GO:0001094 | TFIID-class transcription factor binding(GO:0001094) |
| 0.0 | 0.7 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.0 | 0.4 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.0 | 0.6 | GO:0016779 | nucleotidyltransferase activity(GO:0016779) |
| 0.0 | 0.6 | GO:0003684 | damaged DNA binding(GO:0003684) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 23.2 | PID_INTEGRIN5_PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.3 | 5.9 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
| 0.3 | 1.7 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
| 0.2 | 5.3 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.2 | 2.0 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.2 | 4.5 | PID_ARF6_DOWNSTREAM_PATHWAY | Arf6 downstream pathway |
| 0.1 | 14.8 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 1.4 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.1 | 1.9 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 1.8 | PID_HIF1A_PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.1 | 0.8 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
| 0.1 | 2.4 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
| 0.1 | 3.2 | ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.1 | 1.9 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
| 0.1 | 8.3 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 4.5 | PID_P53_REGULATION_PATHWAY | p53 pathway |
| 0.1 | 1.8 | PID_INSULIN_PATHWAY | Insulin Pathway |
| 0.1 | 1.3 | PID_ARF_3PATHWAY | Arf1 pathway |
| 0.0 | 1.6 | PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 3.4 | PID_MET_PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.0 | 2.4 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 2.5 | PID_NOTCH_PATHWAY | Notch signaling pathway |
| 0.0 | 1.5 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 1.3 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 1.6 | PID_HDAC_CLASSII_PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 0.3 | PID_AR_NONGENOMIC_PATHWAY | Nongenotropic Androgen signaling |
| 0.0 | 0.4 | PID_BCR_5PATHWAY | BCR signaling pathway |
| 0.0 | 1.2 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 0.6 | PID_ATM_PATHWAY | ATM pathway |
| 0.0 | 0.7 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
| 0.0 | 0.3 | PID_HDAC_CLASSI_PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 0.5 | ST_T_CELL_SIGNAL_TRANSDUCTION | T Cell Signal Transduction |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 22.2 | REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.9 | 6.3 | REACTOME_ENDOGENOUS_STEROLS | Genes involved in Endogenous sterols |
| 0.8 | 13.2 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.7 | 11.9 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
| 0.7 | 5.9 | REACTOME_TRANSPORT_OF_ORGANIC_ANIONS | Genes involved in Transport of organic anions |
| 0.4 | 4.5 | REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.4 | 12.1 | REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.4 | 5.8 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.4 | 6.3 | REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.4 | 3.6 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.3 | 7.9 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.3 | 3.0 | REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.3 | 5.1 | REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.3 | 11.4 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.3 | 3.0 | REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.3 | 2.9 | REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.3 | 4.1 | REACTOME_SIGNALING_BY_NOTCH2 | Genes involved in Signaling by NOTCH2 |
| 0.3 | 6.0 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.2 | 3.9 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.2 | 6.7 | REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.2 | 1.9 | REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.2 | 21.1 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.2 | 3.5 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.2 | 6.5 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.2 | 1.9 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.2 | 5.4 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.2 | 1.8 | REACTOME_CALNEXIN_CALRETICULIN_CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.2 | 6.7 | REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.1 | 6.4 | REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS | Genes involved in Glucagon-type ligand receptors |
| 0.1 | 1.1 | REACTOME_AMYLOIDS | Genes involved in Amyloids |
| 0.1 | 2.1 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.1 | 2.8 | REACTOME_MICRORNA_MIRNA_BIOGENESIS | Genes involved in MicroRNA (miRNA) Biogenesis |
| 0.1 | 0.5 | REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION | Genes involved in Platelet Aggregation (Plug Formation) |
| 0.1 | 1.3 | REACTOME_COPI_MEDIATED_TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.1 | 3.8 | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 4.5 | REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.1 | 2.4 | REACTOME_SULFUR_AMINO_ACID_METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 1.1 | REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR1 ligand binding and activation |
| 0.1 | 1.8 | REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.1 | 1.0 | REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX | Genes involved in TRAF6 mediated induction of TAK1 complex |
| 0.1 | 1.3 | REACTOME_IRON_UPTAKE_AND_TRANSPORT | Genes involved in Iron uptake and transport |
| 0.1 | 0.7 | REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.1 | 1.3 | REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.1 | 2.3 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
| 0.1 | 1.5 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.1 | 1.1 | REACTOME_PYRUVATE_METABOLISM | Genes involved in Pyruvate metabolism |
| 0.1 | 1.4 | REACTOME_NEPHRIN_INTERACTIONS | Genes involved in Nephrin interactions |
| 0.1 | 2.5 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 1.2 | REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.1 | 1.9 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 0.3 | REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.0 | 1.0 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 0.6 | REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.0 | 2.5 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 1.1 | REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS | Genes involved in Regulation of Water Balance by Renal Aquaporins |
| 0.0 | 0.7 | REACTOME_LYSOSOME_VESICLE_BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.0 | 0.8 | REACTOME_EGFR_DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.0 | 0.4 | REACTOME_MTORC1_MEDIATED_SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 0.6 | REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.0 | 0.6 | REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.0 | 2.8 | REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.0 | 0.5 | REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |
| 0.0 | 0.3 | REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 0.5 | REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 0.5 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
| 0.0 | 0.4 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 0.4 | REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 1.5 | REACTOME_MRNA_SPLICING | Genes involved in mRNA Splicing |
| 0.0 | 0.4 | REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.0 | 0.3 | REACTOME_ERK_MAPK_TARGETS | Genes involved in ERK/MAPK targets |
