Motif ID: Cux1
Z-value: 1.079

Transcription factors associated with Cux1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Cux1 | ENSMUSG00000029705.11 | Cux1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Cux1 | mm10_v2_chr5_-_136567242_136567287 | 0.75 | 4.3e-15 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 207 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.1 | 23.4 | GO:0097421 | liver regeneration(GO:0097421) |
0.5 | 22.8 | GO:0034605 | cellular response to heat(GO:0034605) |
6.9 | 20.7 | GO:0061075 | cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871) |
0.1 | 17.5 | GO:0031032 | actomyosin structure organization(GO:0031032) |
4.8 | 14.3 | GO:1903002 | regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002) |
1.3 | 11.9 | GO:0071420 | cellular response to histamine(GO:0071420) |
0.1 | 11.4 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
0.6 | 11.0 | GO:1902259 | regulation of delayed rectifier potassium channel activity(GO:1902259) |
3.3 | 10.0 | GO:0016998 | cell wall macromolecule catabolic process(GO:0016998) |
0.4 | 9.5 | GO:0022401 | desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401) |
1.6 | 7.9 | GO:0002677 | negative regulation of chronic inflammatory response(GO:0002677) |
0.1 | 7.9 | GO:0007416 | synapse assembly(GO:0007416) |
2.4 | 7.1 | GO:0099548 | drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by nitric oxide(GO:0099548) |
0.2 | 6.9 | GO:0061014 | positive regulation of mRNA catabolic process(GO:0061014) |
2.3 | 6.8 | GO:0045110 | intermediate filament bundle assembly(GO:0045110) |
1.6 | 6.4 | GO:1904425 | negative regulation of GTP binding(GO:1904425) |
0.9 | 6.3 | GO:0016127 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
3.0 | 6.1 | GO:0034372 | very-low-density lipoprotein particle remodeling(GO:0034372) |
0.5 | 5.9 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
0.1 | 5.8 | GO:0003073 | regulation of systemic arterial blood pressure(GO:0003073) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 107 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
6.7 | 33.3 | GO:0048237 | rough endoplasmic reticulum lumen(GO:0048237) |
5.3 | 21.2 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
4.8 | 14.3 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
0.8 | 11.9 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
0.0 | 10.6 | GO:0000139 | Golgi membrane(GO:0000139) |
0.1 | 10.4 | GO:0005604 | basement membrane(GO:0005604) |
0.2 | 9.0 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
0.7 | 8.0 | GO:0042582 | primary lysosome(GO:0005766) azurophil granule(GO:0042582) |
0.7 | 7.4 | GO:0045298 | tubulin complex(GO:0045298) |
2.3 | 6.8 | GO:0033596 | TSC1-TSC2 complex(GO:0033596) |
0.1 | 6.5 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
0.1 | 6.5 | GO:0016605 | PML body(GO:0016605) |
0.0 | 6.5 | GO:0005759 | mitochondrial matrix(GO:0005759) |
1.5 | 6.1 | GO:0042627 | chylomicron(GO:0042627) |
0.0 | 5.1 | GO:0031225 | anchored component of membrane(GO:0031225) |
0.1 | 5.0 | GO:0055038 | recycling endosome membrane(GO:0055038) |
0.3 | 4.8 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
0.3 | 4.6 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
1.1 | 4.5 | GO:0033185 | dolichol-phosphate-mannose synthase complex(GO:0033185) |
0.9 | 4.4 | GO:0044316 | cone cell pedicle(GO:0044316) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 161 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.3 | 23.2 | GO:0030247 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
5.3 | 21.2 | GO:0031720 | haptoglobin binding(GO:0031720) |
0.1 | 15.7 | GO:0005516 | calmodulin binding(GO:0005516) |
4.8 | 14.3 | GO:0046911 | hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
0.2 | 13.2 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
2.0 | 11.9 | GO:1904315 | GABA-gated chloride ion channel activity(GO:0022851) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315) |
3.3 | 10.0 | GO:0003796 | lysozyme activity(GO:0003796) |
1.6 | 7.9 | GO:0019960 | C-X3-C chemokine binding(GO:0019960) |
0.4 | 7.9 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
0.2 | 7.9 | GO:0017046 | peptide hormone binding(GO:0017046) |
0.4 | 7.8 | GO:0031489 | myosin V binding(GO:0031489) |
0.2 | 7.6 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
2.4 | 7.1 | GO:0004517 | nitric-oxide synthase activity(GO:0004517) |
0.3 | 6.8 | GO:0043274 | phospholipase binding(GO:0043274) |
0.3 | 6.6 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
0.1 | 6.3 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
0.5 | 6.1 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
0.8 | 5.9 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
0.0 | 5.3 | GO:0044325 | ion channel binding(GO:0044325) |
0.3 | 5.1 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 32 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.3 | 23.2 | PID_INTEGRIN5_PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
0.1 | 14.8 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
0.1 | 8.3 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
0.3 | 5.9 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
0.2 | 5.3 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
0.2 | 4.5 | PID_ARF6_DOWNSTREAM_PATHWAY | Arf6 downstream pathway |
0.1 | 4.5 | PID_P53_REGULATION_PATHWAY | p53 pathway |
0.0 | 3.4 | PID_MET_PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
0.1 | 3.2 | ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
0.0 | 2.5 | PID_NOTCH_PATHWAY | Notch signaling pathway |
0.1 | 2.4 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
0.0 | 2.4 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
0.2 | 2.0 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
0.1 | 1.9 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
0.1 | 1.9 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
0.1 | 1.8 | PID_HIF1A_PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
0.1 | 1.8 | PID_INSULIN_PATHWAY | Insulin Pathway |
0.3 | 1.7 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
0.0 | 1.6 | PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY | Signaling mediated by p38-alpha and p38-beta |
0.0 | 1.6 | PID_HDAC_CLASSII_PATHWAY | Signaling events mediated by HDAC Class II |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 70 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.6 | 22.2 | REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
0.2 | 21.1 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
0.8 | 13.2 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
0.4 | 12.1 | REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
0.7 | 11.9 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
0.3 | 11.4 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
0.3 | 7.9 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
0.2 | 6.7 | REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
0.2 | 6.7 | REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
0.2 | 6.5 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
0.1 | 6.4 | REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS | Genes involved in Glucagon-type ligand receptors |
0.9 | 6.3 | REACTOME_ENDOGENOUS_STEROLS | Genes involved in Endogenous sterols |
0.4 | 6.3 | REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
0.3 | 6.0 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
0.7 | 5.9 | REACTOME_TRANSPORT_OF_ORGANIC_ANIONS | Genes involved in Transport of organic anions |
0.4 | 5.8 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
0.2 | 5.4 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |
0.3 | 5.1 | REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
0.4 | 4.5 | REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
0.1 | 4.5 | REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT | Genes involved in Mitochondrial Protein Import |