Motif ID: Cxxc1

Z-value: 0.580


Transcription factors associated with Cxxc1:

Gene SymbolEntrez IDGene Name
Cxxc1 ENSMUSG00000024560.6 Cxxc1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Cxxc1mm10_v2_chr18_+_74216118_74216145-0.621.7e-09Click!


Activity profile for motif Cxxc1.

activity profile for motif Cxxc1


Sorted Z-values histogram for motif Cxxc1

Sorted Z-values for motif Cxxc1



Network of associatons between targets according to the STRING database.



First level regulatory network of Cxxc1

PNG image of the network

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Top targets:


Showing 1 to 20 of 53 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_97415527 9.377 ENSMUST00000121799.1
 Arhgap23
Rho GTPase activating protein 23
chr11_-_89302545 5.541 ENSMUST00000061728.3
 Nog
noggin
chr19_-_19111181 4.549 ENSMUST00000112832.1
 Rorb
RAR-related orphan receptor beta
chr5_+_30588078 4.506 ENSMUST00000066295.2
 Kcnk3
potassium channel, subfamily K, member 3
chr3_-_8964037 3.549 ENSMUST00000091354.5
ENSMUST00000094381.4
 Tpd52

tumor protein D52

chr1_-_124045523 3.095 ENSMUST00000112606.1
 Dpp10
dipeptidylpeptidase 10
chr8_+_70594466 2.878 ENSMUST00000019283.9
 Isyna1
myo-inositol 1-phosphate synthase A1
chr8_-_122443404 2.796 ENSMUST00000006692.4
 Mvd
mevalonate (diphospho) decarboxylase
chr1_-_124045247 2.658 ENSMUST00000112603.2
 Dpp10
dipeptidylpeptidase 10
chr11_-_69921057 2.597 ENSMUST00000108609.1
ENSMUST00000108608.1
ENSMUST00000164359.1
 Eif5a


eukaryotic translation initiation factor 5A


chr11_-_69920581 2.508 ENSMUST00000108610.1
 Eif5a
eukaryotic translation initiation factor 5A
chrX_-_158043266 2.424 ENSMUST00000026750.8
ENSMUST00000112513.1
 Cnksr2

connector enhancer of kinase suppressor of Ras 2

chr5_-_125389177 2.194 ENSMUST00000108707.2
 Ubc
ubiquitin C
chr17_-_14203695 2.184 ENSMUST00000053218.5
 Dact2
dapper homolog 2, antagonist of beta-catenin (xenopus)
chr11_-_69920892 2.131 ENSMUST00000152589.1
ENSMUST00000108612.1
ENSMUST00000108611.1
 Eif5a


eukaryotic translation initiation factor 5A


chr3_+_68869563 1.882 ENSMUST00000054551.2
 1110032F04Rik
RIKEN cDNA 1110032F04 gene
chr2_+_112239468 1.594 ENSMUST00000028554.3
 Lpcat4
lysophosphatidylcholine acyltransferase 4
chr15_+_74516196 1.580 ENSMUST00000042035.9
 Bai1
brain-specific angiogenesis inhibitor 1
chr18_-_43477764 1.544 ENSMUST00000057110.9
 Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chr7_+_45896941 1.503 ENSMUST00000069772.7
ENSMUST00000107716.1
 Tmem143

transmembrane protein 143


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.4 GO:0043547 positive regulation of GTPase activity(GO:0043547)
1.2 7.2 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.1 5.8 GO:1903078 positive regulation of protein localization to plasma membrane(GO:1903078)
1.4 5.5 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.5 4.5 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 3.6 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.5 3.5 GO:0046549 retinal cone cell development(GO:0046549)
0.3 2.9 GO:0006020 inositol metabolic process(GO:0006020)
0.7 2.8 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.7 2.2 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
0.1 1.7 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.1 1.5 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.1 1.4 GO:0000042 protein targeting to Golgi(GO:0000042)
0.2 1.3 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.2 1.1 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.1 1.0 GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway(GO:0071880)
0.0 0.7 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.7 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 0.6 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.1 0.4 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)

Gene overrepresentation in cellular_component category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 7.2 GO:0005642 annulate lamellae(GO:0005642)
0.1 5.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 3.6 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 3.5 GO:0043209 myelin sheath(GO:0043209)
0.1 2.8 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 1.7 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 1.5 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 1.4 GO:0030137 COPI-coated vesicle(GO:0030137)
0.1 1.0 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 0.7 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.7 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.4 GO:0005096 GTPase activator activity(GO:0005096)
0.5 7.2 GO:0017070 U6 snRNA binding(GO:0017070)
1.0 5.8 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 5.5 GO:0019955 cytokine binding(GO:0019955)
1.5 4.5 GO:0008502 melatonin receptor activity(GO:0008502)
0.4 4.5 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 3.5 GO:0002020 protease binding(GO:0002020)
0.0 2.9 GO:0016853 isomerase activity(GO:0016853)
0.1 2.8 GO:0016831 carboxy-lyase activity(GO:0016831)
0.2 2.2 GO:0070097 delta-catenin binding(GO:0070097)
0.4 1.7 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.5 1.6 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.2 1.5 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 1.5 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 1.3 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.1 1.0 GO:0004016 adenylate cyclase activity(GO:0004016)
0.2 0.7 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1 0.7 GO:0048038 quinone binding(GO:0048038)
0.1 0.3 GO:0046923 ER retention sequence binding(GO:0046923)
0.1 0.3 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.3 PID_BMP_PATHWAY BMP receptor signaling
0.0 2.2 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 1.7 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.1 1.0 PID_LPA4_PATHWAY LPA4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 7.2 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.2 5.5 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.6 4.5 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 4.5 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 3.5 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 2.8 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.2 1.6 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS
0.1 1.4 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 1.0 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.7 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 0.2 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling