Motif ID: Cxxc1
Z-value: 0.580
Transcription factors associated with Cxxc1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Cxxc1 | ENSMUSG00000024560.6 | Cxxc1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Cxxc1 | mm10_v2_chr18_+_74216118_74216145 | -0.62 | 1.7e-09 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 5.5 | GO:2000313 | fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313) |
| 1.2 | 7.2 | GO:0006452 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 0.7 | 2.2 | GO:1900108 | negative regulation of nodal signaling pathway(GO:1900108) |
| 0.7 | 2.8 | GO:0019287 | isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) |
| 0.5 | 3.5 | GO:0046549 | retinal cone cell development(GO:0046549) |
| 0.5 | 4.5 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.3 | 2.9 | GO:0006020 | inositol metabolic process(GO:0006020) |
| 0.2 | 1.1 | GO:0010724 | regulation of definitive erythrocyte differentiation(GO:0010724) |
| 0.2 | 1.3 | GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743) |
| 0.1 | 1.7 | GO:0070389 | chaperone cofactor-dependent protein refolding(GO:0070389) |
| 0.1 | 1.4 | GO:0000042 | protein targeting to Golgi(GO:0000042) |
| 0.1 | 3.6 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.1 | 1.0 | GO:0071880 | adenylate cyclase-activating adrenergic receptor signaling pathway(GO:0071880) |
| 0.1 | 5.8 | GO:1903078 | positive regulation of protein localization to plasma membrane(GO:1903078) |
| 0.1 | 0.4 | GO:0060040 | retinal bipolar neuron differentiation(GO:0060040) |
| 0.1 | 1.5 | GO:0070536 | protein K63-linked deubiquitination(GO:0070536) |
| 0.0 | 0.3 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
| 0.0 | 9.4 | GO:0043547 | positive regulation of GTPase activity(GO:0043547) |
| 0.0 | 0.6 | GO:0021521 | ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573) |
| 0.0 | 0.2 | GO:0033564 | anterior/posterior axon guidance(GO:0033564) |
| 0.0 | 0.3 | GO:0046498 | S-adenosylhomocysteine metabolic process(GO:0046498) |
| 0.0 | 0.7 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.0 | 0.2 | GO:0043162 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162) |
| 0.0 | 0.7 | GO:0046513 | ceramide biosynthetic process(GO:0046513) |
| 0.0 | 0.2 | GO:0006353 | DNA-templated transcription, termination(GO:0006353) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 7.2 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.1 | 0.7 | GO:0017059 | serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211) |
| 0.1 | 2.8 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 1.5 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.1 | 1.7 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
| 0.1 | 5.8 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.1 | 1.0 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.1 | 1.4 | GO:0030137 | COPI-coated vesicle(GO:0030137) |
| 0.0 | 3.6 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 0.7 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 3.5 | GO:0043209 | myelin sheath(GO:0043209) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 4.5 | GO:0008502 | melatonin receptor activity(GO:0008502) |
| 1.0 | 5.8 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.5 | 1.6 | GO:0047192 | 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192) |
| 0.5 | 7.2 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.4 | 1.7 | GO:0050220 | prostaglandin-E synthase activity(GO:0050220) |
| 0.4 | 4.5 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.2 | 0.7 | GO:0004758 | serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454) |
| 0.2 | 1.5 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.2 | 2.2 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.1 | 1.0 | GO:0004016 | adenylate cyclase activity(GO:0004016) |
| 0.1 | 0.3 | GO:0046923 | ER retention sequence binding(GO:0046923) |
| 0.1 | 0.3 | GO:0004719 | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719) |
| 0.1 | 0.2 | GO:0004534 | transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160) 5'-3' exoribonuclease activity(GO:0004534) |
| 0.1 | 5.5 | GO:0019955 | cytokine binding(GO:0019955) |
| 0.1 | 2.8 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 0.1 | 0.7 | GO:0048038 | quinone binding(GO:0048038) |
| 0.0 | 1.3 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
| 0.0 | 9.4 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 3.5 | GO:0002020 | protease binding(GO:0002020) |
| 0.0 | 1.5 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 2.9 | GO:0016853 | isomerase activity(GO:0016853) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.3 | PID_BMP_PATHWAY | BMP receptor signaling |
| 0.1 | 1.0 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
| 0.0 | 2.2 | PID_TGFBR_PATHWAY | TGF-beta receptor signaling |
| 0.0 | 1.7 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 4.5 | REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.3 | 7.2 | REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.2 | 5.5 | REACTOME_SIGNALING_BY_BMP | Genes involved in Signaling by BMP |
| 0.2 | 1.6 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PS | Genes involved in Acyl chain remodelling of PS |
| 0.1 | 2.8 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.1 | 1.4 | REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.1 | 1.0 | REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY | Genes involved in Adenylate cyclase activating pathway |
| 0.1 | 4.5 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 3.5 | REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 0.2 | REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.0 | 0.7 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
