Motif ID: Ddit3

Z-value: 0.785


Transcription factors associated with Ddit3:

Gene SymbolEntrez IDGene Name
Ddit3 ENSMUSG00000025408.9 Ddit3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ddit3mm10_v2_chr10_+_127290774_127290803-0.394.8e-04Click!


Activity profile for motif Ddit3.

activity profile for motif Ddit3


Sorted Z-values histogram for motif Ddit3

Sorted Z-values for motif Ddit3



Network of associatons between targets according to the STRING database.



First level regulatory network of Ddit3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_103422010 11.374 ENSMUST00000182089.1
Gm26992
predicted gene, 26992
chr15_-_66948419 11.305 ENSMUST00000167817.1
Ndrg1
N-myc downstream regulated gene 1
chr19_-_59076069 9.941 ENSMUST00000047511.7
ENSMUST00000163821.1
4930506M07Rik

RIKEN cDNA 4930506M07 gene

chr10_-_109823585 8.282 ENSMUST00000161582.1
Nav3
neuron navigator 3
chr6_+_21215472 6.931 ENSMUST00000081542.5
Kcnd2
potassium voltage-gated channel, Shal-related family, member 2
chr3_-_53657339 6.119 ENSMUST00000091137.4
Frem2
Fras1 related extracellular matrix protein 2
chr4_+_103619580 6.022 ENSMUST00000106827.1
Dab1
disabled 1
chr14_-_66868572 5.802 ENSMUST00000022629.8
Dpysl2
dihydropyrimidinase-like 2
chr18_+_37421418 5.700 ENSMUST00000053073.4
Pcdhb11
protocadherin beta 11
chrX_-_162565514 5.222 ENSMUST00000154424.1
Reps2
RALBP1 associated Eps domain containing protein 2
chr3_+_9403049 4.673 ENSMUST00000180874.1
ENSMUST00000181331.1
ENSMUST00000181930.1
C030034L19Rik


RIKEN cDNA C030034L19 gene


chr2_-_45117349 4.511 ENSMUST00000176438.2
Zeb2
zinc finger E-box binding homeobox 2
chr1_-_126492900 4.480 ENSMUST00000161954.1
Nckap5
NCK-associated protein 5
chr16_-_60605226 4.349 ENSMUST00000068860.6
Epha6
Eph receptor A6
chr15_-_93595877 4.332 ENSMUST00000048982.4
Prickle1
prickle homolog 1 (Drosophila)
chr5_+_137288273 4.043 ENSMUST00000024099.4
ENSMUST00000085934.3
Ache

acetylcholinesterase

chr18_+_38993126 3.945 ENSMUST00000097593.2
Arhgap26
Rho GTPase activating protein 26
chr1_-_126492683 3.753 ENSMUST00000162877.1
Nckap5
NCK-associated protein 5
chr9_-_121495678 3.701 ENSMUST00000035120.4
Cck
cholecystokinin
chr3_-_127409014 3.496 ENSMUST00000182008.1
ENSMUST00000182711.1
ENSMUST00000182547.1
Ank2


ankyrin 2, brain


chr15_-_43869993 3.490 ENSMUST00000067469.4
Tmem74
transmembrane protein 74
chr3_-_127408986 3.479 ENSMUST00000182588.1
ENSMUST00000182959.1
ENSMUST00000182452.1
Ank2


ankyrin 2, brain


chr10_+_13501001 3.402 ENSMUST00000060212.6
ENSMUST00000121465.2
Fuca2

fucosidase, alpha-L- 2, plasma

chr3_-_127408937 3.349 ENSMUST00000183095.1
ENSMUST00000182610.1
Ank2

ankyrin 2, brain

chr3_-_127409044 3.328 ENSMUST00000182704.1
Ank2
ankyrin 2, brain
chr13_+_42680565 3.218 ENSMUST00000128646.1
Phactr1
phosphatase and actin regulator 1
chr17_-_46890405 3.115 ENSMUST00000086675.3
A330017A19Rik
RIKEN cDNA A330017A19 gene
chr6_-_99044414 3.104 ENSMUST00000177507.1
ENSMUST00000123992.1
Foxp1

forkhead box P1

chr6_-_138422898 3.070 ENSMUST00000161450.1
ENSMUST00000163024.1
ENSMUST00000162185.1
Lmo3


LIM domain only 3


chrX_-_37104523 2.972 ENSMUST00000130324.1
Upf3b
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr14_+_65970804 2.790 ENSMUST00000138191.1
Clu
clusterin
chr16_-_87432597 2.687 ENSMUST00000039449.7
Ltn1
listerin E3 ubiquitin protein ligase 1
chr14_+_65971049 2.684 ENSMUST00000128539.1
Clu
clusterin
chr16_+_78301458 2.683 ENSMUST00000023572.7
Cxadr
coxsackie virus and adenovirus receptor
chr7_+_107370728 2.639 ENSMUST00000137663.1
ENSMUST00000073459.5
Syt9

synaptotagmin IX

chr5_+_137553517 2.599 ENSMUST00000136088.1
ENSMUST00000139395.1
ENSMUST00000136565.1
ENSMUST00000149292.1
ENSMUST00000125489.1
Actl6b




actin-like 6B




chr1_+_87327008 2.532 ENSMUST00000172794.1
ENSMUST00000164992.2
Gigyf2

GRB10 interacting GYF protein 2

chr14_+_66868850 2.477 ENSMUST00000100453.1
Gm5464
predicted gene 5464
chr3_-_49757257 2.433 ENSMUST00000035931.7
Pcdh18
protocadherin 18
chr11_-_120643643 2.388 ENSMUST00000141254.1
ENSMUST00000170556.1
ENSMUST00000151876.1
ENSMUST00000026133.8
ENSMUST00000139706.1
Pycr1




pyrroline-5-carboxylate reductase 1




chr14_-_103843685 2.360 ENSMUST00000172237.1
Ednrb
endothelin receptor type B
chr7_+_18884679 2.356 ENSMUST00000032573.6
Pglyrp1
peptidoglycan recognition protein 1
chr9_-_70141484 2.329 ENSMUST00000034749.8
Fam81a
family with sequence similarity 81, member A
chr8_+_25720054 2.296 ENSMUST00000068916.8
ENSMUST00000139836.1
Ppapdc1b

phosphatidic acid phosphatase type 2 domain containing 1B

chr1_-_58586191 2.288 ENSMUST00000038372.7
ENSMUST00000097724.3
ENSMUST00000161000.1
ENSMUST00000161600.1
Fam126b



family with sequence similarity 126, member B



chr1_+_87326997 2.285 ENSMUST00000027475.8
Gigyf2
GRB10 interacting GYF protein 2
chr11_-_5152218 2.285 ENSMUST00000163299.1
ENSMUST00000062821.6
Emid1

EMI domain containing 1

chr1_+_34121250 2.226 ENSMUST00000183006.1
Dst
dystonin
chr4_+_101550411 2.212 ENSMUST00000094953.4
ENSMUST00000106933.1
Dnajc6

DnaJ (Hsp40) homolog, subfamily C, member 6

chr15_-_59082026 2.160 ENSMUST00000080371.6
Mtss1
metastasis suppressor 1
chr7_+_24112314 2.120 ENSMUST00000120006.1
ENSMUST00000005413.3
Zfp112

zinc finger protein 112

chr14_+_65971164 2.004 ENSMUST00000144619.1
Clu
clusterin
chr5_-_148399901 1.976 ENSMUST00000048116.8
Slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr8_+_106603351 1.951 ENSMUST00000000312.5
ENSMUST00000167688.1
Cdh1

cadherin 1

chr18_+_37307445 1.844 ENSMUST00000056712.2
Pcdhb4
protocadherin beta 4
chr18_+_37355271 1.793 ENSMUST00000051163.1
Pcdhb8
protocadherin beta 8
chr13_-_104816908 1.792 ENSMUST00000022228.6
Cwc27
CWC27 spliceosome-associated protein homolog (S. cerevisiae)
chr11_-_35798884 1.709 ENSMUST00000160726.2
Fbll1
fibrillarin-like 1
chr1_-_165460430 1.688 ENSMUST00000027856.7
Dcaf6
DDB1 and CUL4 associated factor 6
chr7_-_126082406 1.675 ENSMUST00000073935.5
Gsg1l
GSG1-like
chr16_-_15594507 1.627 ENSMUST00000115776.1
ENSMUST00000115777.3
Ube2v2

ubiquitin-conjugating enzyme E2 variant 2

chr8_-_99416397 1.625 ENSMUST00000155527.1
ENSMUST00000142129.1
ENSMUST00000093249.4
ENSMUST00000142475.2
ENSMUST00000128860.1
Cdh8




cadherin 8




chr6_+_86078070 1.545 ENSMUST00000032069.5
Add2
adducin 2 (beta)
chr8_-_35495487 1.433 ENSMUST00000033927.6
Eri1
exoribonuclease 1
chr2_+_181837854 1.404 ENSMUST00000029116.7
ENSMUST00000108754.1
Pcmtd2

protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2

chr3_+_58526303 1.351 ENSMUST00000138848.1
Eif2a
eukaryotic translation initiation factor 2A
chr11_-_61930197 1.350 ENSMUST00000108710.1
Akap10
A kinase (PRKA) anchor protein 10
chr9_-_44799179 1.332 ENSMUST00000114705.1
ENSMUST00000002100.7
Tmem25

transmembrane protein 25

chr7_+_120677579 1.323 ENSMUST00000060175.6
BC030336
cDNA sequence BC030336
chr1_-_195131536 1.321 ENSMUST00000075451.6
Cr1l
complement component (3b/4b) receptor 1-like
chr9_-_45906369 1.265 ENSMUST00000161187.1
Rnf214
ring finger protein 214
chr2_-_126876117 1.245 ENSMUST00000028843.5
Trpm7
transient receptor potential cation channel, subfamily M, member 7
chr13_+_45965211 1.201 ENSMUST00000038032.3
5033430I15Rik
RIKEN cDNA 5033430I15 gene
chr17_-_33781535 1.199 ENSMUST00000002360.9
Angptl4
angiopoietin-like 4
chr19_-_4042165 1.188 ENSMUST00000042700.9
Gstp2
glutathione S-transferase, pi 2
chr18_+_37333853 1.143 ENSMUST00000061717.2
Pcdhb6
protocadherin beta 6
chr12_-_69681795 1.138 ENSMUST00000183277.1
ENSMUST00000035773.7
Sos2

son of sevenless homolog 2 (Drosophila)

chr11_-_96075655 1.070 ENSMUST00000090541.5
Atp5g1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c1 (subunit 9)
chr12_+_10390756 1.057 ENSMUST00000020947.5
Rdh14
retinol dehydrogenase 14 (all-trans and 9-cis)
chr16_+_24721842 0.996 ENSMUST00000115314.2
Lpp
LIM domain containing preferred translocation partner in lipoma
chr13_-_113618549 0.983 ENSMUST00000109241.3
Snx18
sorting nexin 18
chr16_+_96145391 0.973 ENSMUST00000023913.8
ENSMUST00000135448.1
Wrb

tryptophan rich basic protein

chr11_-_79296906 0.973 ENSMUST00000068448.2
Gm9964
predicted gene 9964
chrX_+_166238901 0.942 ENSMUST00000112235.1
Gpm6b
glycoprotein m6b
chr5_-_36695969 0.917 ENSMUST00000031091.9
ENSMUST00000140063.1
D5Ertd579e

DNA segment, Chr 5, ERATO Doi 579, expressed

chr18_+_40258361 0.893 ENSMUST00000091927.4
Kctd16
potassium channel tetramerisation domain containing 16
chr16_+_35983307 0.862 ENSMUST00000004054.6
Kpna1
karyopherin (importin) alpha 1
chr15_-_27681498 0.857 ENSMUST00000100739.3
Fam105a
family with sequence similarity 105, member A
chr8_-_67818284 0.828 ENSMUST00000120071.1
Psd3
pleckstrin and Sec7 domain containing 3
chr18_+_42275353 0.806 ENSMUST00000046972.7
ENSMUST00000091920.5
Rbm27

RNA binding motif protein 27

chr2_-_120850598 0.804 ENSMUST00000028740.4
Ttbk2
tau tubulin kinase 2
chr6_+_88724667 0.759 ENSMUST00000163271.1
Mgll
monoglyceride lipase
chr7_-_42727017 0.739 ENSMUST00000166837.1
Gm17067
predicted gene 17067
chr1_+_165461037 0.730 ENSMUST00000027853.5
Mpc2
mitochondrial pyruvate carrier 2
chr16_+_35983424 0.721 ENSMUST00000173555.1
Kpna1
karyopherin (importin) alpha 1
chr1_-_39651165 0.702 ENSMUST00000053355.4
Creg2
cellular repressor of E1A-stimulated genes 2
chr2_+_119351222 0.688 ENSMUST00000028780.3
Chac1
ChaC, cation transport regulator 1
chr2_+_23069210 0.652 ENSMUST00000155602.1
Acbd5
acyl-Coenzyme A binding domain containing 5
chr6_+_71831325 0.640 ENSMUST00000064062.6
ENSMUST00000166975.1
ENSMUST00000165331.1
ENSMUST00000114151.3
ENSMUST00000101301.3
ENSMUST00000166938.1
Immt





inner membrane protein, mitochondrial





chr11_+_54303798 0.630 ENSMUST00000093106.5
Acsl6
acyl-CoA synthetase long-chain family member 6
chr1_+_174501796 0.620 ENSMUST00000030039.7
Fmn2
formin 2
chr10_-_121626316 0.597 ENSMUST00000039810.7
Xpot
exportin, tRNA (nuclear export receptor for tRNAs)
chr2_-_148443543 0.588 ENSMUST00000099269.3
Cd93
CD93 antigen
chr2_-_164071089 0.583 ENSMUST00000018466.3
Tomm34
translocase of outer mitochondrial membrane 34
chr5_+_31526989 0.578 ENSMUST00000114533.2
ENSMUST00000117262.1
ENSMUST00000117319.1
Slc4a1ap


solute carrier family 4 (anion exchanger), member 1, adaptor protein


chr11_-_96075581 0.559 ENSMUST00000107686.1
ENSMUST00000107684.1
Atp5g1

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c1 (subunit 9)

chr14_+_50807915 0.552 ENSMUST00000036126.5
Parp2
poly (ADP-ribose) polymerase family, member 2
chrX_+_94724569 0.551 ENSMUST00000101388.2
Zxdb
zinc finger, X-linked, duplicated B
chr14_-_79868398 0.523 ENSMUST00000179430.1
Gm10845
predicted gene 10845
chr10_+_112271123 0.511 ENSMUST00000092175.2
Kcnc2
potassium voltage gated channel, Shaw-related subfamily, member 2
chr2_-_164071124 0.474 ENSMUST00000109384.3
Tomm34
translocase of outer mitochondrial membrane 34
chr18_-_37644185 0.472 ENSMUST00000066272.4
Taf7
TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr5_+_32458974 0.461 ENSMUST00000015100.8
Ppp1cb
protein phosphatase 1, catalytic subunit, beta isoform
chr5_-_74531619 0.412 ENSMUST00000113542.2
ENSMUST00000072857.6
ENSMUST00000121330.1
ENSMUST00000151474.1
Scfd2



Sec1 family domain containing 2



chr9_-_95845215 0.410 ENSMUST00000093800.2
Pls1
plastin 1 (I-isoform)
chr6_-_50382831 0.403 ENSMUST00000114468.2
Osbpl3
oxysterol binding protein-like 3
chr6_-_86793522 0.379 ENSMUST00000001187.8
Anxa4
annexin A4
chr6_+_89643982 0.373 ENSMUST00000000828.6
ENSMUST00000101171.1
Txnrd3

thioredoxin reductase 3

chr11_-_78245942 0.315 ENSMUST00000002121.4
Supt6
suppressor of Ty 6
chr6_+_125494419 0.297 ENSMUST00000181266.1
Gm26728
predicted gene, 26728
chr4_-_101844023 0.294 ENSMUST00000106919.1
B020004J07Rik
RIKEN cDNA B020004J07 gene
chr6_+_71322775 0.276 ENSMUST00000065248.7
Cd8b1
CD8 antigen, beta chain 1
chr19_-_4334001 0.276 ENSMUST00000176653.1
Kdm2a
lysine (K)-specific demethylase 2A
chrM_+_2743 0.237 ENSMUST00000082392.1
mt-Nd1
mitochondrially encoded NADH dehydrogenase 1
chr1_-_64737735 0.235 ENSMUST00000063982.5
ENSMUST00000116133.2
Fzd5

frizzled homolog 5 (Drosophila)

chr11_+_110399115 0.210 ENSMUST00000020949.5
ENSMUST00000100260.1
Map2k6

mitogen-activated protein kinase kinase 6

chr9_-_108428484 0.208 ENSMUST00000076592.2
Ccdc36
coiled-coil domain containing 36
chr8_+_85080939 0.206 ENSMUST00000140621.1
BC056474
cDNA sequence BC056474
chr7_-_44892358 0.198 ENSMUST00000003049.6
Med25
mediator of RNA polymerase II transcription, subunit 25 homolog (yeast)
chr5_-_131538687 0.185 ENSMUST00000161374.1
Auts2
autism susceptibility candidate 2
chr2_-_131328982 0.184 ENSMUST00000110194.1
Rnf24
ring finger protein 24
chr11_+_110997487 0.158 ENSMUST00000106635.1
Kcnj16
potassium inwardly-rectifying channel, subfamily J, member 16
chr7_+_126776939 0.142 ENSMUST00000038614.5
ENSMUST00000170882.1
ENSMUST00000106359.1
ENSMUST00000106357.1
ENSMUST00000145762.1
ENSMUST00000132643.1
ENSMUST00000106356.1
Ypel3






yippee-like 3 (Drosophila)






chr5_-_43981757 0.138 ENSMUST00000061299.7
Fgfbp1
fibroblast growth factor binding protein 1
chr11_+_70214105 0.137 ENSMUST00000094055.3
ENSMUST00000136328.1
ENSMUST00000126296.1
ENSMUST00000153993.2
Slc16a11



solute carrier family 16 (monocarboxylic acid transporters), member 11



chr8_-_47533439 0.128 ENSMUST00000039061.8
Trappc11
trafficking protein particle complex 11
chr16_+_36041184 0.115 ENSMUST00000042203.8
Wdr5b
WD repeat domain 5B
chrX_-_57338598 0.113 ENSMUST00000033468.4
ENSMUST00000114736.1
Arhgef6

Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6

chr17_-_15564322 0.107 ENSMUST00000147532.1
Prdm9
PR domain containing 9
chr11_+_75486813 0.106 ENSMUST00000018449.4
ENSMUST00000102510.1
ENSMUST00000131283.1
Prpf8


pre-mRNA processing factor 8


chr14_-_47568427 0.085 ENSMUST00000042988.6
Atg14
autophagy related 14
chr11_+_51763682 0.082 ENSMUST00000020653.5
Sar1b
SAR1 gene homolog B (S. cerevisiae)
chr11_-_59163696 0.036 ENSMUST00000137433.1
ENSMUST00000054523.5
Iba57

IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)

chr14_-_21052120 0.014 ENSMUST00000130370.1
ENSMUST00000022371.3
Ap3m1

adaptor-related protein complex 3, mu 1 subunit

chr9_-_20644726 0.012 ENSMUST00000148631.1
ENSMUST00000131128.1
ENSMUST00000151861.1
ENSMUST00000131343.1
ENSMUST00000086458.3
Fbxl12




F-box and leucine-rich repeat protein 12




chr8_-_67818218 0.002 ENSMUST00000059374.4
Psd3
pleckstrin and Sec7 domain containing 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 6.0 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
1.5 13.7 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
1.4 4.3 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
1.2 7.5 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
1.0 11.3 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.9 2.7 GO:0086042 cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042)
0.8 2.4 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.8 2.4 GO:0051715 cytolysis in other organism(GO:0051715)
0.8 4.5 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.7 2.2 GO:0034334 adherens junction maintenance(GO:0034334)
0.7 4.0 GO:0019695 choline metabolic process(GO:0019695)
0.5 1.6 GO:0042275 error-free postreplication DNA repair(GO:0042275)
0.5 9.5 GO:0014049 positive regulation of glutamate secretion(GO:0014049)
0.4 3.4 GO:0006004 fucose metabolic process(GO:0006004)
0.4 1.6 GO:0099527 postsynapse to nucleus signaling pathway(GO:0099527)
0.4 2.0 GO:0060066 oviduct development(GO:0060066) response to indole-3-methanol(GO:0071680) cellular response to indole-3-methanol(GO:0071681)
0.4 2.2 GO:0072318 clathrin coat disassembly(GO:0072318)
0.3 1.7 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
0.3 2.4 GO:0006561 proline biosynthetic process(GO:0006561)
0.3 1.2 GO:0010961 cellular magnesium ion homeostasis(GO:0010961) calcium-dependent cell-matrix adhesion(GO:0016340)
0.3 3.1 GO:0061470 interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619)
0.3 6.4 GO:0045475 locomotor rhythm(GO:0045475)
0.2 1.4 GO:1990928 response to amino acid starvation(GO:1990928)
0.2 0.6 GO:0070649 meiotic chromosome movement towards spindle pole(GO:0016344) formin-nucleated actin cable assembly(GO:0070649)
0.2 1.0 GO:0036089 cleavage furrow formation(GO:0036089)
0.2 0.7 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.2 4.8 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.2 0.7 GO:0006751 glutathione catabolic process(GO:0006751)
0.2 1.2 GO:0051004 regulation of lipoprotein lipase activity(GO:0051004)
0.2 1.3 GO:2000258 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.1 0.6 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.1 1.4 GO:0031125 rRNA 3'-end processing(GO:0031125)
0.1 1.1 GO:2000973 regulation of pro-B cell differentiation(GO:2000973)
0.1 0.4 GO:0001951 intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896)
0.1 0.9 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.1 2.0 GO:0015809 arginine transport(GO:0015809)
0.1 1.0 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.1 0.6 GO:0010747 positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747)
0.1 2.6 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.1 0.7 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.1 2.2 GO:0008090 retrograde axonal transport(GO:0008090)
0.1 1.1 GO:0042572 retinol metabolic process(GO:0042572)
0.1 0.7 GO:0030242 pexophagy(GO:0030242)
0.1 0.2 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.1 1.5 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.1 0.2 GO:0097360 chorionic trophoblast cell proliferation(GO:0097360) regulation of chorionic trophoblast cell proliferation(GO:1901382)
0.1 6.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 0.5 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.1 0.4 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
0.1 0.3 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.1 1.8 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 0.6 GO:0051103 DNA ligation involved in DNA repair(GO:0051103)
0.1 1.6 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.1 1.7 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.1 0.8 GO:1990403 embryonic brain development(GO:1990403)
0.1 2.3 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.1 7.5 GO:0007416 synapse assembly(GO:0007416)
0.1 0.2 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.0 3.1 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.0 0.5 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.0 0.6 GO:0042407 cristae formation(GO:0042407)
0.0 0.1 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.0 0.1 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.0 0.2 GO:0032308 positive regulation of prostaglandin secretion(GO:0032308)
0.0 0.3 GO:0033184 positive regulation of histone ubiquitination(GO:0033184)
0.0 0.8 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0 1.6 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 3.2 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0 0.1 GO:0016240 autophagosome docking(GO:0016240)
0.0 0.5 GO:0035067 negative regulation of histone acetylation(GO:0035067)
0.0 4.0 GO:0048839 inner ear development(GO:0048839)
0.0 1.1 GO:0006626 protein targeting to mitochondrion(GO:0006626)
0.0 0.1 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 0.2 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.0 0.2 GO:0033194 response to hydroperoxide(GO:0033194)
0.0 0.4 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 6.5 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.6 2.2 GO:0031673 H zone(GO:0031673)
0.5 1.6 GO:0031372 UBC13-MMS2 complex(GO:0031372)
0.5 13.7 GO:0031430 M band(GO:0031430)
0.4 1.2 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.4 5.7 GO:0043083 synaptic cleft(GO:0043083)
0.3 7.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.3 4.8 GO:1990635 proximal dendrite(GO:1990635)
0.3 11.3 GO:0055038 recycling endosome membrane(GO:0055038)
0.3 3.7 GO:0043203 axon hillock(GO:0043203)
0.2 1.7 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.2 1.4 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.2 2.0 GO:0016600 flotillin complex(GO:0016600)
0.2 1.5 GO:0008290 F-actin capping protein complex(GO:0008290)
0.2 1.4 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1 2.6 GO:0016514 SWI/SNF complex(GO:0016514)
0.1 2.7 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 2.0 GO:0043196 varicosity(GO:0043196)
0.1 1.6 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.4 GO:1990357 terminal web(GO:1990357)
0.1 1.7 GO:0032279 asymmetric synapse(GO:0032279)
0.1 0.6 GO:0061617 MICOS complex(GO:0061617)
0.1 0.5 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.1 2.3 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 6.1 GO:0005604 basement membrane(GO:0005604)
0.0 0.7 GO:0031045 dense core granule(GO:0031045)
0.0 1.7 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.5 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.0 2.3 GO:0005581 collagen trimer(GO:0005581)
0.0 5.6 GO:0005903 brush border(GO:0005903)
0.0 6.8 GO:0030426 growth cone(GO:0030426)
0.0 0.7 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 13.8 GO:0005635 nuclear envelope(GO:0005635)
0.0 0.1 GO:0097629 extrinsic component of omegasome membrane(GO:0097629)
0.0 1.4 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.8 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.8 GO:0035869 ciliary transition zone(GO:0035869)
0.0 1.2 GO:0072562 blood microparticle(GO:0072562)
0.0 0.3 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 1.5 GO:0071013 catalytic step 2 spliceosome(GO:0071013)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 6.9 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
1.1 3.4 GO:0015928 alpha-L-fucosidase activity(GO:0004560) fucosidase activity(GO:0015928)
1.0 4.0 GO:0004104 cholinesterase activity(GO:0004104) choline binding(GO:0033265)
0.8 2.4 GO:0004962 endothelin receptor activity(GO:0004962)
0.6 2.4 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.6 2.4 GO:0042834 peptidoglycan binding(GO:0042834)
0.5 2.7 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.5 1.4 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
0.3 7.5 GO:0051787 misfolded protein binding(GO:0051787)
0.3 1.4 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.3 11.3 GO:0043015 gamma-tubulin binding(GO:0043015)
0.3 15.2 GO:0030507 spectrin binding(GO:0030507)
0.2 2.0 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.2 4.3 GO:0005003 ephrin receptor activity(GO:0005003)
0.2 3.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.2 0.7 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.2 4.8 GO:0070064 proline-rich region binding(GO:0070064)
0.2 2.0 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 6.0 GO:0042169 SH2 domain binding(GO:0042169)
0.1 0.7 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.1 0.5 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.1 4.5 GO:0070412 R-SMAD binding(GO:0070412)
0.1 0.6 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.1 3.2 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 1.7 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.1 1.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 1.1 GO:0008106 alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.1 0.6 GO:0001849 complement component C1q binding(GO:0001849)
0.1 2.2 GO:0003785 actin monomer binding(GO:0003785)
0.1 3.0 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 0.4 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.1 0.7 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 1.6 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 1.2 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.3 GO:0045322 unmethylated CpG binding(GO:0045322)
0.0 5.8 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds(GO:0016810)
0.0 1.8 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 1.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.1 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.3 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.0 0.6 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 0.5 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 1.7 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 3.1 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 1.4 GO:0051018 protein kinase A binding(GO:0051018)
0.0 1.5 GO:0000049 tRNA binding(GO:0000049)
0.0 0.8 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 1.2 GO:0017022 myosin binding(GO:0017022)
0.0 1.0 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.7 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.1 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 2.2 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 3.1 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 5.4 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.2 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.5 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 18.8 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 6.0 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 4.3 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 2.0 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.1 4.0 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 3.1 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 2.4 PID_ENDOTHELIN_PATHWAY Endothelins
0.0 1.6 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt
0.0 1.1 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.0 2.2 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 2.2 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.4 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.0 3.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.9 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.2 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 2.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.2 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 0.6 PID_TELOMERASE_PATHWAY Regulation of Telomerase

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.8 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.3 2.0 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.2 7.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 4.0 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.1 2.7 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 1.6 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 1.6 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 7.5 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 1.9 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 1.1 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 3.0 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.1 2.2 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 2.0 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 1.6 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.2 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.6 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 4.1 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.4 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 2.1 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY Genes involved in Generic Transcription Pathway
0.0 1.4 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production