Motif ID: Dlx1

Z-value: 1.111


Transcription factors associated with Dlx1:

Gene SymbolEntrez IDGene Name
Dlx1 ENSMUSG00000041911.3 Dlx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dlx1mm10_v2_chr2_+_71528657_715286830.652.2e-10Click!


Activity profile for motif Dlx1.

activity profile for motif Dlx1


Sorted Z-values histogram for motif Dlx1

Sorted Z-values for motif Dlx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Dlx1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_121953213 15.340 ENSMUST00000037958.7
ENSMUST00000128366.1
 Arhgap29

Rho GTPase activating protein 29

chr4_-_14621805 15.205 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr15_-_8710734 14.530 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr6_-_36811361 14.132 ENSMUST00000101534.1
 Ptn
pleiotrophin
chrX_+_150547375 13.252 ENSMUST00000066337.6
ENSMUST00000112715.1
 Alas2

aminolevulinic acid synthase 2, erythroid

chr19_-_11604828 12.552 ENSMUST00000025582.4
 Ms4a6d
membrane-spanning 4-domains, subfamily A, member 6D
chr15_-_8710409 12.378 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr12_+_84069325 10.702 ENSMUST00000046422.4
ENSMUST00000072505.4
 Acot5

acyl-CoA thioesterase 5

chr4_+_102570065 10.457 ENSMUST00000097950.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr11_-_42182924 10.270 ENSMUST00000020707.5
ENSMUST00000132971.1
 Gabra1

gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1

chr7_-_140154712 10.042 ENSMUST00000059241.7
 Sprn
shadow of prion protein
chr7_-_45103747 9.970 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter
chr15_-_37458523 9.921 ENSMUST00000116445.2
 Ncald
neurocalcin delta
chr5_+_107403496 9.640 ENSMUST00000049146.5
 Ephx4
epoxide hydrolase 4
chr5_+_66968416 9.550 ENSMUST00000038188.7
 Limch1
LIM and calponin homology domains 1
chr5_+_66968559 9.372 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chr4_-_138396438 9.177 ENSMUST00000105032.2
 Fam43b
family with sequence similarity 43, member B
chr4_-_14621494 8.936 ENSMUST00000149633.1
 Slc26a7
solute carrier family 26, member 7
chr8_+_66386292 8.274 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr4_-_14621669 8.162 ENSMUST00000143105.1
 Slc26a7
solute carrier family 26, member 7

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 175 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.6 32.3 GO:0019532 oxalate transport(GO:0019532)
6.7 26.9 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.1 19.9 GO:0007416 synapse assembly(GO:0007416)
0.1 18.3 GO:0031032 actomyosin structure organization(GO:0031032)
1.4 17.9 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 15.9 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.8 14.9 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
4.7 14.1 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
3.3 13.3 GO:0038128 ERBB2 signaling pathway(GO:0038128)
2.7 10.7 GO:0032788 saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
0.1 10.7 GO:0030032 lamellipodium assembly(GO:0030032)
0.2 10.4 GO:0006605 protein targeting(GO:0006605)
1.1 10.3 GO:0071420 cellular response to histamine(GO:0071420)
1.0 9.3 GO:0001574 ganglioside biosynthetic process(GO:0001574)
2.2 8.7 GO:0010700 negative regulation of norepinephrine secretion(GO:0010700)
0.5 8.3 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
1.0 8.2 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
2.7 8.1 GO:0071492 cellular response to UV-A(GO:0071492)
1.1 8.0 GO:0046549 retinal cone cell development(GO:0046549)
1.1 7.8 GO:0060267 positive regulation of respiratory burst(GO:0060267)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 63.8 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 25.3 GO:0005887 integral component of plasma membrane(GO:0005887)
0.3 20.9 GO:0031594 neuromuscular junction(GO:0031594)
0.0 18.6 GO:0005615 extracellular space(GO:0005615)
0.7 17.9 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 17.4 GO:0000139 Golgi membrane(GO:0000139)
0.1 15.9 GO:0070382 exocytic vesicle(GO:0070382)
0.6 10.7 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.7 10.3 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 10.0 GO:0005759 mitochondrial matrix(GO:0005759)
0.2 9.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 9.6 GO:0031225 anchored component of membrane(GO:0031225)
0.0 8.6 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 8.4 GO:0009897 external side of plasma membrane(GO:0009897)
0.9 8.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.3 8.2 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 8.0 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 7.1 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
1.4 6.9 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.2 6.9 GO:0031672 A band(GO:0031672)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 135 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.9 32.3 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
3.6 21.3 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
1.0 16.4 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.1 15.3 GO:0030165 PDZ domain binding(GO:0030165)
0.4 14.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 14.2 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
4.7 14.1 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.4 13.8 GO:0043014 alpha-tubulin binding(GO:0043014)
4.6 13.7 GO:0016748 succinyltransferase activity(GO:0016748)
1.3 10.6 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
1.7 10.3 GO:1904315 GABA-gated chloride ion channel activity(GO:0022851) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
2.0 10.0 GO:0019770 IgG receptor activity(GO:0019770)
0.1 10.0 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 9.9 GO:0005509 calcium ion binding(GO:0005509)
1.3 9.3 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.2 9.2 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 9.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
1.4 8.2 GO:0070699 type II activin receptor binding(GO:0070699)
2.7 8.0 GO:0008502 melatonin receptor activity(GO:0008502)
0.4 8.0 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 14.1 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 7.1 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 6.7 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 6.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 4.6 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 3.2 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 3.1 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.1 3.0 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 3.0 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.2 2.8 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.1 2.8 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 2.6 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 2.5 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 2.3 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 2.1 PID_EPO_PATHWAY EPO signaling pathway
0.0 2.1 PID_RAC1_PATHWAY RAC1 signaling pathway
0.1 2.0 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 2.0 PID_CXCR4_PATHWAY CXCR4-mediated signaling events
0.1 1.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 1.5 PID_RB_1PATHWAY Regulation of retinoblastoma protein

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 53.1 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.5 17.9 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.7 16.1 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.9 15.9 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 13.6 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.5 13.2 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.6 10.3 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.3 9.8 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.2 8.7 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.2 8.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 7.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.3 7.1 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.7 6.9 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 6.5 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.6 6.3 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.5 6.1 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.6 5.8 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.6 5.7 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.2 4.9 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.5 4.8 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis