Motif ID: Dlx1
Z-value: 1.111
Transcription factors associated with Dlx1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Dlx1 | ENSMUSG00000041911.3 | Dlx1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Dlx1 | mm10_v2_chr2_+_71528657_71528683 | 0.65 | 2.2e-10 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.7 | 26.9 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
| 4.7 | 14.1 | GO:1904395 | positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) |
| 4.6 | 32.3 | GO:0019532 | oxalate transport(GO:0019532) |
| 3.3 | 13.3 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
| 2.7 | 8.1 | GO:0071492 | cellular response to UV-A(GO:0071492) |
| 2.7 | 10.7 | GO:0032788 | saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789) |
| 2.6 | 7.7 | GO:0046110 | xanthine metabolic process(GO:0046110) |
| 2.2 | 8.7 | GO:0010700 | negative regulation of norepinephrine secretion(GO:0010700) |
| 2.0 | 6.1 | GO:0071336 | white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338) |
| 1.7 | 6.9 | GO:0010808 | positive regulation of synaptic vesicle priming(GO:0010808) |
| 1.7 | 6.6 | GO:0072592 | oxygen metabolic process(GO:0072592) |
| 1.4 | 5.7 | GO:1901475 | pyruvate transmembrane transport(GO:1901475) |
| 1.4 | 5.7 | GO:1900533 | medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535) |
| 1.4 | 17.9 | GO:1901898 | negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 1.3 | 6.3 | GO:0015803 | branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820) |
| 1.1 | 10.3 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 1.1 | 8.0 | GO:0046549 | retinal cone cell development(GO:0046549) |
| 1.1 | 7.8 | GO:0060267 | positive regulation of respiratory burst(GO:0060267) |
| 1.0 | 9.3 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 1.0 | 8.2 | GO:0097118 | neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118) |
| 1.0 | 6.0 | GO:0032713 | negative regulation of interleukin-4 production(GO:0032713) |
| 1.0 | 5.0 | GO:0002121 | inter-male aggressive behavior(GO:0002121) |
| 1.0 | 3.0 | GO:0072204 | cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) |
| 1.0 | 2.9 | GO:0060478 | acrosomal vesicle exocytosis(GO:0060478) |
| 1.0 | 2.9 | GO:0031038 | myosin II filament organization(GO:0031038) regulation of myosin II filament organization(GO:0043519) |
| 0.9 | 2.8 | GO:0002554 | serotonin secretion by platelet(GO:0002554) interleukin-3 production(GO:0032632) beta selection(GO:0043366) |
| 0.8 | 14.9 | GO:0042541 | hemoglobin biosynthetic process(GO:0042541) |
| 0.8 | 3.1 | GO:0001692 | histamine metabolic process(GO:0001692) imidazole-containing compound catabolic process(GO:0052805) |
| 0.7 | 6.7 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
| 0.7 | 5.0 | GO:0010273 | detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169) |
| 0.7 | 2.1 | GO:0019085 | early viral transcription(GO:0019085) |
| 0.7 | 2.0 | GO:2001180 | negative regulation of interleukin-18 production(GO:0032701) negative regulation of interleukin-10 secretion(GO:2001180) |
| 0.7 | 6.1 | GO:0035887 | aortic smooth muscle cell differentiation(GO:0035887) |
| 0.7 | 2.0 | GO:0009838 | abscission(GO:0009838) positive regulation of viral budding via host ESCRT complex(GO:1903774) |
| 0.6 | 4.3 | GO:0015824 | proline transport(GO:0015824) |
| 0.6 | 1.8 | GO:0033364 | mast cell secretory granule organization(GO:0033364) |
| 0.6 | 3.0 | GO:0052428 | modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428) |
| 0.6 | 2.4 | GO:0046368 | GDP-L-fucose metabolic process(GO:0046368) |
| 0.6 | 5.0 | GO:0046541 | saliva secretion(GO:0046541) |
| 0.5 | 1.6 | GO:0006556 | S-adenosylmethionine biosynthetic process(GO:0006556) |
| 0.5 | 5.7 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.5 | 3.0 | GO:0061622 | glycolytic process through glucose-1-phosphate(GO:0061622) |
| 0.5 | 2.0 | GO:0006668 | sphinganine-1-phosphate metabolic process(GO:0006668) |
| 0.5 | 8.3 | GO:0002495 | antigen processing and presentation of peptide antigen via MHC class II(GO:0002495) |
| 0.5 | 2.7 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
| 0.4 | 0.9 | GO:0072488 | ammonium transmembrane transport(GO:0072488) |
| 0.4 | 1.3 | GO:0051792 | medium-chain fatty acid biosynthetic process(GO:0051792) |
| 0.4 | 1.3 | GO:2000312 | regulation of kainate selective glutamate receptor activity(GO:2000312) |
| 0.4 | 3.0 | GO:0016185 | synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185) |
| 0.4 | 1.7 | GO:0010891 | negative regulation of sequestering of triglyceride(GO:0010891) positive regulation of triglyceride catabolic process(GO:0010898) |
| 0.4 | 1.1 | GO:1904742 | regulation of telomeric DNA binding(GO:1904742) |
| 0.4 | 1.5 | GO:2001106 | regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106) |
| 0.4 | 2.9 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.4 | 3.2 | GO:0098789 | pre-mRNA cleavage required for polyadenylation(GO:0098789) |
| 0.4 | 1.4 | GO:1903336 | negative regulation of vacuolar transport(GO:1903336) |
| 0.3 | 1.0 | GO:1904956 | regulation of midbrain dopaminergic neuron differentiation(GO:1904956) |
| 0.3 | 1.0 | GO:0061743 | motor learning(GO:0061743) |
| 0.3 | 5.6 | GO:0048240 | sperm capacitation(GO:0048240) |
| 0.3 | 1.3 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 0.3 | 2.5 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.3 | 2.5 | GO:0042167 | porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149) |
| 0.3 | 3.1 | GO:1990118 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
| 0.3 | 3.9 | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) |
| 0.3 | 3.3 | GO:0045607 | regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980) |
| 0.3 | 1.2 | GO:0046604 | positive regulation of mitotic centrosome separation(GO:0046604) |
| 0.3 | 0.9 | GO:2000564 | antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187) |
| 0.3 | 2.3 | GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743) |
| 0.3 | 0.8 | GO:0070543 | response to linoleic acid(GO:0070543) |
| 0.3 | 1.6 | GO:0016255 | attachment of GPI anchor to protein(GO:0016255) |
| 0.3 | 4.8 | GO:0006953 | acute-phase response(GO:0006953) |
| 0.3 | 2.4 | GO:0035095 | behavioral response to nicotine(GO:0035095) |
| 0.3 | 0.5 | GO:0009106 | lipoate metabolic process(GO:0009106) |
| 0.2 | 2.5 | GO:1990253 | cellular response to leucine starvation(GO:1990253) |
| 0.2 | 4.9 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.2 | 5.4 | GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482) |
| 0.2 | 2.2 | GO:0042415 | norepinephrine metabolic process(GO:0042415) |
| 0.2 | 1.0 | GO:0006432 | phenylalanyl-tRNA aminoacylation(GO:0006432) |
| 0.2 | 2.2 | GO:0051001 | negative regulation of nitric-oxide synthase activity(GO:0051001) |
| 0.2 | 2.1 | GO:0006682 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
| 0.2 | 5.7 | GO:1902259 | regulation of delayed rectifier potassium channel activity(GO:1902259) |
| 0.2 | 0.7 | GO:1901856 | negative regulation of cellular respiration(GO:1901856) |
| 0.2 | 15.9 | GO:0003073 | regulation of systemic arterial blood pressure(GO:0003073) |
| 0.2 | 3.0 | GO:0030497 | fatty acid elongation(GO:0030497) |
| 0.2 | 1.2 | GO:0030223 | neutrophil differentiation(GO:0030223) |
| 0.2 | 0.8 | GO:0010749 | regulation of nitric oxide mediated signal transduction(GO:0010749) |
| 0.2 | 2.4 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 0.2 | 0.6 | GO:0007525 | somatic muscle development(GO:0007525) |
| 0.2 | 4.7 | GO:0030212 | hyaluronan metabolic process(GO:0030212) |
| 0.2 | 10.4 | GO:0006605 | protein targeting(GO:0006605) |
| 0.2 | 1.3 | GO:0045002 | double-strand break repair via single-strand annealing(GO:0045002) |
| 0.2 | 2.0 | GO:0051923 | sulfation(GO:0051923) |
| 0.2 | 1.1 | GO:0015791 | polyol transport(GO:0015791) |
| 0.2 | 1.4 | GO:0006451 | selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451) |
| 0.2 | 1.2 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 0.2 | 0.5 | GO:0006097 | glyoxylate cycle(GO:0006097) |
| 0.2 | 0.3 | GO:0060467 | negative regulation of fertilization(GO:0060467) |
| 0.2 | 3.3 | GO:0001886 | endothelial cell morphogenesis(GO:0001886) |
| 0.2 | 1.5 | GO:0036123 | histone H3-K9 dimethylation(GO:0036123) |
| 0.2 | 3.4 | GO:0031115 | negative regulation of microtubule polymerization(GO:0031115) |
| 0.1 | 0.7 | GO:0006048 | glucosamine metabolic process(GO:0006041) UDP-N-acetylglucosamine biosynthetic process(GO:0006048) |
| 0.1 | 0.9 | GO:0072318 | clathrin coat disassembly(GO:0072318) |
| 0.1 | 0.8 | GO:0036438 | positive regulation of heterotypic cell-cell adhesion(GO:0034116) maintenance of lens transparency(GO:0036438) |
| 0.1 | 2.3 | GO:0090036 | regulation of protein kinase C signaling(GO:0090036) |
| 0.1 | 4.5 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
| 0.1 | 10.7 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 0.1 | 19.9 | GO:0007416 | synapse assembly(GO:0007416) |
| 0.1 | 4.9 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.1 | 4.8 | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading(GO:1900026) |
| 0.1 | 1.0 | GO:0009101 | glycoprotein biosynthetic process(GO:0009101) |
| 0.1 | 18.3 | GO:0031032 | actomyosin structure organization(GO:0031032) |
| 0.1 | 0.3 | GO:0006990 | positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990) |
| 0.1 | 0.3 | GO:0045575 | basophil activation involved in immune response(GO:0002276) basophil activation(GO:0045575) |
| 0.1 | 1.7 | GO:0007274 | neuromuscular synaptic transmission(GO:0007274) |
| 0.1 | 3.4 | GO:0007528 | neuromuscular junction development(GO:0007528) |
| 0.1 | 0.4 | GO:0006780 | uroporphyrinogen III biosynthetic process(GO:0006780) |
| 0.1 | 2.7 | GO:0010971 | positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) |
| 0.1 | 2.5 | GO:0060765 | regulation of androgen receptor signaling pathway(GO:0060765) |
| 0.1 | 2.1 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.1 | 0.6 | GO:0036462 | TRAIL-activated apoptotic signaling pathway(GO:0036462) |
| 0.1 | 7.4 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 0.1 | 3.0 | GO:0006829 | zinc II ion transport(GO:0006829) |
| 0.1 | 2.2 | GO:0048148 | behavioral response to cocaine(GO:0048148) |
| 0.1 | 1.6 | GO:0006613 | cotranslational protein targeting to membrane(GO:0006613) |
| 0.1 | 0.9 | GO:0034390 | smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391) |
| 0.1 | 0.4 | GO:0052695 | cellular glucuronidation(GO:0052695) |
| 0.1 | 0.2 | GO:0060126 | somatotropin secreting cell differentiation(GO:0060126) |
| 0.1 | 0.7 | GO:0036376 | sodium ion export from cell(GO:0036376) |
| 0.1 | 0.5 | GO:0061087 | positive regulation of histone H3-K27 methylation(GO:0061087) |
| 0.1 | 2.9 | GO:0006506 | GPI anchor biosynthetic process(GO:0006506) |
| 0.1 | 0.8 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 0.1 | 3.6 | GO:1904893 | negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893) |
| 0.1 | 0.9 | GO:0097186 | amelogenesis(GO:0097186) |
| 0.1 | 1.1 | GO:0060261 | positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) |
| 0.1 | 2.4 | GO:0008333 | endosome to lysosome transport(GO:0008333) |
| 0.1 | 0.6 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
| 0.1 | 1.2 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.1 | 1.7 | GO:0034314 | Arp2/3 complex-mediated actin nucleation(GO:0034314) |
| 0.1 | 2.2 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.1 | 2.5 | GO:0006418 | tRNA aminoacylation for protein translation(GO:0006418) |
| 0.1 | 0.1 | GO:0061357 | Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357) |
| 0.1 | 0.5 | GO:0071222 | response to molecule of bacterial origin(GO:0002237) response to lipopolysaccharide(GO:0032496) cellular response to molecule of bacterial origin(GO:0071219) cellular response to lipopolysaccharide(GO:0071222) |
| 0.1 | 0.5 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.1 | 0.4 | GO:0070317 | negative regulation of G0 to G1 transition(GO:0070317) |
| 0.1 | 0.6 | GO:0070995 | NADPH oxidation(GO:0070995) |
| 0.0 | 3.2 | GO:0006612 | protein targeting to membrane(GO:0006612) |
| 0.0 | 4.4 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) |
| 0.0 | 1.4 | GO:0006790 | sulfur compound metabolic process(GO:0006790) |
| 0.0 | 0.9 | GO:0032292 | myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292) |
| 0.0 | 0.4 | GO:0061032 | visceral serous pericardium development(GO:0061032) |
| 0.0 | 0.5 | GO:0001682 | tRNA 5'-leader removal(GO:0001682) |
| 0.0 | 0.2 | GO:0015819 | lysine transport(GO:0015819) ornithine transport(GO:0015822) |
| 0.0 | 1.2 | GO:0007050 | cell cycle arrest(GO:0007050) |
| 0.0 | 1.5 | GO:0032755 | positive regulation of interleukin-6 production(GO:0032755) |
| 0.0 | 0.2 | GO:1990564 | protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592) |
| 0.0 | 1.3 | GO:0032456 | endocytic recycling(GO:0032456) |
| 0.0 | 0.7 | GO:0001824 | blastocyst development(GO:0001824) |
| 0.0 | 0.9 | GO:1901016 | regulation of potassium ion transmembrane transporter activity(GO:1901016) |
| 0.0 | 2.5 | GO:0006641 | triglyceride metabolic process(GO:0006641) |
| 0.0 | 1.2 | GO:0030514 | negative regulation of BMP signaling pathway(GO:0030514) |
| 0.0 | 4.9 | GO:0030336 | negative regulation of cell migration(GO:0030336) |
| 0.0 | 1.1 | GO:0042982 | amyloid precursor protein metabolic process(GO:0042982) |
| 0.0 | 0.4 | GO:0006103 | 2-oxoglutarate metabolic process(GO:0006103) |
| 0.0 | 1.1 | GO:0051438 | regulation of ubiquitin-protein transferase activity(GO:0051438) |
| 0.0 | 1.6 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.0 | 0.6 | GO:0048873 | homeostasis of number of cells within a tissue(GO:0048873) |
| 0.0 | 0.1 | GO:1902528 | regulation of protein linear polyubiquitination(GO:1902528) positive regulation of protein linear polyubiquitination(GO:1902530) |
| 0.0 | 0.9 | GO:0030968 | endoplasmic reticulum unfolded protein response(GO:0030968) |
| 0.0 | 0.4 | GO:0071385 | cellular response to glucocorticoid stimulus(GO:0071385) |
| 0.0 | 1.0 | GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway(GO:2001243) |
| 0.0 | 0.2 | GO:0019321 | pentose metabolic process(GO:0019321) |
| 0.0 | 0.1 | GO:0030163 | protein catabolic process(GO:0030163) |
| 0.0 | 0.8 | GO:0060048 | cardiac muscle contraction(GO:0060048) |
| 0.0 | 0.3 | GO:0046677 | response to antibiotic(GO:0046677) |
| 0.0 | 0.2 | GO:0003417 | growth plate cartilage development(GO:0003417) |
| 0.0 | 1.3 | GO:0016579 | protein deubiquitination(GO:0016579) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 6.9 | GO:0098831 | presynaptic active zone cytoplasmic component(GO:0098831) |
| 1.0 | 3.0 | GO:0098835 | presynaptic endosome(GO:0098830) presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) |
| 0.9 | 8.2 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.7 | 3.0 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 0.7 | 2.8 | GO:0019815 | B cell receptor complex(GO:0019815) |
| 0.7 | 17.9 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.7 | 10.3 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.7 | 6.7 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
| 0.6 | 10.7 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.5 | 1.6 | GO:0048269 | methionine adenosyltransferase complex(GO:0048269) |
| 0.5 | 1.6 | GO:0097637 | intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637) |
| 0.5 | 2.6 | GO:1990131 | Gtr1-Gtr2 GTPase complex(GO:1990131) |
| 0.5 | 2.1 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.5 | 2.5 | GO:0000839 | Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839) |
| 0.5 | 6.8 | GO:0042581 | specific granule(GO:0042581) |
| 0.4 | 3.4 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.3 | 2.4 | GO:0070695 | FHF complex(GO:0070695) |
| 0.3 | 2.3 | GO:0097524 | sperm plasma membrane(GO:0097524) |
| 0.3 | 3.3 | GO:0034709 | methylosome(GO:0034709) |
| 0.3 | 1.0 | GO:0009328 | phenylalanine-tRNA ligase complex(GO:0009328) |
| 0.3 | 1.5 | GO:0033553 | rDNA heterochromatin(GO:0033553) |
| 0.3 | 1.2 | GO:0030981 | cortical microtubule cytoskeleton(GO:0030981) |
| 0.3 | 3.9 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.3 | 20.9 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.3 | 1.6 | GO:0042765 | GPI-anchor transamidase complex(GO:0042765) |
| 0.3 | 3.2 | GO:0002178 | palmitoyltransferase complex(GO:0002178) |
| 0.3 | 8.2 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.2 | 1.7 | GO:0036195 | muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195) |
| 0.2 | 2.4 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.2 | 1.4 | GO:0097443 | sorting endosome(GO:0097443) |
| 0.2 | 63.8 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.2 | 9.8 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.2 | 1.8 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.2 | 0.6 | GO:0030690 | Noc1p-Noc2p complex(GO:0030690) |
| 0.2 | 1.3 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.2 | 6.7 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.2 | 2.0 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 0.2 | 3.5 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.2 | 6.9 | GO:0031672 | A band(GO:0031672) |
| 0.2 | 3.2 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.2 | 2.4 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.2 | 1.6 | GO:0016272 | prefoldin complex(GO:0016272) |
| 0.2 | 5.6 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.1 | 0.7 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.1 | 2.1 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.1 | 4.9 | GO:0016235 | aggresome(GO:0016235) |
| 0.1 | 3.3 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.1 | 6.0 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.1 | 2.5 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.1 | 8.0 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.1 | 2.7 | GO:0005865 | striated muscle thin filament(GO:0005865) myofilament(GO:0036379) |
| 0.1 | 2.3 | GO:0009986 | cell surface(GO:0009986) |
| 0.1 | 7.1 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.1 | 0.9 | GO:0005688 | U6 snRNP(GO:0005688) |
| 0.1 | 1.4 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.1 | 15.9 | GO:0070382 | exocytic vesicle(GO:0070382) |
| 0.1 | 9.6 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 3.3 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.1 | 2.9 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.1 | 0.9 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.1 | 17.4 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.1 | 1.4 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 8.4 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 3.0 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.1 | 0.2 | GO:0005594 | collagen type IX trimer(GO:0005594) |
| 0.1 | 3.8 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 3.6 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 1.3 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.1 | 1.0 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.0 | 0.6 | GO:0030061 | mitochondrial crista(GO:0030061) |
| 0.0 | 3.0 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 8.6 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 2.1 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 25.3 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.0 | 0.7 | GO:0044291 | cell-cell contact zone(GO:0044291) |
| 0.0 | 2.9 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.0 | 0.5 | GO:0031462 | Cul2-RING ubiquitin ligase complex(GO:0031462) |
| 0.0 | 10.0 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 0.4 | GO:0000812 | Swr1 complex(GO:0000812) |
| 0.0 | 0.5 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.0 | 0.5 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.0 | 1.7 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 0.7 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 0.4 | GO:0036038 | MKS complex(GO:0036038) |
| 0.0 | 18.6 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 1.1 | GO:0005903 | brush border(GO:0005903) |
| 0.0 | 0.7 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.0 | 1.2 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 0.8 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 0.4 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.0 | 0.4 | GO:0005838 | proteasome regulatory particle(GO:0005838) |
| 0.0 | 0.1 | GO:0045252 | dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252) |
| 0.0 | 0.2 | GO:0043189 | NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562) |
| 0.0 | 4.3 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 0.9 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 1.6 | GO:0001650 | fibrillar center(GO:0001650) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.7 | 14.1 | GO:0035373 | chondroitin sulfate proteoglycan binding(GO:0035373) |
| 4.6 | 13.7 | GO:0016748 | succinyltransferase activity(GO:0016748) |
| 3.6 | 21.3 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 2.9 | 32.3 | GO:0019531 | secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531) |
| 2.7 | 8.0 | GO:0008502 | melatonin receptor activity(GO:0008502) |
| 2.2 | 6.5 | GO:0008113 | peptide-methionine (S)-S-oxide reductase activity(GO:0008113) |
| 2.0 | 10.0 | GO:0019770 | IgG receptor activity(GO:0019770) |
| 1.9 | 7.7 | GO:0030151 | molybdenum ion binding(GO:0030151) |
| 1.7 | 10.3 | GO:1904315 | GABA-gated chloride ion channel activity(GO:0022851) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315) |
| 1.6 | 6.6 | GO:0004966 | galanin receptor activity(GO:0004966) |
| 1.5 | 6.1 | GO:0005111 | type 2 fibroblast growth factor receptor binding(GO:0005111) |
| 1.4 | 5.7 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
| 1.4 | 8.2 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 1.3 | 6.7 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
| 1.3 | 9.3 | GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665) |
| 1.3 | 10.6 | GO:0015193 | L-proline transmembrane transporter activity(GO:0015193) |
| 1.2 | 4.8 | GO:0003836 | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836) |
| 1.1 | 6.6 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 1.0 | 16.4 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 1.0 | 3.0 | GO:0019166 | trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166) |
| 0.8 | 5.8 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.8 | 3.2 | GO:0004427 | inorganic diphosphatase activity(GO:0004427) |
| 0.7 | 3.0 | GO:0003872 | 6-phosphofructokinase activity(GO:0003872) |
| 0.7 | 2.1 | GO:0030171 | voltage-gated proton channel activity(GO:0030171) |
| 0.7 | 2.0 | GO:0050656 | 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656) |
| 0.6 | 2.5 | GO:0004074 | biliverdin reductase activity(GO:0004074) |
| 0.6 | 1.7 | GO:0005128 | erythropoietin receptor binding(GO:0005128) |
| 0.5 | 2.1 | GO:0047275 | glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275) |
| 0.5 | 2.5 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.5 | 2.9 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
| 0.4 | 8.0 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.4 | 14.5 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.4 | 3.0 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.4 | 1.3 | GO:0008534 | oxidized purine nucleobase lesion DNA N-glycosylase activity(GO:0008534) |
| 0.4 | 5.0 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.4 | 4.9 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
| 0.4 | 3.2 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
| 0.4 | 13.8 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.4 | 3.1 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
| 0.4 | 2.5 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.3 | 2.8 | GO:0004716 | receptor signaling protein tyrosine kinase activity(GO:0004716) |
| 0.3 | 1.3 | GO:0004315 | 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315) |
| 0.3 | 1.6 | GO:0034235 | GPI anchor binding(GO:0034235) |
| 0.3 | 2.7 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.3 | 2.4 | GO:0008417 | fucosyltransferase activity(GO:0008417) |
| 0.3 | 0.8 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 0.3 | 0.8 | GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109) |
| 0.3 | 6.4 | GO:0042287 | MHC protein binding(GO:0042287) |
| 0.3 | 1.1 | GO:0015254 | glycerol channel activity(GO:0015254) |
| 0.3 | 2.1 | GO:0070290 | N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290) |
| 0.3 | 2.1 | GO:0070180 | large ribosomal subunit rRNA binding(GO:0070180) |
| 0.3 | 1.3 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.3 | 3.0 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.2 | 3.0 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
| 0.2 | 4.8 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.2 | 1.1 | GO:0022821 | calcium, potassium:sodium antiporter activity(GO:0008273) potassium ion antiporter activity(GO:0022821) |
| 0.2 | 1.6 | GO:0045134 | uridine-diphosphatase activity(GO:0045134) |
| 0.2 | 9.2 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.2 | 1.5 | GO:0046974 | histone methyltransferase activity (H3-K9 specific)(GO:0046974) |
| 0.2 | 1.0 | GO:0004826 | phenylalanine-tRNA ligase activity(GO:0004826) |
| 0.2 | 7.8 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.2 | 1.9 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
| 0.2 | 0.5 | GO:0004450 | isocitrate dehydrogenase (NADP+) activity(GO:0004450) |
| 0.2 | 3.2 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.2 | 1.0 | GO:0050694 | galactose 3-O-sulfotransferase activity(GO:0050694) |
| 0.2 | 0.6 | GO:0035877 | death effector domain binding(GO:0035877) |
| 0.2 | 6.9 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.2 | 1.7 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.1 | 1.7 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.1 | 0.5 | GO:0008475 | procollagen-lysine 5-dioxygenase activity(GO:0008475) |
| 0.1 | 3.3 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.1 | 0.5 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 0.1 | 2.3 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.1 | 14.2 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.1 | 0.1 | GO:0031852 | mu-type opioid receptor binding(GO:0031852) |
| 0.1 | 0.7 | GO:0002135 | CTP binding(GO:0002135) |
| 0.1 | 0.3 | GO:0004568 | chitinase activity(GO:0004568) |
| 0.1 | 15.3 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.1 | 0.7 | GO:0031748 | D1 dopamine receptor binding(GO:0031748) |
| 0.1 | 4.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 9.0 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 6.2 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.1 | 3.1 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.1 | 1.4 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
| 0.1 | 3.4 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.1 | 2.1 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.1 | 2.4 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
| 0.1 | 1.2 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.1 | 1.2 | GO:0031702 | type 1 angiotensin receptor binding(GO:0031702) |
| 0.1 | 1.2 | GO:0005242 | inward rectifier potassium channel activity(GO:0005242) |
| 0.1 | 3.0 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.1 | 2.3 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
| 0.1 | 0.6 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 0.1 | 0.9 | GO:0022842 | leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842) |
| 0.1 | 0.4 | GO:0004852 | uroporphyrinogen-III synthase activity(GO:0004852) |
| 0.1 | 0.5 | GO:0042609 | CD4 receptor binding(GO:0042609) |
| 0.1 | 0.8 | GO:0008106 | alcohol dehydrogenase (NADP+) activity(GO:0008106) |
| 0.1 | 2.9 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.1 | 10.0 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.1 | 2.8 | GO:0016876 | aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876) |
| 0.1 | 0.2 | GO:0071568 | UFM1 transferase activity(GO:0071568) |
| 0.1 | 2.9 | GO:0004601 | peroxidase activity(GO:0004601) |
| 0.1 | 2.4 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.1 | 1.1 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.1 | 0.2 | GO:0000064 | L-ornithine transmembrane transporter activity(GO:0000064) |
| 0.0 | 0.5 | GO:0004526 | ribonuclease P activity(GO:0004526) |
| 0.0 | 3.4 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 2.0 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.0 | 3.1 | GO:0008170 | N-methyltransferase activity(GO:0008170) |
| 0.0 | 4.9 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.0 | 0.8 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.0 | 1.8 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 1.4 | GO:0000049 | tRNA binding(GO:0000049) |
| 0.0 | 0.9 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.0 | 1.1 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.0 | 1.8 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 1.2 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.0 | 0.4 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.0 | 0.6 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 9.9 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 1.4 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 0.3 | GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) |
| 0.0 | 1.0 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 1.6 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.0 | 3.2 | GO:0016791 | phosphatase activity(GO:0016791) |
| 0.0 | 0.5 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
| 0.0 | 1.3 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 0.2 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.0 | 0.9 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.0 | 0.8 | GO:0005179 | hormone activity(GO:0005179) |
| 0.0 | 0.5 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.0 | 0.7 | GO:0048029 | monosaccharide binding(GO:0048029) |
| 0.0 | 0.5 | GO:0016298 | lipase activity(GO:0016298) |
| 0.0 | 0.4 | GO:0042826 | histone deacetylase binding(GO:0042826) |
| 0.0 | 3.4 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 14.1 | PID_SYNDECAN_3_PATHWAY | Syndecan-3-mediated signaling events |
| 0.3 | 4.6 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
| 0.2 | 2.8 | PID_NFKAPPAB_ATYPICAL_PATHWAY | Atypical NF-kappaB pathway |
| 0.1 | 6.7 | PID_IL2_PI3K_PATHWAY | IL2 signaling events mediated by PI3K |
| 0.1 | 2.0 | PID_S1P_META_PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.1 | 3.0 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.1 | 2.8 | PID_REG_GR_PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 2.1 | PID_EPO_PATHWAY | EPO signaling pathway |
| 0.1 | 0.6 | SA_FAS_SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.1 | 3.2 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.1 | 1.5 | PID_RB_1PATHWAY | Regulation of retinoblastoma protein |
| 0.1 | 1.8 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 1.3 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 2.1 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
| 0.0 | 6.2 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 2.3 | PID_TRKR_PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 0.8 | PID_ER_NONGENOMIC_PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.0 | 3.1 | PID_MET_PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.0 | 7.1 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 2.6 | PID_MTOR_4PATHWAY | mTOR signaling pathway |
| 0.0 | 2.0 | PID_CXCR4_PATHWAY | CXCR4-mediated signaling events |
| 0.0 | 2.5 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 0.6 | PID_PI3KCI_PATHWAY | Class I PI3K signaling events |
| 0.0 | 3.0 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 1.2 | PID_PDGFRB_PATHWAY | PDGFR-beta signaling pathway |
| 0.0 | 0.8 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 15.9 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.7 | 16.1 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.7 | 6.9 | REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.6 | 5.8 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
| 0.6 | 10.3 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
| 0.6 | 5.7 | REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.6 | 6.3 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.5 | 53.1 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.5 | 6.1 | REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR1 ligand binding and activation |
| 0.5 | 4.8 | REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.5 | 17.9 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
| 0.5 | 13.2 | REACTOME_NEPHRIN_INTERACTIONS | Genes involved in Nephrin interactions |
| 0.3 | 7.1 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.3 | 9.8 | REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.3 | 2.0 | REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.3 | 2.9 | REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.2 | 1.9 | REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.2 | 4.9 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI | Genes involved in N-glycan antennae elongation in the medial/trans-Golgi |
| 0.2 | 3.4 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.2 | 8.7 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.2 | 8.0 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.2 | 3.2 | REACTOME_CRMPS_IN_SEMA3A_SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 2.5 | REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.1 | 1.1 | REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.1 | 2.8 | REACTOME_REGULATION_OF_SIGNALING_BY_CBL | Genes involved in Regulation of signaling by CBL |
| 0.1 | 1.1 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.1 | 2.8 | REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.1 | 7.8 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 1.3 | REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.1 | 1.8 | REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.1 | 0.9 | REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION | Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| 0.1 | 1.7 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 0.9 | REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.1 | 13.6 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 3.0 | REACTOME_GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 6.5 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 1.2 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.1 | 2.0 | REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.1 | 1.6 | REACTOME_SULFUR_AMINO_ACID_METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 0.7 | REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION | Genes involved in Sema3A PAK dependent Axon repulsion |
| 0.1 | 1.5 | REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.1 | 1.9 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.1 | 0.9 | REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.1 | 1.3 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 0.6 | REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.0 | 1.6 | REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
| 0.0 | 0.3 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.0 | 0.6 | REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.0 | 0.4 | REACTOME_GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 0.9 | REACTOME_CA_DEPENDENT_EVENTS | Genes involved in Ca-dependent events |
| 0.0 | 1.0 | REACTOME_TRNA_AMINOACYLATION | Genes involved in tRNA Aminoacylation |
| 0.0 | 2.6 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 4.8 | REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.0 | 1.3 | REACTOME_LYSOSOME_VESICLE_BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.0 | 2.1 | REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.0 | 0.7 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 0.2 | REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
